AR064148A1 - Derivados de quinolina antibacterial - Google Patents
Derivados de quinolina antibacterialInfo
- Publication number
- AR064148A1 AR064148A1 ARP070105441A ARP070105441A AR064148A1 AR 064148 A1 AR064148 A1 AR 064148A1 AR P070105441 A ARP070105441 A AR P070105441A AR P070105441 A ARP070105441 A AR P070105441A AR 064148 A1 AR064148 A1 AR 064148A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- mono
- het
- optionally substituted
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- -1 cyano, formyl Chemical group 0.000 abstract 27
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 10
- 125000001424 substituent group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 7
- 125000001475 halogen functional group Chemical group 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000004414 alkyl thio group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000003386 piperidinyl group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000004076 pyridyl group Chemical group 0.000 abstract 4
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000005984 hexahydro-1H-1,4-diazepinyl group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 2
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 2
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005418 aryl aryl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002632 imidazolidinyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 abstract 1
- 125000001422 pyrrolinyl group Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004306 triazinyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Los compuestos reivindicados son utiles para el tratamiento de una infeccion bacteriana. Incluso, se reivindica una composicion que comprende un vehículo farmacéuticamente aceptable y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reivindicados, el uso de los compuestos o composiciones reivindicadas para la preparacion de un medicamento para el tratamiento de una infeccion bacteriana y un proceso para preparar los compuestos reivindicados. Reivindicacion 1: Un compuesto de formula (1a) o (1b) que incluye cualquier forma estereoquímicamente isomérica del mismo, en donde p es un numero entero igual a 1, 2, 3 o 4; q es un numero entero igual a cero, 1, 2, 3 o 4; R1 es hidrogeno, ciano, formilo, carboxilo, halo, alquilo, alquenilo C2-6, alquinilo C2-6, haloalquilo, hidroxi, alquiloxi, alquiltio, alquiltioalquilo, -C=N-OR11, amino, mono o di(alquil)amino, aminoalquilo, mono o di(alquil)aminoalquilo, alquilcarboniloaminoalquilo, aminocarbonilo, mono o di(alquil)aminocarbonilo, arilalquilo, arilcarbonilo, R5aR4aNalquilo, di(aril)alquilo, arilo, R5aR4aN-, R5aR4aN-C(=O)-, o Het; R2 es hidrogeno, alquiloxi, arilo, ariloxi, hidroxi, mercapto, alquiloxialquiloxi, alquiltio, mono o di(alquilo)amino, pirrolidino o un radical de formula (2) en donde Y es CH2, O, S, NH o N-alquilo; R3 es alquilo, arilalquilo, aril-O-alquilo, aril-alquil-O-alquilo, arilo, aril-arilo, Het, Het-alquilo, Het-O-alquilo, Het-alquil-O-alquilo o un radical de formula (3); R4 es H o alquilo; R5 es -C(=NH)-NH2; arilalquilo; Het-alquilo; mono o dialquilaminoalquilo; biciclo[2.2.2]heptilo; het; o arilo; o R4 y R5 junto con el átomo de nitrogeno al que se encuentran unidos, forman un radical seleccionado del grupo que comprende azetidinilo; 2,3-dihidroisoindol-1-ilo; tiazolidin-3-ilo; 1 2,3,6-tetrahidropiridilo; hexahidro-1H-azepinilo; hexahidro-1H-1,4-diazepinilo; hexahidro-1,4-oxazepinilo; 1 ,2,3,4-tetrahidroisoquinolin-2-ilo; 2,5- diazabiciclo[2.2.1]heptilo; 1,1-dioxido-tiomorfolinilo; cada radical opcionalmente sustituido con 1, 2, 3 o 4 sustituyentes, cada sustituyente seleccionado en forma independiente de alquilo, haloalquilo, alquilcarbonilo, halo, arilalquilo, hidroxi, alquiloxi, amino, mono o dialquilamino, mono o dialquilaminoalquilo, alquiltio, alquiloxialquilo, alquiltioalquilo, arilo, piperidinilo opcionalmente sustituido con alquilo, pirrolidinilo opcionalmente sustituido con arilalquilo, piridilo o pirimidinilo; o R4 y R5 junto con el átomo de nitrogeno al que se encuentran unidos, forman un radical seleccionado del grupo que comprende piperidinilo o piperazinilo, cada uno sustituido con arilo, alquilcarbonilo, piperidinilo o pirrolidinilo opcionalmente sustituido con arilalquilo; R4a y R5a junto con el átomo de nitrogeno al que se encuentran unidos, forman un radical seleccionado del grupo que comprende pirrolidino, piperidino, piperazino, morfolino, 4-tiomorfolino, 2,3- dihidroisoindol-1-ilo, tiazolidin-3-ilo, 1,2,3,6-tetrahidropiridilo, hexahidro-1H-azepinilo, hexahidro-1H-1,4-diazepinilo, hexahidro-1,4-oxazepinilo, 1,2,3,4-tetrahidroisoquinolin-2-ilo, pirrolinilo, pirrolilo, imidazolidinilo, pirazolidinilo, 2- imidazolinilo, 2-pirazolinilo, imidazolilo, pirazolilo, triazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo y triazinilo, cada radical opcionalmente sustituido con 1, 2, 3 o 4 sustituyentes, cada sustituyente seleccionado en forma independiente de alquilo, haloalquilo, halo, arilalquilo, hidroxi, alquiloxi, amino, mono o dialquiloamino, alquiltio, alquiltioalquilo, arilo, piridilo o pirimidinilo; R6 es arilo1 o Het; R7 es hidrogeno, halo, alquilo, arilo o Het; R8 es hidrogeno o alquilo; R9 es oxo; o R8 y R9 forman juntos el radical -CH=CH-N=; R11 es hidrogeno o alquilo; arilo es un homociclo seleccionado de fenilo, naftilo, acenaftilo o tetrahidronaftilo, cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado en forma independiente de hidroxi, halo, ciano, nitro, amino, mono o dialquiloamino, alquilo, alquenilo C2-6 opcionalmente sustituido con fenilo, haloalquilo, alquiloxi, haloalquiloxi, carboxilo, alquiloxicarbonilo, aminocarbonilo, morfolinilo o mono o dialquilaminocarbonilo; arilo1 es un homociclo seleccionado de fenilo, naftilo, acenaftilo o tetrahidronaftilo, cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado en forma independiente de hidroxi, halo, ciano, nitro, amino, mono o dialquilamino, alquilo, haloalquilo, alquiloxi, alquiltio, haloalquiloxi, carboxilo, alquiloxicarbonilo, aminocarbonilo, morfolinilo, Het o mono o dialquilaminocarbonilo; Het es un heterociclo monocíclico seleccionado de N-fenoxipiperidinilo, piperidinilo, piperazina, pirrolilo, pirazolilo, imidazolilo, furanilo, tienilo, oxazolilo, isoxazolilo, tiazolilo, isotiazolilo, piridinilo, pirimidinilo, pirazinilo o piridazinilo; o un heterociclo bicíclico seleccionado de quinolinilo, quinoxalinilo, indolilo, bencimidazolilo, benzoxazolilo, bencisoxazolilo, benzotiazolilo, bencisotiazolilo, benzofuranilo, benzotienilo, 2,3-dihidrobenzo[1,4]dioxinilo o benzo[1,3]dioxolilo; cada heterociclo monocíclico y bicíclico opcionalmente sustituido con 1, 2 o 3 sustituyentes, cada sustituyente seleccionado en forma independiente de halo, hidroxi, alquilo o alquiloxi; con la condicion que R5 no sea bencilo; un N-oxido del mismo, una sal farmacéuticamente aceptable del mismo o un solvato del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125545 | 2006-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064148A1 true AR064148A1 (es) | 2009-03-18 |
Family
ID=38048032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105441A AR064148A1 (es) | 2006-12-06 | 2007-12-05 | Derivados de quinolina antibacterial |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US20100063026A1 (es) |
| EP (1) | EP2099761B1 (es) |
| JP (1) | JP5466013B2 (es) |
| KR (1) | KR101553600B1 (es) |
| CN (1) | CN101547906B (es) |
| AP (1) | AP2477A (es) |
| AR (1) | AR064148A1 (es) |
| AT (1) | ATE486061T1 (es) |
| AU (1) | AU2007328892B2 (es) |
| BR (1) | BRPI0719915A2 (es) |
| CA (1) | CA2668558C (es) |
| CL (1) | CL2007003518A1 (es) |
| CY (1) | CY1112027T1 (es) |
| DE (1) | DE602007010182D1 (es) |
| DK (1) | DK2099761T3 (es) |
| EA (1) | EA016760B1 (es) |
| ES (1) | ES2354755T3 (es) |
| HK (1) | HK1137437A1 (es) |
| HR (1) | HRP20110024T1 (es) |
| IL (1) | IL199082A (es) |
| JO (1) | JO2683B1 (es) |
| ME (1) | ME01230B (es) |
| MX (1) | MX2009005906A (es) |
| MY (1) | MY145940A (es) |
| NO (1) | NO341984B1 (es) |
| NZ (1) | NZ576862A (es) |
| PL (1) | PL2099761T3 (es) |
| PT (1) | PT2099761E (es) |
| RS (1) | RS51582B (es) |
| SI (1) | SI2099761T1 (es) |
| TW (1) | TWI487526B (es) |
| UA (1) | UA101307C2 (es) |
| WO (1) | WO2008068272A2 (es) |
| ZA (1) | ZA200903949B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| MX355050B (es) | 2012-04-27 | 2018-04-02 | Janssen Pharmaceutica Nv | Derivados de quinolina antibacterianos. |
| CN104254528B (zh) | 2012-04-27 | 2017-06-06 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0936866A4 (en) * | 1996-10-28 | 2001-04-11 | Dept Of The Army Us Government | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS |
| JP4484703B2 (ja) * | 2002-07-25 | 2010-06-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用 |
| EA011277B1 (ru) * | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные хинолина и их применение в качестве ингибиторов микобактерий |
| WO2005075428A1 (en) * | 2004-01-29 | 2005-08-18 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| KR20130024969A (ko) * | 2004-05-28 | 2013-03-08 | 얀센 파마슈티카 엔.브이. | 약물 내성 마이코박테리아 질환 치료를 위한 치환된 퀴놀린 유도체의 용도 |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| EE05697B1 (et) * | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| JO2752B1 (en) * | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| RS55601B1 (sr) * | 2005-06-28 | 2017-06-30 | Janssen Pharmaceutica Nv | Derivati kvinolina kao antibakterijski agensi |
| JO2837B1 (en) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2855B1 (en) * | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
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