CY1118137T1 - Αερολυμενες φθοροκινολονες και χρησεις αυτων - Google Patents
Αερολυμενες φθοροκινολονες και χρησεις αυτωνInfo
- Publication number
- CY1118137T1 CY1118137T1 CY20161101069T CY161101069T CY1118137T1 CY 1118137 T1 CY1118137 T1 CY 1118137T1 CY 20161101069 T CY20161101069 T CY 20161101069T CY 161101069 T CY161101069 T CY 161101069T CY 1118137 T1 CY1118137 T1 CY 1118137T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions
- fluoroquinolones
- infections
- aerosolized fluoroquinolones
- aerolysis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Στο παρόν αποκαλύπτονται συνθέσεις φθοροκινολονών κατάλληλες για αερόλυση και χρήση των συνθέσεων αυτών για τη χορήγηση αντιμικροβιακών φθοροκινολόνησης σε μορφή αερολύματος, για τη θεραπεία πνευμονικών βακτηριακών λοιμώξεων. Συγκεκριμένα, περιγράφεται η ειδικά μορφοποιημένη λεβοφλοξασίνη, που χορηγείται για την αντιμετώπιση βακτηριακών λοιμώξεων των πνευμόνων. Οι μέθοδοι περιλαμβάνουν πρωτόκολλα εισπνοής και διαδικασίες παρασκευής για την παραγωγή και τη χρήση των περιγραφόμενων συνθέσεων.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68253005P | 2005-05-18 | 2005-05-18 | |
US69616005P | 2005-07-01 | 2005-07-01 | |
US77330006P | 2006-02-13 | 2006-02-13 | |
PCT/US2006/019351 WO2006125132A2 (en) | 2005-05-18 | 2006-05-18 | Aerosolized fluoroquinolones and uses thereof |
EP06760146.8A EP1901749B1 (en) | 2005-05-18 | 2006-05-18 | Aerosolized fluoroquinolones and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118137T1 true CY1118137T1 (el) | 2017-06-28 |
Family
ID=37056548
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161101069T CY1118137T1 (el) | 2005-05-18 | 2016-10-25 | Αερολυμενες φθοροκινολονες και χρησεις αυτων |
CY2017006C CY2017006I2 (el) | 2005-05-18 | 2017-02-01 | Αερολυμενες φθοροκινολονες και χρησεις αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2017006C CY2017006I2 (el) | 2005-05-18 | 2017-02-01 | Αερολυμενες φθοροκινολονες και χρησεις αυτων |
Country Status (23)
Country | Link |
---|---|
EP (2) | EP1901749B1 (el) |
JP (2) | JP5279487B2 (el) |
KR (3) | KR101488402B1 (el) |
CN (2) | CN104173323B (el) |
AU (1) | AU2006247053B2 (el) |
CA (2) | CA2900093C (el) |
CY (2) | CY1118137T1 (el) |
DK (2) | DK1901749T3 (el) |
ES (2) | ES2599313T3 (el) |
HR (1) | HRP20161230T2 (el) |
HU (3) | HUE038814T2 (el) |
IL (3) | IL187346A (el) |
LT (2) | LT1901749T (el) |
LU (1) | LUC00004I2 (el) |
ME (1) | ME02562B (el) |
MX (1) | MX359219B (el) |
NZ (3) | NZ591509A (el) |
PL (2) | PL2594272T3 (el) |
PT (2) | PT1901749T (el) |
RS (1) | RS55114B1 (el) |
RU (2) | RU2603638C2 (el) |
SI (1) | SI2594272T1 (el) |
WO (1) | WO2006125132A2 (el) |
Families Citing this family (45)
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US7838532B2 (en) | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
WO2007090646A1 (en) * | 2006-02-10 | 2007-08-16 | Pari Pharma Gmbh | Nebulised antibiotics for inhalation therapy |
EP2030644A1 (en) * | 2007-08-31 | 2009-03-04 | PARI Pharma GmbH | Aerosols for sinunasal drug delivery |
CN101910412B (zh) * | 2007-10-25 | 2013-08-21 | 利发利希奥公司 | 调节细胞膜介导的细胞内信号转导的组合物和方法 |
EP2098219A1 (en) | 2008-03-05 | 2009-09-09 | PARI Pharma GmbH | Macrolide compositions having improved taste and stability |
WO2009140587A1 (en) | 2008-05-15 | 2009-11-19 | Novartis Ag | Pulmonary delivery of a fluoroquinolone |
CN105520922A (zh) * | 2008-10-07 | 2016-04-27 | 拉普特制药有限公司 | 用于改进的药物动力学的氟喹诺酮气雾剂制剂 |
US8629139B2 (en) * | 2008-10-07 | 2014-01-14 | Mpex Pharmaceuticals, Inc. | Topical use of Levofloxacin for reducing lung inflammation |
US20100209538A1 (en) * | 2009-02-18 | 2010-08-19 | Cipolla David C | Ph-modulated formulations for pulmonary delivery |
NZ596245A (en) * | 2009-04-24 | 2013-11-29 | Mpex Pharmaceuticals Inc | Methods of treating a pulmonary bacterial infection using fluoroquinolones |
JP5784012B2 (ja) * | 2009-07-02 | 2015-09-24 | アルコン リサーチ, リミテッド | 眼、耳または鼻の感染症を処置するためのフィナフロキサシンを含む組成物および方法 |
RU2012108962A (ru) * | 2009-08-19 | 2013-09-27 | Мпекс Фармасьютикалс, Инк. | Применение антибиотиков в форме аэрозоля для лечения хронической обструктивной болезни легких |
PL2470165T3 (pl) * | 2009-08-28 | 2018-09-28 | Hercules Llc | Kompozycja otoczkowa ze stałych proszkowych związków |
AU2015275224C1 (en) * | 2009-09-04 | 2017-11-16 | Horizon Therapeutics U.S. Holding Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
EP2473170B1 (en) * | 2009-09-04 | 2019-06-19 | Horizon Orphan LLC | Use of aerosolized levofloxacin for treating cystic fibrosis |
AU2011278693B2 (en) * | 2010-07-12 | 2015-02-19 | Xellia Pharmaceuticals Aps | Treatment of lung infections by administration of Tobramycin by aerolisation |
CN101914483B (zh) * | 2010-09-02 | 2013-07-31 | 福建新大陆生物技术股份有限公司 | 一种液基薄层细胞保存处理液及其用途 |
AU2011308865B2 (en) * | 2010-09-29 | 2017-01-05 | Pulmatrix, Inc. | Monovalent metal cation dry powders for inhalation |
US10092552B2 (en) * | 2011-01-31 | 2018-10-09 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
EP2491920A1 (en) * | 2011-02-25 | 2012-08-29 | Deva Holding Anonim Sirketi | Effervescent tablet, sachet and dry syrup of gemifloxacin |
CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
US9707228B2 (en) | 2012-05-21 | 2017-07-18 | Agency For Science, Technology And Research | Dry powder formulation |
CN105209458B (zh) * | 2013-03-15 | 2019-01-04 | 米兰比可卡大学 | 新颖的具有抗革兰氏阳性病原体活性的1,2,4-噁二唑化合物 |
US11064913B2 (en) | 2013-10-25 | 2021-07-20 | Force Impact Technologies, Inc. | Impact sensing wearable device and method |
CA2928736A1 (en) * | 2013-10-30 | 2015-05-07 | Inspirx Inc. | Inhaled aerosolized immuno-chemotherapy for the treatment of mdr tb |
CN103755730B (zh) * | 2014-01-28 | 2016-05-04 | 广西师范大学 | 马波沙星-钙螯合物及其合成方法和应用 |
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US10226426B2 (en) | 2015-03-02 | 2019-03-12 | Takeda Pharmaceutical Company Limited | Suspension containing nano-cocrystal and manufacturing method |
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CN112569211A (zh) * | 2019-09-27 | 2021-03-30 | 盈科瑞(天津)创新医药研究有限公司 | 一种吸入用加替沙星溶液及其制备方法 |
CN110823876B (zh) * | 2019-11-14 | 2022-06-28 | 东南大学 | 一种光学复合金属纳米材料的制备方法和应用 |
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