MX346291B - Reactivos de conjugación. - Google Patents
Reactivos de conjugación.Info
- Publication number
- MX346291B MX346291B MX2014015686A MX2014015686A MX346291B MX 346291 B MX346291 B MX 346291B MX 2014015686 A MX2014015686 A MX 2014015686A MX 2014015686 A MX2014015686 A MX 2014015686A MX 346291 B MX346291 B MX 346291B
- Authority
- MX
- Mexico
- Prior art keywords
- ch2l
- conjugation reagents
- conjugation
- independently represents
- reagents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
- C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
- C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Abstract
La presente invención proporciona un compuesto de la fórmula I,en donde cada X representa independientemente una cadena de polímero, p representa un entero de 1 a 6; Y representa un grupo amida; y Z representa ya sea -CH.(CH2L)2 o -C(CH2LX=CH2), en donde cada L representa independientemente un grupo de partida. Los compuestos son reactivos útiles para la conjugación de polímeros para proteínas, siendo novedosos los conjugados resultantes y formando también parte de la presente invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1210770.2A GB201210770D0 (en) | 2012-06-18 | 2012-06-18 | Novel conjugation reagents |
PCT/GB2013/051567 WO2013190272A1 (en) | 2012-06-18 | 2013-06-17 | Conjugation reagents |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014015686A MX2014015686A (es) | 2015-08-06 |
MX346291B true MX346291B (es) | 2017-03-14 |
Family
ID=46641088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014015686A MX346291B (es) | 2012-06-18 | 2013-06-17 | Reactivos de conjugación. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2861260B1 (es) |
JP (1) | JP6250654B2 (es) |
KR (1) | KR20150032558A (es) |
CN (1) | CN104363926B (es) |
AU (1) | AU2013279079B2 (es) |
BR (1) | BR112014029972A2 (es) |
CA (1) | CA2873957A1 (es) |
ES (1) | ES2602083T3 (es) |
GB (1) | GB201210770D0 (es) |
HK (1) | HK1204555A1 (es) |
IL (1) | IL235647A (es) |
IN (1) | IN2014DN10426A (es) |
MX (1) | MX346291B (es) |
RU (1) | RU2015101332A (es) |
SG (1) | SG11201407596TA (es) |
WO (1) | WO2013190272A1 (es) |
ZA (1) | ZA201408914B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10570151B2 (en) | 2013-03-15 | 2020-02-25 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
WO2015031396A1 (en) | 2013-08-26 | 2015-03-05 | Regeneron Pharmaceuticals, Inc. | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses |
WO2015104374A1 (en) * | 2014-01-10 | 2015-07-16 | Eth Zurich | Polyethylene glycol substituted acyl borates |
CA2950155C (en) | 2014-06-02 | 2021-11-23 | Regeneron Pharmaceuticals, Inc. | Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses |
US10835616B2 (en) | 2014-10-14 | 2020-11-17 | Polytherics Limited | Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG |
ES2960741T3 (es) * | 2014-10-24 | 2024-03-06 | Abzena Uk Ltd | Conjugados y reactivos de conjugación |
AU2015242213A1 (en) | 2015-07-12 | 2018-03-08 | Hangzhou Dac Biotech Co., Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
BR112018014759B1 (pt) | 2016-01-25 | 2024-02-27 | Regeneron Pharmaceuticals, Inc | Compostos derivados de maitasinoide e seus conjugados, composição compreendendo os mesmos, seus métodos de fabricação e uso |
WO2017178828A1 (en) | 2016-04-14 | 2017-10-19 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
KR20220147720A (ko) | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
US10864279B2 (en) | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
KR20220029725A (ko) | 2019-06-29 | 2022-03-08 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 세포-결합 분자-튜불리신 유도체 접합체 및 이의 제조 방법 |
WO2021055816A1 (en) | 2019-09-18 | 2021-03-25 | Molecular Templates, Inc. | Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds |
CA3213295A1 (en) | 2021-03-17 | 2022-09-22 | Molecular Templates, Inc. | Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
ES2597849T3 (es) * | 2007-10-09 | 2017-01-23 | Polytherics Limited | Proteínas y péptidos conjugados novedosos |
KR101763559B1 (ko) * | 2008-07-21 | 2017-08-14 | 폴리테릭스 리미티드 | 생물학적 분자의 컨쥬게이팅을 위한 신규한 시약 및 방법 |
JP5825507B2 (ja) * | 2010-06-25 | 2015-12-02 | 日油株式会社 | 分岐型ヘテロポリエチレングリコール |
-
2012
- 2012-06-18 GB GBGB1210770.2A patent/GB201210770D0/en not_active Ceased
-
2013
- 2013-06-17 SG SG11201407596TA patent/SG11201407596TA/en unknown
- 2013-06-17 RU RU2015101332A patent/RU2015101332A/ru unknown
- 2013-06-17 JP JP2015517840A patent/JP6250654B2/ja active Active
- 2013-06-17 KR KR1020157001170A patent/KR20150032558A/ko not_active Application Discontinuation
- 2013-06-17 MX MX2014015686A patent/MX346291B/es active IP Right Grant
- 2013-06-17 CA CA2873957A patent/CA2873957A1/en not_active Abandoned
- 2013-06-17 CN CN201380031844.6A patent/CN104363926B/zh not_active Expired - Fee Related
- 2013-06-17 WO PCT/GB2013/051567 patent/WO2013190272A1/en active Application Filing
- 2013-06-17 AU AU2013279079A patent/AU2013279079B2/en not_active Ceased
- 2013-06-17 ES ES13731436.5T patent/ES2602083T3/es active Active
- 2013-06-17 BR BR112014029972A patent/BR112014029972A2/pt not_active IP Right Cessation
- 2013-06-17 EP EP13731436.5A patent/EP2861260B1/en not_active Not-in-force
-
2014
- 2014-11-11 IL IL235647A patent/IL235647A/en not_active IP Right Cessation
- 2014-12-04 ZA ZA2014/08914A patent/ZA201408914B/en unknown
- 2014-12-08 IN IN10426DEN2014 patent/IN2014DN10426A/en unknown
-
2015
- 2015-05-28 HK HK15105075.0A patent/HK1204555A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201408914B (en) | 2015-12-23 |
AU2013279079B2 (en) | 2017-05-18 |
IL235647A0 (en) | 2015-01-29 |
MX2014015686A (es) | 2015-08-06 |
CN104363926B (zh) | 2017-06-23 |
BR112014029972A2 (pt) | 2017-06-27 |
WO2013190272A1 (en) | 2013-12-27 |
GB201210770D0 (en) | 2012-08-01 |
JP2015521667A (ja) | 2015-07-30 |
CA2873957A1 (en) | 2013-12-27 |
IL235647A (en) | 2017-05-29 |
SG11201407596TA (en) | 2014-12-30 |
JP6250654B2 (ja) | 2017-12-20 |
ES2602083T3 (es) | 2017-02-17 |
IN2014DN10426A (es) | 2015-08-21 |
CN104363926A (zh) | 2015-02-18 |
KR20150032558A (ko) | 2015-03-26 |
AU2013279079A1 (en) | 2014-12-04 |
EP2861260B1 (en) | 2016-08-10 |
HK1204555A1 (en) | 2015-11-27 |
EP2861260A1 (en) | 2015-04-22 |
RU2015101332A (ru) | 2016-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX346291B (es) | Reactivos de conjugación. | |
EA201001356A1 (ru) | Новые замещенные имидазохинолины | |
PH12014502169A1 (en) | N-cyclylamides as nematicides | |
MX351513B (es) | Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo. | |
EA201591497A1 (ru) | Новые производные октагидропирроло[3,4-c]пиррола и их аналоги в качестве ингибиторов аутотаксина | |
IN2015DN00960A (es) | ||
IN2014DN00176A (es) | ||
EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
IN2012DN03057A (es) | ||
UA114611C2 (uk) | Пестицидні композиції і способи, що їх стосуються | |
TN2012000575A1 (en) | Compositions and methods for modulating the wnt signaling pathway | |
MX2010007587A (es) | Compuestos que comprenden un grupo ciclobutoxi. | |
MX2014004955A (es) | Amida de acido n-(tetrazol-5-il)arilcarboxilico y amida de n-(triazol-5-il)arilcarboxilico sustituidas con 5-fenilo y uso de las mismas como herbicidas. | |
WO2013083859A3 (en) | Substituted n-(tetrazol-5-yl)- and n-(triazol-5-yl)arylcarboxamide compounds and their use as herbicides | |
MX2011007998A (es) | Nuevos herbicidas. | |
MY161132A (en) | Novel herbicides | |
WO2012101011A3 (en) | New aryl-benzocycloalkyl amide derivatives | |
UA102289C2 (ru) | Гербициды, полученные из циклопентадиона | |
CY1115919T1 (el) | Ενωσεις ενεργοποιησης τελομερασης και μεθοδοι χρησης αυτων | |
MX2011007932A (es) | Herbicidas nuevos. | |
WO2013072528A3 (en) | Substituted n-(tetrazol-5-yl)- and n-(triazol-5-yl)pyridin-3-yl-carboxamide compounds and their use as herbicides | |
CY1116974T1 (el) | Παραγωγα 5-υδροξυπυριμιδινο-4-καρβοξαμιδιου | |
UA110128C2 (uk) | Індолкарбоксаміди та бензімідазолкарбоксаміди як інсектициди та акарициди | |
MX2014008373A (es) | Conjugados antagonistas de integrina para suministro dirigido a celulas que expresan alfa-v-beta-3. | |
EA200801549A1 (ru) | Новые производные фенантридина в качестве антагонистов брадикинина |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |