MX2009005906A - Derivados de quinolina antibacterial. - Google Patents

Derivados de quinolina antibacterial.

Info

Publication number
MX2009005906A
MX2009005906A MX2009005906A MX2009005906A MX2009005906A MX 2009005906 A MX2009005906 A MX 2009005906A MX 2009005906 A MX2009005906 A MX 2009005906A MX 2009005906 A MX2009005906 A MX 2009005906A MX 2009005906 A MX2009005906 A MX 2009005906A
Authority
MX
Mexico
Prior art keywords
compounds
quinoline derivatives
pharmaceutically acceptable
treatment
bacterial infection
Prior art date
Application number
MX2009005906A
Other languages
English (en)
Inventor
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Jerome Emile Georges Guillemont
Yvan Rene Ferdinand Simonnet
Ismet Dorange
David Francis Alain Lancois
Magali Madeleine Simone Motte
Jose Manuel Villalgordo-Soto
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38048032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005906(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2009005906A publication Critical patent/MX2009005906A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos derivados de quinolina sustituidos de acuerdo con la Fórmula general (Ia) o Fórmula (lb): (ver fórmulas Ia, lb) con inclusión de cualquier forma estereoquímicamente isomérica de ellos, una sal farmacéuticamente aceptable de ellos, N-óxido o solvato de ellos; los compuestos reclamados son útiles para el tratamiento de una infección bacteriana; incluso, se reclama una composición que comprende un vehículo farmacéuticamente aceptable y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reclamados, el uso de los compuestos o composiciones reclamados para la preparación de un medicamento para el tratamiento de una infección bacteriana y un procedimiento para preparar los compuestos reclamados.
MX2009005906A 2006-12-06 2007-12-04 Derivados de quinolina antibacterial. MX2009005906A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125545 2006-12-06
PCT/EP2007/063319 WO2008068272A2 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (1)

Publication Number Publication Date
MX2009005906A true MX2009005906A (es) 2009-06-16

Family

ID=38048032

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005906A MX2009005906A (es) 2006-12-06 2007-12-04 Derivados de quinolina antibacterial.

Country Status (34)

Country Link
US (1) US20100063026A1 (es)
EP (1) EP2099761B1 (es)
JP (1) JP5466013B2 (es)
KR (1) KR101553600B1 (es)
CN (1) CN101547906B (es)
AP (1) AP2477A (es)
AR (1) AR064148A1 (es)
AT (1) ATE486061T1 (es)
AU (1) AU2007328892B2 (es)
BR (1) BRPI0719915A2 (es)
CA (1) CA2668558C (es)
CL (1) CL2007003518A1 (es)
CY (1) CY1112027T1 (es)
DE (1) DE602007010182D1 (es)
DK (1) DK2099761T3 (es)
EA (1) EA016760B1 (es)
ES (1) ES2354755T3 (es)
HK (1) HK1137437A1 (es)
HR (1) HRP20110024T1 (es)
IL (1) IL199082A (es)
JO (1) JO2683B1 (es)
ME (1) ME01230B (es)
MX (1) MX2009005906A (es)
MY (1) MY145940A (es)
NO (1) NO341984B1 (es)
NZ (1) NZ576862A (es)
PL (1) PL2099761T3 (es)
PT (1) PT2099761E (es)
RS (1) RS51582B (es)
SI (1) SI2099761T1 (es)
TW (1) TWI487526B (es)
UA (1) UA101307C2 (es)
WO (1) WO2008068272A2 (es)
ZA (1) ZA200903949B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
ES2576491T3 (es) * 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
MX358506B (es) 2012-04-27 2018-08-22 Janssen Pharmaceutica Nv Derivados de quinolina antibacterianos.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001503411A (ja) * 1996-10-28 2001-03-13 ディパートメント オブ ジ アーミー，ユー．エス．ガバメント 抗生物質耐性感染症の処置のための化合物、組成物および方法
DK2301544T3 (da) * 2002-07-25 2013-01-02 Janssen Pharmaceutica Nv Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer
DE602005016890D1 (de) * 2004-01-23 2009-11-12 Janssen Pharmaceutica Nv Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren
EP1713776B1 (en) * 2004-01-29 2008-05-14 Janssen Pharmaceutica N.V. Quinoline derivatives for use as mycobacterial inhibitors
MXPA06013888A (es) * 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JO2752B1 (en) * 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
UA88701C2 (ru) * 2005-06-28 2009-11-10 Янссэн Фармацэвтика Н.В. Производные хинолина как антибактериальные агенты
JO2952B1 (en) * 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents

Also Published As

Publication number Publication date
NZ576862A (en) 2012-01-12
IL199082A (en) 2014-04-30
UA101307C2 (ru) 2013-03-25
NO20092541L (no) 2009-09-02
DE602007010182D1 (de) 2010-12-09
JP5466013B2 (ja) 2014-04-09
CL2007003518A1 (es) 2008-07-11
ME01230B (me) 2013-03-20
HK1137437A1 (en) 2010-07-30
ES2354755T3 (es) 2011-03-17
SI2099761T1 (sl) 2011-02-28
JP2010511672A (ja) 2010-04-15
AR064148A1 (es) 2009-03-18
AP2009004873A0 (en) 2009-06-30
NO341984B1 (no) 2018-03-05
HRP20110024T1 (hr) 2011-04-30
EA200970537A1 (ru) 2009-10-30
ATE486061T1 (de) 2010-11-15
DK2099761T3 (da) 2011-02-07
JO2683B1 (en) 2013-03-03
AP2477A (en) 2012-09-27
TW200831095A (en) 2008-08-01
MY145940A (en) 2012-05-31
PT2099761E (pt) 2011-01-18
WO2008068272A3 (en) 2008-07-24
KR20090102778A (ko) 2009-09-30
US20100063026A1 (en) 2010-03-11
CA2668558A1 (en) 2008-06-12
CN101547906A (zh) 2009-09-30
ZA200903949B (en) 2010-08-25
EP2099761B1 (en) 2010-10-27
BRPI0719915A2 (pt) 2014-03-04
KR101553600B1 (ko) 2015-09-16
CN101547906B (zh) 2014-08-06
TWI487526B (zh) 2015-06-11
RS51582B (en) 2011-08-31
CA2668558C (en) 2016-06-07
AU2007328892A1 (en) 2008-06-12
WO2008068272A2 (en) 2008-06-12
EA016760B1 (ru) 2012-07-30
CY1112027T1 (el) 2015-11-04
EP2099761A2 (en) 2009-09-16
AU2007328892B2 (en) 2013-05-16
PL2099761T3 (pl) 2011-04-29

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