BR112014029972A2 - reagentes de conjugação - Google Patents
reagentes de conjugaçãoInfo
- Publication number
- BR112014029972A2 BR112014029972A2 BR112014029972A BR112014029972A BR112014029972A2 BR 112014029972 A2 BR112014029972 A2 BR 112014029972A2 BR 112014029972 A BR112014029972 A BR 112014029972A BR 112014029972 A BR112014029972 A BR 112014029972A BR 112014029972 A2 BR112014029972 A2 BR 112014029972A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugation reagents
- reagents
- independently represents
- conjugation
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
- C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
- C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1210770.2A GB201210770D0 (en) | 2012-06-18 | 2012-06-18 | Novel conjugation reagents |
| PCT/GB2013/051567 WO2013190272A1 (en) | 2012-06-18 | 2013-06-17 | Conjugation reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014029972A2 true BR112014029972A2 (pt) | 2017-06-27 |
Family
ID=46641088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014029972A BR112014029972A2 (pt) | 2012-06-18 | 2013-06-17 | reagentes de conjugação |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP2861260B1 (es) |
| JP (1) | JP6250654B2 (es) |
| KR (1) | KR20150032558A (es) |
| CN (1) | CN104363926B (es) |
| AU (1) | AU2013279079B2 (es) |
| BR (1) | BR112014029972A2 (es) |
| CA (1) | CA2873957A1 (es) |
| ES (1) | ES2602083T3 (es) |
| GB (1) | GB201210770D0 (es) |
| HK (1) | HK1204555A1 (es) |
| IL (1) | IL235647A (es) |
| IN (1) | IN2014DN10426A (es) |
| MX (1) | MX346291B (es) |
| RU (1) | RU2015101332A (es) |
| SG (1) | SG11201407596TA (es) |
| WO (1) | WO2013190272A1 (es) |
| ZA (1) | ZA201408914B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015011348A (es) | 2013-03-15 | 2016-01-15 | Regeneron Pharma | Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos. |
| CN105530942B (zh) | 2013-08-26 | 2019-10-11 | 瑞泽恩制药公司 | 一种包含大环内酯类非对映体的药物组合物、其制备方法和用途 |
| JP6606081B2 (ja) * | 2014-01-10 | 2019-11-20 | エー・テー・ハー・チューリッヒ | ポリエチレングリコール置換されたホウ酸アシル |
| CN106573074B (zh) | 2014-06-02 | 2022-04-12 | 里珍纳龙药品有限公司 | 生物活性分子偶联物、试剂和制备方法及其治疗用途 |
| EP3218009B1 (en) | 2014-10-14 | 2021-04-07 | Polytherics Limited | Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of peg |
| WO2016063006A1 (en) * | 2014-10-24 | 2016-04-28 | Polytherics Limited | Conjugates and conjugating reagents |
| CA2991973C (en) | 2015-07-12 | 2021-12-07 | Suzhou M-Conj Biotech Co., Ltd. | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| CN114478801A (zh) | 2016-01-25 | 2022-05-13 | 里珍纳龙药品有限公司 | 美登素类化合物衍生物、其偶联物和使用方法 |
| EP3442595A1 (en) | 2016-04-14 | 2019-02-20 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
| GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| KR20220150408A (ko) | 2016-11-14 | 2022-11-10 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
| US10864279B2 (en) | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
| WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
| CA3145050A1 (en) | 2019-06-29 | 2021-01-07 | Robert Zhao | Conjugates of tubulysin derivatives and cell binding molecules and methods of making |
| WO2021055816A1 (en) | 2019-09-18 | 2021-03-25 | Molecular Templates, Inc. | Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds |
| EP4308242A1 (en) | 2021-03-17 | 2024-01-24 | Molecular Templates, Inc. | Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US7645860B2 (en) * | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| CN101820920B (zh) * | 2007-10-09 | 2014-08-06 | 宝力泰锐克斯有限公司 | 新的缀合蛋白质和肽 |
| AU2009275358C1 (en) * | 2008-07-21 | 2015-09-24 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
| JP5825507B2 (ja) * | 2010-06-25 | 2015-12-02 | 日油株式会社 | 分岐型ヘテロポリエチレングリコール |
-
2012
- 2012-06-18 GB GBGB1210770.2A patent/GB201210770D0/en not_active Ceased
-
2013
- 2013-06-17 RU RU2015101332A patent/RU2015101332A/ru unknown
- 2013-06-17 ES ES13731436.5T patent/ES2602083T3/es active Active
- 2013-06-17 CN CN201380031844.6A patent/CN104363926B/zh not_active Expired - Fee Related
- 2013-06-17 EP EP13731436.5A patent/EP2861260B1/en not_active Not-in-force
- 2013-06-17 CA CA2873957A patent/CA2873957A1/en not_active Abandoned
- 2013-06-17 WO PCT/GB2013/051567 patent/WO2013190272A1/en active Application Filing
- 2013-06-17 KR KR1020157001170A patent/KR20150032558A/ko not_active Application Discontinuation
- 2013-06-17 SG SG11201407596TA patent/SG11201407596TA/en unknown
- 2013-06-17 AU AU2013279079A patent/AU2013279079B2/en not_active Ceased
- 2013-06-17 JP JP2015517840A patent/JP6250654B2/ja active Active
- 2013-06-17 BR BR112014029972A patent/BR112014029972A2/pt not_active IP Right Cessation
- 2013-06-17 MX MX2014015686A patent/MX346291B/es active IP Right Grant
-
2014
- 2014-11-11 IL IL235647A patent/IL235647A/en not_active IP Right Cessation
- 2014-12-04 ZA ZA2014/08914A patent/ZA201408914B/en unknown
- 2014-12-08 IN IN10426DEN2014 patent/IN2014DN10426A/en unknown
-
2015
- 2015-05-28 HK HK15105075.0A patent/HK1204555A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013279079A1 (en) | 2014-12-04 |
| MX2014015686A (es) | 2015-08-06 |
| ES2602083T3 (es) | 2017-02-17 |
| CN104363926B (zh) | 2017-06-23 |
| IL235647A (en) | 2017-05-29 |
| CN104363926A (zh) | 2015-02-18 |
| JP2015521667A (ja) | 2015-07-30 |
| KR20150032558A (ko) | 2015-03-26 |
| CA2873957A1 (en) | 2013-12-27 |
| IN2014DN10426A (es) | 2015-08-21 |
| EP2861260B1 (en) | 2016-08-10 |
| MX346291B (es) | 2017-03-14 |
| RU2015101332A (ru) | 2016-08-10 |
| WO2013190272A1 (en) | 2013-12-27 |
| GB201210770D0 (en) | 2012-08-01 |
| EP2861260A1 (en) | 2015-04-22 |
| SG11201407596TA (en) | 2014-12-30 |
| AU2013279079B2 (en) | 2017-05-18 |
| ZA201408914B (en) | 2015-12-23 |
| JP6250654B2 (ja) | 2017-12-20 |
| HK1204555A1 (en) | 2015-11-27 |
| IL235647A0 (en) | 2015-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112014029972A2 (pt) | reagentes de conjugação | |
| BR112013031028A2 (pt) | conectores heterobifuncionais com segmentos de polietileno glicol e conjugados de modificadores de resposta imunológica feitos a partir deles | |
| EA201171328A1 (ru) | Производное замещенного изохинолина | |
| CY1119056T1 (el) | Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna | |
| HRP20220455T1 (hr) | Modificirane aminokiseline koje sadrže azid grupu | |
| BR112012028630A2 (pt) | dispositivo para comprimir e secar gás | |
| CY1114906T1 (el) | Νεα παραγωγα 6-τριαζολοπυριδαζινο-σουλφανυλο βενζοθειαζολης και βενζιμιδαζολης, η διαδικασια της παρασκευης τους, η εφαρμογη τους ως φαρμακα, φαρμακευτικες συνθεσεις και νεα χρηση κυριως ως αναστολεις του μετ | |
| EA201001205A1 (ru) | Соединения, содержащие циклобутоксигруппу | |
| BRPI0910388A2 (pt) | agentes terapêutico antivirais. | |
| EA201001356A1 (ru) | Новые замещенные имидазохинолины | |
| CR11861A (es) | Compuestos organicos | |
| BR112012007305A2 (pt) | maitansinoides e o uso dos ditos maitansinoides para preparar conjugados com um anticorpo. | |
| BR112013031405A2 (pt) | piridopirazinas substituídas como novos inibidores de syk | |
| BR112013018732A2 (pt) | novos derivados de amida de aril-benzocicloalquila | |
| DE502008001409D1 (de) | Bisamid-zinkbasen | |
| BR112012017188A2 (pt) | composto agonista de mgluz, sua composição farmacêutica e seu uso | |
| EA201001855A1 (ru) | Соединения, содержащие циклобутоксигруппу | |
| BRPI0517390A (pt) | processo para a preparação de derivados de [1,4,5]-oxadiazepina | |
| BR112012030778A2 (pt) | processo para a preparação de uma mistura de agentes quelantes | |
| MA35742B1 (fr) | Dérivés de n- (4 -quinolinylmethyl) sulfonamide et leur utilisation en tant qu'antihelminthiques | |
| BRPI0909737A2 (pt) | compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos | |
| BR112012029954A2 (pt) | composto de poliamida | |
| BR112015015229A8 (pt) | processo para a preparação de um composto da fórmula, e, composto | |
| BRPI0816830A8 (pt) | Processo para a preparação de derivados de 2,2-diflúor-etilamina por hidrogenação de amida | |
| PH12014502108A1 (en) | Polyamide compositions with improved optical properties |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 47/00 (2006.01), C08G 65/329 (2006.01) |