NO934372L - Nye forbindelser og farmasöytisk preparat derav - Google Patents

Nye forbindelser og farmasöytisk preparat derav

Info

Publication number
NO934372L
NO934372L NO934372A NO934372A NO934372L NO 934372 L NO934372 L NO 934372L NO 934372 A NO934372 A NO 934372A NO 934372 A NO934372 A NO 934372A NO 934372 L NO934372 L NO 934372L
Authority
NO
Norway
Prior art keywords
pharmaceutical preparations
new compounds
release
cytokine release
disease
Prior art date
Application number
NO934372A
Other languages
English (en)
Other versions
NO934372D0 (no
Inventor
Michael Morris Dreyfuss
Albert Leutwiler
Andrew Roland Mackenzie
Jorg Schnyder
Rene Paul Traber
Henri Mattes
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO934372D0 publication Critical patent/NO934372D0/no
Publication of NO934372L publication Critical patent/NO934372L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Abstract

Nye forbindelser med formel (I) hvor Rt, R5, R6, -a-b-, c, -d-e- og -f-g- har en rekke angitte betydninger, er cytokinfrigivelsesinhibitorer og IL-1 anta- gonister og er således indikert for behandling av sykdommer med en aetiologi assosiert med eller omfattende utstrakt cytokinfrigivelse, særlig IL-lfi frigivelse, som inkluderer en rekke forskjellige inflammatoriske tilstander og sykdommer som RA, osteoartritt, septisk sjokk, psoriasis, arterosclerose, inflammatorisk tarmsykdom, Crohn's sykdom og astma. Nærlig- gende kjente forbindelser som zearalenon og radicicol og derivater derav er også blitt funnet å inhibere cytokinfri- givelse og har lignende farmasøytiske anvendelser.
NO934372A 1992-12-04 1993-12-02 Nye forbindelser og farmasöytisk preparat derav NO934372L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929225396A GB9225396D0 (en) 1992-12-04 1992-12-04 Improvements in or relating to organic compounds

Publications (2)

Publication Number Publication Date
NO934372D0 NO934372D0 (no) 1993-12-02
NO934372L true NO934372L (no) 1994-06-06

Family

ID=10726140

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934372A NO934372L (no) 1992-12-04 1993-12-02 Nye forbindelser og farmasöytisk preparat derav

Country Status (18)

Country Link
EP (1) EP0606044A1 (no)
JP (1) JPH06228122A (no)
KR (1) KR940014377A (no)
CN (1) CN1095417A (no)
AU (1) AU5211293A (no)
CA (1) CA2110553A1 (no)
CZ (1) CZ261493A3 (no)
FI (1) FI935409A (no)
GB (1) GB9225396D0 (no)
HU (1) HUT65910A (no)
IL (1) IL107838A0 (no)
MX (1) MX9307608A (no)
NO (1) NO934372L (no)
NZ (1) NZ250344A (no)
PL (1) PL301281A1 (no)
SK (1) SK135493A3 (no)
TW (1) TW258736B (no)
ZA (1) ZA939088B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228328C2 (de) * 1992-08-26 1999-02-11 Agie Sa Maschine und Verfahren zum funkenerosiven Drahtschneiden mit einer im Querschnitt verformten Drahtelektrode
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
US5731343A (en) * 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
AU700840B2 (en) * 1995-04-26 1999-01-14 Kyowa Hakko Kogyo Co. Ltd. Radicicol derivatives
US6635671B1 (en) 1998-12-24 2003-10-21 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
EP1315732B1 (en) 2000-08-25 2006-06-07 Sloan-Kettering Institute For Cancer Research Radicicol and monocillin and their analogues and uses thereof
JP2004292315A (ja) * 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
JP2004292314A (ja) * 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
GB0112522D0 (en) * 2001-05-23 2001-07-11 Ici Plc Catalytic process
EP2308861B1 (en) 2002-03-08 2017-03-01 Eisai R&D Management Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
RU2312863C2 (ru) * 2002-04-17 2007-12-20 Тайсо Фармасьютикал Ко., Лтд. Тоник для роста волос
EP1794137A4 (en) * 2004-09-27 2009-12-02 Kosan Biosciences Inc SPECIFIC KINASE INHIBITORS
US7601852B2 (en) 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
CN105748465A (zh) 2007-07-25 2016-07-13 卫材R&D管理株式会社 用于治疗癌症的多激酶抑制剂
ATE545023T1 (de) 2007-10-29 2012-02-15 Eisai R&D Man Co Ltd Verfahren zur vorhersage der fähigkeit einer zearalenon-analogverbindung für die krebsbehandlung
RU2497803C2 (ru) 2007-12-07 2013-11-10 ЭЙСАЙ Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД Промежуточные продукты в синтезе аналогов зеараленоновых макролидов
BRPI0920246A2 (pt) 2008-10-17 2017-06-27 Winconsin Alumni Res Foundation método de preparação de alfa-beta peptídios biologicamente ativos.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196019A (en) * 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making

Also Published As

Publication number Publication date
NO934372D0 (no) 1993-12-02
EP0606044A1 (en) 1994-07-13
FI935409A (fi) 1994-06-05
TW258736B (no) 1995-10-01
CN1095417A (zh) 1994-11-23
FI935409A0 (fi) 1993-12-02
CZ261493A3 (en) 1994-07-13
SK135493A3 (en) 1994-08-10
JPH06228122A (ja) 1994-08-16
GB9225396D0 (en) 1993-01-27
HUT65910A (en) 1994-07-28
KR940014377A (ko) 1994-07-18
MX9307608A (es) 1995-01-31
NZ250344A (en) 1995-10-26
CA2110553A1 (en) 1994-06-05
IL107838A0 (en) 1994-04-12
PL301281A1 (en) 1994-06-13
HU9303444D0 (en) 1994-04-28
ZA939088B (en) 1995-06-05
AU5211293A (en) 1994-06-16

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