CY1115377T1 - Παραγωγο αζωτουχου αρωματικου 6-μελους δακτυλιου και φαρμακευτικος παραγων που περιλαμβανει αυτο - Google Patents

Παραγωγο αζωτουχου αρωματικου 6-μελους δακτυλιου και φαρμακευτικος παραγων που περιλαμβανει αυτο

Info

Publication number
CY1115377T1
CY1115377T1 CY20141100376T CY141100376T CY1115377T1 CY 1115377 T1 CY1115377 T1 CY 1115377T1 CY 20141100376 T CY20141100376 T CY 20141100376T CY 141100376 T CY141100376 T CY 141100376T CY 1115377 T1 CY1115377 T1 CY 1115377T1
Authority
CY
Cyprus
Prior art keywords
group
ability
compound
heart disease
hydrogen atom
Prior art date
Application number
CY20141100376T
Other languages
English (en)
Inventor
Naohiro Takemoto
Kenji Murata
Norihito Murayama
Chikaomi Yamada
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1115377T1 publication Critical patent/CY1115377T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Παρεχόμενη είναι μια ένωση η οποία έχει την ικανότητα να προάγει αξονική έκφυση σε συνδυασμό με την ικανότητα να προάγει αγγειογένεση και μπορεί συνεπώς να χρησιμοποιηθεί για μείωση βλαβών του κεντρικού νεύρου, όπως βλάβη κεφαλής και νωτιαίου μυελού, εγκεφαλική απόφραξη, ισχαιμικές καρδιακές νόσοι, μυοκαρδιακή απόφραξη και οργανική στηθάγχη, περιφερικές αρτηριακές αποφρακτικές ασθένειες όπως κρίσιμη ισχαιμία σκέλους ή τα επακόλουθα αυτών των ασθενειών. Ειδικότερα, η ένωση αντιπροσωπεύεται από τον ακόλουθο τύπο (I): όπου η Νx ομάδα κατά προτίμηση είναι 6-μελής αρωματικός δακτύλιος που περιέχει δύο άτομα αζώτου, τα R0, R1 και R2 το καθένα ανεξαρτήτως είναι άτομο υδρογόνου, αλκύλ ομάδα, άμινο ομάδα ή οι παρόμοιες, το Ε είναι ένα άτομο οξυγόνου ή -NR8 ομάδα (όπου το R8 είναι αλκύλ ομάδα ή παρόμοιες), το n είναι ακέραιος από 0 έως 5, τα Χ και Υ έκαστο είναι ένας συνδετικός δεσμός, κυκλοαλκύλ ομάδα, -CO- ή οι παρόμοιες και το Q είναι άτομο υδρογόνου ή φαινύλ ομάδα.
CY20141100376T 2007-04-27 2014-05-26 Παραγωγο αζωτουχου αρωματικου 6-μελους δακτυλιου και φαρμακευτικος παραγων που περιλαμβανει αυτο CY1115377T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007118768 2007-04-27
EP20080764246 EP2151439B1 (en) 2007-04-27 2008-04-25 Nitrogenated aromatic 6-membered ring derivative, and pharmaceutical agent comprising the same

Publications (1)

Publication Number Publication Date
CY1115377T1 true CY1115377T1 (el) 2017-01-04

Family

ID=40002110

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100376T CY1115377T1 (el) 2007-04-27 2014-05-26 Παραγωγο αζωτουχου αρωματικου 6-μελους δακτυλιου και φαρμακευτικος παραγων που περιλαμβανει αυτο

Country Status (18)

