MX2015017089A - Tetrapeptidos derivados de quimioquinas c-x-c humanas utiles para tratar diversas afecciones en la piel. - Google Patents
Tetrapeptidos derivados de quimioquinas c-x-c humanas utiles para tratar diversas afecciones en la piel.Info
- Publication number
- MX2015017089A MX2015017089A MX2015017089A MX2015017089A MX2015017089A MX 2015017089 A MX2015017089 A MX 2015017089A MX 2015017089 A MX2015017089 A MX 2015017089A MX 2015017089 A MX2015017089 A MX 2015017089A MX 2015017089 A MX2015017089 A MX 2015017089A
- Authority
- MX
- Mexico
- Prior art keywords
- skin
- treatment
- psoriasis
- human
- various skin
- Prior art date
Links
- 108050006947 CXC Chemokine Proteins 0.000 title 1
- 102000019388 CXC chemokine Human genes 0.000 title 1
- 210000003491 skin Anatomy 0.000 abstract 5
- 201000004681 Psoriasis Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000000770 proinflammatory effect Effects 0.000 abstract 2
- 206010000591 Acrochordon Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 241001303601 Rosacea Species 0.000 abstract 1
- 206010040925 Skin striae Diseases 0.000 abstract 1
- 208000031439 Striae Distensae Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 230000037311 normal skin Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 210000003606 umbilical vein Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Birds (AREA)
- Toxicology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Tetrapéptidos que consisten en la secuencia (I o V)-X1-K-X2, donde X1 puede seleccionarse entre E, Q o K y X2 puede seleccionarse entre M, F, I, W o V, que presentan actividades biológicas diversas. Pueden ser útiles para estimular la migración de los queratinocitos, para neutralizar el efecto proinflamatorio propio de determinados componentes de la pared de las bacterias, tales como los ácidos lipoteicoicos de las bacterias Gram positivas S. aureus, o para inducir la angiogénesis en las células provenientes del endotelio de la vena umbilical humana en cultivo. Mediante el uso de un modelo de la psoriasis basado en un tejido SOR-300-FT, también se ha demostrado que un péptido representativo fue útil para combatir diversas afecciones relacionadas con la inflamación. Por otro lado, la actividad biológica se analizó en función del perfil de diversos genes, en el contexto de un tratamiento sobre sustitutos de piel EPIDERMTM. Los péptidos de acuerdo con la presente invención, que presentan actividades biológicas diversas, pueden resultar útiles para tratar una variedad de afecciones en la piel, entre las que pueden mencionarse a modo de ejemplos no limitativos las heridas agudas o crónicas, las estrías, los efectos del envejecimiento, el deterioro del cabello y las afecciones relacionadas con la inflamación, tales como la psoriasis o la dermatitis atópica o la rosácea, así como para remover el cabello indeseable o las marcas en la piel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361835424P | 2013-06-14 | 2013-06-14 | |
| PCT/US2014/037978 WO2014200651A1 (en) | 2013-06-14 | 2014-05-14 | Tetrapeptides derived from human c-x-c chemokines useful for treatment of various skin conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015017089A true MX2015017089A (es) | 2016-04-11 |
| MX362846B MX362846B (es) | 2019-02-19 |
Family
ID=50943603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015017089A MX362846B (es) | 2013-06-14 | 2014-05-14 | Tetrapeptidos derivados de quimioquinas c-x-c humanas utiles para tratar diversas afecciones en la piel. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10195245B2 (es) |
| EP (1) | EP3007716B1 (es) |
| JP (1) | JP6416240B2 (es) |
| KR (1) | KR102254260B1 (es) |
| CN (1) | CN105324122B (es) |
| AR (1) | AR096594A1 (es) |
| AU (1) | AU2014278708B2 (es) |
| BR (1) | BR112015031018B1 (es) |
| CA (1) | CA2915174C (es) |
| CY (1) | CY1119191T1 (es) |
| DK (1) | DK3007716T3 (es) |
| ES (1) | ES2631804T3 (es) |
| HK (1) | HK1217436A1 (es) |
| HU (1) | HUE032970T2 (es) |
| MX (1) | MX362846B (es) |
| MY (1) | MY168981A (es) |
| PL (1) | PL3007716T3 (es) |
| RU (1) | RU2687151C2 (es) |
| SG (1) | SG11201509048VA (es) |
| SI (1) | SI3007716T1 (es) |
| TW (1) | TWI511737B (es) |
| WO (1) | WO2014200651A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302088A (zh) * | 2019-04-29 | 2019-10-08 | 杭州肽佳生物科技有限公司 | 一种包含修饰芋螺肽的化妆品组合物 |
| BR112022013144A2 (pt) * | 2020-01-21 | 2022-09-06 | Asc Regenity Ltd | Formulação cosmética para administração tópica compreendendo peptídeos que melhoram o aspecto e a regeneração da pele |
| PL245202B1 (pl) | 2020-03-06 | 2024-06-03 | Gdanski Univ Medyczny | Lipopeptydowe koniugaty i ich sole, sposób wytwarzania lipopeptydowych koniugatów i ich soli, kompozycja farmaceutyczna zawierająca lipopeptydowy koniugat i jego sole do leczenia ran przewlekłych |
| WO2022098051A1 (ko) | 2020-11-05 | 2022-05-12 | 한국생명공학연구원 | 항염 및 조직 재생작용을 갖는 신규 펩타이드 |
| CN113698452B (zh) * | 2021-08-23 | 2023-08-18 | 四川丽妍工坊生物科技有限公司 | 一种促皮肤修复肽、制备方法及其应用 |
| CA3233983A1 (en) * | 2021-11-02 | 2023-05-11 | Ole-Jan Iversen (Deceased) | Tri-, tetra and pentapeptides, compositions thereof and their use in the therapy of psoriasis |
| CN116407611A (zh) * | 2021-12-29 | 2023-07-11 | 四川好医生攀西药业有限责任公司 | 一种多肽在制备预防或治疗皮肤损伤疾病产品上的应用 |
| KR20230156265A (ko) | 2022-05-03 | 2023-11-14 | 한국생명공학연구원 | 신규 펩타이드 및 이의 항염 및 재생 용도 |
| KR20240086709A (ko) * | 2022-11-18 | 2024-06-19 | (주)케어젠 | 피부 상태 개선 활성을 갖는 펩타이드 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT62312A (en) * | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
| FR2814076B1 (fr) | 2000-09-21 | 2002-12-20 | Centre Nat Rech Scient | Agent angiogenique et ses utilisations |
| EP2462944A3 (en) | 2005-08-29 | 2012-09-12 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
| PT2409988E (pt) | 2006-06-13 | 2015-10-12 | Helix Biomedix Inc | Fragmentos peptídicos para induzir síntese de proteínas da matriz extracelular |
| JP2007001981A (ja) | 2006-07-10 | 2007-01-11 | Nippon Meat Packers Inc | 皮膚組織の再生及び肌質改善効果のあるペプチドを含有する化粧品 |
| SI2125878T1 (sl) * | 2007-01-05 | 2013-06-28 | Helix Biomedix, Inc. | Kratki bioaktivni peptidi za celično in imunološko modulacijo |
| ES2567706T3 (es) | 2007-10-29 | 2016-04-26 | Helix Biomedix Inc. | Tetrapéptidos protectores para cuidado cutáneo |
| EP2109054A1 (en) * | 2008-04-09 | 2009-10-14 | Biotempt B.V. | Methods for identifying biologically active peptides and predicting their function |
| TWI429451B (zh) * | 2011-10-26 | 2014-03-11 | Nat Univ Tsing Hua | 對具有ｅｌｒ－ｃｘｃ趨化素高度親和力的受體蛋白細胞所引發疾病之拮抗治療劑 |
-
2014
- 2014-05-14 BR BR112015031018-4A patent/BR112015031018B1/pt active IP Right Grant
- 2014-05-14 SI SI201430262T patent/SI3007716T1/sl unknown
- 2014-05-14 KR KR1020157037042A patent/KR102254260B1/ko active IP Right Grant
- 2014-05-14 PL PL14730697T patent/PL3007716T3/pl unknown
- 2014-05-14 JP JP2016519511A patent/JP6416240B2/ja active Active
- 2014-05-14 CN CN201480033362.9A patent/CN105324122B/zh active Active
- 2014-05-14 MY MYPI2015704511A patent/MY168981A/en unknown
- 2014-05-14 DK DK14730697.1T patent/DK3007716T3/en active
- 2014-05-14 RU RU2015146679A patent/RU2687151C2/ru active
- 2014-05-14 EP EP14730697.1A patent/EP3007716B1/en active Active
- 2014-05-14 CA CA2915174A patent/CA2915174C/en active Active
- 2014-05-14 AU AU2014278708A patent/AU2014278708B2/en active Active
- 2014-05-14 WO PCT/US2014/037978 patent/WO2014200651A1/en active Application Filing
- 2014-05-14 SG SG11201509048VA patent/SG11201509048VA/en unknown
- 2014-05-14 US US14/907,811 patent/US10195245B2/en active Active
- 2014-05-14 HU HUE14730697A patent/HUE032970T2/en unknown
- 2014-05-14 MX MX2015017089A patent/MX362846B/es active IP Right Grant
- 2014-05-14 ES ES14730697.1T patent/ES2631804T3/es active Active
- 2014-06-12 TW TW103120387A patent/TWI511737B/zh active
- 2014-06-12 AR ARP140102248A patent/AR096594A1/es not_active Application Discontinuation
-
2016
- 2016-05-12 HK HK16105420.1A patent/HK1217436A1/zh unknown
-
2017
- 2017-06-22 CY CY20171100663T patent/CY1119191T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |