ATE429910T1 - Chlor enthaltende guanabenz derivate zur behandlung von prionerkrankungen - Google Patents
Chlor enthaltende guanabenz derivate zur behandlung von prionerkrankungenInfo
- Publication number
- ATE429910T1 ATE429910T1 AT06291548T AT06291548T ATE429910T1 AT E429910 T1 ATE429910 T1 AT E429910T1 AT 06291548 T AT06291548 T AT 06291548T AT 06291548 T AT06291548 T AT 06291548T AT E429910 T1 ATE429910 T1 AT E429910T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- containing chlorine
- derivatives containing
- prion diseases
- guanabenz derivatives
- Prior art date
Links
- 229910052801 chlorine Inorganic materials 0.000 title abstract 3
- 239000000460 chlorine Substances 0.000 title abstract 3
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 title 1
- WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz Chemical class NC(N)=N\N=C\C1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-YIXHJXPBSA-N 0.000 title 1
- 208000024777 Prion disease Diseases 0.000 title 1
- 102000029797 Prion Human genes 0.000 abstract 2
- 108091000054 Prion Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 chlorine Guanabenz derivatives Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06291548A EP1908465B1 (de) | 2006-10-04 | 2006-10-04 | Chlor enthaltende Guanabenz Derivate zur Behandlung von Prionerkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429910T1 true ATE429910T1 (de) | 2009-05-15 |
Family
ID=37836911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06291548T ATE429910T1 (de) | 2006-10-04 | 2006-10-04 | Chlor enthaltende guanabenz derivate zur behandlung von prionerkrankungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110251428A1 (de) |
| EP (2) | EP1908465B1 (de) |
| JP (1) | JP5186503B2 (de) |
| AT (1) | ATE429910T1 (de) |
| CA (1) | CA2664959A1 (de) |
| DE (1) | DE602006006578D1 (de) |
| WO (1) | WO2008041134A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012083397A1 (en) | 2010-12-22 | 2012-06-28 | Silvestre Labs Químia E Farmaceutica Ltda. | Guanabenz-containing compound for the treatment of primary cutaneous amyloidosis |
| GB201300435D0 (en) * | 2013-01-10 | 2013-02-27 | Medical Res Council | Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases |
| DK3280404T3 (da) | 2015-04-08 | 2021-11-08 | Res & Innovation Uk | Fremgangsmåder til valg af phosphatase-selektive og ikke-selektive phosphatasehæmmere |
| EP3529237A1 (de) | 2016-10-18 | 2019-08-28 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Naturproduktderivate zur hemmung von zellularer nekroptose, ferroptose und oxytose |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
| WO2019215470A1 (en) | 2018-05-09 | 2019-11-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975533A (en) * | 1970-04-29 | 1976-08-17 | Shell Oil Company | Therapeutic agents |
| US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
| US6413962B1 (en) * | 1988-05-02 | 2002-07-02 | N. Eric Naftchi | Guanidino compounds effective as anesthetics |
| AU5636300A (en) * | 1999-06-25 | 2001-01-31 | Avicena Group, Inc. | Use of creatine or creatine analogs for the prevention and treatment of transmissible spongiform encephalopathies |
| US7521479B2 (en) * | 2001-04-16 | 2009-04-21 | Panacea Pharmaceuticals, Inc. | Methods of treating prion disease in mammals |
| WO2003006426A1 (en) * | 2001-07-13 | 2003-01-23 | Axxima Pharmaceuticals Ag | Aromatic guanylhydrazones as effective compounds against neurodiseases |
| FR2846009B1 (fr) * | 2002-10-18 | 2007-10-12 | Centre Nat Rech Scient | Criblage de molecules a activite anti-prion:kits, methodes et molecules criblees |
| ES2328033T3 (es) * | 2002-10-18 | 2009-11-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulacion de la actividad quinasa s6 para el tratamiento de la obesidad. |
| FR2893844B1 (fr) * | 2005-11-28 | 2008-02-01 | Centre Nat Rech Scient | Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| EP1908464A1 (de) * | 2006-10-04 | 2008-04-09 | Centre National De La Recherche Scientifique (Cnrs) | Verwendung von Chlorine-Guanabenz-Deriaten zur Behandlung von Polyglutaminexpansionskrankheiten |
-
2006
- 2006-10-04 EP EP06291548A patent/EP1908465B1/de not_active Not-in-force
- 2006-10-04 DE DE602006006578T patent/DE602006006578D1/de active Active
- 2006-10-04 AT AT06291548T patent/ATE429910T1/de not_active IP Right Cessation
-
2007
- 2007-10-03 US US12/311,460 patent/US20110251428A1/en not_active Abandoned
- 2007-10-03 WO PCT/IB2007/004178 patent/WO2008041134A2/en not_active Ceased
- 2007-10-03 EP EP07859241A patent/EP2076253A2/de not_active Withdrawn
- 2007-10-03 JP JP2009530967A patent/JP5186503B2/ja not_active Expired - Fee Related
- 2007-10-03 CA CA002664959A patent/CA2664959A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2664959A1 (en) | 2008-04-10 |
| US20110251428A1 (en) | 2011-10-13 |
| EP1908465B1 (de) | 2009-04-29 |
| WO2008041134A2 (en) | 2008-04-10 |
| EP1908465A1 (de) | 2008-04-09 |
| EP2076253A2 (de) | 2009-07-08 |
| JP2010505815A (ja) | 2010-02-25 |
| DE602006006578D1 (de) | 2009-06-10 |
| WO2008041134A3 (en) | 2008-06-19 |
| JP5186503B2 (ja) | 2013-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE548032T1 (de) | Verwendung von chlorguanabenzderivaten zur behandlung von mit polyglutaminexpansion assoziierten erkrankungen | |
| EA201000050A1 (ru) | Замещенные бициклолактамные соединения | |
| EA201071045A1 (ru) | Соединения оксадиазоантрацена для лечения диабета | |
| ATE517882T1 (de) | Chinolinderivate | |
| CY1107956T1 (el) | Χρηση υποκατεστημενων 2-αμινοτετραλινιων για την προληπτικη αντιμετωπιση της νοσου του παρκινσον | |
| NO20072461L (no) | Fremstilling og anvendelse av bifenyl-4-yl-karbonylaminosyre derivater for behandling av fedme | |
| EA200900023A1 (ru) | Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли | |
| DK2212283T3 (da) | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf | |
| EA200501771A1 (ru) | Лиганды каннабиноидных рецепторов и их применения | |
| CY1111702T1 (el) | Τα παραγωγα ινδολης ως αγωνιστες υποδοχεων s1p1 | |
| ATE547417T1 (de) | Dihydropyrimidinverbindungen und ihre verwendungen bei der herstellung von medikamenten zur behandlung und prävention antiviraler krankheiten | |
| DK2212282T3 (da) | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf | |
| NO20082096L (no) | Azaindol-2-karboksamidderivativer | |
| EA201071006A1 (ru) | Набор, композиция, продукт или лекарственное средство для лечения нарушения познавательной способности | |
| MA32505B1 (fr) | 5-alcynyl-pyrimidines | |
| ATE534391T1 (de) | 3,11b-cis-dihydrotetrabenazin zur behandlung von psychosen | |
| CY1115729T1 (el) | Τρικυκλικη ενωση και φαρμακευτικη χρηση αυτης | |
| DE602007011434D1 (de) | 1h-indol-5-ylpiperazin-1-ylmethanonderivate | |
| WO2008041134A3 (en) | Use of chlorine guanabenz derivatives for treating prion-based diseases | |
| DE602006010738D1 (de) | Pyrroloä2,3-cüpyridinderivate | |
| MX2009013482A (es) | Derivados de [1,10]-fenantrolina para el tratamiento de enfermedades neurodegenerativas o hematologicas. | |
| DE602004019778D1 (de) | Verwendung von 2-amino-1,3-propandiolderivaten zur herstellung eines medikaments zur behandlung von bestimmten schmerzen | |
| DE602005014632D1 (de) | Pyrrol- bzw. imidazolamide zur behandlung von obesitas | |
| EA200801425A1 (ru) | Диазепиноны | |
| ATE466007T1 (de) | 5-substituierte indol-2-carbonsäureamidderivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |