TW261615B - - Google Patents

Info

Publication number
TW261615B
TW261615B TW083106090A TW83106090A TW261615B TW 261615 B TW261615 B TW 261615B TW 083106090 A TW083106090 A TW 083106090A TW 83106090 A TW83106090 A TW 83106090A TW 261615 B TW261615 B TW 261615B
Authority
TW
Taiwan
Prior art keywords
compounds
gcs
sugar1
gcs1
glucocorticosteroid
Prior art date
Application number
TW083106090A
Other languages
English (en)
Chinese (zh)
Inventor
Erik Ulmius Jan
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of TW261615B publication Critical patent/TW261615B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
TW083106090A 1993-01-08 1994-07-04 TW261615B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives

Publications (1)

Publication Number Publication Date
TW261615B true TW261615B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-11-01

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083106090A TW261615B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-01-08 1994-07-04

Country Status (22)

Country Link
US (2) US5908833A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0678097B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3366640B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR960700266A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE183192T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9307746A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2152374A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ171095A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0678097T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2137353T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI953358A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3031789T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU221584B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IS (1) IS4111A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LV (1) LV10961B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO305367B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ259596A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL178307B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU95115547A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK87295A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW261615B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1994015947A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3366640B2 (ja) * 1993-01-08 2003-01-14 アストラ・アクチエボラーグ 新規な結腸−または回腸−特異的ステロイド誘導体
DE69425439D1 (de) * 1993-09-29 2000-09-07 Nissin Food Products Ltd In stellung 21 substituierte steroide
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
DE60021720T2 (de) 1999-05-04 2006-06-01 Strakan International Ltd. Androgen glykoside und die androgenische aktivität davon
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
EP1183014B1 (en) 1999-06-14 2003-10-08 Cosmo S.p.A. Controlled release and taste masking oral pharmaceutical compositions
AU2001225363A1 (en) * 2000-01-14 2001-07-24 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
DE602004017164D1 (de) * 2004-08-09 2008-11-27 Deutsches Krebsforsch Albuminkonjugate, die eine Glucuron-Verknüpfung enthalten
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US10711032B2 (en) 2016-11-08 2020-07-14 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
EP3604322B1 (en) * 2017-03-30 2023-10-18 Fruithy Holdings Limited Lactulose glycoside compound and preparation method and use thereof
US11491237B2 (en) 2017-05-18 2022-11-08 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
IL313068A (en) 2017-11-07 2024-07-01 Regeneron Pharma Hydrophilic linkers for drug-antibody conjugates
SG11202006510XA (en) * 2018-01-08 2020-08-28 Regeneron Pharma Steroids and antibody-conjugates thereof
CN112533951A (zh) 2018-05-09 2021-03-19 里珍纳龙药品有限公司 抗msr1抗体及其使用方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE378109B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-05-19 1975-08-18 Bofors Ab
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2967070D1 (en) * 1978-01-25 1984-08-02 Schering Ag 11,17-substituted pregnanes, their preparation and application for the preparation of pharmaceutical compositions
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
AU594468B2 (en) * 1986-05-12 1990-03-08 Mect Corporation Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
JP3366640B2 (ja) * 1993-01-08 2003-01-14 アストラ・アクチエボラーグ 新規な結腸−または回腸−特異的ステロイド誘導体

Also Published As

Publication number Publication date
CZ171095A3 (en) 1996-01-17
FI953358A7 (fi) 1995-07-07
AU678803B2 (en) 1997-06-12
HUT73227A (en) 1996-07-29
RU95115547A (ru) 1997-06-10
WO1994015947A1 (en) 1994-07-21
FI953358L (fi) 1995-07-07
US5908833A (en) 1999-06-01
NZ259596A (en) 1997-04-24
EP0678097B1 (en) 1999-08-11
FI953358A0 (fi) 1995-07-07
NO952683D0 (no) 1995-07-06
BR9307746A (pt) 1995-11-14
DK0678097T3 (da) 2000-02-07
HU221584B (hu) 2002-11-28
KR960700266A (ko) 1996-01-19
GR3031789T3 (en) 2000-02-29
AU5844794A (en) 1994-08-15
LV10961B (en) 1996-08-20
NO952683L (no) 1995-07-06
US6140308A (en) 2000-10-31
LV10961A (lv) 1995-12-20
HU9502087D0 (en) 1995-09-28
PL309777A1 (en) 1995-11-13
SK87295A3 (en) 1996-04-03
IS4111A (is) 1994-07-09
PL178307B1 (pl) 2000-04-28
CA2152374A1 (en) 1994-07-21
JPH08505616A (ja) 1996-06-18
NO305367B1 (no) 1999-05-18
JP3366640B2 (ja) 2003-01-14
EP0678097A1 (en) 1995-10-25
ATE183192T1 (de) 1999-08-15
ES2137353T3 (es) 1999-12-16

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