ES2565985T3 - Síntesis de sal disódica de N4-(2,2-dimetil-4-[(dihidrogeno fosfonoxi)metil]-3-oxo-5-pirido[1,4]oxazin-6-il)-5-fluoro-N2-(3,4,5-trimetoxifenil)-2,4-pirimidindiamina - Google Patents

Síntesis de sal disódica de N4-(2,2-dimetil-4-[(dihidrogeno fosfonoxi)metil]-3-oxo-5-pirido[1,4]oxazin-6-il)-5-fluoro-N2-(3,4,5-trimetoxifenil)-2,4-pirimidindiamina Download PDF

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Publication number
ES2565985T3
ES2565985T3 ES10730679.7T ES10730679T ES2565985T3 ES 2565985 T3 ES2565985 T3 ES 2565985T3 ES 10730679 T ES10730679 T ES 10730679T ES 2565985 T3 ES2565985 T3 ES 2565985T3
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Spain
Prior art keywords
compound
formula
amide
solvate
appropriate conditions
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ES10730679.7T
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English (en)
Spanish (es)
Inventor
Ulfried Felfer
Karl-Heinz Giselbrecht
Michael Wolberg
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES10730679.7T 2009-07-02 2010-07-01 Síntesis de sal disódica de N4-(2,2-dimetil-4-[(dihidrogeno fosfonoxi)metil]-3-oxo-5-pirido[1,4]oxazin-6-il)-5-fluoro-N2-(3,4,5-trimetoxifenil)-2,4-pirimidindiamina Active ES2565985T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27007309P 2009-07-02 2009-07-02
US270073P 2009-07-02
PCT/US2010/040792 WO2011002999A1 (en) 2009-07-02 2010-07-01 Synthesis of n4- (2, 2-dimethyl-4- [ (dihydrogen phosphonoxy ] -3-oxo-5-pyrido [1, 4] oxazin-6-yl)-5-fluoro-n2- (3, 4, 5,-trimethoxyphenyl) -2, 4- pyrimidinediamine disodium salt

Publications (1)

Publication Number Publication Date
ES2565985T3 true ES2565985T3 (es) 2016-04-08

Family

ID=42937685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10730679.7T Active ES2565985T3 (es) 2009-07-02 2010-07-01 Síntesis de sal disódica de N4-(2,2-dimetil-4-[(dihidrogeno fosfonoxi)metil]-3-oxo-5-pirido[1,4]oxazin-6-il)-5-fluoro-N2-(3,4,5-trimetoxifenil)-2,4-pirimidindiamina

Country Status (21)

