CZ282759B6 - Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje - Google Patents

Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje Download PDF

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Publication number
CZ282759B6
CZ282759B6 CZ94395A CZ39594A CZ282759B6 CZ 282759 B6 CZ282759 B6 CZ 282759B6 CZ 94395 A CZ94395 A CZ 94395A CZ 39594 A CZ39594 A CZ 39594A CZ 282759 B6 CZ282759 B6 CZ 282759B6
Authority
CZ
Czechia
Prior art keywords
isatinoxime
group
formula
branched
carbon atoms
Prior art date
Application number
CZ94395A
Other languages
Czech (cs)
English (en)
Other versions
CZ39594A3 (en
Inventor
Frank Watjen
Bjarne Hugo Dahl
Jorgen Drejer
Leif Helth Jensen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of CZ39594A3 publication Critical patent/CZ39594A3/cs
Publication of CZ282759B6 publication Critical patent/CZ282759B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CZ94395A 1991-08-28 1992-08-27 Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje CZ282759B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75116591A 1991-08-28 1991-08-28
US83185192A 1992-02-05 1992-02-05
PCT/EP1992/001999 WO1993005043A1 (en) 1991-08-28 1992-08-27 Novel isatinoxime derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
CZ39594A3 CZ39594A3 (en) 1994-11-16
CZ282759B6 true CZ282759B6 (cs) 1997-09-17

Family

ID=27115380

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ94395A CZ282759B6 (cs) 1991-08-28 1992-08-27 Derivát isatinoximu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje

Country Status (18)

Country Link
EP (1) EP0529636B1 (enrdf_load_stackoverflow)
JP (1) JP3170584B2 (enrdf_load_stackoverflow)
KR (1) KR100277481B1 (enrdf_load_stackoverflow)
AT (1) ATE181552T1 (enrdf_load_stackoverflow)
AU (1) AU655672B2 (enrdf_load_stackoverflow)
CA (1) CA2076948C (enrdf_load_stackoverflow)
CZ (1) CZ282759B6 (enrdf_load_stackoverflow)
DE (1) DE69229461T2 (enrdf_load_stackoverflow)
DK (1) DK0529636T3 (enrdf_load_stackoverflow)
FI (1) FI107156B (enrdf_load_stackoverflow)
GE (1) GEP20002329B (enrdf_load_stackoverflow)
HU (2) HUT70753A (enrdf_load_stackoverflow)
MX (1) MX9204914A (enrdf_load_stackoverflow)
NO (1) NO301117B1 (enrdf_load_stackoverflow)
PL (1) PL170920B1 (enrdf_load_stackoverflow)
RU (1) RU2114827C1 (enrdf_load_stackoverflow)
SK (1) SK280578B6 (enrdf_load_stackoverflow)
WO (1) WO1993005043A1 (enrdf_load_stackoverflow)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502483A (ja) 1992-10-13 1996-03-19 ワーナー−ランバート・コンパニー 新規なキノキサリンジオン誘導体、それらの製造および使用
US5843945A (en) * 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
CA2161783C (en) * 1993-05-13 2006-08-15 Frank Watjen Ampa antagonists and a method of treatment therewith
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
JP3164372B2 (ja) * 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ 融合インドール及びキノキサリン誘導体、その製造および使用
NZ293265A (en) * 1994-09-14 1998-01-26 Neurosearch As 5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring
UA54403C2 (uk) * 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2768624B1 (fr) 1997-09-25 1999-11-12 Oreal Utilisation d'un inhibiteur d'acides amines excitateurs dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue
ATE420636T1 (de) 1999-05-19 2009-01-15 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
DE60120925T2 (de) 2000-01-24 2006-11-09 Neurosearch A/S Isatinderivate mit neurotropen aktivität
JP4505410B2 (ja) 2002-10-29 2010-07-21 サングキュンクワン ユニヴァースィティ モルヒネへの心理的依存又は耐性を防止及び処置するのに有効成分としてベルベリンを含有する医薬組成物
KR20080070749A (ko) 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
UA118182C2 (uk) * 2012-12-19 2018-12-10 Байєр Кропсайєнс Акцієнгезелльшафт Дифторметилнікотинові інданілкарбоксаміди
WO2015129592A1 (ja) * 2014-02-28 2015-09-03 住友化学株式会社 ２－（ハロゲノメチル）－３－メチルニトロベンゼンの製造方法
CA3017751A1 (en) * 2016-03-17 2017-09-21 Fmc Corporation Process for converting s-enantiomer to its racemic form
CN112266368B (zh) * 2017-11-15 2024-03-19 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
CN108912127B (zh) * 2018-08-27 2019-12-10 青岛农业大学 一种基于靛红骨架的苯并[b,e]氮杂卓化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use

Also Published As

Publication number Publication date
HU211632A9 (en) 1995-12-28
SK23894A3 (en) 1994-12-07
MX9204914A (es) 1993-07-01
EP0529636A1 (en) 1993-03-03
RU2114827C1 (ru) 1998-07-10
DE69229461D1 (de) 1999-07-29
CA2076948C (en) 2002-04-16
FI940889A7 (fi) 1994-02-25
AU2482092A (en) 1993-04-05
NO940676L (enrdf_load_stackoverflow) 1994-04-27
AU655672B2 (en) 1995-01-05
EP0529636B1 (en) 1999-06-23
JP3170584B2 (ja) 2001-05-28
HUT70753A (en) 1995-10-30
GEP20002329B (en) 2000-12-25
WO1993005043A1 (en) 1993-03-18
ATE181552T1 (de) 1999-07-15
JPH06510056A (ja) 1994-11-10
FI107156B (fi) 2001-06-15
HU9400595D0 (en) 1994-05-30
CA2076948A1 (en) 1993-03-01
NO940676D0 (no) 1994-02-25
SK280578B6 (sk) 2000-04-10
CZ39594A3 (en) 1994-11-16
FI940889A0 (fi) 1994-02-25
PL170920B1 (pl) 1997-02-28
DK0529636T3 (da) 1999-12-13
NO301117B1 (no) 1997-09-15
DE69229461T2 (de) 1999-10-21
KR100277481B1 (ko) 2001-02-01

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20030827