CY1120039T1 - Ογκολυτικοι αδενοϊικοι φορεις και μεθοδοι και χρησεις οι οποιες σχετιζονται με αυτους - Google Patents
Ογκολυτικοι αδενοϊικοι φορεις και μεθοδοι και χρησεις οι οποιες σχετιζονται με αυτουςInfo
- Publication number
- CY1120039T1 CY1120039T1 CY20171100126T CY171100126T CY1120039T1 CY 1120039 T1 CY1120039 T1 CY 1120039T1 CY 20171100126 T CY20171100126 T CY 20171100126T CY 171100126 T CY171100126 T CY 171100126T CY 1120039 T1 CY1120039 T1 CY 1120039T1
- Authority
- CY
- Cyprus
- Prior art keywords
- relates
- subject
- present
- methods
- adhesive
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000853 adhesive Substances 0.000 title 1
- 230000001070 adhesive effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000037455 tumor specific immune response Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20080671A FI20080671A0 (fi) | 2008-12-22 | 2008-12-22 | Onkolyyttiset virukset |
| FI20095466A FI121508B (fi) | 2008-12-22 | 2009-04-27 | Adenovirusvektoreita ja niihin liittyviä menetelmiä ja käyttöjä |
| US58597109A | 2009-09-29 | 2009-09-29 | |
| PCT/FI2009/051025 WO2010072900A1 (en) | 2008-12-22 | 2009-12-21 | Oncolytic adenoviral vectors and methods and uses related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120039T1 true CY1120039T1 (el) | 2018-12-12 |
Family
ID=44502296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100126T CY1120039T1 (el) | 2008-12-22 | 2017-01-27 | Ογκολυτικοι αδενοϊικοι φορεις και μεθοδοι και χρησεις οι οποιες σχετιζονται με αυτους |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2379586B1 (enExample) |
| JP (2) | JP2012513209A (enExample) |
| KR (1) | KR101761094B1 (enExample) |
| CN (1) | CN102264760B (enExample) |
| AU (1) | AU2009332883B2 (enExample) |
| BR (1) | BRPI0924123B8 (enExample) |
| CA (1) | CA2748180C (enExample) |
| CY (1) | CY1120039T1 (enExample) |
| DK (1) | DK2379586T3 (enExample) |
| ES (1) | ES2612889T3 (enExample) |
| HR (1) | HRP20170165T1 (enExample) |
| HU (1) | HUE031689T2 (enExample) |
| LT (1) | LT2379586T (enExample) |
| PL (1) | PL2379586T3 (enExample) |
| PT (1) | PT2379586T (enExample) |
| RU (1) | RU2520823C2 (enExample) |
| SG (1) | SG173432A1 (enExample) |
| SI (1) | SI2379586T1 (enExample) |
| WO (1) | WO2010072900A1 (enExample) |
| ZA (1) | ZA201104224B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2510088B1 (en) | 2009-12-10 | 2016-10-05 | Ottawa Hospital Research Institute | Oncolytic rhabdovirus |
| EP2619312A1 (en) * | 2010-09-24 | 2013-07-31 | Oncos Therapeutics Oy | Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies |
| EP2619224A1 (en) * | 2010-09-24 | 2013-07-31 | Oncos Therapeutics Oy | Oncolytic adenoviral vectors and methods and uses related thereto |
| FI123955B (en) | 2011-11-25 | 2014-01-15 | Oncos Therapeutics Ltd | Oncolytic adenovirus |
| EP2806883B1 (en) | 2012-01-25 | 2019-04-24 | DNAtrix, Inc. | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
| WO2014127478A1 (en) | 2013-02-21 | 2014-08-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Vaccine composition |
