CY1110460T1 - Παραγωγα κιναζολινης ως αναστολεις κινασης - Google Patents

Παραγωγα κιναζολινης ως αναστολεις κινασης

Info

Publication number
CY1110460T1
CY1110460T1 CY20081101177T CY081101177T CY1110460T1 CY 1110460 T1 CY1110460 T1 CY 1110460T1 CY 20081101177 T CY20081101177 T CY 20081101177T CY 081101177 T CY081101177 T CY 081101177T CY 1110460 T1 CY1110460 T1 CY 1110460T1
Authority
CY
Cyprus
Prior art keywords
phosphorylation
kinazoline
derivatives
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
CY20081101177T
Other languages
Greek (el)
English (en)
Inventor
Anjali Pandey
Robert M Scarborough
Kenji Matsuno
Michio Ichimura
Yuji Nomoto
Shinichi Ide
Eiji Tsukuda
Junko Irie
Shoji Oda
Original Assignee
Millennium Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals, Inc. filed Critical Millennium Pharmaceuticals, Inc.
Publication of CY1110460T1 publication Critical patent/CY1110460T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CY20081101177T 2000-08-18 2008-10-21 Παραγωγα κιναζολινης ως αναστολεις κινασης CY1110460T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22612200P 2000-08-18 2000-08-18
EP01964612A EP1315715B1 (en) 2000-08-18 2001-08-17 Quinazoline derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1110460T1 true CY1110460T1 (el) 2015-04-29

Family

ID=22847639

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101177T CY1110460T1 (el) 2000-08-18 2008-10-21 Παραγωγα κιναζολινης ως αναστολεις κινασης

Country Status (24)

Country Link
US (5) US6982266B2 (enExample)
EP (3) EP1315715B1 (enExample)
JP (1) JP5073147B2 (enExample)
KR (1) KR100831116B1 (enExample)
CN (1) CN100358890C (enExample)
AT (1) ATE402169T1 (enExample)
AU (1) AU8544901A (enExample)
BR (1) BR0113356A (enExample)
CA (1) CA2426440C (enExample)
CY (1) CY1110460T1 (enExample)
CZ (1) CZ304061B6 (enExample)
DE (1) DE60134990D1 (enExample)
DK (1) DK1315715T3 (enExample)
EA (1) EA005809B1 (enExample)
ES (1) ES2311023T3 (enExample)
HU (1) HU228668B1 (enExample)
IL (2) IL154514A0 (enExample)
MX (1) MXPA03001359A (enExample)
NO (1) NO323782B1 (enExample)
NZ (1) NZ524461A (enExample)
PT (1) PT1315715E (enExample)
SI (1) SI1315715T1 (enExample)
WO (1) WO2002016351A1 (enExample)
ZA (1) ZA200301510B (enExample)

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DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
WO2002072578A2 (en) 2001-03-08 2002-09-19 Millennium Pharmaceuticals (homo) piperazine substituted quinolines for inhibiting the phosphorylation of kinases
DE60205776T2 (de) 2001-12-27 2006-06-14 Theravance Inc Indolinon-derivative als protein-kinasehemmer
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US7195876B2 (en) 2002-08-09 2007-03-27 Theravance, Inc. Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
UA83814C2 (ru) * 2002-12-24 2008-08-26 Астразенека Аб Производные фосфонооксихиназолина и их фармацевтическое применение
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JP5250901B2 (ja) * 2007-02-23 2013-07-31 学校法人慶應義塾 アニリノキナゾリン系化合物及びその用途
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CN102942529B (zh) * 2012-11-09 2015-06-24 贵州大学 4-(4-取代哌嗪)-5,6,7-三烷氧基喹唑啉类化合物及其制备方法和应用
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Also Published As

Publication number Publication date
IL154514A (en) 2011-03-31
NZ524461A (en) 2004-12-24
KR100831116B1 (ko) 2008-05-20
US20100113468A1 (en) 2010-05-06
PT1315715E (pt) 2008-10-30
NO20030747D0 (no) 2003-02-17
CZ2003765A3 (cs) 2004-08-18
US20050101609A1 (en) 2005-05-12
WO2002016351A1 (en) 2002-02-28
HK1057206A1 (en) 2004-03-19
US20150133439A1 (en) 2015-05-14
EP2277877A1 (en) 2011-01-26
HU228668B1 (hu) 2013-05-28
US6982266B2 (en) 2006-01-03
EP1315715B1 (en) 2008-07-23
US8324205B2 (en) 2012-12-04
ES2311023T3 (es) 2009-02-01
AU2001285449B2 (en) 2007-04-05
EP1964839A3 (en) 2008-11-05
NO20030747L (no) 2003-04-14
ZA200301510B (en) 2004-06-22
CN1633431A (zh) 2005-06-29
HUP0302615A3 (en) 2008-03-28
KR20030082537A (ko) 2003-10-22
EP1964839A2 (en) 2008-09-03
US20130274252A1 (en) 2013-10-17
CA2426440C (en) 2011-03-15
BR0113356A (pt) 2004-04-20
CA2426440A1 (en) 2002-02-28
EA200300265A1 (ru) 2003-12-25
US7560461B2 (en) 2009-07-14
JP2005501796A (ja) 2005-01-20
CN100358890C (zh) 2008-01-02
EP1315715A1 (en) 2003-06-04
MXPA03001359A (es) 2004-12-13
IL154514A0 (en) 2003-09-17
CZ304061B6 (cs) 2013-09-11
ATE402169T1 (de) 2008-08-15
HUP0302615A2 (hu) 2003-12-29
US20050288297A1 (en) 2005-12-29
SI1315715T1 (sl) 2008-12-31
EA005809B1 (ru) 2005-06-30
DK1315715T3 (da) 2008-11-17
JP5073147B2 (ja) 2012-11-14
NO323782B1 (no) 2007-07-02
DE60134990D1 (de) 2008-09-04
AU8544901A (en) 2002-03-04

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