CY1124500T1 - Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου - Google Patents

Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου

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Publication number
CY1124500T1
CY1124500T1 CY20211100819T CY211100819T CY1124500T1 CY 1124500 T1 CY1124500 T1 CY 1124500T1 CY 20211100819 T CY20211100819 T CY 20211100819T CY 211100819 T CY211100819 T CY 211100819T CY 1124500 T1 CY1124500 T1 CY 1124500T1
Authority
CY
Cyprus
Prior art keywords
composition
her2
binds
antibody
region
Prior art date
Application number
CY20211100819T
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English (en)
Inventor
Reed J. Harris
Paul A. Motchnik
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40672664&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124500(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1124500T1 publication Critical patent/CY1124500T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφεται σύνθεση που περιλαμβάνει κύριο είδος αντισώματος HER2 το οποίο δεσμεύεται με την περιοχή II του HER2 και όξινες παραλλαγές αυτού. Αποκαλύπτονται επίσης φαρμακευτικά σκευάσματα που περιλαμβάνουν την σύνθεση, και θεραπευτικές χρήσεις για την σύνθεση.
CY20211100819T 2008-01-30 2021-09-20 Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου CY1124500T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2482508P 2008-01-30 2008-01-30
EP09709065.8A EP2238172B1 (en) 2008-01-30 2009-01-28 Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
PCT/US2009/032220 WO2009099829A1 (en) 2008-01-30 2009-01-28 Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof

Publications (1)

Publication Number Publication Date
CY1124500T1 true CY1124500T1 (el) 2022-07-22

Family

ID=40672664

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20181100481T CY1120191T1 (el) 2008-01-30 2018-05-10 Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου
CY20211100819T CY1124500T1 (el) 2008-01-30 2021-09-20 Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20181100481T CY1120191T1 (el) 2008-01-30 2018-05-10 Συνθεση που περιλαμβανει αντισωμα που δεσμευεται με περιοχη ii toy her2 και οξινες παραλλαγες αυτου

Country Status (37)

Country Link
US (7) US8652474B2 (el)
EP (3) EP2238172B1 (el)
JP (2) JP5933179B2 (el)
KR (1) KR101223941B1 (el)
CN (1) CN101981056B (el)
AR (2) AR070276A1 (el)
AU (1) AU2009210545C1 (el)
BR (1) BRPI0905733B8 (el)
CA (1) CA2711798C (el)
CL (1) CL2009000178A1 (el)
CO (1) CO6231039A2 (el)
CR (2) CR11648A (el)
CY (2) CY1120191T1 (el)
DK (2) DK2238172T3 (el)
EC (1) ECSP10010433A (el)
ES (2) ES2882041T3 (el)
HK (1) HK1151543A1 (el)
HR (2) HRP20211469T1 (el)
HU (2) HUE037471T2 (el)
IL (2) IL206931A (el)
LT (2) LT3401335T (el)
MA (1) MA32099B1 (el)
MX (1) MX2010008035A (el)
MY (1) MY158560A (el)
NO (1) NO2238172T3 (el)
NZ (1) NZ586754A (el)
PE (3) PE20091352A1 (el)
PL (2) PL3401335T3 (el)
PT (2) PT3401335T (el)
RS (2) RS57109B1 (el)
RU (3) RU2543664C2 (el)
SG (1) SG190607A1 (el)
SI (2) SI3401335T1 (el)
TW (1) TWI472339B (el)
UA (1) UA104585C2 (el)
WO (1) WO2009099829A1 (el)
ZA (1) ZA201004898B (el)

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