CY1122223T1 - Προσμειξεις dna σε συνθεση που περιεχει ενα παρβοϊικο ιοσωματιο - Google Patents

Προσμειξεις dna σε συνθεση που περιεχει ενα παρβοϊικο ιοσωματιο

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Publication number
CY1122223T1
CY1122223T1 CY20191101141T CY191101141T CY1122223T1 CY 1122223 T1 CY1122223 T1 CY 1122223T1 CY 20191101141 T CY20191101141 T CY 20191101141T CY 191101141 T CY191101141 T CY 191101141T CY 1122223 T1 CY1122223 T1 CY 1122223T1
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CY
Cyprus
Prior art keywords
composition containing
parabiotic
virus
parvoviral
relates
Prior art date
Application number
CY20191101141T
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English (en)
Inventor
Jacek Lubelski
Wilhelmus Theodorus Johannes M. C. HERMENS
Original Assignee
Uniqure Ip B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52000715&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122223(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Uniqure Ip B.V. filed Critical Uniqure Ip B.V.
Publication of CY1122223T1 publication Critical patent/CY1122223T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με προσμείξεις νουκλεϊνικού οξέος σε μία σύνθεση που περιέχει έναν παρβοϊικό διαβιβαστή. Συγκεκριμένα, η παρούσα εφεύρεση υποδεικνύει ότι οι προσμείξεις του DNA δεν είναι τυχαία εγκλεισμένες εντός ενός παρβοϊικού ιοσωματίου. Η εφεύρεση επομένως σχετίζεται με μία μέθοδο για τον προσδιορισμό και την ποσοτικοποίηση πρόσμειξης νουκλεϊνικού οξέος σε μία σύνθεση που περιέχει έναν παρβοϊικό διαβιβαστή. Τέλος, η παρούσα εφεύρεση σχετίζεται με τη μέθοδο προσδιορισμού του κατά πόσον μία σύνθεση που περιέχει έναν παρβοϊικό διαβιβαστή θεωρείται κλινικά καθαρή.
CY20191101141T 2014-11-28 2019-11-01 Προσμειξεις dna σε συνθεση που περιεχει ενα παρβοϊικο ιοσωματιο CY1122223T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14195464 2014-11-28
PCT/EP2015/077882 WO2016083560A1 (en) 2014-11-28 2015-11-27 Dna impurities in a composition comprising a parvoviral virion

Publications (1)

Publication Number Publication Date
CY1122223T1 true CY1122223T1 (el) 2020-11-25

Family

ID=52000715

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101141T CY1122223T1 (el) 2014-11-28 2019-11-01 Προσμειξεις dna σε συνθεση που περιεχει ενα παρβοϊικο ιοσωματιο

Country Status (19)

