CY1125274T1 - Μεθοδοι για την θεραπεια συνθηκων που σχετιζονται με την ενεργοποιηση συμπληρωματικου εξαρτωμενου απο την masp-2 - Google Patents
Μεθοδοι για την θεραπεια συνθηκων που σχετιζονται με την ενεργοποιηση συμπληρωματικου εξαρτωμενου απο την masp-2Info
- Publication number
- CY1125274T1 CY1125274T1 CY20201100332T CY201100332T CY1125274T1 CY 1125274 T1 CY1125274 T1 CY 1125274T1 CY 20201100332 T CY20201100332 T CY 20201100332T CY 201100332 T CY201100332 T CY 201100332T CY 1125274 T1 CY1125274 T1 CY 1125274T1
- Authority
- CY
- Cyprus
- Prior art keywords
- masp
- complement activation
- dependent complement
- methods
- dependent
- Prior art date
Links
- 230000024203 complement activation Effects 0.000 title abstract 5
- 102100026046 Mannan-binding lectin serine protease 2 Human genes 0.000 abstract 6
- 101710117460 Mannan-binding lectin serine protease 2 Proteins 0.000 abstract 6
- 230000001419 dependent effect Effects 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000004856 Lectins Human genes 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
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Abstract
Σε μία άποψη, η αποκάλυψη παρέχει μεθόδους αναστολής των επιδράσεων της εξαρτώμενης από την ΜΑSΡ-2 ενεργοποίησης συμπληρώματος σε ένα ζωντανό όν. Οι μέθοδοι περιλαμβάνουν το στάδιο της χορήγησης, σε ένα υποκείμενο που έχει ανάγκη αυτής, μιας ποσότητας ανασταλτικού παράγοντα ΜΑSΡ-2 αποτελεσματικού για την αναστολή της ενεργοποίησης συμπληρωματικού εξαρτώμενου από ΜΑSP-2. Σε μερικές ενσωματώσεις, ο ανασταλτικός παράγοντας ΜΑSP-2 αναστέλλει την κυτταρική βλάβη που σχετίζεται με ενεργοποίηση εναλλακτικής οδού συμπληρώματος με τη μεσολάβηση ΜΑSΡ-2, αφήνοντας άθικτο το κλασικό (εξαρτώμενο από Clq) συστατικό της οδού του ανοσοποιητικού συστήματος. Σε άλλη άποψη, η αποκάλυψη παρέχει συνθέσεις για την αναστολή των επιδράσεων της εξαρτώμενης από την λεκτίνη ενεργοποίησης συμπληρώματος, η οποία περιλαμβάνει μία θεραπευτικώς αποτελεσματική ποσότητα ενός ανασταλτικού παράγοντα ΜΑSΡ-2 και ενός φαρμακευτικά αποδεκτού φορέα.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78887606P | 2006-04-03 | 2006-04-03 | |
US11/645,359 US7919094B2 (en) | 2004-06-10 | 2006-12-22 | Methods for treating conditions associated with MASP-2 dependent complement activation |
EP07759500.7A EP2007425B1 (en) | 2006-04-03 | 2007-03-27 | Methods for treating conditions associated with masp-2 dependent complement activation |
PCT/US2007/065274 WO2007117996A2 (en) | 2006-04-03 | 2007-03-27 | Methods for treating conditions associated with masp-2 dependent complement activation |
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