CY1120503T1 - Συνθεσεις οι οποιες περιλαμβανουν ζολεδρονικο οξυ ή σχετικες ενωσεις για ανακουφιση φλεγμονωδους πονου και σχετικων παθησεων - Google Patents
Συνθεσεις οι οποιες περιλαμβανουν ζολεδρονικο οξυ ή σχετικες ενωσεις για ανακουφιση φλεγμονωδους πονου και σχετικων παθησεωνInfo
- Publication number
- CY1120503T1 CY1120503T1 CY20181100458T CY181100458T CY1120503T1 CY 1120503 T1 CY1120503 T1 CY 1120503T1 CY 20181100458 T CY20181100458 T CY 20181100458T CY 181100458 T CY181100458 T CY 181100458T CY 1120503 T1 CY1120503 T1 CY 1120503T1
- Authority
- CY
- Cyprus
- Prior art keywords
- zoledronic acid
- compositions containing
- related compounds
- inflammatory pain
- containing zoledronic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Στοματικές δοσολογικές μορφές διφωσφονικών ενώσεων, όπως το ζολεδρονικό οξύ, μπορεί να χρησιμοποιηθούν για αντιμετώπιση ή ανακούφιση πόνου ή σχετικών παθήσεων. Αν και μια στοματική δοσολογική μορφή με ενισχυμένη βιοδιαθεσιμότητα σε σχέση με την διφωσφονική ένωση μπορεί να χρησιμοποιηθεί, η αγωγή μπορεί επίσης να είναι αποτελεσματική χρησιμοποιώντας μια στοματική δοσολογική μορφή η οποία περιλαμβάνει μία διφωσφονική ένωση, όπως το ζολεδρονικό οξύ, όπου η βιοδιαθεσιμότητα του δισφωσφονικού είναι μη-ενισχυμένη, ή είναι ουσιαστικά μη-ενισχυμένη.
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646538P | 2012-05-14 | 2012-05-14 | |
| US201261647478P | 2012-05-15 | 2012-05-15 | |
| US201261654292P | 2012-06-01 | 2012-06-01 | |
| US201261654383P | 2012-06-01 | 2012-06-01 | |
| US201261655541P | 2012-06-05 | 2012-06-05 | |
| US201261655527P | 2012-06-05 | 2012-06-05 | |
| US201361762225P | 2013-02-07 | 2013-02-07 | |
| US201361764563P | 2013-02-14 | 2013-02-14 | |
| US201361767676P | 2013-02-21 | 2013-02-21 | |
| US201361767647P | 2013-02-21 | 2013-02-21 | |
| US201361803721P | 2013-03-20 | 2013-03-20 | |
| PCT/US2013/040939 WO2013173330A1 (en) | 2012-05-14 | 2013-05-14 | Compositions comprising zoledronic acid or related compounds for relieving inflammatory pain and related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120503T1 true CY1120503T1 (el) | 2019-07-10 |
Family
ID=49549077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100458T CY1120503T1 (el) | 2012-05-14 | 2018-05-03 | Συνθεσεις οι οποιες περιλαμβανουν ζολεδρονικο οξυ ή σχετικες ενωσεις για ανακουφιση φλεγμονωδους πονου και σχετικων παθησεων |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US20130303485A1 (el) |
| EP (2) | EP3323418A1 (el) |
| JP (2) | JP2015518828A (el) |
| KR (3) | KR20190004381A (el) |
| CN (2) | CN104349781A (el) |
| AU (3) | AU2013262995B2 (el) |
| CA (2) | CA2873742C (el) |
| CY (1) | CY1120503T1 (el) |
| DK (1) | DK2849758T3 (el) |
| ES (1) | ES2667535T3 (el) |
| HK (1) | HK1255373A1 (el) |
| HR (1) | HRP20180606T1 (el) |
| HU (1) | HUE038905T2 (el) |
| LT (1) | LT2849758T (el) |
| NZ (1) | NZ702414A (el) |
| PL (1) | PL2849758T3 (el) |
| PT (1) | PT2849758T (el) |
| RS (1) | RS57294B1 (el) |
| SI (1) | SI2849758T1 (el) |
| WO (1) | WO2013173330A1 (el) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| ES2650665T3 (es) | 2009-07-31 | 2018-01-19 | Grünenthal GmbH | Método de cristalización y biodisponibilidad |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| US10493085B2 (en) | 2012-05-14 | 2019-12-03 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US20140349974A1 (en) * | 2014-08-12 | 2014-11-27 | Antecip Bioventures Ii Llc | Zoledronic acid dosage forms for the treatment of pain |
| US9956238B2 (en) | 2014-05-15 | 2018-05-01 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9707247B2 (en) | 2012-05-14 | 2017-07-18 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US9694023B2 (en) | 2012-05-14 | 2017-07-04 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US10173986B2 (en) | 2012-05-14 | 2019-01-08 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US9211257B2 (en) | 2012-05-14 | 2015-12-15 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9616078B2 (en) | 2012-05-14 | 2017-04-11 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US10350227B2 (en) | 2012-05-14 | 2019-07-16 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9943531B2 (en) | 2014-08-08 | 2018-04-17 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US10111837B2 (en) | 2012-05-14 | 2018-10-30 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds |
| US8802658B2 (en) | 2012-05-14 | 2014-08-12 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US9827256B2 (en) | 2014-05-27 | 2017-11-28 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating lower back pain |
