CZ171095A3 - Novel steroidal derivatives specific for colon or ilium - Google Patents
Novel steroidal derivatives specific for colon or ilium Download PDFInfo
- Publication number
- CZ171095A3 CZ171095A3 CZ951710A CZ171095A CZ171095A3 CZ 171095 A3 CZ171095 A3 CZ 171095A3 CZ 951710 A CZ951710 A CZ 951710A CZ 171095 A CZ171095 A CZ 171095A CZ 171095 A3 CZ171095 A3 CZ 171095A3
- Authority
- CZ
- Czechia
- Prior art keywords
- compound
- sugar
- formula
- gcs
- epimer
- Prior art date
Links
- 0 C[C@@](C[C@@](C)(C(CC1*2(C)C)C3CC(C*4)[C@]5*)[C@@]12C(CO)=O)[C@]34[C@@](C)(CCC1C)C5=CC1=O Chemical compound C[C@@](C[C@@](C)(C(CC1*2(C)C)C3CC(C*4)[C@]5*)[C@@]12C(CO)=O)[C@]34[C@@](C)(CCC1C)C5=CC1=O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9300030A SE9300030D0 (sv) | 1993-01-08 | 1993-01-08 | Novel colon- or ileum-specific steroid derivatives |
| SE9300082A SE9300082D0 (sv) | 1993-01-14 | 1993-01-14 | Novel colon- or ileum-specific steroid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ171095A3 true CZ171095A3 (en) | 1996-01-17 |
Family
ID=26661623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ951710A CZ171095A3 (en) | 1993-01-08 | 1993-12-17 | Novel steroidal derivatives specific for colon or ilium |
Country Status (22)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3366640B2 (ja) * | 1993-01-08 | 2003-01-14 | アストラ・アクチエボラーグ | 新規な結腸−または回腸−特異的ステロイド誘導体 |
| DE69425439D1 (de) * | 1993-09-29 | 2000-09-07 | Nissin Food Products Ltd | In stellung 21 substituierte steroide |
| US6028190A (en) | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
| US6166024A (en) | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| JP4610734B2 (ja) * | 1998-03-19 | 2011-01-12 | 三笠製薬株式会社 | ２１−置換グリコシルステロイド化合物 |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
| DE60021720T2 (de) | 1999-05-04 | 2006-06-01 | Strakan International Ltd. | Androgen glykoside und die androgenische aktivität davon |
| US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| EP1183014B1 (en) | 1999-06-14 | 2003-10-08 | Cosmo S.p.A. | Controlled release and taste masking oral pharmaceutical compositions |
| AU2001225363A1 (en) * | 2000-01-14 | 2001-07-24 | Strakan Limited | Glycosides and orthoester glycosides of glucocorticoids and uses thereof |
| SE0101220D0 (sv) * | 2001-04-04 | 2001-04-04 | Astrazeneca Ab | New use |
| DE602004017164D1 (de) * | 2004-08-09 | 2008-11-27 | Deutsches Krebsforsch | Albuminkonjugate, die eine Glucuron-Verknüpfung enthalten |
| US20080200441A1 (en) * | 2007-02-14 | 2008-08-21 | University Of Southern California | Estrogen receptor modulators associated pharmaceutical compositions and methods of use |
| US10154964B2 (en) | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
| US10711032B2 (en) | 2016-11-08 | 2020-07-14 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| EP3604322B1 (en) * | 2017-03-30 | 2023-10-18 | Fruithy Holdings Limited | Lactulose glycoside compound and preparation method and use thereof |
| US11491237B2 (en) | 2017-05-18 | 2022-11-08 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
| IL313068A (en) | 2017-11-07 | 2024-07-01 | Regeneron Pharma | Hydrophilic linkers for drug-antibody conjugates |
| SG11202006510XA (en) * | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
| CN112533951A (zh) | 2018-05-09 | 2021-03-19 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE378109B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| US3992534A (en) * | 1972-05-19 | 1976-11-16 | Ab Bofors | Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods |
| US3996359A (en) * | 1972-05-19 | 1976-12-07 | Ab Bofors | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
| SE378110B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| US3938233A (en) * | 1974-08-12 | 1976-02-17 | Cannon Robert B | Heat transfer apparatus |
| DE2967070D1 (en) * | 1978-01-25 | 1984-08-02 | Schering Ag | 11,17-substituted pregnanes, their preparation and application for the preparation of pharmaceutical compositions |
