CY1121036T1 - Παρεμποδιστης για αμφιβληστροειδοχοριοειδικες διαταραχες - Google Patents
Παρεμποδιστης για αμφιβληστροειδοχοριοειδικες διαταραχεςInfo
- Publication number
- CY1121036T1 CY1121036T1 CY181101204T CY181101204T CY1121036T1 CY 1121036 T1 CY1121036 T1 CY 1121036T1 CY 181101204 T CY181101204 T CY 181101204T CY 181101204 T CY181101204 T CY 181101204T CY 1121036 T1 CY1121036 T1 CY 1121036T1
- Authority
- CY
- Cyprus
- Prior art keywords
- retinal
- inhibitor
- disorders
- retiremental
- chorial
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 230000002207 retinal effect Effects 0.000 abstract 5
- 206010003694 Atrophy Diseases 0.000 abstract 1
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- YTFHCXIPDIHOIA-DHZHZOJOSA-N Palovarotene Chemical compound C1=CC=NN1CC=1C=C2C(C)(C)CCC(C)(C)C2=CC=1\C=C\C1=CC=C(C(O)=O)C=C1 YTFHCXIPDIHOIA-DHZHZOJOSA-N 0.000 abstract 1
- 201000007737 Retinal degeneration Diseases 0.000 abstract 1
- 206010038848 Retinal detachment Diseases 0.000 abstract 1
- 206010038895 Retinal scar Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000037444 atrophy Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
- 210000004498 neuroglial cell Anatomy 0.000 abstract 1
- 208000012286 optic choroid disease Diseases 0.000 abstract 1
- 230000004264 retinal detachment Effects 0.000 abstract 1
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036573 scar formation Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J9/00—Feeding-bottles in general
- A61J9/08—Protective covers for bottles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση χειρίζεται το πρόβλημα παροχής ενός παρεμποδιστή για αμφιβληστροειδοχοριοειδικές διαταραχές, ιδιαιτέρως, παρεμποδιστή για αμφιβληστροειδοχοριοειδικό σχηματισμό ουλής και αμφιβληστροειδοχοριοειδική ατροφία σε ένα επιαμφιβληστροειδικό, ενδοαμφιβληστροειδικό ή υποαμφιβληστροειδικό ιστό. Αυτό το πρόβλημα μπορεί να επιλύεται με παρασκευή ενός παρεμποδιστή για αμφιβληστροειδοχοριοειδικές διαταραχές που περιλαμβάνει ως δραστικό συστατικό (Ε)-4-(2-{3-[(1 Η-πυραζολ-1-υλ)μεθυλ]-5,5,8,8-τετραμεθυλ-5,6,7,8-τετραϋδροναφθαλινο-2-υλ}βινυλ)βενζοϊκό οξύ, εστέρα αυτού ή άλας αυτού. Ο παρεμποδιστής για αμφιβληστροειδοχοριοειδικές διαταραχές μπορεί να παρεμποδίζει ατροφία κολλαγόνου των κυττάρων επιθηλίου αμφιβληστροειδικού πηγμέντου, ινοβλαστών, γλοιακών κυττάρων και των παρομοίων και έτσι να παρεμποδίζει αμφιβληστροειδοχοριοειδικές διαταραχές.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013107706 | 2013-05-22 | ||
| PCT/JP2014/002667 WO2014188716A1 (ja) | 2013-05-22 | 2014-05-21 | 網脈絡膜障害の抑制剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121036T1 true CY1121036T1 (el) | 2019-12-11 |
Family
ID=51933283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY181101204T CY1121036T1 (el) | 2013-05-22 | 2018-11-14 | Παρεμποδιστης για αμφιβληστροειδοχοριοειδικες διαταραχες |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US10702502B2 (el) |
| EP (2) | EP3000466B1 (el) |
| JP (2) | JP6407145B2 (el) |
| KR (1) | KR102303316B1 (el) |
| CN (1) | CN105377258B (el) |
| AU (1) | AU2014269762B2 (el) |
| BR (1) | BR112015029114B1 (el) |
| CA (1) | CA2913005C (el) |
| CY (1) | CY1121036T1 (el) |
| DK (1) | DK3000466T3 (el) |
| ES (1) | ES2694831T3 (el) |
| HK (1) | HK1221909A1 (el) |
| HR (1) | HRP20181876T1 (el) |
| LT (1) | LT3000466T (el) |
| MX (1) | MX362239B (el) |
| PL (1) | PL3000466T3 (el) |
| PT (1) | PT3000466T (el) |
| RS (1) | RS58045B1 (el) |
| RU (1) | RU2672057C2 (el) |
| SI (1) | SI3000466T1 (el) |
| WO (1) | WO2014188716A1 (el) |
| ZA (1) | ZA201508940B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103200937B (zh) | 2010-09-01 | 2020-07-03 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
| CA2890424C (en) | 2012-11-08 | 2020-11-17 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
| ES2694831T3 (es) * | 2013-05-22 | 2018-12-27 | Yamaguchi University | Inhibidor para trastornos retinocoroideos |
| MX2018015108A (es) | 2016-06-08 | 2019-08-29 | Clementia Pharmaceuticals Inc | Metodos para tratar la osificacion heterotopica. |
| AU2017359673B2 (en) | 2016-11-16 | 2021-10-21 | Clementia Pharmaceuticals Inc. | Methods for treating multiple osteochondroma (MO) |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT678086E (pt) | 1993-01-11 | 2000-05-31 | Ligand Pharm Inc | Compostos com selectividade para receptores de retinoides x |
| US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
| US5624957A (en) | 1995-06-06 | 1997-04-29 | Bristol-Myers Squibb Company | Rary-specific retinobenzoic acid derivatives |
| US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6204288B1 (en) | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
| US6313168B1 (en) | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
| US20030114482A1 (en) | 1999-12-15 | 2003-06-19 | Maurizio Pacifici | Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies |
| CA2402413A1 (en) | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
| DK1324970T3 (da) | 2000-10-02 | 2009-01-05 | Hoffmann La Roche | Retinoider til behandling af emfysem |
| KR100891224B1 (ko) | 2001-09-18 | 2009-04-01 | 에프. 호프만-라 로슈 아게 | 치환된 우레아 레티노이드 작용제 ⅱ |
| AU2002329276B2 (en) | 2001-09-18 | 2008-04-24 | F. Hoffmann-La Roche Ag | Alkyl urea retinoid agonists I |
| AUPR892501A0 (en) | 2001-11-16 | 2001-12-13 | Peter Maccallum Cancer Institute, The | Method of enhancing self renewal of stem cells and uses thereof |
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| WO2007037188A1 (ja) | 2005-09-27 | 2007-04-05 | Sapporo Medical University | 血管透過性亢進に起因する眼疾患の予防及び治療のための医薬 |
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| BRPI0709886A2 (pt) | 2006-03-31 | 2011-07-26 | Hoffmann La Roche | processo para a preparaÇço de compostos retinàides |
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| JP2009235031A (ja) | 2008-03-28 | 2009-10-15 | Nano Egg:Kk | 角膜組織の再生促進剤 |
| WO2010071583A1 (en) | 2008-12-18 | 2010-06-24 | Astrazeneca Ab | Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient |
| WO2010088735A1 (en) | 2009-02-05 | 2010-08-12 | Regenertech Pty Ltd | Method of producing progenitor cells from differentiated cells |
| CN103200937B (zh) | 2010-09-01 | 2020-07-03 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
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| CA2890424C (en) | 2012-11-08 | 2020-11-17 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
| ES2694831T3 (es) * | 2013-05-22 | 2018-12-27 | Yamaguchi University | Inhibidor para trastornos retinocoroideos |
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2014
- 2014-05-21 ES ES14800477.3T patent/ES2694831T3/es active Active
- 2014-05-21 PL PL14800477T patent/PL3000466T3/pl unknown
- 2014-05-21 EP EP14800477.3A patent/EP3000466B1/en active Active
- 2014-05-21 DK DK14800477.3T patent/DK3000466T3/en active
- 2014-05-21 EP EP18183955.6A patent/EP3446690B1/en active Active
- 2014-05-21 PT PT14800477T patent/PT3000466T/pt unknown
- 2014-05-21 AU AU2014269762A patent/AU2014269762B2/en active Active
- 2014-05-21 RS RS20181364A patent/RS58045B1/sr unknown
- 2014-05-21 BR BR112015029114-7A patent/BR112015029114B1/pt active IP Right Grant
- 2014-05-21 MX MX2015016083A patent/MX362239B/es active IP Right Grant
- 2014-05-21 US US14/892,536 patent/US10702502B2/en active Active
- 2014-05-21 WO PCT/JP2014/002667 patent/WO2014188716A1/ja active Application Filing
- 2014-05-21 KR KR1020157035402A patent/KR102303316B1/ko active IP Right Grant
- 2014-05-21 RU RU2015154741A patent/RU2672057C2/ru active
- 2014-05-21 CA CA2913005A patent/CA2913005C/en active Active
- 2014-05-21 SI SI201430951T patent/SI3000466T1/sl unknown
- 2014-05-21 CN CN201480041392.4A patent/CN105377258B/zh active Active
- 2014-05-21 LT LTEP14800477.3T patent/LT3000466T/lt unknown
- 2014-05-21 JP JP2015518078A patent/JP6407145B2/ja active Active
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2015
- 2015-12-08 ZA ZA2015/08940A patent/ZA201508940B/en unknown
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2016
- 2016-08-25 HK HK16110132.0A patent/HK1221909A1/zh unknown
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2018
- 2018-05-07 JP JP2018089396A patent/JP6749962B2/ja active Active
- 2018-11-08 HR HRP20181876TT patent/HRP20181876T1/hr unknown
- 2018-11-14 CY CY181101204T patent/CY1121036T1/el unknown
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2020
- 2020-06-04 US US16/893,120 patent/US11730718B2/en active Active
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2023
- 2023-07-10 US US18/219,765 patent/US20240180873A1/en active Pending
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