CY1110123T1 - Φορεις eiav βελτιστοποιημενων κωδικονιων - Google Patents

Φορεις eiav βελτιστοποιημενων κωδικονιων

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Publication number
CY1110123T1
CY1110123T1 CY20101100538T CY101100538T CY1110123T1 CY 1110123 T1 CY1110123 T1 CY 1110123T1 CY 20101100538 T CY20101100538 T CY 20101100538T CY 101100538 T CY101100538 T CY 101100538T CY 1110123 T1 CY1110123 T1 CY 1110123T1
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CY
Cyprus
Prior art keywords
nucleotide sequence
eiav
options
iii
producer cell
Prior art date
Application number
CY20101100538T
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English (en)
Inventor
Alan John Kingsman
Narry Kim
Ekaterini Kotsopoulou
Jonathan Rohll
Kyriacos Andreou Mitrophanous
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Oxford Biomedica (Uk) Limited
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Publication date
Application filed by Oxford Biomedica (Uk) Limited filed Critical Oxford Biomedica (Uk) Limited
Publication of CY1110123T1 publication Critical patent/CY1110123T1/el

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material
    • C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Semiconductor Lasers (AREA)

Abstract

Μέθοδος παραγωγής ρετροϊού ελλειμματικού αναδιπλασιασμού που περιλαμβάνει διαμόλυνση κυττάρου-παραγωγού με τα ακόλουθα: (i) ρετροϊικό γονιδίωμα, (ii) αλληλουχία νουκλεοτιδίων που κωδικοποιεί ρετροϊικές πρωτεΐνες gag και pol, και (iii) αλληλουχίες νουκλεοτιδίων που κωδικοποιούν άλλα απαραίτητα συστατικά ιικής συσκευασίας που δεν κωδικοποιούνται από την αλληλουχία νουκλεοτιδίων του (ii), που χαρακτηρίζεται από το ότι η αλληλουχία νουκλεοτιδίων που κωδικοποιεί τις ρετροιϊκές πρωτεΐνες gag και pol περιέχει κωδικόνια βελτιστοποιημένα για έκφραση στο κύτταρο-παραγωγό.
CY20101100538T 2000-04-19 2010-06-11 Φορεις eiav βελτιστοποιημενων κωδικονιων CY1110123T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0009760.0A GB0009760D0 (en) 2000-04-19 2000-04-19 Method
EP01921651A EP1278878B1 (en) 2000-04-19 2001-04-18 Codon optimized eiav vectors

Publications (1)

Publication Number Publication Date
CY1110123T1 true CY1110123T1 (el) 2015-01-14

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CY20101100538T CY1110123T1 (el) 2000-04-19 2010-06-11 Φορεις eiav βελτιστοποιημενων κωδικονιων

Country Status (14)

Country Link
US (3) US20050042234A1 (el)
EP (2) EP1278878B1 (el)
JP (1) JP4981231B2 (el)
CN (2) CN1254543C (el)
AT (1) ATE462796T1 (el)
AU (1) AU4861901A (el)
CA (1) CA2404129A1 (el)
CY (1) CY1110123T1 (el)
DE (1) DE60141690D1 (el)
DK (2) DK2194137T3 (el)
ES (2) ES2618508T3 (el)
GB (1) GB0009760D0 (el)
PT (1) PT1278878E (el)
WO (1) WO2001079518A2 (el)

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