CY1105519T1 - Παραγωγα πυρρολιδινης χρησιμα ως αναστολεις πρωτεϊνης βax - Google Patents
Παραγωγα πυρρολιδινης χρησιμα ως αναστολεις πρωτεϊνης βaxInfo
- Publication number
- CY1105519T1 CY1105519T1 CY20061101060T CY061101060T CY1105519T1 CY 1105519 T1 CY1105519 T1 CY 1105519T1 CY 20061101060 T CY20061101060 T CY 20061101060T CY 061101060 T CY061101060 T CY 061101060T CY 1105519 T1 CY1105519 T1 CY 1105519T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrrolidine derivatives
- formula
- group
- present
- compounds
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- 102000055102 bcl-2-Associated X Human genes 0.000 title 1
- 108700000707 bcl-2-Associated X Proteins 0.000 title 1
- 229940121649 protein inhibitor Drugs 0.000 title 1
- 239000012268 protein inhibitor Substances 0.000 title 1
- 150000003235 pyrrolidines Chemical class 0.000 abstract 4
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 2
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
- 101800000989 Oxytocin Proteins 0.000 abstract 1
- 102000004279 Oxytocin receptors Human genes 0.000 abstract 1
- 108090000876 Oxytocin receptors Proteins 0.000 abstract 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000037805 labour Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
- 229960001723 oxytocin Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Η παρούσα εφεύρεση σχετίζεται με παράγωγα πυρρολιδίνης του τύπου (I). Οι εν λόγω ενώσεις προορίζονται κατά προτίμηση για χρήση ως φαρμακευτικά δραστικές ενώσεις. Συγκεκριμένα, παράγωγα πυρρολιδίνης του τύπου (I) είναι χρήσιμα στη θεραπεία και/ή πρόληψη πρόωρου τοκετού, πρόωρης γέννας και δυσμηνόρροιας. Ιδιαίτερα, η παρούσα εφεύρεση σχετίζεται με παράγωγα πυρρολιδίνης που παρουσιάζουν ουσιαστική ρυθμιστική, αξιοσημείωτα ανταγωνιστική δραστηριότητα του υποδοχέα ωκυτοκίνης. Ακόμα προτιμότερα, οι εν λόγω ενώσεις είναι χρήσιμες για τη θεραπεία και/ή πρόληψη νοσηρών καταστάσεων που προκαλούνται από ωκυτοκίνη, συμπεριλαμβανομένων πρόωρου τοκετού, πρόωρης γέννας και δυσμηνόρροιας. Η παρούσα εφεύρεση σχετίζεται περαιτέρω με νεωτεριστικά παράγωγα πυρρολιδίνης καθώς και με μεθόδους για την παρασκευή τους, όπου Χ επιλέγεται από την ομάδα που αποτελείται από CR6R7, NOR6, NNR6R7∙Α επιλέγεται από την ομάδα που συνίσταται από -(C=Ο)-, -(C=Ο)-Ο-, -C(=ΝH)-, -(C=Ο)-NH-, -(C=S)-NH, -SO2-, -SO2NH-, -CH2-∙Β είναι είτε μία ομάδα -(C=Ο)-NR8R9 ή αντιπροσωπεύει ένα ετεροκυκλικό υπόλειμμα που έχει τον τύπο (a) όπου Q είναι NR10, Ο ή S∙n είναι ακέραιος που επιλέγεται από 0, 1 ή 2·Υ, Ζ και Ε σχηματίζουν μαζί με τους 2 άνθρακες με τους οποίους είναι συνδεδεμένα έναν 5-6μελή αρυλικό ή ετεροαρυλικό δακτύλιο.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00106034 | 2000-03-27 | ||
EP01929439A EP1268419B1 (en) | 2000-03-27 | 2001-03-20 | Pyrrolidine derivatives useful as bax inhibitors |
PCT/EP2001/003171 WO2001072705A1 (en) | 2000-03-27 | 2001-03-20 | Pharmaceutically active pyrrolidine derivatives as bax inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105519T1 true CY1105519T1 (el) | 2010-07-28 |
Family
ID=8168169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101060T CY1105519T1 (el) | 2000-03-27 | 2006-07-28 | Παραγωγα πυρρολιδινης χρησιμα ως αναστολεις πρωτεϊνης βax |
Country Status (33)
Country | Link |
---|---|
US (2) | US7211601B2 (el) |
EP (1) | EP1268419B1 (el) |
JP (2) | JP2003528854A (el) |
KR (1) | KR100714585B1 (el) |
CN (1) | CN1296354C (el) |
AR (1) | AR029499A1 (el) |
AT (1) | ATE330940T1 (el) |
AU (2) | AU2001256209B2 (el) |
BG (1) | BG107132A (el) |
BR (1) | BR0109900A (el) |
CA (1) | CA2401242A1 (el) |
CY (1) | CY1105519T1 (el) |
CZ (1) | CZ20023243A3 (el) |
DE (1) | DE60120940T2 (el) |
DK (1) | DK1268419T3 (el) |
EA (1) | EA006424B1 (el) |
EE (1) | EE200200555A (el) |
ES (1) | ES2261404T3 (el) |
HK (1) | HK1054031B (el) |
HR (1) | HRP20020705A2 (el) |
HU (1) | HUP0300994A2 (el) |
IL (1) | IL151912A0 (el) |
MX (1) | MXPA02009382A (el) |
NO (1) | NO323969B1 (el) |
NZ (1) | NZ521060A (el) |
PL (1) | PL358001A1 (el) |
PT (1) | PT1268419E (el) |
SI (1) | SI1268419T1 (el) |
SK (1) | SK13832002A3 (el) |
UA (1) | UA74362C2 (el) |
WO (1) | WO2001072705A1 (el) |
YU (1) | YU73502A (el) |
ZA (1) | ZA200206799B (el) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL151911A0 (en) * | 2000-03-27 | 2003-04-10 | Applied Research Systems | Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them |
IL159219A0 (en) * | 2001-06-18 | 2004-06-01 | Applied Research Systems | Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
AR034897A1 (es) | 2001-08-07 | 2004-03-24 | Hoffmann La Roche | Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos |
US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
UA78058C2 (en) * | 2002-07-05 | 2007-02-15 | Applied Research Systems | Pyrrolidine derivative as oxitocin antagonists |
EP1567487A4 (en) * | 2002-11-15 | 2005-11-16 | Bristol Myers Squibb Co | OPEN-CHAINED, PROLYL-FROSTED MODULATORS OF ANDROGEN RECEPTOR FUNCTION |
WO2004076407A2 (en) * | 2003-02-27 | 2004-09-10 | Applied Research Systems Ars Holding N.V. | Pyrrolidine derivatives as oxytocin antagonists |
US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
SI1725526T1 (sl) * | 2004-02-26 | 2008-04-30 | Serono Lab | Postopek priprave pirolidoin-oksimov |
US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
EP2379524A1 (en) * | 2008-12-18 | 2011-10-26 | Boehringer Ingelheim International GmbH | Serotonin 5-ht2b receptor inhibitors |
EP2759533B1 (en) | 2011-09-22 | 2017-08-02 | Takeda Pharmaceutical Company Limited | Condensed heterocyclic compound |
EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
EP2886107A1 (en) | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
MX371068B (es) | 2014-07-02 | 2020-01-15 | ObsEva SA | ((3z,5s)-5-(hidroximetil)-1-[(2'-metil-1,1'-bifenil-4-il)carbonil ]pirrolidin-3-ona o-metiloxima cristalina y métodos de uso de la misma. |
CN117044622A (zh) * | 2023-09-22 | 2023-11-14 | 贵州师范大学 | 一种无花瓣芥菜型油菜的选育方式 |
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JP4511042B2 (ja) * | 1998-08-07 | 2010-07-28 | メルク セローノ ソシエテ アノニム | 不妊症の治療のためのfsh模倣物 |
EE200100391A (et) * | 1999-01-27 | 2002-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon |
AU759022B2 (en) * | 1999-02-18 | 2003-04-03 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
DK1178958T3 (da) * | 1999-03-15 | 2004-06-21 | Axys Pharm Inc | N-cyanomethylamider som proteaseinhibitorer |
