BR112014011733A2 - suspensões autoclaváveis da forma 2 de ciclosporina a - Google Patents

suspensões autoclaváveis da forma 2 de ciclosporina a

Info

Publication number
BR112014011733A2
BR112014011733A2 BR112014011733A BR112014011733A BR112014011733A2 BR 112014011733 A2 BR112014011733 A2 BR 112014011733A2 BR 112014011733 A BR112014011733 A BR 112014011733A BR 112014011733 A BR112014011733 A BR 112014011733A BR 112014011733 A2 BR112014011733 A2 BR 112014011733A2
Authority
BR
Brazil
Prior art keywords
formulations
autoclavable
methods
cyclosporine
suspensions
Prior art date
Application number
BR112014011733A
Other languages
English (en)
Inventor
A Marsh David
Ma Rivers Hongwen
Luu Michelle
M Blanda Wendy
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112014011733A2 publication Critical patent/BR112014011733A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Abstract

abstract disclosed herein are autoclavable formulations of cyclosporin a form 2, methods of making such formulations, and methods of treating diseases of the eye with such formulations. tradução do resumo resumo patente de invenção: "suspensões autoclaváveis da forma 2 de ciclosporina a". formulações autoclaváveis da forma 2 de ciclosporina a, métodos de produção de tais formulações, e métodos de tratamento de doenças dos olhos com tais formulações são aqui divulgados.
BR112014011733A 2011-11-15 2012-11-14 suspensões autoclaváveis da forma 2 de ciclosporina a BR112014011733A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161559849P 2011-11-15 2011-11-15
PCT/US2012/064998 WO2013074616A1 (en) 2011-11-15 2012-11-14 Autoclavable suspensions of cyclosporin a form 2

Publications (1)

Publication Number Publication Date
BR112014011733A2 true BR112014011733A2 (pt) 2017-05-09

Family

ID=47192237

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011733A BR112014011733A2 (pt) 2011-11-15 2012-11-14 suspensões autoclaváveis da forma 2 de ciclosporina a

Country Status (12)

Country Link
US (3) US20130123194A1 (pt)
EP (2) EP2779993B1 (pt)
JP (2) JP6368244B2 (pt)
KR (1) KR102015151B1 (pt)
CN (2) CN104039308B (pt)
AU (3) AU2012339701B8 (pt)
BR (1) BR112014011733A2 (pt)
CA (1) CA2856074C (pt)
ES (1) ES2675269T3 (pt)
HK (1) HK1202078A1 (pt)
RU (1) RU2630970C2 (pt)
WO (1) WO2013074616A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013267435B2 (en) 2012-06-01 2017-11-09 Allergan, Inc. Cyclosporin A analogs
BR112017001017A2 (pt) 2014-07-18 2018-01-23 Allergan Inc composições em suspensão de ciclosporina a para injeção subconjuntival e periocular
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
US11452783B2 (en) * 2017-02-14 2022-09-27 Gi Supply Tissue stain and use thereof
CN108066745A (zh) * 2017-12-26 2018-05-25 兆科药业（广州）有限公司 一种环孢素眼凝胶的处理工艺

