CY1123667T1 - Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτου - Google Patents
Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτουInfo
- Publication number
- CY1123667T1 CY1123667T1 CY20201100869T CY201100869T CY1123667T1 CY 1123667 T1 CY1123667 T1 CY 1123667T1 CY 20201100869 T CY20201100869 T CY 20201100869T CY 201100869 T CY201100869 T CY 201100869T CY 1123667 T1 CY1123667 T1 CY 1123667T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- spherine
- immune
- polysorbate
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Περιγράφεται ένα σταθερό υδατικό φαρμακευτικό παρασκεύασμα που περιλαμβάνει μία θεραπευτικά αποτελεσματική ποσότητα ενός αντισώματος, polysorbate 80, ένα ρυθμιστικό διάλυμα το οποίο αναστέλλει την οξείδωση του πολυσορβικού μαζί με μεθόδους δημιουργίας του παρασκευάσματος. Επίσης περιγράφονται παρασκευάσματα με υψηλές συγκεντρώσεις αντισώματος τα οποία διατηρούν σταθερούς όγκους και τα οποία μπορούν να χρησιμοποιούνται σε ασθενείς κυμαινόμενου βάρους.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44581803P | 2003-02-10 | 2003-02-10 | |
EP10005235.6A EP2236154B1 (en) | 2003-02-10 | 2004-02-09 | Immunoglobulin formulation and method of preparation thereof |
PCT/US2004/003873 WO2004071439A2 (en) | 2003-02-10 | 2004-02-09 | Immunoglobulin formulation and method of preparation thereof |
EP04709508A EP1592440A4 (en) | 2003-02-10 | 2004-02-09 | IMMUNOGLOBULIN PREPARATION AND METHOD OF PRODUCING THE SAME |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123667T1 true CY1123667T1 (el) | 2022-03-24 |
Family
ID=32869424
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100682T CY1120574T1 (el) | 2003-02-10 | 2018-06-29 | Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτου |
CY20201100869T CY1123667T1 (el) | 2003-02-10 | 2020-09-15 | Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτου |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100682T CY1120574T1 (el) | 2003-02-10 | 2018-06-29 | Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτου |
Country Status (29)
Country | Link |
---|---|
US (7) | US20050053598A1 (el) |
EP (4) | EP2236154B1 (el) |
JP (3) | JP4728948B2 (el) |
KR (1) | KR20050110628A (el) |
CN (2) | CN103040732B (el) |
AR (1) | AR043144A1 (el) |
AU (2) | AU2004210679A1 (el) |
CA (1) | CA2515444C (el) |
CL (1) | CL2004000224A1 (el) |
CY (2) | CY1120574T1 (el) |
DK (2) | DK3417875T3 (el) |
ES (1) | ES2819011T3 (el) |
HK (1) | HK1182021A1 (el) |
HU (1) | HUE051878T2 (el) |
IL (1) | IL170008A (el) |
MX (1) | MXPA05008409A (el) |
MY (1) | MY162623A (el) |
NO (1) | NO346070B1 (el) |
PE (1) | PE20050190A1 (el) |
PT (2) | PT2236154T (el) |
RU (1) | RU2358763C2 (el) |
SI (2) | SI2236154T1 (el) |
SK (1) | SK50672005A3 (el) |
TR (1) | TR201808801T4 (el) |
TW (1) | TWI367766B (el) |
UA (1) | UA82685C2 (el) |
UY (1) | UY28184A1 (el) |
WO (1) | WO2004071439A2 (el) |
ZA (1) | ZA200506159B (el) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2336184E (pt) | 2002-02-25 | 2015-03-09 | Biogen Idec Inc | Administração de agentes para o tratamento da inflamação |
US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
WO2004022096A1 (en) * | 2002-09-06 | 2004-03-18 | Alexion Pharmaceuticals, Inc. | Method of treatment of asthma using antibodies to complement component c5 |
US20050271660A1 (en) * | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
ZA200506159B (en) | 2003-02-10 | 2006-10-25 | Elan Pharm Inc | Immunoglobulin formulation and method of preparation thereof |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
AU2005231822B2 (en) * | 2004-04-02 | 2011-07-21 | Swedish Orphan Biovitrum Ab (Publ) | Methods of reducing aggregation of IL-1ra |
CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
AU2005306399B2 (en) * | 2004-11-19 | 2012-02-09 | Biogen Ma Inc. | Treatment for multiple sclerosis |
CA2600836A1 (en) * | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | Composition comprising an antibody against macrophage colony-stimulating factor (m-csf) and a chelating agent |
MX2007014148A (es) * | 2005-05-19 | 2008-01-11 | Amgen Inc | Composiciones y metodos para incrementar la estabilidad de anticuerpos. |
WO2007033230A2 (en) * | 2005-09-12 | 2007-03-22 | Novimmune S.A. | Anti-cd3 antibody formulations |
US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
HUE034269T2 (en) | 2005-12-29 | 2018-02-28 | Janssen Biotech Inc | Human anti-IL-23 antibodies, preparations, methods and applications |
EP4316465A3 (en) | 2006-03-15 | 2024-04-24 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
KR20090060453A (ko) * | 2006-09-25 | 2009-06-12 | 메디뮨 엘엘씨 | 안정화된 항체 제제 및 그것의 용도 |
EP2081553B1 (en) * | 2006-10-06 | 2020-08-12 | Amgen Inc. | Stable antibody formulations |
EP2094247B1 (en) | 2006-10-20 | 2022-06-29 | Amgen Inc. | Stable polypeptide formulations |
CL2008000058A1 (es) * | 2007-01-09 | 2008-05-23 | Wyeth Corp | Formulacion que comprende un anticuerpo anti-il13, un criprotector, y una solucion amortiguadora; composicion farmaceutica que la comprende; metodo para tratar un trastorno relacionado con il13; y formas farmaceuticas que la comprenden. |
SI2111124T1 (sl) * | 2007-02-12 | 2012-03-30 | Lassaad Boujbel | Sterilna raztopina sukraloze brez konzervansov inpostopek priprave le te |
CN103977404A (zh) * | 2007-06-14 | 2014-08-13 | 比奥根艾迪克Ma公司 | 抗体制剂 |
US20090208492A1 (en) * | 2007-06-14 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Lyophilized Immunoglobulin Formulations and Methods of Preparation |
WO2009003010A2 (en) * | 2007-06-25 | 2008-12-31 | Becton, Dickinson And Company | Methods for evaluating the aggregation of a protein in a suspension including organopolysiloxane and medical articles coated with organopolysiloxane containing a protein solution |
CN106443002A (zh) * | 2007-10-22 | 2017-02-22 | 贝克顿·迪金森公司 | 评价在含有机基聚硅氧烷的悬浮液中蛋白质聚集的方法 |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
TWI489994B (zh) | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
WO2009124294A2 (en) * | 2008-04-05 | 2009-10-08 | Lpath, Inc. | Pharmaceutical compositions for binding sphingosine-1-phosphate |
US8772461B2 (en) | 2008-04-15 | 2014-07-08 | Grifols Therapeutics Inc. | Two-stage ultrafiltration/diafiltration |
CA2734919C (en) | 2008-08-27 | 2016-08-16 | Schering Corporation | Lyophilized formulations of engineered anti-il-23p19 antibodies |
TWI516501B (zh) * | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Pcsk9拮抗劑類 |
WO2010062896A1 (en) * | 2008-11-28 | 2010-06-03 | Abbott Laboratories | Stable antibody compositions and methods for stabilizing same |
US20110263481A1 (en) * | 2008-12-29 | 2011-10-27 | Samyang Corporation | Pharmaceutical Composition of Lyophilized Formulation and Preparation Method of the Same |
FR2940617B1 (fr) * | 2008-12-30 | 2012-04-20 | Fractionnement Et Des Biotechonologies Lab Franc | Composition d'immunoglobulines g |
AU2010236257A1 (en) * | 2009-04-17 | 2011-11-03 | Biogen Idec Ma Inc. | Compositions and methods to treat acute myelogenous leukemia |
RU2560701C2 (ru) * | 2009-05-04 | 2015-08-20 | Эббви Байотекнолоджи Лтд. | Стабильные композиции с высокими концентрациями белков антител человека против tnf-альфа |
IN2012DN03219A (el) * | 2009-09-17 | 2015-10-23 | Baxter Healthcare Sa | |
US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
MX2012009755A (es) | 2010-02-26 | 2012-09-12 | Novo Nordisk As | Composiciones que contienen anticuerpo estable. |
SG10201502967RA (en) | 2010-04-16 | 2015-05-28 | Biogen Ma Inc | Anti-vla-4 antibodies |
US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
CN102933229A (zh) | 2010-06-04 | 2013-02-13 | 惠氏有限责任公司 | 疫苗制剂 |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
PL2616090T3 (pl) | 2010-09-17 | 2023-12-18 | Takeda Pharmaceutical Company Limited | Stabilizowanie immunoglobulin poprzez wodną formulację z histydyną o ph od słabo kwaśnego do obojętnego |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
EP3326645B1 (en) | 2010-10-25 | 2020-03-18 | Biogen MA Inc. | Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels |
CA2815689C (en) | 2010-11-11 | 2016-11-22 | Abbvie Biotechnology Ltd. | Improved high concentration anti-tnf.alpha. antibody liquid formulations |
AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
CN103429264A (zh) | 2011-03-31 | 2013-12-04 | 默沙东公司 | 针对人程序性死亡受体pd-1的抗体的稳定制剂和有关的治疗 |
EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
EP2714076A1 (en) * | 2011-05-26 | 2014-04-09 | GlaxoSmithKline Biologicals S.A. | Inactivated dengue virus vaccine |
KR102061355B1 (ko) * | 2011-07-01 | 2019-12-31 | 바이오젠 엠에이 인코포레이티드 | 아르기닌-없는 tnfr : fc-융합 폴리펩티드 조성물 및 이용 방법 |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
CA2850624A1 (en) | 2011-10-03 | 2013-04-11 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
SG11201403792TA (en) * | 2012-01-23 | 2014-10-30 | Regeneron Pharma | Stabilized formulations containing anti-ang2 antibodies |
CA3204402A1 (en) * | 2012-03-26 | 2013-10-03 | Sanofi | Stable anti-cxcr5 igg4 antibody formulations |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
CA2868398A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
AR091902A1 (es) * | 2012-07-25 | 2015-03-11 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de un conjugado de insulina de accion prolongada |
US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
EP2727602A1 (en) * | 2012-10-31 | 2014-05-07 | Takeda GmbH | Method for preparation of a high concentration liquid formulation of an antibody |
JP6144355B2 (ja) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドModernaTX,Inc. | 化学修飾mRNA |
UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
EP3760639A1 (en) | 2013-09-08 | 2021-01-06 | Kodiak Sciences Inc. | Zwitterionic polymer conjugates |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
CN113521016A (zh) | 2013-11-21 | 2021-10-22 | 根马布股份公司 | 抗体-药物缀合物冻干制剂 |
WO2015095568A1 (en) * | 2013-12-18 | 2015-06-25 | Kelvin Lee | Reduction of lipase activity in product formulations |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
TWI752912B (zh) * | 2015-07-17 | 2022-01-21 | 美商寇西勒斯生物科技股份有限公司 | 那他珠單抗的穩定水性調配物 |
US10484453B2 (en) * | 2015-07-29 | 2019-11-19 | Xerox Corporation | System and method for printing documents using print hardware and automatic context inference |
RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
JP2019505520A (ja) | 2016-01-13 | 2019-02-28 | ゲンマブ エー/エス | 抗体およびその薬物コンジュゲートの製剤 |
ES2797298T3 (es) | 2016-02-10 | 2020-12-01 | Becton Dickinson France | Procedimiento para evaluar la estabilidad de una formulación a base de proteína |
US20190374639A1 (en) | 2016-11-21 | 2019-12-12 | Polpharma Biologics S.A. | Aqueous pharmaceutical formulations |
CA3060581A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
EP3459527B1 (en) * | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
CA3084436A1 (en) | 2017-12-06 | 2019-07-18 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
MX2020005981A (es) * | 2017-12-08 | 2020-08-24 | Argenx Bvba | Uso de antagonistas del fcrn para el tratamiento de la miastenia gravis generalizada. |
US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
WO2019173767A1 (en) | 2018-03-08 | 2019-09-12 | Coherus Biosciences Inc. | Stable aqueous formulations of aflibercept |
US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
BR112020020741A2 (pt) * | 2018-04-10 | 2021-01-19 | Dr. Reddy's Laboratories Limited | Formulação farmacêutica estável de um anticorpo, e, formulação de anticorpo alfa4beta7 estável. |
US20210147555A1 (en) * | 2018-04-10 | 2021-05-20 | Dr. Reddy?s Laboratories Limited | Antibody formulation |
US20230009902A1 (en) | 2018-06-20 | 2023-01-12 | Progenity, Inc. | Treatment of a disease or condition in a tissue orginating from the endoderm |
WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
EP3810085A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
WO2019246273A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a jak or other kinase inhibitor |
US20210363233A1 (en) | 2018-06-20 | 2021-11-25 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
EP3810095A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
KR20210024082A (ko) | 2018-06-25 | 2021-03-04 | 제이씨알 파마 가부시키가이샤 | 단백질 함유 수성 액제 |
WO2020104943A2 (en) | 2018-11-20 | 2020-05-28 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-il-23 specific antibody |
AU2019401535B2 (en) | 2018-12-19 | 2023-12-14 | Merck Sharp & Dohme Llc | Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
JP2022534020A (ja) | 2019-05-23 | 2022-07-27 | ヤンセン バイオテツク,インコーポレーテツド | Il-23及びtnfアルファに対する抗体の併用療法による炎症性腸疾患の治療方法 |
MA56102A (fr) * | 2019-06-07 | 2022-04-13 | Argenx Bvba | Formulations pharmaceutique d'inhibiteurs de fcrn appropriées pour une administration par voie sous-cutanée |
US20220323583A1 (en) * | 2019-06-11 | 2022-10-13 | Macrogenics, Inc. | Pharmaceutical Formulations of Bi-Specific Diabodies and Use of the Same |
WO2021050687A1 (en) | 2019-09-10 | 2021-03-18 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
JPWO2021124793A1 (el) * | 2019-12-16 | 2021-06-24 | ||
BR112022013730A2 (pt) * | 2020-01-13 | 2022-10-11 | Aptevo Res & Development Llc | Métodos e composições para prevenir a adsorção de proteínas terapêuticas aos componentes do sistema de distribuição de drogas |
US20230077205A1 (en) * | 2020-01-29 | 2023-03-09 | Merck Sharp & Dohme Llc | Methods of separating host cell lipases from an anti-lag3 antibody production |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2508132C3 (de) * | 1974-03-08 | 1980-10-16 | Teijin Ltd., Osaka (Japan) | Verfahren zur Herstellung von Humanimmunglobulin-Derivaten und parenteral applizierbare Lösung hiervon |
US4362661A (en) * | 1979-08-09 | 1982-12-07 | Teijin Limited | Immunoglobulin composition having a high monomer content, and process for production thereof |
US4597966A (en) * | 1985-01-09 | 1986-07-01 | Ortho Diagnostic Systems, Inc. | Histidine stabilized immunoglobulin and method of preparation |
US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
JPH03504499A (ja) * | 1988-05-27 | 1991-10-03 | セントカー・インコーポレーテツド | 抗体試薬のための配合物 |
US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
US7435802B2 (en) * | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
JPH11510170A (ja) * | 1995-07-27 | 1999-09-07 | ジェネンテック インコーポレーテッド | タンパク質の処方 |
GB9610992D0 (en) | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
EP0999853B1 (en) | 1997-06-13 | 2003-01-02 | Genentech, Inc. | Stabilized antibody formulation |
