NO20073619L - Genes for coding the synthetic path for the production of Disorazole - Google Patents

Genes for coding the synthetic path for the production of Disorazole

Info

Publication number
NO20073619L
NO20073619L NO20073619A NO20073619A NO20073619L NO 20073619 L NO20073619 L NO 20073619L NO 20073619 A NO20073619 A NO 20073619A NO 20073619 A NO20073619 A NO 20073619A NO 20073619 L NO20073619 L NO 20073619L
Authority
NO
Norway
Prior art keywords
disorazole
genes
coding
production
synthetic path
Prior art date
Application number
NO20073619A
Other languages
Norwegian (no)
Inventor
Herbert Irschik
Maren Kopp
Rolf Mueller
Original Assignee
Helmholtz Infektionsforschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Infektionsforschung filed Critical Helmholtz Infektionsforschung
Publication of NO20073619L publication Critical patent/NO20073619L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse angår nukleinsyre-sekvenser og proteiner som er utledbare derfra, som har blitt identifisert i Sorangium cellulosum, idet proteinene er katalytisk aktive eller deltar i den biosyntetiske ruten for disorazoler. Oppfinnelsen framskaffer nye sekvenser som er nødvendige komponenter i disorazol biosyntese ruten i tillegg til genene dszA-D.The present invention relates to nucleic acid sequences and proteins deducible therefrom, which have been identified in Sorangium cellulosum, the proteins being catalytically active or participating in the biosynthetic pathway for disorazoles. The invention provides novel sequences that are necessary components of the disorazole biosynthesis pathway in addition to the dszA-D genes.

NO20073619A 2005-01-13 2007-07-13 Genes for coding the synthetic path for the production of Disorazole NO20073619L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100190 2005-01-13
PCT/EP2006/050169 WO2006075013A1 (en) 2005-01-13 2006-01-12 Genes encoding the synthetic pathway for the production of disorazole

Publications (1)

Publication Number Publication Date
NO20073619L true NO20073619L (en) 2007-10-05

Family

ID=36218522

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073619A NO20073619L (en) 2005-01-13 2007-07-13 Genes for coding the synthetic path for the production of Disorazole

Country Status (7)

Country Link
EP (1) EP1838848A1 (en)
JP (1) JP2008526246A (en)
CN (1) CN101142313A (en)
CA (1) CA2594790A1 (en)
NO (1) NO20073619L (en)
TW (1) TW200637913A (en)
WO (1) WO2006075013A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900742A1 (en) 2006-09-07 2008-03-19 AEterna Zentaris GmbH Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
CN108048472B (en) * 2017-12-18 2020-12-04 山东大学 Engineering strain for high-efficiency heterologous expression of Disorazole Z, gene cluster for constructing strain and application of gene cluster

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298864A1 (en) * 2002-12-06 2004-06-30 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides

Also Published As

Publication number Publication date
EP1838848A1 (en) 2007-10-03
CN101142313A (en) 2008-03-12
TW200637913A (en) 2006-11-01
JP2008526246A (en) 2008-07-24
WO2006075013A1 (en) 2006-07-20
CA2594790A1 (en) 2006-07-20

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