ATE548032T1 - Verwendung von chlorguanabenzderivaten zur behandlung von mit polyglutaminexpansion assoziierten erkrankungen - Google Patents
Verwendung von chlorguanabenzderivaten zur behandlung von mit polyglutaminexpansion assoziierten erkrankungenInfo
- Publication number
- ATE548032T1 ATE548032T1 AT07859240T AT07859240T ATE548032T1 AT E548032 T1 ATE548032 T1 AT E548032T1 AT 07859240 T AT07859240 T AT 07859240T AT 07859240 T AT07859240 T AT 07859240T AT E548032 T1 ATE548032 T1 AT E548032T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- polyglutamine expansion
- chlorguanabenz
- treatment
- diseases associated
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 229920000155 polyglutamine Polymers 0.000 title abstract 3
- 108010040003 polyglutamine Proteins 0.000 title abstract 3
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- -1 chlorine Guanabenz derivatives Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06291547A EP1908464A1 (de) | 2006-10-04 | 2006-10-04 | Verwendung von Chlorine-Guanabenz-Deriaten zur Behandlung von Polyglutaminexpansionskrankheiten |
| PCT/IB2007/004177 WO2008041133A2 (en) | 2006-10-04 | 2007-10-03 | Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE548032T1 true ATE548032T1 (de) | 2012-03-15 |
Family
ID=37492124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07859240T ATE548032T1 (de) | 2006-10-04 | 2007-10-03 | Verwendung von chlorguanabenzderivaten zur behandlung von mit polyglutaminexpansion assoziierten erkrankungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7932422B2 (de) |
| EP (2) | EP1908464A1 (de) |
| JP (1) | JP5264739B2 (de) |
| AT (1) | ATE548032T1 (de) |
| CA (1) | CA2664933C (de) |
| WO (1) | WO2008041133A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2893844B1 (fr) * | 2005-11-28 | 2008-02-01 | Centre Nat Rech Scient | Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| ATE429910T1 (de) * | 2006-10-04 | 2009-05-15 | Centre Nat Rech Scient | Chlor enthaltende guanabenz derivate zur behandlung von prionerkrankungen |
| US20130274235A1 (en) * | 2010-10-08 | 2013-10-17 | The General Hospital Corporation | Treatment of motor neuron disease |
| GB201300435D0 (en) | 2013-01-10 | 2013-02-27 | Medical Res Council | Benzylideneguanidine Derivatives and Therapeutic Use for the Treatment of Protein Misfolding Diseases |
| WO2014138298A1 (en) | 2013-03-05 | 2014-09-12 | University Of Chicago | Treatment of demyelinating disorders |
| PL3164391T3 (pl) * | 2014-07-02 | 2019-12-31 | Inflectis Bioscience | Pochodne O-alkilo-benzylidenoguanidyny i zastosowanie terapeutyczne w leczeniu zaburzeń związanych z akumulacją nieprawidłowo pofałdowanych białek |
| ES2812800T3 (es) * | 2014-07-02 | 2021-03-18 | Inflectis Bioscience | Nuevos usos terapéuticos de derivados de la bencilidenguanidina para el tratamiento de proteopatías |
| EP3280404B1 (de) | 2015-04-08 | 2021-10-06 | United Kingdom Research and Innovation | Verfahren zur auswahl von phosphataseselektiven und nichtselektiven phosphataseinhibitoren |
| US20180230105A1 (en) | 2017-01-13 | 2018-08-16 | Regents Of The University Of Minnesota | Therapeutic compounds |
| EP3790539A1 (de) | 2018-05-09 | 2021-03-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verwendung von guanabenz oder derivaten davon zur behandlung vom typ-1-ifn-abhängigen pathologien |
| EP3996697A1 (de) | 2019-07-09 | 2022-05-18 | Université de Bretagne Occidentale (U.B.O.) | Neue pfar-hemmende verbindungen |
| US20240293343A1 (en) * | 2023-02-13 | 2024-09-05 | Inflectis Bioscience | Benzylideneaminoguanidine derivatives as NR2B-selective NMDA receptor antagonists and their therapeutic applications |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0705100T3 (da) * | 1993-05-27 | 2003-11-17 | Cenes Ltd | Terapeutiske substituerede guanidiner |
| US20050148673A1 (en) * | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
-
2006
- 2006-10-04 EP EP06291547A patent/EP1908464A1/de not_active Withdrawn
-
2007
- 2007-10-03 AT AT07859240T patent/ATE548032T1/de active
- 2007-10-03 EP EP07859240A patent/EP2066312B1/de active Active
- 2007-10-03 US US12/311,433 patent/US7932422B2/en active Active
- 2007-10-03 CA CA2664933A patent/CA2664933C/en active Active
- 2007-10-03 WO PCT/IB2007/004177 patent/WO2008041133A2/en not_active Ceased
- 2007-10-03 JP JP2009530966A patent/JP5264739B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008041133A3 (en) | 2008-10-16 |
| US7932422B2 (en) | 2011-04-26 |
| CA2664933C (en) | 2014-12-09 |
| CA2664933A1 (en) | 2008-04-10 |
| EP2066312B1 (de) | 2012-03-07 |
| US20100036166A1 (en) | 2010-02-11 |
| WO2008041133A2 (en) | 2008-04-10 |
| EP1908464A1 (de) | 2008-04-09 |
| JP2010505814A (ja) | 2010-02-25 |
| JP5264739B2 (ja) | 2013-08-14 |
| EP2066312A2 (de) | 2009-06-10 |
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