CY1112559T1 - Βιοσυνθετικα συναθροισματα γονιδιων λαντιβιοτικων απο α. garbadinensis και α. liguriae - Google Patents

Βιοσυνθετικα συναθροισματα γονιδιων λαντιβιοτικων απο α. garbadinensis και α. liguriae

Info

Publication number
CY1112559T1
CY1112559T1 CY20121100166T CY121100166T CY1112559T1 CY 1112559 T1 CY1112559 T1 CY 1112559T1 CY 20121100166 T CY20121100166 T CY 20121100166T CY 121100166 T CY121100166 T CY 121100166T CY 1112559 T1 CY1112559 T1 CY 1112559T1
Authority
CY
Cyprus
Prior art keywords
actagardine
garbadinensis
liguriae
summaries
biosynthetic
Prior art date
Application number
CY20121100166T
Other languages
English (en)
Inventor
Steven Boakes
Bargallo Jesus Cortes
Michael John Dawson
Original Assignee
Novacta Biosystems Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novacta Biosystems Limited filed Critical Novacta Biosystems Limited
Publication of CY1112559T1 publication Critical patent/CY1112559T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/045—Actinoplanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Αυτή η εφεύρεση σχετίζεται με τον χαρακτηρισμό του συναθροίσματος βιοσυνθετικών γονιδίων για το λαντιβιοτικό ακταγαρδίνη, την ταυτοποίηση ενός καινοφανούς παραλλάγματος της ακταγαρδίνης και του βιοσυνθετικού συναθροίσματος αυτού, και με μεθόδους παραγωγής και χρήσης της ακταγαρδίνης, ενός καινοφανούς παραλλάγματος της ακταγαρδίνης που αναφέρεται εις το παρόν και ως ακταγαρδίνη Β, και των παραλλαγμάτων αμφότερων εξ αυτών που παράγονται σύμφωνα με αυτήν την εφεύρεση, χρησιμοποιώντας γονίδια από χαρακτηρισμένα βιοσυνθετικά συναθροίσματα γονιδίων.
CY20121100166T 2006-01-17 2012-02-17 Βιοσυνθετικα συναθροισματα γονιδιων λαντιβιοτικων απο α. garbadinensis και α. liguriae CY1112559T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0600928.6A GB0600928D0 (en) 2006-01-17 2006-01-17 Improvements relating to lantibiotics
EP07704921A EP1979375B9 (en) 2006-01-17 2007-01-17 Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae

Publications (1)

Publication Number Publication Date
CY1112559T1 true CY1112559T1 (el) 2016-02-10

Family

ID=35998187

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100166T CY1112559T1 (el) 2006-01-17 2012-02-17 Βιοσυνθετικα συναθροισματα γονιδιων λαντιβιοτικων απο α. garbadinensis και α. liguriae

Country Status (20)