Country Link
US (2) US11021762B2 (el)
EP (3) EP3591070B1 (el)
JP (1) JP6741345B2 (el)
KR (1) KR102528156B1 (el)
CN (1) CN107208142B (el)
AU (1) AU2015352469B2 (el)
BR (1) BR112017011217A2 (el)
CA (1) CA2968622A1 (el)
CY (1) CY1122223T1 (el)
DK (2) DK3591070T3 (el)
EA (1) EA035747B1 (el)
ES (1) ES2751919T5 (el)
FI (1) FI3224376T4 (el)
HK (1) HK1244849B (el)
HU (1) HUE046643T2 (el)
PL (1) PL3224376T5 (el)
PT (1) PT3224376T (el)
SI (1) SI3224376T2 (el)
WO (1) WO2016083560A1 (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10335466B2 (en) 2014-11-05 2019-07-02 Voyager Therapeutics, Inc. AADC polynucleotides for the treatment of parkinson's disease
JP2017535266A (ja) 2014-11-14 2017-11-30 ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 筋萎縮性側索硬化症（ａｌｓ）を治療する組成物および方法
CN112410339A (zh) 2014-11-14 2021-02-26 沃雅戈治疗公司 调节性多核苷酸
EA035747B1 (ru) 2014-11-28 2020-08-05 ЮНИКЬЮРЕ АйПи Б.В. Днк-примеси в композиции, содержащей парвовирусный вирион
EP3230441A4 (en) 2014-12-12 2018-10-03 Voyager Therapeutics, Inc. Compositions and methods for the production of scaav
GB2536650A (en) 2015-03-24 2016-09-28 Augmedics Ltd Method and system for combining video-based and optic-based augmented reality in a near eye display
AU2017267665C1 (en) 2016-05-18 2023-10-05 Voyager Therapeutics, Inc. Modulatory polynucleotides
SG11201909870SA (en) 2017-05-05 2019-11-28 Voyager Therapeutics Inc Compositions and methods of treating amyotrophic lateral sclerosis (als)
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
US11980507B2 (en) 2018-05-02 2024-05-14 Augmedics Ltd. Registration of a fiducial marker for an augmented reality system
US11766296B2 (en) 2018-11-26 2023-09-26 Augmedics Ltd. Tracking system for image-guided surgery
US11980506B2 (en) 2019-07-29 2024-05-14 Augmedics Ltd. Fiducial marker
US11382712B2 (en) 2019-12-22 2022-07-12 Augmedics Ltd. Mirroring in image guided surgery
WO2022188797A1 (en) 2021-03-09 2022-09-15 Huigene Therapeutics Co., Ltd. Engineered crispr/cas13 system and uses thereof
US11896445B2 (en) 2021-07-07 2024-02-13 Augmedics Ltd. Iliac pin and adapter
WO2023283962A1 (en) 2021-07-16 2023-01-19 Huigene Therapeutics Co., Ltd. Modified aav capsid for gene therapy and methods thereof
CN117660534B (zh) * 2023-12-13 2024-05-07 广州派真生物技术有限公司 一种降低重组腺相关病毒中宿主细胞dna残留的辅助质粒及应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE69132905T2 (de) * 1990-12-06 2002-08-01 Affymetrix Inc N D Ges D Staat Detektion von Nukleinsäuresequenzen
US6491907B1 (en) 1998-11-10 2002-12-10 The University Of North Carolina At Chapel Hill Recombinant parvovirus vectors and method of making
JP2003511037A (ja) 1999-10-01 2003-03-25 ジェノボ， インコーポレイテッド ＡＡＶｒｅｐ／ｃａｐ遺伝子を含むアデノウイルスを使用する組換えＡＡＶの産生
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
SI2657248T1 (sl) 2003-06-19 2017-07-31 Genzyme Corporation AAV virioni z zmanjšano imunoreaktivnostjo in njihova uporaba
CN101018858A (zh) * 2004-06-01 2007-08-15 建新公司 防止aav载体聚集的组合物和方法
PT3272872T (pt) 2005-10-20 2020-06-26 Uniqure Ip Bv Vetores aav melhorados produzidos em células de insetos
DK3023500T3 (da) 2006-06-21 2020-04-20 Uniqure Ip Bv Insektceller til fremstilling af AAV-vektorer
BRPI0716724A2 (pt) * 2006-09-15 2013-10-01 Medimmune Llc cÉlula renal canina de madin-darby, e, mÉtodos para proliferar a mesma, para produzir vÍrus da influenza adaptados ao frio e apra eliminar contaminantes de dna de uma preparaÇço viral
BRPI0814459B1 (pt) 2007-07-26 2023-01-24 Uniqure Ip B.V Método para produzir um vírion parvoviral recombinante em uma célula de inseto, e, construção de ácido nucleico
US8642314B2 (en) 2008-02-19 2014-02-04 Amsterdam Molecular Therapeutics (Amt) B.V. Optimization of expression of parvoviral rep and cap proteins in insect cells
BR112012018899A2 (pt) 2010-01-28 2015-09-15 Philadelphia Children Hospital "método para purificar partículas de vetor de vírus adeno-associado."
EP3792348A3 (en) * 2010-03-11 2021-06-23 uniQure IP B.V. Mutated rep encoding sequences for use in aav production
KR101334072B1 (ko) * 2010-11-25 2013-11-29 한국표준과학연구원 핵산 정량 방법 및 키트
JP5822929B2 (ja) 2011-07-19 2015-11-25 株式会社日立ハイテクノロジーズ 核酸分析装置
FR2986239A1 (fr) 2012-01-31 2013-08-02 Univ Strasbourg Biomarqueur pour les maladies inflammatoires pulmonaires chroniques
EP2871239B1 (en) * 2012-07-06 2018-08-29 Takara Bio Inc. Cell capable of producing adeno-associated virus vector
KR101890466B1 (ko) * 2012-07-24 2018-08-21 내테라, 인코포레이티드 고도의 다중 ｐｃｒ 방법 및 조성물
CN105612253A (zh) 2013-03-15 2016-05-25 费城儿童医院 含有填充者/填充物多核苷酸序列的载体及其制备方法
EA035747B1 (ru) 2014-11-28 2020-08-05 ЮНИКЬЮРЕ АйПи Б.В. Днк-примеси в композиции, содержащей парвовирусный вирион

Also Published As

Publication number Publication date
EP3224376A1 (en) 2017-10-04
EP3591070A1 (en) 2020-01-08
ES2751919T5 (es) 2023-10-04
EA035747B1 (ru) 2020-08-05
BR112017011217A2 (pt) 2018-02-06
HUE046643T2 (hu) 2021-11-29
DK3224376T4 (da) 2023-05-30
US11021762B2 (en) 2021-06-01
JP2017535278A (ja) 2017-11-30
DK3591070T3 (da) 2023-01-30
EP4219742A1 (en) 2023-08-02
PL3224376T3 (pl) 2020-03-31
CN107208142A (zh) 2017-09-26
US20210332447A1 (en) 2021-10-28
AU2015352469A1 (en) 2017-06-01
EP3591070B1 (en) 2022-12-21
ES2751919T3 (es) 2020-04-02
AU2015352469B2 (en) 2021-09-16
DK3224376T3 (da) 2019-09-30
EP3224376B2 (en) 2023-04-26
SI3224376T1 (sl) 2020-01-31
CN107208142B (zh) 2024-03-26
US20170321290A1 (en) 2017-11-09
KR102528156B1 (ko) 2023-05-03
SI3224376T2 (sl) 2023-07-31
JP6741345B2 (ja) 2020-08-19
WO2016083560A1 (en) 2016-06-02
EP3224376B1 (en) 2019-08-07
EA201791184A1 (ru) 2017-09-29
HK1244849B (zh) 2020-04-09
CA2968622A1 (en) 2016-06-02
FI3224376T4 (fi) 2023-08-31
KR20170081704A (ko) 2017-07-12
PT3224376T (pt) 2019-10-25
PL3224376T5 (pl) 2023-08-21

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