CZ261493A3 - Pharmacologically active compounds, process of their preparation and pharmaceutical preparations in which they are comprised - Google Patents
Pharmacologically active compounds, process of their preparation and pharmaceutical preparations in which they are comprised Download PDFInfo
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- CZ261493A3 CZ261493A3 CZ932614A CZ261493A CZ261493A3 CZ 261493 A3 CZ261493 A3 CZ 261493A3 CZ 932614 A CZ932614 A CZ 932614A CZ 261493 A CZ261493 A CZ 261493A CZ 261493 A3 CZ261493 A3 CZ 261493A3
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 112
- 238000000034 method Methods 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 13
- 230000008569 process Effects 0.000 title claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
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- 108090000695 Cytokines Proteins 0.000 claims abstract description 11
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- 208000006673 asthma Diseases 0.000 claims abstract description 4
- 201000008482 osteoarthritis Diseases 0.000 claims abstract description 4
- 208000035475 disorder Diseases 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 48
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 33
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 239000002207 metabolite Substances 0.000 claims description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 238000000855 fermentation Methods 0.000 claims description 11
- 230000004151 fermentation Effects 0.000 claims description 11
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- 125000006239 protecting group Chemical group 0.000 claims description 6
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
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- Urology & Nephrology (AREA)
- Botany (AREA)
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929225396A GB9225396D0 (en) | 1992-12-04 | 1992-12-04 | Improvements in or relating to organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ261493A3 true CZ261493A3 (en) | 1994-07-13 |
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| CZ932614A CZ261493A3 (en) | 1992-12-04 | 1993-12-02 | Pharmacologically active compounds, process of their preparation and pharmaceutical preparations in which they are comprised |
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|---|---|
| EP (1) | EP0606044A1 (enExample) |
| JP (1) | JPH06228122A (enExample) |
| KR (1) | KR940014377A (enExample) |
| CN (1) | CN1095417A (enExample) |
| AU (1) | AU5211293A (enExample) |
| CA (1) | CA2110553A1 (enExample) |
| CZ (1) | CZ261493A3 (enExample) |
| FI (1) | FI935409L (enExample) |
| GB (1) | GB9225396D0 (enExample) |
| HU (1) | HUT65910A (enExample) |
| IL (1) | IL107838A0 (enExample) |
| MX (1) | MX9307608A (enExample) |
| NO (1) | NO934372L (enExample) |
| NZ (1) | NZ250344A (enExample) |
| PL (1) | PL301281A1 (enExample) |
| SK (1) | SK135493A3 (enExample) |
| TW (1) | TW258736B (enExample) |
| ZA (1) | ZA939088B (enExample) |
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| DE4228328C2 (de) * | 1992-08-26 | 1999-02-11 | Agie Sa | Maschine und Verfahren zum funkenerosiven Drahtschneiden mit einer im Querschnitt verformten Drahtelektrode |
| US5795910A (en) * | 1994-10-28 | 1998-08-18 | Cor Therapeutics, Inc. | Method and compositions for inhibiting protein kinases |
| US5731343A (en) * | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
| EP0823429B1 (en) * | 1995-04-26 | 2000-07-12 | Kyowa Hakko Kogyo Co., Ltd. | Radicicol derivatives |
| WO2000038674A1 (en) * | 1998-12-24 | 2000-07-06 | Novation Pharmaceuticals Inc. | COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR |
| US7115651B2 (en) | 2000-08-25 | 2006-10-03 | Sloan-Kettering Institute For Cancer Research | Macrocycles and uses thereof |
| JP2004292315A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | Ｔａｋ１阻害剤 |
| JP2004292314A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
| GB0112522D0 (en) * | 2001-05-23 | 2001-07-11 | Ici Plc | Catalytic process |
| US7915306B2 (en) | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| US7799827B2 (en) * | 2002-03-08 | 2010-09-21 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
| US20050182129A1 (en) * | 2002-04-17 | 2005-08-18 | Akiko Ikeda | Hair growth tonic |
| EP1794137A4 (en) * | 2004-09-27 | 2009-12-02 | Kosan Biosciences Inc | SPECIFIC KINASE INHIBITORS |
| US7601852B2 (en) | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
| JP5484327B2 (ja) | 2007-07-25 | 2014-05-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癌の処置において使用するための多キナーゼインヒビター |
| ATE545023T1 (de) | 2007-10-29 | 2012-02-15 | Eisai R&D Man Co Ltd | Verfahren zur vorhersage der fähigkeit einer zearalenon-analogverbindung für die krebsbehandlung |
| US8350059B2 (en) | 2007-12-07 | 2013-01-08 | Eisai R&D Management Co., Ltd. | Intermediates and methods for making zearalenone macrolide analogs |
| EP2337788B1 (en) | 2008-10-17 | 2016-03-23 | Wisconsin Alumni Research Foundation | Method of making biologically active alpha-beta peptides |
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| US3196019A (en) * | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
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1993
- 1993-11-29 EP EP93810835A patent/EP0606044A1/en not_active Withdrawn
- 1993-12-02 CA CA002110553A patent/CA2110553A1/en not_active Abandoned
- 1993-12-02 AU AU52112/93A patent/AU5211293A/en not_active Abandoned
- 1993-12-02 MX MX9307608A patent/MX9307608A/es unknown
- 1993-12-02 SK SK1354-93A patent/SK135493A3/sk unknown
- 1993-12-02 NZ NZ250344A patent/NZ250344A/en unknown
- 1993-12-02 PL PL93301281A patent/PL301281A1/xx unknown
- 1993-12-02 FI FI935409A patent/FI935409L/fi not_active Application Discontinuation
- 1993-12-02 IL IL10783893A patent/IL107838A0/xx unknown
- 1993-12-02 NO NO934372A patent/NO934372L/no unknown
- 1993-12-02 CZ CZ932614A patent/CZ261493A3/cs unknown
- 1993-12-03 CN CN93120777A patent/CN1095417A/zh active Pending
- 1993-12-03 ZA ZA939088A patent/ZA939088B/xx unknown
- 1993-12-03 HU HU9303444A patent/HUT65910A/hu unknown
- 1993-12-03 JP JP5303866A patent/JPH06228122A/ja active Pending
- 1993-12-03 KR KR1019930026567A patent/KR940014377A/ko not_active Withdrawn
- 1993-12-06 TW TW082110279A patent/TW258736B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| AU5211293A (en) | 1994-06-16 |
| ZA939088B (en) | 1995-06-05 |
| KR940014377A (ko) | 1994-07-18 |
| NO934372D0 (no) | 1993-12-02 |
| NO934372L (no) | 1994-06-06 |
| PL301281A1 (en) | 1994-06-13 |
| IL107838A0 (en) | 1994-04-12 |
| CN1095417A (zh) | 1994-11-23 |
| EP0606044A1 (en) | 1994-07-13 |
| CA2110553A1 (en) | 1994-06-05 |
| HU9303444D0 (en) | 1994-04-28 |
| SK135493A3 (en) | 1994-08-10 |
| FI935409A7 (fi) | 1994-06-05 |
| NZ250344A (en) | 1995-10-26 |
| HUT65910A (en) | 1994-07-28 |
| MX9307608A (es) | 1995-01-31 |
| GB9225396D0 (en) | 1993-01-27 |
| TW258736B (enExample) | 1995-10-01 |
| JPH06228122A (ja) | 1994-08-16 |
| FI935409A0 (fi) | 1993-12-02 |
| FI935409L (fi) | 1994-06-05 |
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