TW200637913A - Genes encoding the synthetic pathway for the production of disorazole - Google Patents

Genes encoding the synthetic pathway for the production of disorazole

Info

Publication number
TW200637913A
TW200637913A TW095101196A TW95101196A TW200637913A TW 200637913 A TW200637913 A TW 200637913A TW 095101196 A TW095101196 A TW 095101196A TW 95101196 A TW95101196 A TW 95101196A TW 200637913 A TW200637913 A TW 200637913A
Authority
TW
Taiwan
Prior art keywords
disorazole
production
genes encoding
synthetic pathway
proteins
Prior art date
Application number
TW095101196A
Other languages
Chinese (zh)
Inventor
Herbert Irschik
Maren Kopp
Rolf Muller
Original Assignee
Biotechnolog Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh
Publication of TW200637913A publication Critical patent/TW200637913A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to nucleic acid sequences and proteins derivable therefrom that have been identified in Sorangium cellulosum, which proteins are catalytically active or participate in the biosynthetic pathway of disorazoles. The invention provides novel sequences which are necessary components of the disorazole biosynthetic pathway in addition to genes dszA-D.
TW095101196A 2005-01-13 2006-01-12 Genes encoding the synthetic pathway for the production of disorazole TW200637913A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100190 2005-01-13
US64389905P 2005-01-14 2005-01-14

Publications (1)

Publication Number Publication Date
TW200637913A true TW200637913A (en) 2006-11-01

Family

ID=36218522

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095101196A TW200637913A (en) 2005-01-13 2006-01-12 Genes encoding the synthetic pathway for the production of disorazole

Country Status (7)

Country Link
EP (1) EP1838848A1 (en)
JP (1) JP2008526246A (en)
CN (1) CN101142313A (en)
CA (1) CA2594790A1 (en)
NO (1) NO20073619L (en)
TW (1) TW200637913A (en)
WO (1) WO2006075013A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
CN108048472B (en) * 2017-12-18 2020-12-04 山东大学 Engineering strain for high-efficiency heterologous expression of Disorazole Z, gene cluster for constructing strain and application of gene cluster

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298864A1 (en) * 2002-12-06 2004-06-30 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides

Also Published As

Publication number Publication date
NO20073619L (en) 2007-10-05
EP1838848A1 (en) 2007-10-03
CN101142313A (en) 2008-03-12
JP2008526246A (en) 2008-07-24
WO2006075013A1 (en) 2006-07-20
CA2594790A1 (en) 2006-07-20

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TW200637913A (en) Genes encoding the synthetic pathway for the production of disorazole