CY1118696T1 - Μεθοδοι για θεραπεια διαχυτης ενδοαγγειακης πηξης με παρεμποδιση εξαρτωμενης απο masp-2 ενεργοποιησης συμπληρωματος - Google Patents
Μεθοδοι για θεραπεια διαχυτης ενδοαγγειακης πηξης με παρεμποδιση εξαρτωμενης απο masp-2 ενεργοποιησης συμπληρωματοςInfo
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- CY1118696T1 CY1118696T1 CY20171100279T CY171100279T CY1118696T1 CY 1118696 T1 CY1118696 T1 CY 1118696T1 CY 20171100279 T CY20171100279 T CY 20171100279T CY 171100279 T CY171100279 T CY 171100279T CY 1118696 T1 CY1118696 T1 CY 1118696T1
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- Prior art keywords
- masp
- intervention
- complement
- dependent
- activation
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- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
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Abstract
Σε μία άποψη, η εφεύρεση παρέχει μεθόδους παρεμπόδισης των αποτελεσμάτων της εξαρτώμενης από MASP-2 ενεργοποίησης συμπληρώματος σε ένα ζωντανό υποκείμενο. Σε μία πραγματοποίηση, η εφεύρεση παρέχει μεθόδους θεραπείας υποκειμένου που υποφέρει από προκαλούμενη από συμπλήρωμα διαταραχή πήξης, όπως διάχυτη ενδοαγγειακή πήξη. Οι μέθοδοι περιλαμβάνουν το στάδιο χορήγησης, σε ένα υποκείμενο που έχει ανάγκη αυτής, μιας ποσότητας ενός ανασταλτικού MASP-2 παράγοντα αποτελεσματική για να παρεμποδίζει εξαρτώμενη από MASP-2 ενεργοποίηση συμπληρώματος. Σε μερικές πραγματοποιήσεις, ο MASP-2 ανασταλτικός παράγων παρεμποδίζει κυτταρική βλάβη που συνδυάζεται με προκαλούμενη από MASP-2 ενεργοποίηση εναλλακτικού μονοπατιού συμπληρώματος, ενώ αφήνει το κλασικό (C1q-εξαρτώμενο) συστατικό μονοπάτι του ανοσοποιητικού συστήματος ανέπαφο. Σε άλλη άποψη, η εφεύρεση παρέχει συνθέσεις για παρεμπόδιση των αποτελεσμάτων της εξαρτώμενης από λεκτίνη ενεργοποίησης συμπληρώματος, που περιλαμβάνει θεραπευτικώς αποτελεσματική ποσότητα ενός ανασταλτικού MASP-2 παράγοντα και φαρμακευτικώς αποδεκτό φορέα.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US27927909P | 2009-10-16 | 2009-10-16 | |
US32272210P | 2010-04-09 | 2010-04-09 | |
PCT/US2010/052954 WO2011047346A1 (en) | 2009-10-16 | 2010-10-15 | Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation |
Publications (1)
Publication Number | Publication Date |
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CY1118696T1 true CY1118696T1 (el) | 2017-07-12 |
Family
ID=43876603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20171100279T CY1118696T1 (el) | 2009-10-16 | 2017-03-02 | Μεθοδοι για θεραπεια διαχυτης ενδοαγγειακης πηξης με παρεμποδιση εξαρτωμενης απο masp-2 ενεργοποιησης συμπληρωματος |
Country Status (20)
Country | Link |
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US (4) | US8652477B2 (el) |
EP (2) | EP2488203B1 (el) |
JP (2) | JP5911804B2 (el) |
KR (2) | KR101788040B1 (el) |
CN (2) | CN106390117A (el) |
AU (1) | AU2010306581B2 (el) |
BR (1) | BR112012008970A2 (el) |
CA (2) | CA2777845C (el) |
CY (1) | CY1118696T1 (el) |
DK (1) | DK2488203T3 (el) |
ES (1) | ES2617920T3 (el) |
HU (1) | HUE030897T2 (el) |
LT (1) | LT2488203T (el) |
MX (2) | MX344322B (el) |
NZ (2) | NZ624065A (el) |
PL (1) | PL2488203T3 (el) |
PT (1) | PT2488203T (el) |
RU (1) | RU2600876C2 (el) |
SI (1) | SI2488203T1 (el) |
WO (1) | WO2011047346A1 (el) |
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