DE19912637A1 (de) | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | 2,4-Diamino-1,3,5-triazine, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
KR101222450B1 (ko) | 1999-03-25 | 2013-01-16 | 애보트 게엠베하 운트 콤파니 카게 | 사람 il-12에 결합하는 사람 항체 및 이의 제조방법 |
DE10013029A1 (de) | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
US7288390B2 (en) * | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
ATE380022T1 (de) * | 2001-01-31 | 2007-12-15 | Evonik Roehm Gmbh | Multipartikuläre arzneiform, enthaltend mindestens zwei unterschiedlich überzogene pelletformen |
DE10133394A1 (de) * | 2001-07-13 | 2003-01-30 | Merck Patent Gmbh | Flüssige Formulierung enthaltend Cetuximab |
MXPA04000747A (es) * | 2001-07-25 | 2004-07-08 | Protein Desing Labs Inc | Formulacion farmaceutica liofilizada estable de anticuerpos igg. |
JP4364645B2 (ja) * | 2002-02-14 | 2009-11-18 | 中外製薬株式会社 | 抗体含有溶液製剤 |
PT2336184E (pt) * | 2002-02-25 | 2015-03-09 | Biogen Idec Inc | Administração de agentes para o tratamento da inflamação |
US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
ZA200506159B (en) * | 2003-02-10 | 2006-10-25 | Elan Pharm Inc | Immunoglobulin formulation and method of preparation thereof |
WO2004100984A1 (en) | 2003-05-13 | 2004-11-25 | The University Of Massachusetts | Endogenous adjuvant molecules and uses thereof |
WO2005076843A2 (en) | 2004-02-06 | 2005-08-25 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating tumors and metastatic disease |
MY162179A (en) | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
CN103977404A (zh) | 2007-06-14 | 2014-08-13 | 比奥根艾迪克Ma公司 | 抗体制剂 |
-
2004
- 2004-02-09 ZA ZA200506159A patent/ZA200506159B/en unknown
- 2004-02-09 EP EP10005235.6A patent/EP2236154B1/en not_active Expired - Lifetime
- 2004-02-09 KR KR1020057014654A patent/KR20050110628A/ko active Search and Examination
- 2004-02-09 SK SK5067-2005A patent/SK50672005A3/sk not_active Application Discontinuation
- 2004-02-09 PT PT100052356T patent/PT2236154T/pt unknown
- 2004-02-09 CL CL200400224A patent/CL2004000224A1/es unknown
- 2004-02-09 MY MYPI20040377A patent/MY162623A/en unknown
- 2004-02-09 HU HUE18174115A patent/HUE051878T2/hu unknown
- 2004-02-09 ES ES18174115T patent/ES2819011T3/es not_active Expired - Lifetime
- 2004-02-09 PT PT181741158T patent/PT3417875T/pt unknown
- 2004-02-09 EP EP20180019.0A patent/EP3777880A1/en active Pending
- 2004-02-09 EP EP18174115.8A patent/EP3417875B1/en not_active Expired - Lifetime
- 2004-02-09 NO NO20054164A patent/NO346070B1/no unknown
- 2004-02-09 CN CN201210292453.7A patent/CN103040732B/zh not_active Expired - Lifetime
- 2004-02-09 US US10/773,406 patent/US20050053598A1/en not_active Abandoned
- 2004-02-09 WO PCT/US2004/003873 patent/WO2004071439A2/en active Application Filing
- 2004-02-09 JP JP2006503453A patent/JP4728948B2/ja not_active Expired - Lifetime
- 2004-02-09 SI SI200432441T patent/SI2236154T1/en unknown
- 2004-02-09 EP EP04709508A patent/EP1592440A4/en not_active Withdrawn
- 2004-02-09 DK DK18174115.8T patent/DK3417875T3/da active
- 2004-02-09 MX MXPA05008409A patent/MXPA05008409A/es active IP Right Grant
- 2004-02-09 CN CN2004800094412A patent/CN1771053B/zh not_active Expired - Lifetime
- 2004-02-09 DK DK10005235.6T patent/DK2236154T3/en active
- 2004-02-09 TR TR2018/08801T patent/TR201808801T4/tr unknown
- 2004-02-09 CA CA2515444A patent/CA2515444C/en not_active Expired - Lifetime
- 2004-02-09 AU AU2004210679A patent/AU2004210679A1/en not_active Abandoned
- 2004-02-09 SI SI200432502T patent/SI3417875T1/sl unknown
- 2004-02-09 RU RU2005128280/15A patent/RU2358763C2/ru active IP Right Revival
- 2004-02-10 TW TW093103043A patent/TWI367766B/zh not_active IP Right Cessation
- 2004-02-10 PE PE2004000149A patent/PE20050190A1/es active IP Right Grant
- 2004-02-10 UY UY28184A patent/UY28184A1/es not_active Application Discontinuation
- 2004-02-10 AR ARP040100411A patent/AR043144A1/es unknown
- 2004-09-02 UA UAA200508632A patent/UA82685C2/uk unknown
-
2005
- 2005-08-01 IL IL170008A patent/IL170008A/en active IP Right Grant
-
2009
- 2009-10-02 US US12/572,978 patent/US8349321B2/en not_active Expired - Lifetime
-
2010
- 2010-06-01 AU AU2010202254A patent/AU2010202254B2/en not_active Expired
- 2010-12-13 JP JP2010277365A patent/JP2011088913A/ja active Pending
-
2012
- 2012-09-06 US US13/605,590 patent/US8900577B2/en active Active
- 2012-11-14 US US13/676,866 patent/US8815236B2/en not_active Expired - Lifetime
-
2013
- 2013-08-12 HK HK13109421.5A patent/HK1182021A1/xx not_active IP Right Cessation
- 2013-09-17 JP JP2013192276A patent/JP2014028831A/ja not_active Withdrawn
-
2014
- 2014-10-27 US US14/524,687 patent/US20150044206A1/en not_active Abandoned
-
2018
- 2018-03-07 US US15/914,980 patent/US10954303B2/en not_active Expired - Lifetime
- 2018-06-29 CY CY20181100682T patent/CY1120574T1/el unknown
-
2020
- 2020-09-15 CY CY20201100869T patent/CY1123667T1/el unknown
-
2021
- 2021-03-03 US US17/191,589 patent/US20210292419A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1123667T1 (el) | Παρασκευασμα ανοσοσφαιρινης και μεθοδος παρασκευης αυτου | |
DE60125797D1 (de) | Impfstoffzusammesetzung | |
EA200301222A1 (ru) | Легочное введение химически модифицированного инсулина | |
CY1118991T1 (el) | Φαρμακοτεχνικη μορφη ανθρωπινων αντισωματων για θεραπεια σχετικων με tnf-αλφα διαταραχων | |
ES2152421T3 (es) | Vacunas de conjugados polisacarido neumococcico-neumolisina recombinante para la inmunizacion contra las infecciones neumococcicas. | |
CY1113826T1 (el) | Ανοσοενισχυτικα για εμβολια | |
CY1113477T1 (el) | Ετερολογος εκφραση πρωτεϊνων της neisseria | |
CY1105779T1 (el) | Εμβολιο ανθρωπινου ιου θηλωματων με αποσυγκροτημενα και επανασυγκροτημενα σωματιδια ομοιαζοντα με αυτα του ιου | |
CY1105389T1 (el) | Hpv-e7 ως αγωγη εναντι του ιου θηλωματων ανθρωπου | |
CY1112507T1 (el) | Μορια αντισωματος που εχουν ειδικοτητα για την ανθρωπινη ιl-1β | |
DE68927348D1 (de) | Künstlicher impfstoff gegen aids-virus | |
DK1734995T3 (da) | Monoklonale antistoffer og hepatocyytvækstfaktor | |
CY1108147T1 (el) | Εμβολιο κατα των σεξουαλικως μεταδιδομενων νοσων | |
CY1109034T1 (el) | Τροποποιημενες κυτοκινες για χρηση σε θεραπεια καρκινου | |
CY1104971T1 (el) | Παρασκευασμα αποϊνιδοτιδιου και g-csf και η χρηση του για να κινητοποιει αιμοποιητικους προγονους | |
ATE458496T1 (de) | Hiv-vakzine und anwendungsverfahren | |
EE200100366A (et) | Antikehade kasutamine vähivastase farmatseutilisekompositsiooni valmistamiseks | |
CY1108711T1 (el) | Συνθεσεις βενζοθειαζολιου και η χρηση αυτων | |
EA200400197A1 (ru) | Способы получения поливалентных бактериофагов для лечения бактериальных инфекций | |
DE50113974D1 (de) | Kombinationspräparate von 3-n-formylhydroxylaminopropylphosphonsäurederivaten oder 3-n-acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen | |
ATE495758T1 (de) | Virulentes systemisches felines calicivirus | |
ES2166763T3 (es) | Inmunizacion parenteral contra rotavirus. | |
DE602004015141D1 (de) | Modifizierte ganzzell-, zellextrakt- und omv-basierte impfstoffe | |
DE60210936D1 (de) | Polypeptid, das neutralisierende antikörper gegen hiv induziert | |
EA200300535A1 (ru) | Способ получения антигенных структур, усиливающих специфическую перекрестную реактивность |