| CA2903582C (en) | 2013-03-14 | 2021-06-08 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
| US12421502B2 (en) | 2013-04-18 | 2025-09-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| WO2014170389A1 (en) * | 2013-04-18 | 2014-10-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| US10350275B2 (en) * | 2013-09-21 | 2019-07-16 | Advantagene, Inc. | Methods of cytotoxic gene therapy to treat tumors |
| ES2987442T3 (es) | 2015-05-04 | 2024-11-14 | Theriva Biologics S L | Adenovirus oncolíticos con mutaciones en epítopos de adenovirus inmunodominantes y su uso en el tratamiento del cáncer |
| FI127460B (en) | 2016-01-15 | 2018-06-29 | Targovax Oy | Combining adenovirus and chemotherapeutic agents for treating cancer |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| WO2017147265A1 (en) | 2016-02-23 | 2017-08-31 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| WO2017156349A1 (en) | 2016-03-10 | 2017-09-14 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
| HUE053236T2 (hu) | 2016-09-12 | 2021-06-28 | Targovax Oy | Adenovírus és ellenõrzõpont-gátlók kombinálása rák kezelésére |
| WO2018085461A1 (en) * | 2016-11-01 | 2018-05-11 | Dnatrix, Inc. | Combination therapy for treatment of brain cancers |
| CA3045892A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| KR20190104051A (ko) * | 2017-01-06 | 2019-09-05 | 스타빌리테크 바이오파마 리미티드 | 바이러스 |
| EP4599893A3 (en) | 2017-04-14 | 2025-11-05 | CG Oncology, Inc. | Cg0070 for treating bcg resistant bladder carcinoma in situ |
| CA3060573A1 (en) | 2017-04-21 | 2018-10-25 | Baylor College Of Medicine | Oncolytic virotherapy and immunotherapy |
| KR20240132124A (ko) | 2017-05-25 | 2024-09-02 | 유니버시티 오브 센트럴 플로리다 리서치 파운데이션, 인코포레이티드 | 천연 살해 세포에 의해 사멸하는 종양 세포를 감작시키기 위한 신규한 종양용해 바이러스 |
| JP7277926B2 (ja) * | 2017-11-08 | 2023-05-19 | 国立大学法人 鹿児島大学 | 安全を確保しながら転移性がんまで効果的に治療可能な、搭載する免疫誘導遺伝子の最適発現レベルを与える発現制御システムを有する腫瘍溶解性ウイルス（腫瘍溶解性免疫治療） |
| GB201804473D0 (en) * | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | Modified oncolytic adenoviruses |
| BR112020019942A2 (pt) | 2018-04-09 | 2021-01-26 | Salk Institute For Biological Studies | composições de adenovírus oncolítico com propriedades de replicação aprimoradas |
| EP3725322A1 (en) | 2019-04-17 | 2020-10-21 | Targovax Asa | Oncolytic adenoviral vector expressing granzyme and perforin |
| EP3725888A1 (en) | 2019-04-17 | 2020-10-21 | Targovax Asa | Oncolytic adenoviral vector expressing peptidylarginine deiminase and tissue inhibitor of metalloproteinase |
| EP3725323A1 (en) * | 2019-04-17 | 2020-10-21 | Targovax Asa | Oncolytic adenoviral vector expressing a member of the b7 family of costimulatory ligands and ada |
| WO2021194183A1 (ko) * | 2020-03-25 | 2021-09-30 | ㈜큐리진 | 면역 회피성 항종양 아데노바이러스 |
| CN111909962A (zh) * | 2020-07-23 | 2020-11-10 | 药鼎(北京)国际细胞医学技术有限公司 | 一种治疗肝癌的病毒构建体及其用途和构建方法 |
| CN118853767A (zh) * | 2024-08-22 | 2024-10-29 | 华中科技大学同济医学院附属同济医院 | 一种新型溶瘤腺病毒载体及其构建方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU780231B2 (en) * | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| EP1181382B1 (en) * | 1999-06-01 | 2005-03-23 | The University of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