| US9700570B2 (en) | 2014-05-27 | 2017-07-11 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9789128B2 (en) | 2012-05-14 | 2017-10-17 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9999629B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9669040B2 (en) | 2012-05-14 | 2017-06-06 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10028908B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9655908B2 (en) | 2012-05-14 | 2017-05-23 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US9782421B1 (en) | 2012-05-14 | 2017-10-10 | Antecip Bioventures Ii Llc | Neridronic acid molecular complex for treating complex regional pain syndrome |
| US10016445B2 (en) | 2012-05-14 | 2018-07-10 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9675626B2 (en) | 2012-05-14 | 2017-06-13 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| US10413560B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds for treating disease |
| US10463682B2 (en) | 2012-05-14 | 2019-11-05 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating low back pain |
| US9867839B2 (en) | 2012-05-14 | 2018-01-16 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for joint conditions |
| US9427403B2 (en) | 2012-05-14 | 2016-08-30 | Antecip Bioventures Ii Llc | Methods for the safe administration of imidazole or imidazolium compounds |
| US10028969B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9895383B2 (en) | 2012-05-14 | 2018-02-20 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9877977B2 (en) | 2012-05-14 | 2018-01-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9844559B2 (en) | 2012-05-14 | 2017-12-19 | Antecip Bioventures Ii Llc | Neridronic acid for treating bone marrow lesions |
| US9770457B2 (en) | 2012-05-14 | 2017-09-26 | Antecip Bioventures Ii Llc | Neridronic acid for treating bone marrow lesion |
| US9956234B2 (en) | 2012-05-14 | 2018-05-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for joint conditions |
| US10016446B2 (en) | 2012-05-14 | 2018-07-10 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating Paget's disease of bone |
| US9717747B2 (en) | 2012-05-14 | 2017-08-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| WO2015184003A1 (en) * | 2014-05-27 | 2015-12-03 | Antecip Bioventures Ii Llp | Osteoclast inhibitors for pain |
| US9999628B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9901589B2 (en) | 2012-05-14 | 2018-02-27 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9662343B2 (en) | 2012-05-14 | 2017-05-30 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9867840B2 (en) | 2014-05-27 | 2018-01-16 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10034890B2 (en) | 2012-05-14 | 2018-07-31 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9795622B2 (en) | 2012-05-14 | 2017-10-24 | Antecip Bioventures Ii Llc | Neridronic acid for treating pain associated with a joint |
| US9707245B2 (en) | 2012-05-14 | 2017-07-18 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US9956237B2 (en) | 2012-05-14 | 2018-05-01 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US9949993B2 (en) | 2012-05-14 | 2018-04-24 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US10039773B2 (en) | 2012-05-14 | 2018-08-07 | Antecip Bioventures Ii Llc | Neridronic acid for treating arthritis |
| US9861648B2 (en) | 2012-05-14 | 2018-01-09 | Antecip Boiventures Ii Llc | Osteoclast inhibitors for knee conditions |
| US10080765B2 (en) | 2012-05-14 | 2018-09-25 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| US10092581B2 (en) | 2014-05-15 | 2018-10-09 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US9827192B2 (en) | 2012-05-14 | 2017-11-28 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10004756B2 (en) | 2014-05-15 | 2018-06-26 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US8865757B1 (en) | 2014-05-28 | 2014-10-21 | Antecip Bioventures Ii Llp | Therapeutic compositions comprising imidazole and imidazolium compounds |
| US9289441B2 (en) | 2014-08-08 | 2016-03-22 | Antecip Bioventures Ii Llc | Osteoclast inhibitors such as zoledronic acid for low back pain treatment |
| US9925203B2 (en) | 2012-05-14 | 2018-03-27 | Antecip Bioventures Ii Llc | Compositions for administration of zoledronic acid or related compounds for treating low back pain |
| US10413561B2 (en) | 2012-05-14 | 2019-09-17 | Antecip Bioventures Ii Llc | Neridronic acid and other bisphosphonates for treating complex regional pain syndrome and other diseases |
| US9820999B2 (en) | 2012-05-14 | 2017-11-21 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
| EP2945385A4 (en) | 2013-01-08 | 2016-07-06 | Lg Electronics Inc | METHOD AND APPARATUS FOR PROCESSING VIDEO SIGNAL |
| JP6166471B2 (ja) * | 2013-10-25 | 2017-07-19 | アンテシップ バイオベンチャーズ トゥー エルエルシー | ゾレドロン酸の増強された経口バイオアベイラビリティーを有する経口剤形を調製する方法 |
| US9079927B1 (en) | 2014-05-27 | 2015-07-14 | Antecip Bioventures Ii Llc | Substituted imidazolium compounds for treating disease |
| US20170182072A1 (en) * | 2014-05-27 | 2017-06-29 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| CA2950443A1 (en) * | 2014-05-27 | 2015-12-03 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for pain |
| CN106456610A (zh) * | 2014-05-27 | 2017-02-22 | 安泰赛普生物风投二代有限责任公司 | 用于疼痛的破骨细胞抑制剂 |
| US9127069B1 (en) | 2014-06-11 | 2015-09-08 | Antecip Bioventures LLC | Compositions comprising rank/rankl antagonists and related compounds for treating pain |
| SG10201706414SA (en) * | 2014-05-27 | 2017-09-28 | Antecip Bioventures Ii Llc | Osteoclast inhibitors for pain |
| US9688765B2 (en) | 2014-06-11 | 2017-06-27 | Antecip Bioventures Ii Llc | Methods using RANK/RANKL antagonist antibodies for treating pain |
| CA2997378A1 (en) * | 2015-09-18 | 2017-03-23 | Grunenthal Gmbh | Crystallization method and bioavailability |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| US20190328755A1 (en) * | 2018-04-30 | 2019-10-31 | Grunenthal Gmbh | Methods of treating complex regional pain syndrome (crps) or symptoms comprising administration of neridronic acid |
| CN109908159B (zh) * | 2019-03-15 | 2021-12-07 | 暨南大学 | 唑来膦酸和有机硒化合物联用在制备抗肿瘤药物中的应用 |
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| RU2359678C2 (ru) * | 2004-05-24 | 2009-06-27 | Дзе Проктер Энд Гэмбл Компани | Лекарственные формы на основе бисфосфонатов |
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| BRPI0710503A2 (pt) * | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| EP2400851A4 (en) * | 2009-02-25 | 2012-09-05 | Merrion Res Iii Ltd | COMPOSITION AND ACTIVE COMPOSITION OF BISPHOSPHONATES |
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2013
- 2013-05-14 SI SI201330993T patent/SI2849758T1/en unknown
- 2013-05-14 EP EP17206293.7A patent/EP3323418A1/en active Pending
- 2013-05-14 LT LTEP13791356.2T patent/LT2849758T/lt unknown
- 2013-05-14 HU HUE13791356A patent/HUE038905T2/hu unknown
- 2013-05-14 PL PL13791356T patent/PL2849758T3/pl unknown
- 2013-05-14 KR KR1020197000076A patent/KR20190004381A/ko not_active Application Discontinuation
- 2013-05-14 US US13/894,244 patent/US20130303485A1/en not_active Abandoned
- 2013-05-14 EP EP13791356.2A patent/EP2849758B1/en active Active
- 2013-05-14 WO PCT/US2013/040939 patent/WO2013173330A1/en active Application Filing
- 2013-05-14 RS RS20180483A patent/RS57294B1/sr unknown
- 2013-05-14 US US13/894,252 patent/US20130303486A1/en not_active Abandoned
- 2013-05-14 AU AU2013262995A patent/AU2013262995B2/en active Active
- 2013-05-14 US US13/894,274 patent/US20130303488A1/en not_active Abandoned
- 2013-05-14 ES ES13791356.2T patent/ES2667535T3/es active Active
- 2013-05-14 JP JP2015512753A patent/JP2015518828A/ja active Pending
- 2013-05-14 NZ NZ702414A patent/NZ702414A/en unknown
- 2013-05-14 KR KR1020167032879A patent/KR20160139050A/ko not_active Application Discontinuation
- 2013-05-14 CN CN201380025570.XA patent/CN104349781A/zh active Pending
- 2013-05-14 CN CN201811173434.6A patent/CN109331027A/zh active Pending
- 2013-05-14 PT PT137913562T patent/PT2849758T/pt unknown
- 2013-05-14 CA CA2873742A patent/CA2873742C/en active Active
- 2013-05-14 US US13/894,262 patent/US20130303487A1/en not_active Abandoned
- 2013-05-14 CA CA2987470A patent/CA2987470A1/en not_active Abandoned
- 2013-05-14 DK DK13791356.2T patent/DK2849758T3/en active
- 2013-05-14 KR KR1020147034760A patent/KR20150035597A/ko active Application Filing
-
2016
- 2016-02-03 US US15/014,994 patent/US20160151398A1/en not_active Abandoned
- 2016-11-08 AU AU2016256701A patent/AU2016256701B2/en active Active
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2018
- 2018-04-11 JP JP2018075822A patent/JP2018127477A/ja active Pending
- 2018-04-17 HR HRP20180606TT patent/HRP20180606T1/hr unknown
- 2018-05-03 CY CY20181100458T patent/CY1120503T1/el unknown
- 2018-08-10 AU AU2018214132A patent/AU2018214132B2/en active Active
- 2018-11-14 HK HK18114512.0A patent/HK1255373A1/zh unknown
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