MX336299B - Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos. - Google Patents

Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos.

Info

Publication number
MX336299B
MX336299B MX2011012838A MX2011012838A MX336299B MX 336299 B MX336299 B MX 336299B MX 2011012838 A MX2011012838 A MX 2011012838A MX 2011012838 A MX2011012838 A MX 2011012838A MX 336299 B MX336299 B MX 336299B
Authority
MX
Mexico
Prior art keywords
fibrosis
mir
treatment
microrna
prevention
Prior art date
Application number
MX2011012838A
Other languages
English (en)
Inventor
Thomas Thum
Johann Bauersachs
Stefan Engelhardt
Carina Gross
Original Assignee
Julius Maximilians Universität Würzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius Maximilians Universität Würzburg filed Critical Julius Maximilians Universität Würzburg
Publication of MX336299B publication Critical patent/MX336299B/es

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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  • Heart & Thoracic Surgery (AREA)
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Abstract

La presente invención se refiere a un compuesto caracterizado porque comprende un aligonucleótido modificado que consiste de 12 a 30 nucleósidos ligados, en donde el oligonucleótido modificado comprende una secuencia de nucleobase complementaria a miR-21 o un precursor del mismo, para uso en el diagnóstico fibrosis o un trastorno fibroproliferativo en un sujeto.
MX2011012838A 2008-02-27 2009-02-26 Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos. MX336299B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3183508P 2008-02-27 2008-02-27
EP20080003570 EP2096171A1 (en) 2008-02-27 2008-02-27 MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
US3334008P 2008-03-03 2008-03-03
PCT/EP2009/051986 WO2009106477A1 (en) 2008-02-27 2009-02-19 Microrna (mirna) and down-stream targets for diagnostic and therapeutic purposes
PCT/EP2009/001590 WO2009106367A1 (en) 2008-02-27 2009-02-26 Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes

Publications (1)

Publication Number Publication Date
MX336299B true MX336299B (es) 2016-01-14

Family

ID=39639202

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010009346A MX2010009346A (es) 2008-02-27 2009-02-26 Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos.
MX2011012838A MX336299B (es) 2008-02-27 2009-02-26 Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos.

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MX2010009346A MX2010009346A (es) 2008-02-27 2009-02-26 Objetivos de microacido ribonucleico (miarn) y en direccion 3' para propositos de diagnostico y terapeuticos.

Country Status (23)

Country Link
US (10) US8236777B2 (es)
EP (3) EP2096171A1 (es)
JP (2) JP6033527B2 (es)
KR (1) KR101697482B1 (es)
CN (1) CN102027113B (es)
AU (1) AU2009218704C1 (es)
BR (1) BRPI0907565B1 (es)
CA (2) CA3123067A1 (es)
CY (1) CY1114426T1 (es)
DK (1) DK2260101T3 (es)
EA (1) EA020335B1 (es)
ES (1) ES2436885T3 (es)
HR (1) HRP20130766T1 (es)
IL (1) IL207704A (es)
ME (1) ME01600B (es)
MX (2) MX2010009346A (es)
MY (1) MY159454A (es)
NZ (1) NZ588185A (es)
PL (1) PL2260101T3 (es)
PT (1) PT2260101E (es)
SI (1) SI2260101T1 (es)
UA (1) UA100727C2 (es)
WO (2) WO2009106477A1 (es)

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CN102038959B (zh) * 2009-10-26 2012-12-19 中国科学院上海生命科学研究院 let-7/miR-98家族在制备治疗FAS基因相关疾病的药物中的应用
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US20130150256A1 (en) 2010-06-11 2013-06-13 Jane Synnergren Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types
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AR084319A1 (es) * 2010-12-15 2013-05-08 Miragen Therapeutics INHIBIDORES DE microARN (miARN O miR) QUE COMPRENDEN NUCLEOTIDOS BLOQUEADOS
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KR20140091688A (ko) 2011-10-06 2014-07-22 미라젠 세러퓨틱스 인코포레이티드 마이크로rna 조절에 의한 전신 에너지 항상성의 제어
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AU2013251696B2 (en) 2012-04-25 2018-11-15 Sanofi MicroRNA compounds and methods for modulating miR-21 activity
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CA2782942C (en) 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
UA116639C2 (uk) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
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