| DE2803660A1 (de) * | 1978-01-25 | 1979-07-26 | Schering Ag | Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung |
| US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
| SE8008524L (sv) * | 1980-12-04 | 1982-06-05 | Draco Ab | 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand |
| US4456602A (en) * | 1982-08-23 | 1984-06-26 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4472392A (en) * | 1983-01-21 | 1984-09-18 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
| US4469689A (en) * | 1983-03-30 | 1984-09-04 | The Upjohn Company | Sulfonate containing ester prodrugs of corticosteroids |
| WO1984004041A1 (en) * | 1983-04-14 | 1984-10-25 | Univ California | Colon-specific drug delivery system |
| US4548922A (en) * | 1983-06-06 | 1985-10-22 | Beth Israel Hospital | Drug administration |
| US4959358A (en) * | 1983-06-06 | 1990-09-25 | Beth Israel Hospital Assn. | Drug administration |
| SE8306370D0 (sv) * | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
| US4588718A (en) * | 1984-03-28 | 1986-05-13 | The Upjohn Company | Carboxy containing ester prodrugs of corticosteroids |
| SE8403905D0 (sv) * | 1984-07-30 | 1984-07-30 | Draco Ab | Liposomes and steroid esters |
| US5215979A (en) * | 1985-12-19 | 1993-06-01 | Aktiebolaget Draco | 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
| GB8600489D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside steroids |
| GB8600490D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid lactams |
| GB8600491D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid derivatives |
| AU594468B2 (en) * | 1986-05-12 | 1990-03-08 | Mect Corporation | Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system |
| CA1299653C (en) * | 1988-07-07 | 1992-04-28 | Markwell Medical Institute, Inc. | Biological fluid measuring device |
| US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
| SE8903914D0 (sv) * | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
| US5888995A (en) * | 1991-02-04 | 1999-03-30 | Astra Aktiebolag | Steroid esters |
| SE9100342D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroid esters |
| SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
| WO1993022334A1 (en) * | 1992-05-04 | 1993-11-11 | Sri International | Pharmaceutical compositions and methods for colonic delivery of corticosteroids |
| JP3366640B2 (ja) * | 1993-01-08 | 2003-01-14 | アストラ・アクチエボラーグ | 新規な結腸−または回腸−特異的ステロイド誘導体 |
-
1993
- 1993-12-17 JP JP51591394A patent/JP3366640B2/ja not_active Expired - Lifetime
- 1993-12-17 WO PCT/SE1993/001081 patent/WO1994015947A1/en not_active Application Discontinuation
- 1993-12-17 AT AT94904364T patent/ATE183192T1/de not_active IP Right Cessation
- 1993-12-17 RU RU95115547/04A patent/RU95115547A/ru unknown
- 1993-12-17 KR KR1019950702801A patent/KR960700266A/ko not_active Withdrawn
- 1993-12-17 SK SK872-95A patent/SK87295A3/sk unknown
- 1993-12-17 BR BR9307746A patent/BR9307746A/pt not_active Application Discontinuation
- 1993-12-17 CA CA002152374A patent/CA2152374A1/en not_active Abandoned
- 1993-12-17 CZ CZ951710A patent/CZ171095A3/cs unknown
- 1993-12-17 FI FI953358A patent/FI953358A0/fi unknown
- 1993-12-17 NZ NZ259596A patent/NZ259596A/xx unknown
- 1993-12-17 PL PL93309777A patent/PL178307B1/pl unknown
- 1993-12-17 HU HU9502087A patent/HU221584B/hu not_active IP Right Cessation
- 1993-12-17 ES ES94904364T patent/ES2137353T3/es not_active Expired - Lifetime
- 1993-12-17 EP EP94904364A patent/EP0678097B1/en not_active Expired - Lifetime
- 1993-12-17 DK DK94904364T patent/DK0678097T3/da active
- 1993-12-22 IS IS4111A patent/IS4111A/is unknown
-
1994
- 1994-07-04 TW TW083106090A patent/TW261615B/zh active
-
1995
- 1995-07-05 LV LVP-95-207A patent/LV10961B/en unknown
- 1995-07-06 NO NO952683A patent/NO305367B1/no unknown
-
1996
- 1996-12-13 US US08/764,985 patent/US5908833A/en not_active Expired - Lifetime
-
1999
- 1999-03-03 US US09/261,247 patent/US6140308A/en not_active Expired - Lifetime
- 1999-11-09 GR GR990402882T patent/GR3031789T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic |