DE602006006578D1 - Chlor enthaltende Guanabenz Derivate zur Behandlung von Prionerkrankungen - Google Patents
Chlor enthaltende Guanabenz Derivate zur Behandlung von PrionerkrankungenInfo
- Publication number
- DE602006006578D1 DE602006006578D1 DE602006006578T DE602006006578T DE602006006578D1 DE 602006006578 D1 DE602006006578 D1 DE 602006006578D1 DE 602006006578 T DE602006006578 T DE 602006006578T DE 602006006578 T DE602006006578 T DE 602006006578T DE 602006006578 D1 DE602006006578 D1 DE 602006006578D1
- Authority
- DE
- Germany
- Prior art keywords
- chlorine
- treatment
- prion diseases
- guanabenz derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06291548A EP1908465B1 (de) | 2006-10-04 | 2006-10-04 | Chlor enthaltende Guanabenz Derivate zur Behandlung von Prionerkrankungen |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006006578D1 true DE602006006578D1 (de) | 2009-06-10 |
Family
ID=37836911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006006578T Active DE602006006578D1 (de) | 2006-10-04 | 2006-10-04 | Chlor enthaltende Guanabenz Derivate zur Behandlung von Prionerkrankungen |
Country Status (7)
Country | Link |
---|---|
US (1) | US20110251428A1 (de) |
EP (2) | EP1908465B1 (de) |
JP (1) | JP5186503B2 (de) |
AT (1) | ATE429910T1 (de) |
CA (1) | CA2664959A1 (de) |
DE (1) | DE602006006578D1 (de) |
WO (1) | WO2008041134A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012083397A1 (en) | 2010-12-22 | 2012-06-28 | Silvestre Labs Químia E Farmaceutica Ltda. | Guanabenz-containing compound for the treatment of primary cutaneous amyloidosis |
GB201300435D0 (en) | 2013-01-10 | 2013-02-27 | Medical Res Council | Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases |
WO2016162689A1 (en) | 2015-04-08 | 2016-10-13 | Medical Research Council | Inhibitors and their uses |
US11224586B2 (en) * | 2016-10-18 | 2022-01-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Natural product derivatives for inhibiting cellular necroptosis, ferroptosis and oxytosis |
US20210177814A1 (en) | 2018-05-09 | 2021-06-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3975533A (en) * | 1970-04-29 | 1976-08-17 | Shell Oil Company | Therapeutic agents |
US3816531A (en) * | 1970-07-01 | 1974-06-11 | American Home Prod | (2,6-disubstituted benzylidene)amino guanidines and related compounds |
US6413962B1 (en) * | 1988-05-02 | 2002-07-02 | N. Eric Naftchi | Guanidino compounds effective as anesthetics |
AU5636300A (en) * | 1999-06-25 | 2001-01-31 | Avicena Group, Inc. | Use of creatine or creatine analogs for the prevention and treatment of transmissible spongiform encephalopathies |
US7521479B2 (en) * | 2001-04-16 | 2009-04-21 | Panacea Pharmaceuticals, Inc. | Methods of treating prion disease in mammals |
WO2003006426A1 (en) * | 2001-07-13 | 2003-01-23 | Axxima Pharmaceuticals Ag | Aromatic guanylhydrazones as effective compounds against neurodiseases |
JP2006502744A (ja) * | 2002-10-18 | 2006-01-26 | ノバルティス・フォルシュングスシュティフトゥング・ツヴァイクニーダーラッスング・フリードリッヒ・ミーシェー・インスティトゥート・フォー・バイオメディカル・リサーチ | 肥満処置のためのs6キナーゼ活性のモジュレーション |
FR2846009B1 (fr) * | 2002-10-18 | 2007-10-12 | Centre Nat Rech Scient | Criblage de molecules a activite anti-prion:kits, methodes et molecules criblees |
FR2893844B1 (fr) * | 2005-11-28 | 2008-02-01 | Centre Nat Rech Scient | Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
EP1908464A1 (de) * | 2006-10-04 | 2008-04-09 | Centre National De La Recherche Scientifique (Cnrs) | Verwendung von Chlorine-Guanabenz-Deriaten zur Behandlung von Polyglutaminexpansionskrankheiten |
-
2006
- 2006-10-04 DE DE602006006578T patent/DE602006006578D1/de active Active
- 2006-10-04 EP EP06291548A patent/EP1908465B1/de not_active Not-in-force
- 2006-10-04 AT AT06291548T patent/ATE429910T1/de not_active IP Right Cessation
-
2007
- 2007-10-03 EP EP07859241A patent/EP2076253A2/de not_active Withdrawn
- 2007-10-03 CA CA002664959A patent/CA2664959A1/en not_active Abandoned
- 2007-10-03 WO PCT/IB2007/004178 patent/WO2008041134A2/en active Application Filing
- 2007-10-03 US US12/311,460 patent/US20110251428A1/en not_active Abandoned
- 2007-10-03 JP JP2009530967A patent/JP5186503B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2010505815A (ja) | 2010-02-25 |
WO2008041134A3 (en) | 2008-06-19 |
US20110251428A1 (en) | 2011-10-13 |
CA2664959A1 (en) | 2008-04-10 |
EP2076253A2 (de) | 2009-07-08 |
EP1908465A1 (de) | 2008-04-09 |
WO2008041134A2 (en) | 2008-04-10 |
JP5186503B2 (ja) | 2013-04-17 |
ATE429910T1 (de) | 2009-05-15 |
EP1908465B1 (de) | 2009-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |