CY1117489T1 - Συνθεση δινατριου αλατος της ν4-(2,2-διμεθυλ-4-[(διυδρογονο φωσφονοξυ) μεθυλ]-3-οξο-5-πυριδο [1,4] οξαζιν-6-υλ)-5-φθορο-ν2-(3,4,5-τριμεθοξυφαινυλ)-2,4-πυριμιδινοδιαμινης - Google Patents
Συνθεση δινατριου αλατος της ν4-(2,2-διμεθυλ-4-[(διυδρογονο φωσφονοξυ) μεθυλ]-3-οξο-5-πυριδο [1,4] οξαζιν-6-υλ)-5-φθορο-ν2-(3,4,5-τριμεθοξυφαινυλ)-2,4-πυριμιδινοδιαμινηςInfo
- Publication number
- CY1117489T1 CY1117489T1 CY20161100304T CY161100304T CY1117489T1 CY 1117489 T1 CY1117489 T1 CY 1117489T1 CY 20161100304 T CY20161100304 T CY 20161100304T CY 161100304 T CY161100304 T CY 161100304T CY 1117489 T1 CY1117489 T1 CY 1117489T1
- Authority
- CY
- Cyprus
- Prior art keywords
- oxazin
- trimethoxyphenyl
- oxo
- dimethyl
- methyl
- Prior art date
Links
- -1 [1,4] OXAZIN-6-YL Chemical class 0.000 title abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- GKVDWQYJWNBHEV-UHFFFAOYSA-N 2-n-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine Chemical compound COC1=C(OC)C(OC)=CC(NC=2N=C(N)C=CN=2)=C1 GKVDWQYJWNBHEV-UHFFFAOYSA-N 0.000 abstract 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004687 hexahydrates Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27007309P | 2009-07-02 | 2009-07-02 | |
| EP10730679.7A EP2448950B1 (en) | 2009-07-02 | 2010-07-01 | Synthesis of n4-(2,2-dimethyl-4-[(dihydrogen phosphonoxy)methyl]-3-oxo-5-pyrido[1,4]oxazin-6-yl)-5-fluoro-n2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine disodium salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117489T1 true CY1117489T1 (el) | 2017-04-26 |
Family
ID=42937685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100304T CY1117489T1 (el) | 2009-07-02 | 2016-04-12 | Συνθεση δινατριου αλατος της ν4-(2,2-διμεθυλ-4-[(διυδρογονο φωσφονοξυ) μεθυλ]-3-οξο-5-πυριδο [1,4] οξαζιν-6-υλ)-5-φθορο-ν2-(3,4,5-τριμεθοξυφαινυλ)-2,4-πυριμιδινοδιαμινης |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8299242B2 (enExample) |
| EP (1) | EP2448950B1 (enExample) |
| JP (1) | JP5739882B2 (enExample) |
| CN (1) | CN102482305B (enExample) |
| AU (1) | AU2010266213B2 (enExample) |
| BR (1) | BRPI1011888A2 (enExample) |
| CA (1) | CA2766801C (enExample) |
| CY (1) | CY1117489T1 (enExample) |
| DK (1) | DK2448950T3 (enExample) |
| EA (1) | EA021657B1 (enExample) |
| ES (1) | ES2565985T3 (enExample) |
| HR (1) | HRP20160319T1 (enExample) |
| HU (1) | HUE027212T2 (enExample) |
| ME (1) | ME02388B (enExample) |
| PL (1) | PL2448950T3 (enExample) |
| RS (1) | RS54679B1 (enExample) |
| SG (1) | SG176799A1 (enExample) |
| SI (1) | SI2448950T1 (enExample) |
| SM (1) | SMT201600084B (enExample) |
| UA (1) | UA108077C2 (enExample) |
| WO (1) | WO2011002999A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| UA108077C2 (xx) | 2009-07-02 | 2015-03-25 | Синтез динатрієвої солі n4-(2,2-диметил-4-$(дигідрофосфонокси)метил]-3-оксо-5-піридо$1,4]оксазин-6-іл)-5-фтор-n2-(3,4,5-триметоксифеніл)-2,4-піримідиндіаміну | |
| US20110206661A1 (en) * | 2010-02-24 | 2011-08-25 | Auspex Pharmaceuticals, Inc. | Trimethoxyphenyl inhibitors of tyrosine kinase |
| EP2736487B2 (en) * | 2011-07-28 | 2024-08-28 | Rigel Pharmaceuticals, Inc. | New (trimethoxyphenylamino)pyrimidinyl formulations |
| TWI526437B (zh) * | 2011-09-09 | 2016-03-21 | 台灣神隆股份有限公司 | 卡巴他賽之結晶型 |
| US8426450B1 (en) * | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| MY170437A (en) | 2012-06-19 | 2019-07-31 | Debiopharm Int Sa | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
| CN102746337B (zh) * | 2012-06-21 | 2014-12-17 | 成都苑东药业有限公司 | 一种2，4-嘧啶二胺类化合物及其制备方法 |
| TW201410657A (zh) | 2012-08-02 | 2014-03-16 | Endo Pharmaceuticals Inc | 經取代胺基－嘧啶衍生物 |
| LT3083648T (lt) * | 2013-12-20 | 2019-01-25 | Rigel Pharmaceuticals, Inc. | Farmacinis būdas ir tarpiniai junginiai |
| PL3419628T3 (pl) | 2016-02-26 | 2021-05-31 | Debiopharm International Sa | Lek do leczenia zakażeń stopy cukrzycowej |
| EP3509578B1 (en) | 2016-09-08 | 2022-12-21 | Glykon Technologies Group, LLC | Monomeric bimetal hydroxycitric acid compounds and methods of making and using the same |
| JP2020536100A (ja) * | 2017-10-04 | 2020-12-10 | セルジーン コーポレイション | シス−４−［２−｛［（３ｓ，４ｒ）−３−フルオロキサン−４−イル］アミノ｝−８−（２，４，６−トリクロロアニリノ）−９ｈ−プリン−９−イル］−１−メチルシクロヘキサン−１−カルボキサミドの製造プロセス |
| HRP20230437T1 (hr) | 2019-02-14 | 2023-07-07 | Debiopharm International S.A. | Formulacija afabicina, postupak izrade iste |
| CN113939306B (zh) | 2019-06-14 | 2024-07-19 | 德彪药业国际股份公司 | 用于治疗涉及生物膜的细菌感染的药物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US303022A (en) | 1884-08-05 | Egg-beater | ||
| US324087A (en) | 1885-08-11 | Abel combs | ||
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| US20040024716A1 (en) | 2002-04-12 | 2004-02-05 | James Malatesta | Mail sorting processes and systems |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | 里格尔药品股份有限公司 | 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| US20060047135A1 (en) | 2004-08-30 | 2006-03-02 | Chadwick Scott T | Process for preparing chloromethyl di-tert-butylphosphate |
| US7449458B2 (en) * | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| US20090114877A1 (en) * | 2005-09-13 | 2009-05-07 | Eisai R&D Management Co., Ltd. | Composition Containing Stability-Improved Chloromethyl Phosphate Derivatve and Process for Producing Same |
| US8163902B2 (en) * | 2006-11-21 | 2012-04-24 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| UA108077C2 (xx) | 2009-07-02 | 2015-03-25 | Синтез динатрієвої солі n4-(2,2-диметил-4-$(дигідрофосфонокси)метил]-3-оксо-5-піридо$1,4]оксазин-6-іл)-5-фтор-n2-(3,4,5-триметоксифеніл)-2,4-піримідиндіаміну |
-
2010
- 2010-01-07 UA UAA201201072A patent/UA108077C2/ru unknown
- 2010-07-01 EP EP10730679.7A patent/EP2448950B1/en active Active
- 2010-07-01 PL PL10730679T patent/PL2448950T3/pl unknown
- 2010-07-01 HR HRP20160319TT patent/HRP20160319T1/hr unknown
- 2010-07-01 BR BRPI1011888A patent/BRPI1011888A2/pt not_active Application Discontinuation
- 2010-07-01 US US12/829,126 patent/US8299242B2/en active Active
- 2010-07-01 CN CN201080039108.1A patent/CN102482305B/zh active Active
- 2010-07-01 WO PCT/US2010/040792 patent/WO2011002999A1/en not_active Ceased
- 2010-07-01 HU HUE10730679A patent/HUE027212T2/en unknown
- 2010-07-01 DK DK10730679.7T patent/DK2448950T3/en active
- 2010-07-01 JP JP2012518607A patent/JP5739882B2/ja active Active
- 2010-07-01 AU AU2010266213A patent/AU2010266213B2/en active Active
- 2010-07-01 SG SG2011091733A patent/SG176799A1/en unknown
- 2010-07-01 SI SI201031148A patent/SI2448950T1/sl unknown
- 2010-07-01 RS RS20160220A patent/RS54679B1/sr unknown
- 2010-07-01 EA EA201270114A patent/EA021657B1/ru unknown
- 2010-07-01 ES ES10730679.7T patent/ES2565985T3/es active Active
- 2010-07-01 ME MEP-2016-57A patent/ME02388B/me unknown
- 2010-07-01 CA CA2766801A patent/CA2766801C/en active Active
-
2012
- 2012-09-24 US US13/625,552 patent/US8481724B2/en active Active
-
2013
- 2013-06-07 US US13/912,856 patent/US8691798B2/en active Active
-
2016
- 2016-03-24 SM SM201600084T patent/SMT201600084B/xx unknown
- 2016-04-12 CY CY20161100304T patent/CY1117489T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102482305B (zh) | 2016-07-13 |
| CA2766801C (en) | 2018-03-13 |
| US20110003986A1 (en) | 2011-01-06 |
| CN102482305A (zh) | 2012-05-30 |
| BRPI1011888A2 (pt) | 2016-04-12 |
| US20130274499A1 (en) | 2013-10-17 |
| HRP20160319T1 (hr) | 2016-04-22 |
| AU2010266213A1 (en) | 2012-02-02 |
| SI2448950T1 (sl) | 2016-05-31 |
| JP5739882B2 (ja) | 2015-06-24 |
| HUE027212T2 (en) | 2016-10-28 |
| RS54679B1 (sr) | 2016-08-31 |
| WO2011002999A1 (en) | 2011-01-06 |
| EP2448950A1 (en) | 2012-05-09 |
| AU2010266213B2 (en) | 2015-06-18 |
| EP2448950B1 (en) | 2016-01-13 |
| DK2448950T3 (en) | 2016-04-04 |
| US8691798B2 (en) | 2014-04-08 |
| SMT201600084B (it) | 2016-04-29 |
| EA021657B1 (ru) | 2015-08-31 |
| US8481724B2 (en) | 2013-07-09 |
| CA2766801A1 (en) | 2011-01-06 |
| US8299242B2 (en) | 2012-10-30 |
| EA201270114A1 (ru) | 2012-05-30 |
| ME02388B (me) | 2016-09-20 |
| PL2448950T3 (pl) | 2016-06-30 |
| SG176799A1 (en) | 2012-01-30 |
| US20130018185A1 (en) | 2013-01-17 |
| UA108077C2 (xx) | 2015-03-25 |
| HK1169996A1 (zh) | 2013-02-15 |
| ES2565985T3 (es) | 2016-04-08 |
| JP2012532143A (ja) | 2012-12-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1117489T1 (el) | Συνθεση δινατριου αλατος της ν4-(2,2-διμεθυλ-4-[(διυδρογονο φωσφονοξυ) μεθυλ]-3-οξο-5-πυριδο [1,4] οξαζιν-6-υλ)-5-φθορο-ν2-(3,4,5-τριμεθοξυφαινυλ)-2,4-πυριμιδινοδιαμινης | |
| CY1125100T1 (el) | Υδατικο φαρμακευτικο σκευασμα ταπενταδολης για απο του στοματος χορηγηση | |
| CY1120503T1 (el) | Συνθεσεις οι οποιες περιλαμβανουν ζολεδρονικο οξυ ή σχετικες ενωσεις για ανακουφιση φλεγμονωδους πονου και σχετικων παθησεων | |
| CY1122984T1 (el) | Καρβαμιδικες ενωσεις και μεθοδοι παρασκευης και χρησης τους | |
| CY1120778T1 (el) | Αναστολεις αντιγραφης ιων γριπης | |
| EA201692506A2 (ru) | Ингибиторы репликации вирусов гриппа | |
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| UA107112C2 (uk) | Активатори розчинної гуанілатциклази | |
| CY1120378T1 (el) | Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης) | |
| BR112015003188A2 (pt) | Composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente | |
| NZ700761A (en) | Salt form of a human histone methyltransferase ezh2 inhibitor | |
| HN2010000653A (es) | Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas quinasas b | |
| CY1117424T1 (el) | Βενζοδιαζεπινικος αναστολεας bromodomain | |
| CY1117143T1 (el) | Νεα καρβονυλιωμενα (αζα)κυκλοεξανια ως προσδετες του d3 υποδοχεα ντοπαμινης | |
| EA201891018A1 (ru) | Липиды и липидные композиции для доставки активных агентов | |
| CY1118379T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
| EA201590118A1 (ru) | Производные пирролидина и их применение в качестве модуляторов пути активации комплемента | |
| ECSP13012611A (es) | Derivados de pirazol-aminopirimidina como moduladores de la lrrk2 | |
| ECSP16005566A (es) | Sulfonamidas como moduladores de canales de sodio | |
| CR20110016A (es) | Compuestos quimicos 251 | |
| BR112012018670A2 (pt) | combinação, uso de um composto, composição farmacêutica, e, pacote de paciente | |
| UY30316A1 (es) | Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones | |
| EA201390908A1 (ru) | Производные бицикло[3.2.1]октиламида и их применение | |
| EA200901423A1 (ru) | Бензимидазолы и содержащие их фармацевтические композиции | |
| MX389600B (es) | Nueva composición terapéutica que contiene ingrediente activo de apomorfinas. |