EA201491992A1 - Новые соединения и новое применение - Google Patents
Новые соединения и новое применениеInfo
- Publication number
- EA201491992A1 EA201491992A1 EA201491992A EA201491992A EA201491992A1 EA 201491992 A1 EA201491992 A1 EA 201491992A1 EA 201491992 A EA201491992 A EA 201491992A EA 201491992 A EA201491992 A EA 201491992A EA 201491992 A1 EA201491992 A1 EA 201491992A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- new
- compounds
- connections
- applications
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к новым соединениям формулы Iили их фармацевтически приемлемым солям, где переменные являются такими, как определено в описании. Заявленные соединения являются применимыми для лечения бактериальной инфекции. Также заявляется композиция, содержащая фармацевтически приемлемый носитель и, в качестве активного ингредиента, терапевтически эффективное количество заявленных соединений, применение заявленных соединений или композиций для получения лекарственного средства для лечения бактериальной инфекции и способ получения заявленных соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12166140 | 2012-04-30 | ||
| PCT/EP2013/058980 WO2013164337A1 (en) | 2012-04-30 | 2013-04-30 | New compounds and new use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491992A1 true EA201491992A1 (ru) | 2015-02-27 |
| EA030899B1 EA030899B1 (ru) | 2018-10-31 |
Family
ID=48430690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201491992A EA030899B1 (ru) | 2012-04-30 | 2013-04-30 | Производные 5-фенилпиримидина с антибактериальными свойствами |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9725432B2 (ru) |
| EP (1) | EP2938599B1 (ru) |
| JP (2) | JP6349303B2 (ru) |
| KR (1) | KR102186851B1 (ru) |
| CN (1) | CN104487425B (ru) |
| AR (1) | AR090880A1 (ru) |
| AU (1) | AU2013255843B2 (ru) |
| BR (1) | BR112014026776B1 (ru) |
| CA (1) | CA2868930C (ru) |
| EA (1) | EA030899B1 (ru) |
| ES (1) | ES2676189T3 (ru) |
| HK (1) | HK1208454A1 (ru) |
| IN (1) | IN2014MN02363A (ru) |
| MX (1) | MX358189B (ru) |
| NZ (2) | NZ724424A (ru) |
| TW (1) | TWI598099B (ru) |
| WO (1) | WO2013164337A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR090880A1 (es) * | 2012-04-30 | 2014-12-10 | Janssen R & D Ireland | Derivados de pirimidina |
| WO2019121352A1 (en) * | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887870B1 (en) * | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| ES2290436T3 (es) * | 2002-03-15 | 2008-02-16 | Ciba Specialty Chemicals Holding Inc. | Uso de 4-aminopiridinas para el tratamiento antimicrobiano de superficies. |
| DE102004003493A1 (de) | 2004-01-23 | 2005-08-11 | Bayer Cropscience Ag | 5-Phenylpyrimidine |
| JP2008536950A (ja) * | 2005-04-18 | 2008-09-11 | ニューロジェン・コーポレーション | 置換ヘテロアリールのｃｂ１拮抗薬 |
| JP5704924B2 (ja) * | 2008-02-01 | 2015-04-22 | オーキッド リサーチ ラボラトリーズ リミティド | 新規複素環化合物 |
| AU2010320963B2 (en) * | 2009-11-18 | 2015-07-09 | Fab Pharma Sas | Novel heterocyclic acrylamides and their use as pharmaceuticals |
| WO2011060976A1 (en) * | 2009-11-20 | 2011-05-26 | Universite De Liege | Tryptamine-derived compounds as antibacterial agents |
| DK2513115T3 (da) * | 2009-12-18 | 2014-01-13 | Basilea Pharmaceutica Ag | Tricycliske antibiotika |
| AR090880A1 (es) * | 2012-04-30 | 2014-12-10 | Janssen R & D Ireland | Derivados de pirimidina |
-
2013
- 2013-04-29 AR ARP130101454A patent/AR090880A1/es active IP Right Grant
- 2013-04-29 TW TW102115187A patent/TWI598099B/zh not_active IP Right Cessation
- 2013-04-30 NZ NZ724424A patent/NZ724424A/en not_active IP Right Cessation
- 2013-04-30 KR KR1020147029515A patent/KR102186851B1/ko active IP Right Grant
- 2013-04-30 ES ES13722329.3T patent/ES2676189T3/es active Active
- 2013-04-30 CA CA2868930A patent/CA2868930C/en active Active
- 2013-04-30 CN CN201380022591.6A patent/CN104487425B/zh active Active
- 2013-04-30 EP EP13722329.3A patent/EP2938599B1/en active Active
- 2013-04-30 EA EA201491992A patent/EA030899B1/ru not_active IP Right Cessation
- 2013-04-30 MX MX2014013165A patent/MX358189B/es active IP Right Grant
- 2013-04-30 US US14/397,501 patent/US9725432B2/en active Active
- 2013-04-30 JP JP2015509418A patent/JP6349303B2/ja active Active
- 2013-04-30 IN IN2363MUN2014 patent/IN2014MN02363A/en unknown
- 2013-04-30 AU AU2013255843A patent/AU2013255843B2/en active Active
- 2013-04-30 NZ NZ700507A patent/NZ700507A/en not_active IP Right Cessation
- 2013-04-30 WO PCT/EP2013/058980 patent/WO2013164337A1/en active Application Filing
- 2013-04-30 BR BR112014026776-6A patent/BR112014026776B1/pt active IP Right Grant
-
2015
- 2015-09-17 HK HK15109091.2A patent/HK1208454A1/zh not_active IP Right Cessation
-
2017
- 2017-08-04 US US15/668,773 patent/US10221157B2/en active Active
-
2018
- 2018-03-20 JP JP2018052573A patent/JP6622839B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2868930C (en) | 2023-11-28 |
| BR112014026776A2 (pt) | 2017-06-27 |
| EP2938599A1 (en) | 2015-11-04 |
| EA030899B1 (ru) | 2018-10-31 |
| US9725432B2 (en) | 2017-08-08 |
| AU2013255843B2 (en) | 2017-11-02 |
| KR102186851B1 (ko) | 2020-12-07 |
| IN2014MN02363A (ru) | 2015-08-14 |
| AU2013255843A1 (en) | 2014-10-23 |
| JP6349303B2 (ja) | 2018-06-27 |
| CN104487425A (zh) | 2015-04-01 |
| CA2868930A1 (en) | 2013-11-07 |
| BR112014026776B1 (pt) | 2020-03-17 |
| ES2676189T3 (es) | 2018-07-17 |
| NZ724424A (en) | 2018-02-23 |
| JP2015515967A (ja) | 2015-06-04 |
| TWI598099B (zh) | 2017-09-11 |
| KR20150003749A (ko) | 2015-01-09 |
| EP2938599B1 (en) | 2018-04-11 |
| TW201350121A (zh) | 2013-12-16 |
| US20150087651A1 (en) | 2015-03-26 |
| US20170334880A1 (en) | 2017-11-23 |
| MX358189B (es) | 2018-08-07 |
| JP6622839B2 (ja) | 2019-12-18 |
| AR090880A1 (es) | 2014-12-10 |
| US10221157B2 (en) | 2019-03-05 |
| MX2014013165A (es) | 2015-01-19 |
| CN104487425B (zh) | 2016-09-14 |
| JP2018135338A (ja) | 2018-08-30 |
| NZ700507A (en) | 2016-09-30 |
| WO2013164337A9 (en) | 2014-09-18 |
| HK1208454A1 (zh) | 2016-03-04 |
| WO2013164337A1 (en) | 2013-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KG TJ TM |