| EP1228234A2 (en) * | 2000-03-14 | 2002-08-07 | Neurologix, Inc. | Production of chimeric capsid vectors |
| AU2003265873A1 (en) * | 2003-08-28 | 2005-04-14 | Cell Genesys, Inc. | Oncolytic adenoviral vectors encoding gm-csf |
| ES2276623B1 (es) * | 2005-12-12 | 2008-06-01 | Proyecto De Biomedicina Cima, S.L | Nuevos adenovirus recombinantes de replicacion condicionada (crad). |
| US20070292396A1 (en) | 2006-03-02 | 2007-12-20 | Juan Fueyo | Combination therapy with oncolytic adenovirus |
-
2009
- 2009-12-21 ES ES09796016.5T patent/ES2612889T3/es active Active
- 2009-12-21 CN CN200980151762.9A patent/CN102264760B/zh not_active Expired - Fee Related
- 2009-12-21 KR KR1020117016272A patent/KR101761094B1/ko not_active Expired - Fee Related
- 2009-12-21 JP JP2011542856A patent/JP2012513209A/ja active Pending
- 2009-12-21 RU RU2011130511/10A patent/RU2520823C2/ru active
- 2009-12-21 CA CA2748180A patent/CA2748180C/en active Active
- 2009-12-21 HR HRP20170165TT patent/HRP20170165T1/hr unknown
- 2009-12-21 PL PL09796016T patent/PL2379586T3/pl unknown
- 2009-12-21 SI SI200931586A patent/SI2379586T1/sl unknown
- 2009-12-21 DK DK09796016.5T patent/DK2379586T3/en active
- 2009-12-21 LT LTEP09796016.5T patent/LT2379586T/lt unknown
- 2009-12-21 EP EP09796016.5A patent/EP2379586B1/en active Active
- 2009-12-21 PT PT97960165T patent/PT2379586T/pt unknown
- 2009-12-21 WO PCT/FI2009/051025 patent/WO2010072900A1/en not_active Ceased
- 2009-12-21 BR BRPI0924123A patent/BRPI0924123B8/pt not_active IP Right Cessation
- 2009-12-21 AU AU2009332883A patent/AU2009332883B2/en not_active Ceased
- 2009-12-21 HU HUE09796016A patent/HUE031689T2/en unknown
- 2009-12-21 SG SG2011046109A patent/SG173432A1/en unknown
-
2011
- 2011-06-07 ZA ZA2011/04224A patent/ZA201104224B/en unknown
-
2015
- 2015-08-06 JP JP2015156226A patent/JP6280084B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-27 CY CY20171100126T patent/CY1120039T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009332883B2 (en) | 2015-05-21 |
| CA2748180C (en) | 2017-06-20 |
| ES2612889T3 (es) | 2017-05-19 |
| LT2379586T (lt) | 2017-03-10 |
| WO2010072900A1 (en) | 2010-07-01 |
| CA2748180A1 (en) | 2010-07-01 |
| ZA201104224B (en) | 2012-09-26 |
| CN102264760B (zh) | 2017-03-22 |
| BRPI0924123B1 (pt) | 2020-10-20 |
| JP6280084B2 (ja) | 2018-02-14 |
| HUE031689T2 (en) | 2017-07-28 |
| EP2379586A1 (en) | 2011-10-26 |
| BRPI0924123B8 (pt) | 2021-05-25 |
| RU2011130511A (ru) | 2013-01-27 |
| EP2379586B1 (en) | 2016-11-02 |
| PT2379586T (pt) | 2017-02-09 |
| JP2012513209A (ja) | 2012-06-14 |
| HRP20170165T1 (hr) | 2017-04-07 |
| KR20110096579A (ko) | 2011-08-30 |
| CN102264760A (zh) | 2011-11-30 |
| SG173432A1 (en) | 2011-09-29 |
| DK2379586T3 (en) | 2017-02-06 |
| JP2016019530A (ja) | 2016-02-04 |
| RU2520823C2 (ru) | 2014-06-27 |
| AU2009332883A1 (en) | 2011-07-07 |
| KR101761094B1 (ko) | 2017-08-04 |
| PL2379586T3 (pl) | 2017-08-31 |
| SI2379586T1 (sl) | 2017-02-28 |
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