JP2002543129A (ja) * | 1999-05-05 | 2002-12-17 | メルク エンド カムパニー インコーポレーテッド | 抗微生物剤としての新規なプロリン類 |
GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
IL151911A0 (en) * | 2000-03-27 | 2003-04-10 | Applied Research Systems | Pyrolidine derivatives, their preparation and pharmaceutical compositions containing them |
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2001
- 2001-03-20 BR BR0109900-0A patent/BR0109900A/pt not_active IP Right Cessation
- 2001-03-20 DE DE60120940T patent/DE60120940T2/de not_active Expired - Lifetime
- 2001-03-20 PL PL01358001A patent/PL358001A1/xx not_active Application Discontinuation
- 2001-03-20 AU AU2001256209A patent/AU2001256209B2/en not_active Ceased
- 2001-03-20 MX MXPA02009382A patent/MXPA02009382A/es active IP Right Grant
- 2001-03-20 EA EA200201026A patent/EA006424B1/ru unknown
- 2001-03-20 CA CA002401242A patent/CA2401242A1/en not_active Abandoned
- 2001-03-20 CN CNB018071767A patent/CN1296354C/zh not_active Expired - Fee Related
- 2001-03-20 PT PT01929439T patent/PT1268419E/pt unknown
- 2001-03-20 EE EEP200200555A patent/EE200200555A/xx unknown
- 2001-03-20 CZ CZ20023243A patent/CZ20023243A3/cs unknown
- 2001-03-20 DK DK01929439T patent/DK1268419T3/da active
- 2001-03-20 ES ES01929439T patent/ES2261404T3/es not_active Expired - Lifetime
- 2001-03-20 SK SK1383-2002A patent/SK13832002A3/sk unknown
- 2001-03-20 AT AT01929439T patent/ATE330940T1/de not_active IP Right Cessation
- 2001-03-20 EP EP01929439A patent/EP1268419B1/en not_active Expired - Lifetime
- 2001-03-20 JP JP2001570618A patent/JP2003528854A/ja not_active Withdrawn
- 2001-03-20 WO PCT/EP2001/003171 patent/WO2001072705A1/en not_active Application Discontinuation
- 2001-03-20 NZ NZ521060A patent/NZ521060A/en unknown
- 2001-03-20 AU AU5620901A patent/AU5620901A/xx active Pending
- 2001-03-20 KR KR1020027012744A patent/KR100714585B1/ko not_active IP Right Cessation
- 2001-03-20 YU YU73502A patent/YU73502A/sh unknown
- 2001-03-20 SI SI200130566T patent/SI1268419T1/sl unknown
- 2001-03-20 US US10/239,912 patent/US7211601B2/en not_active Expired - Fee Related
- 2001-03-20 HU HU0300994A patent/HUP0300994A2/hu unknown
- 2001-03-20 IL IL15191201A patent/IL151912A0/xx unknown
- 2001-03-20 UA UA2002097675A patent/UA74362C2/uk unknown
- 2001-03-26 AR ARP010101425A patent/AR029499A1/es not_active Application Discontinuation
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2002
- 2002-08-26 ZA ZA200206799A patent/ZA200206799B/en unknown
- 2002-08-28 HR HRP20020705 patent/HRP20020705A2/hr not_active Application Discontinuation
- 2002-09-23 BG BG107132A patent/BG107132A/bg unknown
- 2002-09-25 NO NO20024598A patent/NO323969B1/no unknown
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2003
- 2003-09-05 HK HK03106333.0A patent/HK1054031B/zh not_active IP Right Cessation
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2006
- 2006-07-28 CY CY20061101060T patent/CY1105519T1/el unknown
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2007
- 2007-04-09 US US11/783,341 patent/US20080167318A1/en not_active Abandoned
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2012
- 2012-05-09 JP JP2012107898A patent/JP5580364B2/ja not_active Expired - Fee Related
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