BR112017001017A2 - composições em suspensão de ciclosporina a para injeção subconjuntival e periocular - Google Patents
composições em suspensão de ciclosporina a para injeção subconjuntival e periocularInfo
- Publication number
- BR112017001017A2 BR112017001017A2 BR112017001017A BR112017001017A BR112017001017A2 BR 112017001017 A2 BR112017001017 A2 BR 112017001017A2 BR 112017001017 A BR112017001017 A BR 112017001017A BR 112017001017 A BR112017001017 A BR 112017001017A BR 112017001017 A2 BR112017001017 A2 BR 112017001017A2
- Authority
- BR
- Brazil
- Prior art keywords
- cyclosporine
- suspension
- subconjunctival
- suspension compositions
- periocular injection
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mechanical Engineering (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
a presente divulgação refere-se a formulações em suspensão e a sistemas para o tratamento de condições oculares. as formulações em suspensão podem incluir ciclosporina a e, em algumas modalidades, a ciclosporina a da forma 1 ou de forma 2. pode ser fornecido um sistema de distribuição que inclui duas partes, uma primeira parte que contém partículas de ciclosporina, e uma segunda parte que contém outros componentes que podem ser combinados com a primeira parte para produzir uma formulação em suspensão. a suspensão pode ser injetada no espaço subconjuntival ou em outro espaço periocular para tratar condições oculares, tais como a doença do olho seco.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462026200P | 2014-07-18 | 2014-07-18 | |
PCT/US2015/041166 WO2016011449A1 (en) | 2014-07-18 | 2015-07-20 | Suspension compositions of cyclosporin a for subconjunctival and periocular injection |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017001017A2 true BR112017001017A2 (pt) | 2018-01-23 |
Family
ID=53762390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017001017A BR112017001017A2 (pt) | 2014-07-18 | 2015-07-20 | composições em suspensão de ciclosporina a para injeção subconjuntival e periocular |
Country Status (14)
Country | Link |
---|---|
US (1) | US10780048B2 (pt) |
EP (1) | EP3169308B1 (pt) |
KR (1) | KR20170030093A (pt) |
AU (1) | AU2015289387B2 (pt) |
BR (1) | BR112017001017A2 (pt) |
CA (1) | CA2955037A1 (pt) |
CL (1) | CL2017000120A1 (pt) |
CO (1) | CO2017001454A2 (pt) |
MX (1) | MX2017000855A (pt) |
MY (1) | MY196111A (pt) |
PH (1) | PH12017500098A1 (pt) |
RU (1) | RU2713953C2 (pt) |
SA (1) | SA517380738B1 (pt) |
WO (1) | WO2016011449A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101587412B1 (ko) * | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물 |
GB201522441D0 (en) | 2015-12-18 | 2016-02-03 | Midatech Pharma Wales Ltd | Sustained release cyclosporine-loaded microparticles |
US20180098937A1 (en) * | 2016-10-12 | 2018-04-12 | Ps Therapies Ltd | Artificial tear, contact lens and drug vehicle compositions and methods of use thereof |
WO2020037530A1 (en) | 2018-08-22 | 2020-02-27 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Crystalline form of compound and uses thereof in medicine |
CN112315901B (zh) * | 2019-07-17 | 2022-10-25 | 四川弘合生物科技有限公司 | 一种注射用浓溶液及其制备方法 |
US11298315B2 (en) | 2020-08-26 | 2022-04-12 | Somerset Therapeutics, Llc. | Triamcinolone and moxifloxacin compositions |
US11484538B2 (en) | 2020-08-26 | 2022-11-01 | Somerset Therapeutics, Llc | Bromfenac, prednisolone, and moxifloxacin compositions and methods |