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203564B (en) * 1987-12-21 1991-08-28 Sandoz Ag Process for producing new orthorombos cyclosporin without solvatation
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
KR980008239A (ko) * 1996-07-26 1998-04-30 김충환 사이클로스포린-함유 약학적 조성물
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
DE19819273A1 (de) * 1998-04-30 1999-11-11 Pharmatec International S Giul Pharmazeutische Ciclosporin-Formulierung mit verbesserten biopharmazeutischen Eigenschaften, erhöhter physikalischer Qualität und Stabilität sowie Verfahren zur Herstellung
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
PT1142566E (pt) * 2000-04-07 2004-02-27 Medidom Lab Formulacao oftalmica topica na forma de uma solucao aquosa e uso de uma ciclosporina em associacao com acido hialuronico ou um de seus sais e com polisorbato 80
JP2004529934A (ja) * 2001-05-01 2004-09-30 アンジオテック ファーマシューティカルズ，インコーポレイテッド 抗微小管剤およびポリペプチドまたはポリサッカリドを含む組成物、ならびに炎症状態を処置するための医薬品の調製のためのそれらの組成物の使用
CN1456350A (zh) * 2002-05-10 2003-11-19 刘继东 环孢素眼用凝胶
GB2391472B (en) 2002-08-02 2004-12-08 Satishchandra Punambhai Patel Pharmaceutical compositions
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
DE602005011928D1 (de) * 2004-01-20 2009-02-05 Allergan Inc Zusammensetzungen für die lokalisierte therapie des auges, vorzugsweise enthaltend triamcinolon-acetonid und hyaluronsäure
WO2006003519A2 (en) * 2004-07-02 2006-01-12 Novagali Pharma Sa Use of emulsions for intra: and periocular injection
DE602004017477D1 (de) 2004-11-09 2008-12-11 Novagali Pharma Sa Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential
WO2006073786A2 (en) * 2004-12-30 2006-07-13 Bausch & Lomb Incorporated Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
CN100431601C (zh) * 2005-04-25 2008-11-12 北京大学 环孢素微球制剂治疗眼内炎症
US20070015691A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. Cyclosporin compositions
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
DE102006051512A1 (de) * 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
DK1834635T3 (da) * 2006-03-13 2011-10-24 Advancell Advanced In Vitro Cell Technologies S A Stabile nanokapselsystemer til administrtion af aktive molekyler
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
FR2909876A1 (fr) * 2006-12-19 2008-06-20 Galderma Res & Dev S N C Snc Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques
JP2011508776A (ja) * 2008-01-04 2011-03-17 アルコン ファーマシューティカルズ リミテッド 安定な水性シクロスポリン組成物
WO2010006117A2 (en) * 2008-07-10 2010-01-14 Allergan, Inc. Cyclosporin derivatives for treating ocular and dermal diseases and conditions
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
WO2011049958A2 (en) * 2009-10-21 2011-04-28 Otonomy, Inc. Modulation of gel temperature of poloxamer-containing formulations
JP6163482B2 (ja) * 2011-05-27 2017-07-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａの結晶形態、その調製方法、およびその使用のための方法

Also Published As

Publication number Publication date
ES2675269T3 (es) 2018-07-10
EP2779993B1 (en) 2018-04-04
AU2012339701B2 (en) 2017-10-05
WO2013074616A1 (en) 2013-05-23
US20180207230A1 (en) 2018-07-26
CN108714137B (zh) 2022-02-01
AU2019204332A1 (en) 2019-07-11
KR20140104960A (ko) 2014-08-29
AU2017276176A1 (en) 2018-01-18
AU2012339701A1 (en) 2014-06-05
JP2015502351A (ja) 2015-01-22
CN108714137A (zh) 2018-10-30
CA2856074C (en) 2017-07-04
CA2856074A1 (en) 2013-05-23
CN104039308A (zh) 2014-09-10
EP2779993A1 (en) 2014-09-24
US20160271207A1 (en) 2016-09-22
RU2630970C2 (ru) 2017-09-15
US20130123194A1 (en) 2013-05-16
HK1202078A1 (en) 2015-09-18
JP6829706B2 (ja) 2021-02-10
US9919028B2 (en) 2018-03-20
CN104039308B (zh) 2018-06-05
JP2018165270A (ja) 2018-10-25
AU2012339701A8 (en) 2017-11-16
AU2012339701B8 (en) 2017-11-16
AU2019204332B2 (en) 2020-12-24
RU2014123466A (ru) 2015-12-27
KR102015151B1 (ko) 2019-08-27
EP3403645A1 (en) 2018-11-21
JP6368244B2 (ja) 2018-08-01

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09S Decision of refusal: publication cancelled [chapter 9.2.2 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 9.2 NA RPI NO 2700 DE 04/10/2022 POR TER SIDO INDEVIDA.

B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.