CY1114426T1 - Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους - Google Patents

Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους

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Publication number
CY1114426T1
CY1114426T1 CY20131100690T CY131100690T CY1114426T1 CY 1114426 T1 CY1114426 T1 CY 1114426T1 CY 20131100690 T CY20131100690 T CY 20131100690T CY 131100690 T CY131100690 T CY 131100690T CY 1114426 T1 CY1114426 T1 CY 1114426T1
Authority
CY
Cyprus
Prior art keywords
fibrosis
mir
treatment
prevention
microrna
Prior art date
Application number
CY20131100690T
Other languages
Greek (el)
English (en)
Inventor
Thomas Thum
Johann Bauersachs
Stefan Engelhardt
Carina Gross
Original Assignee
Julius-Maximilians-Universität Würzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius-Maximilians-Universität Würzburg filed Critical Julius-Maximilians-Universität Würzburg
Publication of CY1114426T1 publication Critical patent/CY1114426T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CY20131100690T 2008-02-27 2013-08-13 Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους CY1114426T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3183508P 2008-02-27 2008-02-27
EP20080003570 EP2096171A1 (en) 2008-02-27 2008-02-27 MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US3334008P 2008-03-03 2008-03-03
EP09714079.2A EP2260101B1 (en) 2008-02-27 2009-02-26 Microrna (mirna) mir-21 for diagnostic and therapeutic purposes

Publications (1)

Publication Number Publication Date
CY1114426T1 true CY1114426T1 (el) 2016-08-31

Family

ID=39639202

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100690T CY1114426T1 (el) 2008-02-27 2013-08-13 Microrna (mirna) mir-21 για διαγνωστικους και θεραπευτικους σκοπους

Country Status (23)

Country Link
US (10) US8236777B2 (https=)
EP (3) EP2096171A1 (https=)
JP (2) JP6033527B2 (https=)
KR (1) KR101697482B1 (https=)
CN (1) CN102027113B (https=)
AU (1) AU2009218704C1 (https=)
BR (1) BRPI0907565B1 (https=)
CA (2) CA3123067A1 (https=)
CY (1) CY1114426T1 (https=)
DK (1) DK2260101T3 (https=)
EA (1) EA020335B1 (https=)
ES (1) ES2436885T3 (https=)
HR (1) HRP20130766T1 (https=)
IL (1) IL207704A (https=)
ME (1) ME01600B (https=)
MX (2) MX336299B (https=)
MY (1) MY159454A (https=)
NZ (1) NZ588185A (https=)
PL (1) PL2260101T3 (https=)
PT (1) PT2260101E (https=)
SI (1) SI2260101T1 (https=)
UA (1) UA100727C2 (https=)
WO (2) WO2009106477A1 (https=)

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EP2096171A1 (en) 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US20110190372A1 (en) * 2009-08-07 2011-08-04 New York University Compositions and methods for treating inflammatory disorders
CN102038959B (zh) * 2009-10-26 2012-12-19 中国科学院上海生命科学研究院 let-7/miR-98家族在制备治疗FAS基因相关疾病的药物中的应用
WO2011126842A2 (en) * 2010-03-30 2011-10-13 Regulus Therapeutics Inc. Targeting micrornas for the treatment of cardiac disorders
US20130150256A1 (en) 2010-06-11 2013-06-13 Jane Synnergren Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types
WO2012012716A2 (en) 2010-07-23 2012-01-26 Regulus Therapeutics, Inc. Targeting micrornas for the treatment of fibrosis
KR20140004646A (ko) * 2010-12-15 2014-01-13 미라젠 세러퓨틱스 잠금 뉴클레오티드를 포함하는 마이크로rna 억제제
HUE031595T2 (en) * 2011-04-25 2017-07-28 Regulus Therapeutics Inc Micro RNA Compounds s Methods for Modulating Mir-21 Activity
EP2753696B1 (en) * 2011-09-06 2017-11-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The mirna-212/132 family as a therapeutic target
KR20140091688A (ko) 2011-10-06 2014-07-22 미라젠 세러퓨틱스 인코포레이티드 마이크로rna 조절에 의한 전신 에너지 항상성의 제어
EP2592145A1 (en) * 2011-11-11 2013-05-15 Medizinische Hochschule Hannover Medicament for the treatment of cardiac disease
JP2015504307A (ja) * 2011-11-22 2015-02-12 インターミューン， インコーポレイテッド 特発性肺線維症を診断および治療する方法
AU2012352265B2 (en) * 2011-12-13 2017-02-16 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
JP2015518475A (ja) * 2012-04-10 2015-07-02 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） 非アルコール性脂肪性肝炎の治療方法
EA030211B1 (ru) 2012-04-25 2018-07-31 Регьюлэс Терапьютикс Инк. Соединения на основе микрорнк и способы модулирования активности mir-21
CN107236735B (zh) 2012-06-21 2019-11-08 米拉根医疗股份有限公司 包含锁核酸基序的基于寡核苷酸的抑制剂
CA2782942C (en) 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
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