US11382910B2 (en) | 2020-08-26 | 2022-07-12 | Somerset Therapeutics, Llc. | Loteprednol and moxifloxacin compositions and methods |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5252319A (en) | 1990-06-12 | 1993-10-12 | Insite Vision Incorporated | Aminosteroids for ophthalmic use |
SG45449A1 (en) | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
EP1142566B1 (fr) * | 2000-04-07 | 2003-10-01 | Laboratoire Medidom S.A. | Formulations ophtalmiques à base de ciclosporine, d'acide hyaluronique et du polysorbate |
GB0122318D0 (en) | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
KR20100102749A (ko) | 2002-02-22 | 2010-09-24 | 산텐 세이야꾸 가부시키가이샤 | 미립자 결막하 투여를 위한 약물 수송 시스템 |
AU2005209201B2 (en) | 2004-01-20 | 2010-06-03 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
US8288348B2 (en) * | 2005-07-13 | 2012-10-16 | Allergan, Inc. | Cyclosporin compositions |
MX2008012794A (es) * | 2006-04-03 | 2008-10-15 | Teva Pharma | Microparticulas de farmacos. |
US20080146497A1 (en) * | 2006-07-25 | 2008-06-19 | Graham Richard S | Cyclosporin Compositions |
US20090081277A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
UA113627C2 (xx) | 2011-05-27 | 2017-02-27 | Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування | |
ES2666191T3 (es) | 2011-11-15 | 2018-05-03 | Allergan, Inc. | Un proceso para la cristalización de la forma 2 de la ciclosporina A |
WO2013074616A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Autoclavable suspensions of cyclosporin a form 2 |
US8785394B2 (en) | 2011-11-15 | 2014-07-22 | Allergan, Inc. | Sustained action formulation of cyclosporin form 2 |
ES2791751T3 (es) | 2011-11-15 | 2020-11-05 | Allergan Inc | Suspensiones de forma 2 de ciclosporina A |
-
2015
- 2015-07-20 CA CA2955037A patent/CA2955037A1/en not_active Abandoned
- 2015-07-20 US US14/804,011 patent/US10780048B2/en active Active
- 2015-07-20 AU AU2015289387A patent/AU2015289387B2/en active Active
- 2015-07-20 BR BR112017001017A patent/BR112017001017A2/pt not_active Application Discontinuation
- 2015-07-20 MX MX2017000855A patent/MX2017000855A/es unknown
- 2015-07-20 WO PCT/US2015/041166 patent/WO2016011449A1/en active Application Filing
- 2015-07-20 KR KR1020177003920A patent/KR20170030093A/ko not_active Application Discontinuation
- 2015-07-20 MY MYPI2017000064A patent/MY196111A/en unknown
- 2015-07-20 RU RU2017103632A patent/RU2713953C2/ru active
- 2015-07-20 EP EP15744833.3A patent/EP3169308B1/en not_active Revoked
-
2017
- 2017-01-16 PH PH12017500098A patent/PH12017500098A1/en unknown
- 2017-01-17 CL CL2017000120A patent/CL2017000120A1/es unknown
- 2017-01-18 SA SA517380738A patent/SA517380738B1/ar unknown
- 2017-02-13 CO CONC2017/0001454A patent/CO2017001454A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2017000855A (es) | 2017-05-01 |
CL2017000120A1 (es) | 2017-09-08 |
MY196111A (en) | 2023-03-15 |
EP3169308B1 (en) | 2021-01-27 |
WO2016011449A1 (en) | 2016-01-21 |
KR20170030093A (ko) | 2017-03-16 |
US20160015632A1 (en) | 2016-01-21 |
RU2017103632A (ru) | 2018-08-20 |
EP3169308A1 (en) | 2017-05-24 |
RU2713953C2 (ru) | 2020-02-11 |
PH12017500098A1 (en) | 2017-05-22 |
CO2017001454A2 (es) | 2017-02-28 |
RU2017103632A3 (pt) | 2019-02-01 |
CA2955037A1 (en) | 2016-01-21 |
AU2015289387B2 (en) | 2020-10-22 |
SA517380738B1 (ar) | 2021-04-11 |
AU2015289387A1 (en) | 2017-02-23 |
US10780048B2 (en) | 2020-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |