CY1119191T1 - Τετραπεπτιδια τα οποια παραγονται απο ανθρωπινες c-x-c χημειοκινες χρησιμα για τη θεραπεια διαφορων παθησεων του δερματος - Google Patents
Τετραπεπτιδια τα οποια παραγονται απο ανθρωπινες c-x-c χημειοκινες χρησιμα για τη θεραπεια διαφορων παθησεων του δερματοςInfo
- Publication number
- CY1119191T1 CY1119191T1 CY20171100663T CY171100663T CY1119191T1 CY 1119191 T1 CY1119191 T1 CY 1119191T1 CY 20171100663 T CY20171100663 T CY 20171100663T CY 171100663 T CY171100663 T CY 171100663T CY 1119191 T1 CY1119191 T1 CY 1119191T1
- Authority
- CY
- Cyprus
- Prior art keywords
- skin
- treatment
- inflammatory
- diseases
- psoriasis
- Prior art date
Links
- 208000017520 skin disease Diseases 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 210000003491 skin Anatomy 0.000 abstract 4
- 201000004681 Psoriasis Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 206010040925 Skin striae Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000029774 keratinocyte migration Effects 0.000 abstract 1
- 230000037311 normal skin Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000000770 proinflammatory effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Birds (AREA)
- Toxicology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Τετραπεπτίδια τα οποία αποτελούνται από (I ή V)-X1-K-X2, όπου το Χ1 μπορεί να επιλέγεται από Ε, Q ή Κ, και το Χ2 μπορεί να επιλέγεται από Μ, F, I, W ή V επιδεικνύουν διάφορες βιοδραστικότητες. Είναι πολυλειτουργικά μόρια τελεστή για να διεγείρουν τη μετανάστευση κερατινοκυττάρων να εξουδετερώνουν το προ-φλεγμονώδες αποτέλεσμα των βακτηριακών συστατικών κυτταρικού τοιχώματος όπως τα λιποτεϊχοϊκά οξέα του θετικού κατά Gram S. Aureus· και να επάγουν αγγειογένεση σε καλλιεργημένα ανθρώπινα ενδοθηλιακά κύτταρα της ομφαλικής φλέβας. Ρύθμιση προς τα κάτω της φλεγμονώδους πάθησης επιδεικνύεται επίσης με τη χρήση του μοντέλου δέρματος ψωρίασης SOR-300-FT για αντιπροσωπευτικό πεπτίδιο. Η βιοδραστικότητα υποστηρίζεται επίσης από τη μελέτη σχηματισμού προφίλ γονιδίου μετά από αγωγή κανονικών ιστών δέρματος με τη χρήση υποκατάστατων δέρματος EPIDERM™. Τα εφευρετικά πεπτίδια με διάφορες βιοδραστικότητες είναι χρήσιμα για την αγωγή διαφόρων παθήσεων του δέρματος, όπου συμπεριλαμβάνονται, μεταξύ άλλων, οξείες ή χρόνιες πληγές, striae disensae, γήρανση του δέρματος, έλεγχος των τριχών, φλεγμονώδες δέρμα όπως ψωρίαση, ατοπική δερματίτιδα και ροδόχρους ακμή και για απομάκρυνση ανεπιθύμητων τριχών ή για παθήσεις όπως απομάκρυνση δερματοϊνωμάτων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361835424P | 2013-06-14 | 2013-06-14 | |
| PCT/US2014/037978 WO2014200651A1 (en) | 2013-06-14 | 2014-05-14 | Tetrapeptides derived from human c-x-c chemokines useful for treatment of various skin conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119191T1 true CY1119191T1 (el) | 2018-02-14 |
Family
ID=50943603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100663T CY1119191T1 (el) | 2013-06-14 | 2017-06-22 | Τετραπεπτιδια τα οποια παραγονται απο ανθρωπινες c-x-c χημειοκινες χρησιμα για τη θεραπεια διαφορων παθησεων του δερματος |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10195245B2 (el) |
| EP (1) | EP3007716B1 (el) |
| JP (1) | JP6416240B2 (el) |
| KR (1) | KR102254260B1 (el) |
| CN (1) | CN105324122B (el) |
| AR (1) | AR096594A1 (el) |
| AU (1) | AU2014278708B2 (el) |
| BR (1) | BR112015031018B1 (el) |
| CA (1) | CA2915174C (el) |
| CY (1) | CY1119191T1 (el) |
| DK (1) | DK3007716T3 (el) |
| ES (1) | ES2631804T3 (el) |
| HK (1) | HK1217436A1 (el) |
| HU (1) | HUE032970T2 (el) |
| MX (1) | MX362846B (el) |
| MY (1) | MY168981A (el) |
| PL (1) | PL3007716T3 (el) |
| RU (1) | RU2687151C2 (el) |
| SG (1) | SG11201509048VA (el) |
| SI (1) | SI3007716T1 (el) |
| TW (1) | TWI511737B (el) |
| WO (1) | WO2014200651A1 (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302088A (zh) * | 2019-04-29 | 2019-10-08 | 杭州肽佳生物科技有限公司 | 一种包含修饰芋螺肽的化妆品组合物 |
| EP4093369A1 (en) * | 2020-01-21 | 2022-11-30 | ASC Regenity Ltd. | Cosmetic formulation for topical administration comprising novel peptides that improve appearance and regeneration of skin |
| PL245202B1 (pl) | 2020-03-06 | 2024-06-03 | Gdanski Univ Medyczny | Lipopeptydowe koniugaty i ich sole, sposób wytwarzania lipopeptydowych koniugatów i ich soli, kompozycja farmaceutyczna zawierająca lipopeptydowy koniugat i jego sole do leczenia ran przewlekłych |
| WO2022098051A1 (ko) | 2020-11-05 | 2022-05-12 | 한국생명공학연구원 | 항염 및 조직 재생작용을 갖는 신규 펩타이드 |
| CN113698452B (zh) * | 2021-08-23 | 2023-08-18 | 四川丽妍工坊生物科技有限公司 | 一种促皮肤修复肽、制备方法及其应用 |
| WO2023080790A1 (en) * | 2021-11-02 | 2023-05-11 | Tosoj As | Tri-, tetra and pentapeptides, compositions thereof and their use in the therapy of psoriasis |
| KR20230156265A (ko) | 2022-05-03 | 2023-11-14 | 한국생명공학연구원 | 신규 펩타이드 및 이의 항염 및 재생 용도 |
| WO2024106587A1 (ko) * | 2022-11-18 | 2024-05-23 | (주)케어젠 | 피부 상태 개선 활성을 갖는 펩타이드 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2077665A1 (en) * | 1990-03-05 | 1991-09-06 | Robert Siman | Chymotrypsin-like proteases and their inhibitors |
| FR2814076B1 (fr) | 2000-09-21 | 2002-12-20 | Centre Nat Rech Scient | Agent angiogenique et ses utilisations |
| WO2007026356A2 (en) | 2005-08-29 | 2007-03-08 | Healor Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| JP5535620B2 (ja) | 2006-06-13 | 2014-07-02 | ヘリックス バイオメディックス，インコーポレイテッド | 細胞外マトリックスタンパク質の合成を誘導するペプチドフラグメント |
| JP2007001981A (ja) | 2006-07-10 | 2007-01-11 | Nippon Meat Packers Inc | 皮膚組織の再生及び肌質改善効果のあるペプチドを含有する化粧品 |
| US7696174B2 (en) | 2007-01-05 | 2010-04-13 | Helix Biomedix, Inc. | Short bio-active peptides for cellular and immunological modulation |
| CA2701420C (en) | 2007-10-29 | 2016-02-09 | Helix Biomedix Inc. | Protective skin care tetrapeptides |
| EP2109054A1 (en) | 2008-04-09 | 2009-10-14 | Biotempt B.V. | Methods for identifying biologically active peptides and predicting their function |
| TWI429451B (zh) | 2011-10-26 | 2014-03-11 | Nat Univ Tsing Hua | 對具有ｅｌｒ－ｃｘｃ趨化素高度親和力的受體蛋白細胞所引發疾病之拮抗治療劑 |
-
2014
- 2014-05-14 AU AU2014278708A patent/AU2014278708B2/en active Active
- 2014-05-14 MX MX2015017089A patent/MX362846B/es active IP Right Grant
- 2014-05-14 BR BR112015031018-4A patent/BR112015031018B1/pt active IP Right Grant
- 2014-05-14 CN CN201480033362.9A patent/CN105324122B/zh active Active
- 2014-05-14 HU HUE14730697A patent/HUE032970T2/en unknown
- 2014-05-14 SI SI201430262T patent/SI3007716T1/sl unknown
- 2014-05-14 RU RU2015146679A patent/RU2687151C2/ru active
- 2014-05-14 SG SG11201509048VA patent/SG11201509048VA/en unknown
- 2014-05-14 PL PL14730697T patent/PL3007716T3/pl unknown
- 2014-05-14 WO PCT/US2014/037978 patent/WO2014200651A1/en active Application Filing
- 2014-05-14 JP JP2016519511A patent/JP6416240B2/ja active Active
- 2014-05-14 DK DK14730697.1T patent/DK3007716T3/en active
- 2014-05-14 US US14/907,811 patent/US10195245B2/en active Active
- 2014-05-14 MY MYPI2015704511A patent/MY168981A/en unknown
- 2014-05-14 KR KR1020157037042A patent/KR102254260B1/ko active IP Right Grant
- 2014-05-14 CA CA2915174A patent/CA2915174C/en active Active
- 2014-05-14 EP EP14730697.1A patent/EP3007716B1/en active Active
- 2014-05-14 ES ES14730697.1T patent/ES2631804T3/es active Active
- 2014-06-12 TW TW103120387A patent/TWI511737B/zh active
- 2014-06-12 AR ARP140102248A patent/AR096594A1/es not_active Application Discontinuation
-
2016
- 2016-05-12 HK HK16105420.1A patent/HK1217436A1/zh unknown
-
2017
- 2017-06-22 CY CY20171100663T patent/CY1119191T1/el unknown
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