BRPI0909737A2 - compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos - Google Patents

compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos

Info

Publication number
BRPI0909737A2
BRPI0909737A2 BRPI0909737-6A BRPI0909737A BRPI0909737A2 BR PI0909737 A2 BRPI0909737 A2 BR PI0909737A2 BR PI0909737 A BRPI0909737 A BR PI0909737A BR PI0909737 A2 BRPI0909737 A2 BR PI0909737A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compounds
pyrrolidinyl
pyrrolidinyl compounds
methods
Prior art date
Application number
BRPI0909737-6A
Other languages
English (en)
Inventor
C. Lucas Matthew
Craig Schoenfeld Ryan
James Weikert Robert
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BRPI0909737A2 publication Critical patent/BRPI0909737A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

derivados de pirrolidinila e usos dos mesmos. a presente invenção refere-se a derivados de pirrol 3,3 dissubstituídos úteis para tratamento de doenças associadas com inibidores da recaptação de monoamina. também são proporcionadas composições far-macêuticas, métodos de uso, e métodos para preparar os compostos.
BRPI0909737-6A 2008-03-20 2009-03-10 compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos BRPI0909737A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3816008P 2008-03-20 2008-03-20
US61/038,160 2008-03-20
PCT/EP2009/052748 WO2009115427A1 (en) 2008-03-20 2009-03-10 Pyrrolidinyl derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0909737A2 true BRPI0909737A2 (pt) 2019-03-06

Family

ID=40651460

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909737-6A BRPI0909737A2 (pt) 2008-03-20 2009-03-10 compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos

Country Status (17)

Country Link
US (1) US20110021556A1 (pt)
EP (1) EP2257545B1 (pt)
JP (1) JP2011515355A (pt)
KR (1) KR101209373B1 (pt)
CN (1) CN101977907A (pt)
AR (1) AR070930A1 (pt)
AT (1) ATE522519T1 (pt)
AU (1) AU2009226868A1 (pt)
BR (1) BRPI0909737A2 (pt)
CA (1) CA2718736A1 (pt)
CL (1) CL2009000665A1 (pt)
ES (1) ES2370593T3 (pt)
IL (1) IL207223A0 (pt)
MX (1) MX2010009147A (pt)
PE (1) PE20091649A1 (pt)
TW (1) TW200942529A (pt)
WO (1) WO2009115427A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807538A1 (en) * 2010-08-10 2012-02-16 Abbvie Inc. Novel trpv3 modulators
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
CA3055215A1 (en) * 2017-03-12 2018-09-20 Xiaodong Wang Polycyclic amines as opioid receptor modulators
US11584765B2 (en) 2017-03-12 2023-02-21 Ecstasy LLC Polycyclic amines as sigma receptor modulators
AU2021296163A1 (en) * 2020-06-22 2023-02-02 Corcept Therapeutics Incorporated Quaternary indazole glucocorticoid receptor antagonists
US11548879B1 (en) 2020-07-01 2023-01-10 Ecstasy LLC Polycyclics as sigma receptor modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002006231A1 (fr) * 2000-07-18 2002-01-24 Sumitomo Pharmaceuticals Co., Ltd. Inhibiteurs de recaptage de la serotonine
TWI449692B (zh) * 2005-05-13 2014-08-21 Otsuka Pharma Co Ltd 吡咯烷化合物（三）
MX2009006334A (es) * 2006-12-19 2009-06-23 Hoffmann La Roche Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona.

Also Published As

Publication number Publication date
IL207223A0 (en) 2010-12-30
KR20100118601A (ko) 2010-11-05
CA2718736A1 (en) 2009-09-24
PE20091649A1 (es) 2009-11-04
TW200942529A (en) 2009-10-16
EP2257545A1 (en) 2010-12-08
AR070930A1 (es) 2010-05-12
WO2009115427A1 (en) 2009-09-24
CL2009000665A1 (es) 2010-04-09
ATE522519T1 (de) 2011-09-15
EP2257545B1 (en) 2011-08-31
JP2011515355A (ja) 2011-05-19
CN101977907A (zh) 2011-02-16
US20110021556A1 (en) 2011-01-27
AU2009226868A1 (en) 2009-09-24
KR101209373B1 (ko) 2012-12-06
ES2370593T3 (es) 2011-12-20
MX2010009147A (es) 2010-09-07

Similar Documents

Publication Publication Date Title
BRPI0919447B8 (pt) compostos derivados de ácido 1-amino-2- ciclobutiletilborônico, composição farmacêutica e uso dos mesmos para tratar câncer
CY1119056T1 (el) Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna
BRPI0813499B8 (pt) compostos pirimidina carboxamidas úteis como inibidores da quinase raf, composição farmacêutica compreendendo os mesmos e método de preparação dos mesmos
BRPI0910388A2 (pt) agentes terapêutico antivirais.
BRPI0721905B8 (pt) composto inibidor de proteassoma, sua composição farmacêutica e seu uso
CO6321282A2 (es) Derivados de piperidinilindol como inhibidores de aldosterona sintasa
EA200901133A1 (ru) Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
BRPI0608604B8 (pt) moduladores de 2,3-dioxigenase de indolamina e composição farmacêutica
BRPI0610850A2 (pt) derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados
EA201070327A1 (ru) Катехоламиновые производные и их пролекарства
UY31639A1 (es) Derivados de amida espirocíclica de fórmula i, sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolas, procesos de preparación y aplicaciones
EA201170772A1 (ru) Органические соединения
CU20110204A7 (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750
UY30319A1 (es) Formulaciones de inhibidores de dpp iv
BR112012017269A2 (pt) compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos
BRPI0510453A (pt) composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central
BR112012027034A2 (pt) inibidores da arginase e suas aplicações terapêuticas
CR11857A (es) Compuestos pirazolicos 436
BR112014028841A2 (pt) processo para preparação de n-[5-(3,5-difluoro-benzil)-1h-indazol-3-il]-4-(4-metil-piperazin-l-il)-2-(tetra-hidro-piran-4-ilamino)-benzamida
BR112013018515A2 (pt) derivados de pirrol tricíclico, processo para preparação e seu uso como inibidores da quinase
EA200901138A1 (ru) Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
BRPI0513901A (pt) derivados de uréia cìclicos substituìdos, preparação dos mesmos e uso farmacêutico dos mesmos como inibidores de cinase
BRPI0507198A (pt) derivados de bisariluréia
EP2321264A4 (en) DEACETYLASEINHIBITORS AND APPLICATIONS THEREOF
BRPI0909737A2 (pt) compostos de pirrolidinila, composição farmacêutica compreendendo os mesmos e usos dos mesmos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2514 DE 12-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]