Country Link
US (4) US8592435B2 (el)
EP (2) EP2151439B1 (el)
JP (1) JP5197584B2 (el)
KR (1) KR101456316B1 (el)
CN (2) CN101730691A (el)
AU (1) AU2008249329C1 (el)
BR (1) BRPI0810821A8 (el)
CA (1) CA2683941C (el)
CY (1) CY1115377T1 (el)
DK (1) DK2151439T3 (el)
ES (2) ES2453590T3 (el)
HR (1) HRP20140326T1 (el)
MX (1) MX2009011369A (el)
PL (1) PL2151439T3 (el)
PT (1) PT2151439E (el)
RU (1) RU2470927C2 (el)
SI (1) SI2151439T1 (el)
WO (1) WO2008139894A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012002807B1 (pt) * 2009-08-07 2018-07-10 Adama Makhteshim Ltd. Derivados de 5-flúor-2-oxopirimidina-1(2h)- caboxilato, composição e processo para controle e prevenção de ataque fúngico em uma planta de ataque fúngico em uma planta
UA112284C2 (uk) * 2009-08-07 2016-08-25 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Похідні 5-фторпіримідинону
UA115462C2 (uk) 2012-12-28 2017-11-10 Адама Махтешім Лтд. Похідні n-(заміщеного)-5-фтор-4-іміно-3-метил-2-оксо-3,4-дигідропіримідин-1(2h)-карбоксилату
UA117743C2 (uk) 2012-12-28 2018-09-25 Адама Махтешім Лтд. N-(заміщені)-5-фтор-4-іміно-3-метил-2-оксо-3,4-дигідропіримідин-1(2h)-карбоксамідні похідні
MX2015008565A (es) 2012-12-31 2015-09-07 Dow Agrosciences Llc Derivados de 3-alquil-5-fluoro-4-sustituido-imino-3,4-dihidropirim idin-2(1h)-ona como fungicidas.
WO2016047662A1 (ja) * 2014-09-25 2016-03-31 第一三共株式会社 脳卒中の治療剤
WO2016086105A1 (en) * 2014-11-25 2016-06-02 Shriners Hospitals For Children MODEL SYSTEMS FOR SCREENING MODULATORS OF mTOR SIGNALING
CN114570418B (zh) * 2022-02-22 2023-10-17 陕西延长石油（集团）有限责任公司 一种羟基乙酸甲酯制备肌氨酸甲酯及肌氨酸的催化剂及其制备方法与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1260474A (en) 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
GB8912700D0 (en) * 1989-06-02 1989-07-19 Shell Int Research Herbicidal compounds
DE68914197T2 (de) * 1988-06-20 1994-11-10 Ihara Chemical Ind Co Alkansäurederivate und herbizide Mittel.
JP2771604B2 (ja) * 1988-06-20 1998-07-02 クミアイ化学工業株式会社 除草剤及びその有効成分となる新規なアルカン酸誘導体
GB8917476D0 (en) * 1989-07-31 1989-09-13 Shell Int Research Sulphonamide herbicides
JP2002527477A (ja) 1998-10-16 2002-08-27 サントリー株式会社 神経細胞保護作用物質としてのアミノフェノキシ酢酸誘導体
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1264821C (zh) * 2000-04-13 2006-07-19 第一阿斯比奥制药株式会社 氨基苯氧基乙酰胺衍生物和含有它们的药物组合物
US7115635B2 (en) 2001-04-27 2006-10-03 Mitsubishi Pharma Corporation Benzylpiperidine compound
US7205307B2 (en) * 2002-02-14 2007-04-17 Icagen, Inc. Pyrimidines as novel openers of potassium ion channels
CA2490397A1 (en) * 2002-06-24 2003-12-31 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
JP4916115B2 (ja) 2004-01-29 2012-04-11 大塚製薬株式会社 血管新生促進剤
TW200538098A (en) * 2004-03-22 2005-12-01 Astrazeneca Ab Therapeutic agents
US20090197914A1 (en) 2006-03-07 2009-08-06 Peter Cage Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them

Also Published As

Publication number Publication date
JPWO2008139894A1 (ja) 2010-07-29
EP2151439A1 (en) 2010-02-10
EP2151439B1 (en) 2014-02-26
US9156817B2 (en) 2015-10-13
EP2679586A1 (en) 2014-01-01
US20100130739A1 (en) 2010-05-27
JP5197584B2 (ja) 2013-05-15
US8685989B2 (en) 2014-04-01
EP2151439A4 (en) 2012-08-01
US20140221409A1 (en) 2014-08-07
US20120258978A1 (en) 2012-10-11
EP2679586B1 (en) 2016-02-10
CA2683941A1 (en) 2008-11-20
PL2151439T3 (pl) 2014-08-29
CA2683941C (en) 2014-08-12
WO2008139894A1 (ja) 2008-11-20
CN101730691A (zh) 2010-06-09
AU2008249329C1 (en) 2013-07-04
US8592435B2 (en) 2013-11-26
SI2151439T1 (sl) 2014-05-30
US9139559B2 (en) 2015-09-22
CN103396399B (zh) 2015-04-29
KR101456316B1 (ko) 2014-11-03
RU2470927C2 (ru) 2012-12-27
BRPI0810821A8 (pt) 2015-09-15
ES2453590T3 (es) 2014-04-08
DK2151439T3 (en) 2014-03-10
RU2009143850A (ru) 2011-06-10
AU2008249329A1 (en) 2008-11-20
ES2566327T3 (es) 2016-04-12
HRP20140326T1 (hr) 2014-05-09
MX2009011369A (es) 2009-12-15
US20140336209A1 (en) 2014-11-13
KR20100017388A (ko) 2010-02-16
PT2151439E (pt) 2014-04-10
AU2008249329B2 (en) 2012-12-06
BRPI0810821A2 (pt) 2014-10-29
CN103396399A (zh) 2013-11-20

Similar Documents

Publication Publication Date Title
CY1115377T1 (el) Παραγωγο αζωτουχου αρωματικου 6-μελους δακτυλιου και φαρμακευτικος παραγων που περιλαμβανει αυτο
CY1122246T1 (el) Πολυκυκλικες ενωσεις καρβαμοϋλπυριδονης και φαρμακευτικη χρηση αυτων
CY1105617T1 (el) Νεα αρωματικα παραγωγα των φθορογλυκοσιδων, φαρμακα περιεχοντα αυτες τις ενωσεις και η χρηση τους
CY1116103T1 (el) Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης
CY1109644T1 (el) 2,4-διαμινο-πυριμιδινες ως αναστολεις audora
CY1117193T1 (el) Φαρμακευτικη συνθεση για θεραπεια ή αποτροπη γλαυκωματος
NO20054264L (no) Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer
CY1117374T1 (el) Παραγωγα ιμιδαζοπυριδινης, διαδικασια για την παρασκευη αυτων και θεραπευτικη χρηση αυτων
CY1118129T1 (el) 5-αλκυνυλ-πυριμιδινες
MY140012A (en) Heterocylic substituted phenyl methanones
UY32462A (es) Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
AR104417A2 (es) Compuestos de tiadiazolidina, procedimiento para su preparación, composición farmacéutica que lo compone y usos de dichos compuestos
CY1107982T1 (el) Υποκατεστημενα παραγωγα 8’-πυρι(μι)δινυλο-διϋδροσπειρο-[κυκλοαλκυλαμινο]-πυριμιδο[1,2-a]πυριμιδιν-6ονης.
CY1114223T1 (el) Πρωτοτυπες φαινυλοπυραζινονες ως αναστολεις κινασης
CY1117113T1 (el) Αναστολεις πρωτεασης σερινης hcv λαμβανομενοι απο μακροκυκλικη προλινη
HUP0402307A2 (hu) Kisméretű szerves molekulák a sejtproliferáció szabályozásához és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
CY1112286T1 (el) Παραγωγα πυραζολιου χρησιμα για τη θεραπεια γυναικολογικων ασθενειων
CY1108183T1 (el) Θειαζολυλο-διυδρο-ινδαζολια
NI201200139A (es) Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales.
CY1113282T1 (el) Αντιικα νουκλεοζιτικα αναλογα
CY1105519T1 (el) Παραγωγα πυρρολιδινης χρησιμα ως αναστολεις πρωτεϊνης βax
CY1108094T1 (el) Κινολινικα παραγωγα ως αναστολεις φωσφοδιεστερασης
AR082667A1 (es) 6-cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del snc
AR054347A1 (es) Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
MA33819B1 (fr) Dérivés de pyridino-pyridinones, leur préparation et leur application en thérapeutique