Country Link
US (3) US8299242B2 (enExample)
EP (1) EP2448950B1 (enExample)
JP (1) JP5739882B2 (enExample)
CN (1) CN102482305B (enExample)
AU (1) AU2010266213B2 (enExample)
BR (1) BRPI1011888A2 (enExample)
CA (1) CA2766801C (enExample)
CY (1) CY1117489T1 (enExample)
DK (1) DK2448950T3 (enExample)
EA (1) EA021657B1 (enExample)
ES (1) ES2565985T3 (enExample)
HR (1) HRP20160319T1 (enExample)
HU (1) HUE027212T2 (enExample)
ME (1) ME02388B (enExample)
PL (1) PL2448950T3 (enExample)
RS (1) RS54679B1 (enExample)
SG (1) SG176799A1 (enExample)
SI (1) SI2448950T1 (enExample)
SM (1) SMT201600084B (enExample)
UA (1) UA108077C2 (enExample)
WO (1) WO2011002999A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
UA108077C2 (xx) 2009-07-02 2015-03-25 Синтез динатрієвої солі n4-(2,2-диметил-4-$(дигідрофосфонокси)метил]-3-оксо-5-піридо$1,4]оксазин-6-іл)-5-фтор-n2-(3,4,5-триметоксифеніл)-2,4-піримідиндіаміну
US20110206661A1 (en) * 2010-02-24 2011-08-25 Auspex Pharmaceuticals, Inc. Trimethoxyphenyl inhibitors of tyrosine kinase
EP2736487B2 (en) * 2011-07-28 2024-08-28 Rigel Pharmaceuticals, Inc. New (trimethoxyphenylamino)pyrimidinyl formulations
TWI526437B (zh) * 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
MY170437A (en) 2012-06-19 2019-07-31 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
CN102746337B (zh) * 2012-06-21 2014-12-17 成都苑东药业有限公司 一种2，4-嘧啶二胺类化合物及其制备方法
TW201410657A (zh) 2012-08-02 2014-03-16 Endo Pharmaceuticals Inc 經取代胺基－嘧啶衍生物
LT3083648T (lt) * 2013-12-20 2019-01-25 Rigel Pharmaceuticals, Inc. Farmacinis būdas ir tarpiniai junginiai
PL3419628T3 (pl) 2016-02-26 2021-05-31 Debiopharm International Sa Lek do leczenia zakażeń stopy cukrzycowej
EP3509578B1 (en) 2016-09-08 2022-12-21 Glykon Technologies Group, LLC Monomeric bimetal hydroxycitric acid compounds and methods of making and using the same
JP2020536100A (ja) * 2017-10-04 2020-12-10 セルジーン コーポレイション シス−４−［２−｛［（３ｓ，４ｒ）−３−フルオロキサン−４−イル］アミノ｝−８−（２，４，６−トリクロロアニリノ）−９ｈ−プリン−９−イル］−１−メチルシクロヘキサン−１−カルボキサミドの製造プロセス
HRP20230437T1 (hr) 2019-02-14 2023-07-07 Debiopharm International S.A. Formulacija afabicina, postupak izrade iste
CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US303022A (en) 1884-08-05 Egg-beater
US324087A (en) 1885-08-11 Abel combs
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
US20040024716A1 (en) 2002-04-12 2004-02-05 James Malatesta Mail sorting processes and systems
CN103169708B (zh) 2002-07-29 2018-02-02 里格尔药品股份有限公司 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
US20060047135A1 (en) 2004-08-30 2006-03-02 Chadwick Scott T Process for preparing chloromethyl di-tert-butylphosphate
US7449458B2 (en) * 2005-01-19 2008-11-11 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
US20090114877A1 (en) * 2005-09-13 2009-05-07 Eisai R&D Management Co., Ltd. Composition Containing Stability-Improved Chloromethyl Phosphate Derivatve and Process for Producing Same
US8163902B2 (en) * 2006-11-21 2012-04-24 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
UA108077C2 (xx) 2009-07-02 2015-03-25 Синтез динатрієвої солі n4-(2,2-диметил-4-$(дигідрофосфонокси)метил]-3-оксо-5-піридо$1,4]оксазин-6-іл)-5-фтор-n2-(3,4,5-триметоксифеніл)-2,4-піримідиндіаміну

Also Published As

Publication number Publication date
CN102482305B (zh) 2016-07-13
CA2766801C (en) 2018-03-13
US20110003986A1 (en) 2011-01-06
CN102482305A (zh) 2012-05-30
BRPI1011888A2 (pt) 2016-04-12
US20130274499A1 (en) 2013-10-17
HRP20160319T1 (hr) 2016-04-22
AU2010266213A1 (en) 2012-02-02
SI2448950T1 (sl) 2016-05-31
JP5739882B2 (ja) 2015-06-24
HUE027212T2 (en) 2016-10-28
RS54679B1 (sr) 2016-08-31
WO2011002999A1 (en) 2011-01-06
EP2448950A1 (en) 2012-05-09
AU2010266213B2 (en) 2015-06-18
CY1117489T1 (el) 2017-04-26
EP2448950B1 (en) 2016-01-13
DK2448950T3 (en) 2016-04-04
US8691798B2 (en) 2014-04-08
SMT201600084B (it) 2016-04-29
EA021657B1 (ru) 2015-08-31
US8481724B2 (en) 2013-07-09
CA2766801A1 (en) 2011-01-06
US8299242B2 (en) 2012-10-30
EA201270114A1 (ru) 2012-05-30
ME02388B (me) 2016-09-20
PL2448950T3 (pl) 2016-06-30
SG176799A1 (en) 2012-01-30
US20130018185A1 (en) 2013-01-17
UA108077C2 (xx) 2015-03-25
HK1169996A1 (zh) 2013-02-15
JP2012532143A (ja) 2012-12-13

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