Country Link
US (3) USRE45003E1 (el)
EP (2) EP2189472A1 (el)
JP (1) JP5219837B2 (el)
KR (1) KR101573536B1 (el)
CN (1) CN101389641B (el)
AT (1) ATE534659T1 (el)
AU (1) AU2007206769B2 (el)
BR (1) BRPI0706525A2 (el)
CA (1) CA2637315A1 (el)
CY (1) CY1112559T1 (el)
DK (1) DK1979375T3 (el)
ES (1) ES2378090T3 (el)
GB (1) GB0600928D0 (el)
IL (1) IL192446A0 (el)
MX (1) MX2008009047A (el)
NZ (1) NZ569486A (el)
PL (1) PL1979375T3 (el)
PT (1) PT1979375E (el)
SI (1) SI1979375T1 (el)
WO (1) WO2007083112A2 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
CN102348718B (zh) * 2009-01-14 2015-06-03 诺瓦克塔生物系统有限公司 去氧阿肽加定衍生物
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
EP2393829A1 (en) 2009-02-04 2011-12-14 Novacta Biosystems Limited Actagardine derivatives
CA2789164A1 (en) * 2010-02-02 2011-08-11 Novacta Biosystems Limited Lantibiotic salts
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
CN103052383A (zh) * 2010-07-14 2013-04-17 诺瓦克塔生物系统有限公司 含有b型羊毛硫抗生素的制剂
GB201013507D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
GB201013508D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013509D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
WO2014085637A1 (en) * 2012-11-30 2014-06-05 Sentinella Pharmaceuticals, Inc. New lantibiotic derivatives and a process for their preparation
CN103483433B (zh) * 2013-09-10 2015-05-27 中国科学院微生物研究所 一种新型高效的羊毛硫细菌素cerecidin及其应用
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
GB8507528D0 (en) 1985-03-22 1985-05-01 Lepetit Spa Basis monocarboxyamide derivatives
US5304540A (en) 1988-06-22 1994-04-19 Applied Microbiology, Inc. Pharmaceutical bacteriocin compositions and methods for using the same
IN167138B (el) 1988-08-17 1990-09-01 Hoechst India
GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
IT1260505B (it) 1992-06-01 1996-04-09 Poli Ind Chimica Spa Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon
IL107887A (en) 1992-12-08 2003-07-06 Ambi Inc Stabilized lanthionine containing bacteriocin compositions
US5512269A (en) 1993-06-09 1996-04-30 Burroughs Wellcome, Co. Method of treating retained pulmonary secretions
EP0700998B1 (en) 1994-09-12 2003-11-26 Aventis Pharma Deutschland GmbH Recombinant mersacidin and a method for production
DE69629691T2 (de) 1995-06-23 2004-02-26 Ambi, Inc. Verfahren zur kontrolle von antibiotikaresistenten grampositiven bakterien und behandlung von infektionen
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5985823A (en) 1997-06-09 1999-11-16 Ambi Inc. Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
US5958873A (en) 1997-06-09 1999-09-28 University Of Cincinnati Oral formulation for treatment of bacteria-induced diseases of the colon
DE19745583A1 (de) * 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US6569830B1 (en) 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
HU230396B1 (hu) 2000-06-28 2016-04-28 Smithkline Beecham Plc Nedves őrlési eljárás
GB0110432D0 (en) * 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
WO2002103010A1 (en) 2001-06-14 2002-12-27 Plant Bioscience Limited Methods and materials for targeted gene disruption in actinomycete bacteria
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
US7199230B2 (en) 2002-10-10 2007-04-03 Molichem Medicines, Inc. Nucleic acids encoding duramycin
US7351687B2 (en) 2003-07-18 2008-04-01 Vicuron Pharmaceuticals, Inc. Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
ATE356143T1 (de) 2003-07-18 2007-03-15 Vicuron Pharm Inc Antibiotikum 107891, dessen faktoren a1 und a2, pharmazeutisch unbedenkliche salze und zusammensetzungen, und anwendung davon
US20050271650A1 (en) * 2004-02-17 2005-12-08 Cellmatrix, Inc. Method and composition for angiogenesis inhibition
GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
JP2009509519A (ja) 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
ES2895666T3 (es) 2006-10-27 2022-02-22 Capsugel Belgium Nv Cápsulas duras de hidroxipropilmetilcelulosa y proceso de fabricación
US20110150917A1 (en) 2007-06-12 2011-06-23 The University Of British Columbia Small Cationic Antimicrobial Peptides
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
KR20110086582A (ko) 2008-11-24 2011-07-28 센티넬라 파마세티컬즈, 인크. 항균활성이 강화된 란티바이오틱 카르복시아미드 유도체
CN102348718B (zh) 2009-01-14 2015-06-03 诺瓦克塔生物系统有限公司 去氧阿肽加定衍生物
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
EP2393829A1 (en) 2009-02-04 2011-12-14 Novacta Biosystems Limited Actagardine derivatives
EP2216937A1 (en) 2009-02-10 2010-08-11 Alcatel Lucent Alarm notification between customer premises equipment and a remote management server

Also Published As

Publication number Publication date
US20100048459A1 (en) 2010-02-25
EP1979375B9 (en) 2012-05-09
US8465947B2 (en) 2013-06-18
US20110306091A1 (en) 2011-12-15
JP5219837B2 (ja) 2013-06-26
AU2007206769B2 (en) 2013-06-20
MX2008009047A (es) 2008-12-18
WO2007083112A3 (en) 2008-05-08
US7989416B2 (en) 2011-08-02
EP2189472A1 (en) 2010-05-26
BRPI0706525A2 (pt) 2011-03-29
AU2007206769A1 (en) 2007-07-26
PT1979375E (pt) 2012-03-06
EP1979375B1 (en) 2011-11-23
DK1979375T3 (da) 2012-03-19
USRE45003E1 (en) 2014-07-08
CN101389641B (zh) 2013-06-05
CN101389641A (zh) 2009-03-18
KR20080086517A (ko) 2008-09-25
EP1979375A2 (en) 2008-10-15
GB0600928D0 (en) 2006-02-22
IL192446A0 (en) 2008-12-29
CA2637315A1 (en) 2007-07-26
JP2009523777A (ja) 2009-06-25
PL1979375T3 (pl) 2012-04-30
ES2378090T3 (es) 2012-04-04
NZ569486A (en) 2011-07-29
ATE534659T1 (de) 2011-12-15
SI1979375T1 (sl) 2012-03-30
KR101573536B1 (ko) 2015-12-11
WO2007083112A2 (en) 2007-07-26

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