CY1112249T1 - Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου - Google Patents

Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου

Info

Publication number
CY1112249T1
CY1112249T1 CY20111100775T CY111100775T CY1112249T1 CY 1112249 T1 CY1112249 T1 CY 1112249T1 CY 20111100775 T CY20111100775 T CY 20111100775T CY 111100775 T CY111100775 T CY 111100775T CY 1112249 T1 CY1112249 T1 CY 1112249T1
Authority
CY
Cyprus
Prior art keywords
amino
cyanoethenyl
benzonitrile
dimethylphenyl
pyrimidinyl
Prior art date
Application number
CY20111100775T
Other languages
Greek (el)
English (en)
Inventor
Paul Theodoor Agnes Stevens
Jozef Peeters
Roger Petrus Gerebern Vandecruys
Alfred Elisabeth Stappers
Alex Herman Copmans
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38091637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112249(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from MYPI20043578A external-priority patent/MY169670A/en
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1112249T1 publication Critical patent/CY1112249T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Hybrid Cells (AREA)
CY20111100775T 2004-09-02 2011-08-10 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου CY1112249T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
MYPI20043578A MY169670A (en) 2003-09-03 2004-09-02 Combinations of a pyrimidine containing nnrti with rt inhibitors
EP05101467 2005-02-25
EP05108086.9A EP1632232B3 (en) 2004-09-02 2005-09-02 Salt of 4[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-Pyrimidinyl]amino]benzonitrile

Publications (1)

Publication Number Publication Date
CY1112249T1 true CY1112249T1 (el) 2015-12-09

Family

ID=38091637

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20111100775T CY1112249T1 (el) 2004-09-02 2011-08-10 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου
CY2016051C CY2016051I1 (el) 2004-09-02 2016-12-20 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου
CY2016050C CY2016050I1 (el) 2004-09-02 2016-12-20 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY2016051C CY2016051I1 (el) 2004-09-02 2016-12-20 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου
CY2016050C CY2016050I1 (el) 2004-09-02 2016-12-20 Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου

Country Status (23)

Country Link
EP (1) EP1632232B3 (https=)
JP (1) JP4912309B2 (https=)
KR (1) KR101284361B1 (https=)
CN (1) CN104586850A (https=)
AT (1) ATE508748T1 (https=)
BR (1) BRPI0514871A (https=)
CY (3) CY1112249T1 (https=)
DK (1) DK1632232T6 (https=)
EA (1) EA013686B1 (https=)
ES (1) ES2371442T7 (https=)
FR (2) FR16C1023I2 (https=)
HK (1) HK1210029A1 (https=)
HU (2) HUS1600061I1 (https=)
IL (1) IL181650A (https=)
LT (2) LTC1632232I2 (https=)
ME (1) ME01246B (https=)
MX (1) MX2007002595A (https=)
NI (1) NI200700068A (https=)
NO (3) NO340654B1 (https=)
PL (1) PL1632232T6 (https=)
PT (1) PT1632232E (https=)
RS (1) RS51923B2 (https=)
SI (1) SI1632232T1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
PT1981506E (pt) * 2006-01-20 2013-06-25 Janssen R & D Ireland Tratamento a longo prazo da infeção pelo vih com tmc278
AR065720A1 (es) 2007-03-14 2009-06-24 Tibotec Pharm Ltd Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso.
JP2014500261A (ja) * 2010-11-19 2014-01-09 ギリアード サイエンシーズ， インコーポレイテッド リルピビリンＨＣｌおよびフマル酸テノホビルジソプロキシルを含有する治療用組成物
KR101879468B1 (ko) * 2011-04-15 2018-07-17 엠큐어 파마슈티컬즈 리미티드 릴피비린 중간체의 제조를 위한 공정
EP2604593A1 (en) 2011-12-14 2013-06-19 Sandoz AG Polymorph of Rilpivirine hydrochloride and its use as antiviral
WO2013087794A1 (en) 2011-12-14 2013-06-20 Sandoz Ag Polymorph of rilpivirine hydrochloride and its use as antiviral
EP2628732A1 (en) 2012-02-20 2013-08-21 Sandoz AG Novel crystalline form of rilpivirine hydrochloride
WO2013153162A1 (en) 2012-04-11 2013-10-17 Sandoz Ag Polymorph of rilpivirine hydrochloride
WO2013153161A2 (en) 2012-04-11 2013-10-17 Sandoz Ag Novel polymorph of rilpivirine hydrochloride
CN103570688B (zh) * 2012-07-19 2016-06-08 中国科学院上海药物研究所 2，5-二氨甲基吡嗪类化合物、其药物组合物、制备方法和用途
GR1008965B (el) * 2015-12-02 2017-02-28 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα που περιλαμβανει δαρουναβιρη και μεθοδος παρασκευης αυτου
RU2616267C1 (ru) * 2016-01-25 2017-04-13 Закрытое Акционерное Общество "БИОКОМ" Твердая лекарственная форма индинавира немедленного высвобождения и способ ее получения
US11065198B2 (en) * 2016-10-24 2021-07-20 Janssen Sciences Ireland Unlimited Company Dispersible compositions
CN110958883A (zh) * 2017-06-30 2020-04-03 Viiv保健公司 组合及其用途和疗法
CN114392241B (zh) * 2022-01-10 2023-07-25 安徽贝克生物制药有限公司 一种利匹韦林片及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6307543B1 (en) * 1998-09-10 2001-10-23 Silicon Image, Inc. Bi-directional data transfer using two pair of differential lines as a single additional differential pair
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
DK1529032T3 (da) * 2002-08-09 2013-07-08 Janssen Pharmaceutica Nv Fremgangsmåder til fremstilling af 4-4-4-(2-cyanoethenyl)-2,6-dimethylphenyl)amino)-2-pyrimidinyl)aminobenzonitrill
WO2004050068A1 (en) * 2002-11-29 2004-06-17 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
BRPI0407329A (pt) * 2003-02-07 2006-01-10 Janssen Pharmaceutica Nv Derivados de pirimidina para a prevenção de infecção de hiv

Also Published As

Publication number Publication date
FR16C1023I1 (fr) 2017-02-03
PT1632232E (pt) 2011-08-02
CY2016050I1 (el) 2017-07-12
FR16C1025I1 (fr) 2017-02-03
CY2016051I1 (el) 2017-07-12
NO2017065I1 (no) 2017-11-21
NO20071745L (no) 2007-04-02
EP1632232B1 (en) 2011-05-11
DK1632232T3 (da) 2011-08-22
EA013686B1 (ru) 2010-06-30
RS51923B (sr) 2012-02-29
DK1632232T6 (da) 2022-04-19
HUS1600061I1 (hu) 2017-01-30
MX2007002595A (es) 2007-04-25
ES2371442T3 (es) 2012-01-02
NI200700068A (es) 2016-09-29
BRPI0514871A (pt) 2008-06-24
KR20070074555A (ko) 2007-07-12
CN104586850A (zh) 2015-05-06
KR101284361B1 (ko) 2013-07-15
NO2017063I1 (no) 2017-11-21
NO340654B1 (no) 2017-05-22
LTC1632232I2 (lt) 2024-09-10
PL1632232T6 (pl) 2022-06-27
FR16C1023I2 (fr) 2025-11-21
EP1632232A1 (en) 2006-03-08
ME01246B (me) 2013-06-20
HUS1600060I1 (hu) 2017-01-30
LTPA2016042I1 (lt) 2017-01-10
EA200700536A1 (ru) 2007-08-31
JP4912309B2 (ja) 2012-04-11
ES2371442T7 (es) 2022-05-12
FR16C1025I2 (fr) 2025-11-21
RS51923B2 (sr) 2022-05-31
JP2008511592A (ja) 2008-04-17
HK1210029A1 (en) 2016-04-15
LTPA2016043I1 (lt) 2017-01-10
PL1632232T3 (pl) 2011-10-31
ATE508748T1 (de) 2011-05-15
SI1632232T1 (sl) 2011-09-30
EP1632232B3 (en) 2022-03-30
IL181650A (en) 2012-08-30
IL181650A0 (en) 2007-07-04

Similar Documents

Publication Publication Date Title
CY1112249T1 (el) Αλας του 4-[[4-[[4-(2-κυανοαιθενυλο)-2,6-διμεθυλοφαινυλο]αμινο]-2-πυριμιδινυλο]αμινο]βενζονιτριλιου
NO2014032I1 (no) (E)-4-[[4-[[4-(2-cyanoetenyl)-2,6-dimetylfenyl-amino]--2-pyrfmidinyl]-amino]-benzonitril Rilpivirine) samt enhver terapeutisk ekvivalent form derav som er beskyttet av det aktuelle patentet så som farmasøytisk akseptable salter innbefattende hydrokloridsaltet av Rilpiverine; tenofovir og spesielt tenofovirdisproksilfumatat og emtricitabine.
AR023624A1 (es) Composiciones farmaceuticas que comprenden un inhibidor de hmg coa reductasa
UA97641C2 (xx) Водна суспензія 4-$$4-$$4-(2-ціаноетеніл)-2,6-диметилфеніл]аміно]-2-піримідиніл]аміно]бензонітрилу (tmc278)$водная суспензия 4-$$4-$$4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила (тмс278)
CY1113594T1 (el) Φουμαρικο αλας της (αλφα s, βητα r)-6-βρωμο-αλφα-[2-(διμεθυλαμινο)αιθυλ]-2-μεθοξυ-αλφα-1-ναφθαλινυλ-βητα-φαινυλ-3-κινολινοαιθανολης
CY1110906T1 (el) Φαρμακευτικη συνθεση για ρινικη χορηγηση φεντανυλης
WO2009007441A3 (en) Crystalline form of (e) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2 pyrimidinyl]amino]benzonitrile
NO20071720L (no) Fumarat av 4-[[4-[[4-(2-cyanoetenyl)-2,6-dimetylfenyl]amino]-2-pyrimidinyl]amino]benzonitril.
ATE294154T1 (de) Apfelsäureadditionssalze von terbinafin
UA92467C2 (ru) Гидрохлорид 4-[[4-[[4-(2-цианоэтенил)-2,6-диметилфенил]амино]-2-пиримидинил]амино]бензонитрила
CY1105105T1 (el) Χρηση του διστροντιου αλατος του 2-[ν,ν-δι(καρβοξυμεξυλ) amino]- 3-κυανο-4-καρβοξυμεθυλ-θειοφενο-5-καρβοξυλικου οξεος για τη ληψη φαρμακων που προοριζονται για τη θεραπεια γαστρο-δωδεκαδακτυλικων πονων
HRP20110563T1 (en) Salt of 4[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
UA54880C2 (uk) Застосування (s)-2-аміно-5-гуанідинопентанової кислоти (s)-2-аміноглутарату (l-аргініну l-глутамат) як фармацевтичного препарату, що має гепатопротекторну та детоксикуючу дію, спосіб його одержання, фармацевтична композиція на його основі