EA200970537A1 - Антибактериальные производные хинолина - Google Patents

Антибактериальные производные хинолина

Info

Publication number
EA200970537A1
EA200970537A1 EA200970537A EA200970537A EA200970537A1 EA 200970537 A1 EA200970537 A1 EA 200970537A1 EA 200970537 A EA200970537 A EA 200970537A EA 200970537 A EA200970537 A EA 200970537A EA 200970537 A1 EA200970537 A1 EA 200970537A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
pharmaceutically acceptable
treatment
quinoline
formula
Prior art date
Application number
EA200970537A
Other languages
English (en)
Other versions
EA016760B1 (ru
Inventor
Жером Эмиль Жорж Гийемон
Исмет Доранж
Давид Франсис Ален Лансуа
Хосе Мануэль Виллалгордо-Сото
Иван Рене Фердинан Симонне
Магали Мадлен Симон Мотт
Кунрад Йозеф Лодевейк Марсель Андрис
Анил Коул
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38048032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200970537(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200970537A1 publication Critical patent/EA200970537A1/ru
Publication of EA016760B1 publication Critical patent/EA016760B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Настоящее изобретение относится к новым производным замещенных хинолинов общей формулы (Ia) или формулы (Ib), включая любую их стереохимически изомерную форму, их фармацевтически приемлемую соль, их N-оксидную форму или их сольват. Заявляемые соединения полезны при лечении бактериальной инфекции. Также заявляется композиция, содержащая фармацевтически приемлемый носитель и в качестве активного ингредиента терапевтически эффективное количество заявляемых соединений, применение заявляемых соединений или композиций для изготовления лекарственного средства для лечения бактериальной инфекции и способ получения заявляемых соединений.
EA200970537A 2006-12-06 2007-12-04 Антибактериальные производные хинолина EA016760B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125545 2006-12-06
PCT/EP2007/063319 WO2008068272A2 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (2)

Publication Number Publication Date
EA200970537A1 true EA200970537A1 (ru) 2009-10-30
EA016760B1 EA016760B1 (ru) 2012-07-30

Family

ID=38048032

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970537A EA016760B1 (ru) 2006-12-06 2007-12-04 Антибактериальные производные хинолина

Country Status (34)

Country Link
US (1) US20100063026A1 (ru)
EP (1) EP2099761B1 (ru)
JP (1) JP5466013B2 (ru)
KR (1) KR101553600B1 (ru)
CN (1) CN101547906B (ru)
AP (1) AP2477A (ru)
AR (1) AR064148A1 (ru)
AT (1) ATE486061T1 (ru)
AU (1) AU2007328892B2 (ru)
BR (1) BRPI0719915A2 (ru)
CA (1) CA2668558C (ru)
CL (1) CL2007003518A1 (ru)
CY (1) CY1112027T1 (ru)
DE (1) DE602007010182D1 (ru)
DK (1) DK2099761T3 (ru)
EA (1) EA016760B1 (ru)
ES (1) ES2354755T3 (ru)
HK (1) HK1137437A1 (ru)
HR (1) HRP20110024T1 (ru)
IL (1) IL199082A (ru)
JO (1) JO2683B1 (ru)
ME (1) ME01230B (ru)
MX (1) MX2009005906A (ru)
MY (1) MY145940A (ru)
NO (1) NO341984B1 (ru)
NZ (1) NZ576862A (ru)
PL (1) PL2099761T3 (ru)
PT (1) PT2099761E (ru)
RS (1) RS51582B (ru)
SI (1) SI2099761T1 (ru)
TW (1) TWI487526B (ru)
UA (1) UA101307C2 (ru)
WO (1) WO2008068272A2 (ru)
ZA (1) ZA200903949B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
EA038350B1 (ru) * 2012-04-27 2021-08-12 Янссен Фармацевтика Нв Антибактериальные хинолиновые производные
PL2841425T3 (pl) 2012-04-27 2016-10-31 Antybakteryjne pochodne chinoliny

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (en) * 1996-10-28 2001-04-11 Dept Of The Army Us Government COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS
RS52431B (en) * 2002-07-25 2013-02-28 Janssen Pharmaceutica N.V. QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS
US7902225B2 (en) * 2004-01-23 2011-03-08 Janssen Pharmaceutica Nv Mycobacterial inhibitors
JP4919810B2 (ja) * 2004-01-29 2012-04-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイコバクテリア抑制剤としての使用のためのキノリン誘導体
CN102908347A (zh) * 2004-05-28 2013-02-06 詹森药业有限公司 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JP5193857B2 (ja) * 2005-06-28 2013-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗菌剤としてのキノリン誘導体
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents

Also Published As

Publication number Publication date
US20100063026A1 (en) 2010-03-11
TWI487526B (zh) 2015-06-11
AR064148A1 (es) 2009-03-18
CL2007003518A1 (es) 2008-07-11
MX2009005906A (es) 2009-06-16
UA101307C2 (ru) 2013-03-25
NO20092541L (no) 2009-09-02
DK2099761T3 (da) 2011-02-07
ES2354755T3 (es) 2011-03-17
ZA200903949B (en) 2010-08-25
TW200831095A (en) 2008-08-01
BRPI0719915A2 (pt) 2014-03-04
JO2683B1 (en) 2013-03-03
AP2477A (en) 2012-09-27
PL2099761T3 (pl) 2011-04-29
ATE486061T1 (de) 2010-11-15
EP2099761B1 (en) 2010-10-27
CY1112027T1 (el) 2015-11-04
CA2668558A1 (en) 2008-06-12
WO2008068272A2 (en) 2008-06-12
HK1137437A1 (en) 2010-07-30
MY145940A (en) 2012-05-31
ME01230B (me) 2013-03-20
IL199082A (en) 2014-04-30
EA016760B1 (ru) 2012-07-30
CA2668558C (en) 2016-06-07
SI2099761T1 (sl) 2011-02-28
CN101547906A (zh) 2009-09-30
NZ576862A (en) 2012-01-12
CN101547906B (zh) 2014-08-06
KR20090102778A (ko) 2009-09-30
JP5466013B2 (ja) 2014-04-09
KR101553600B1 (ko) 2015-09-16
HRP20110024T1 (hr) 2011-04-30
PT2099761E (pt) 2011-01-18
WO2008068272A3 (en) 2008-07-24
AP2009004873A0 (en) 2009-06-30
NO341984B1 (no) 2018-03-05
DE602007010182D1 (de) 2010-12-09
RS51582B (en) 2011-08-31
EP2099761A2 (en) 2009-09-16
JP2010511672A (ja) 2010-04-15
AU2007328892B2 (en) 2013-05-16
AU2007328892A1 (en) 2008-06-12

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