CY1107882T1 - Κατιονικα παραγωγα πορφυρινης ως αντιβακτηριακοι παραγοντες - Google Patents

Κατιονικα παραγωγα πορφυρινης ως αντιβακτηριακοι παραγοντες

Info

Publication number
CY1107882T1
CY1107882T1 CY20081100157T CY081100157T CY1107882T1 CY 1107882 T1 CY1107882 T1 CY 1107882T1 CY 20081100157 T CY20081100157 T CY 20081100157T CY 081100157 T CY081100157 T CY 081100157T CY 1107882 T1 CY1107882 T1 CY 1107882T1
Authority
CY
Cyprus
Prior art keywords
cortional
porphyrine
producers
bacterial agents
compound
Prior art date
Application number
CY20081100157T
Other languages
English (en)
Inventor
Derek Brundish
Xiangdong Feng
William Love
William Rhys-Williams
Benoit Pugin
Original Assignee
Destiny Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9950107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1107882(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Destiny Pharma Limited filed Critical Destiny Pharma Limited
Publication of CY1107882T1 publication Critical patent/CY1107882T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04Amoebicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • A61P33/12Schistosomicides

Abstract

Μία ένωση του τύπου (I): όπου τα Χ1, Χ2, Χ3, Χ4, Υ1, Υ2, Υ3, Υ4 και Ζ έχουν έννοιες που δίδονται στην περιγραφή και μεταλλωμένες μορφές τέτοιων ενώσεων, οι οποίες είναι χρήσιμες στην θεραπεία ιατρικών καταστάσεων για τις οποίες ενδείκνυται μια φωτοδυναμική ένωση. Αποκαλύπτονται επίσης, φαρμακευτικές συνταγοποιήσεις και μέθοδοι θεραπείας μιας ιατρικής κατάστασης για την οποία ενδείκνυται ένας φωτοδυναμικός παράγων. Αποκαλύπτονται επίσης διαλύματα αποστείρωσης που περιλαμβάνουν μία ένωση της εφεύρεσης και η χρήση αυτών.
CY20081100157T 2002-12-23 2008-02-11 Κατιονικα παραγωγα πορφυρινης ως αντιβακτηριακοι παραγοντες CY1107882T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0229742A GB2397067B (en) 2002-12-23 2002-12-23 Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
EP03786158A EP1578750B1 (en) 2002-12-23 2003-12-23 Cationic porphyrin derivatives as antibacterial agents

Publications (1)

Publication Number Publication Date
CY1107882T1 true CY1107882T1 (el) 2013-06-19

Family

ID=9950107

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100157T CY1107882T1 (el) 2002-12-23 2008-02-11 Κατιονικα παραγωγα πορφυρινης ως αντιβακτηριακοι παραγοντες

Country Status (14)

Country Link
US (2) US7244841B2 (el)
EP (2) EP1578750B1 (el)
JP (2) JP4786182B2 (el)
CN (2) CN100360536C (el)
AU (1) AU2003295157B8 (el)
CA (1) CA2527155C (el)
CY (1) CY1107882T1 (el)
DE (1) DE60317711T2 (el)
DK (1) DK1578750T3 (el)
ES (1) ES2301864T3 (el)
GB (1) GB2397067B (el)
NZ (1) NZ540918A (el)
PT (1) PT1578750E (el)
WO (1) WO2004056828A2 (el)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
WO2005000854A2 (en) * 2003-06-06 2005-01-06 Eukarion, Inc. Orally bioavailable low molecular weight metalloporphyrins as antioxidants
GB2415373A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Porphyrins for sonodynamic therapy
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
WO2006005137A1 (en) 2004-07-15 2006-01-19 The Unversity Of Sydney Porphyrin linked metronidazole against gum disease: porphyromonas gingivalis
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
GB0526474D0 (en) * 2005-12-24 2006-02-08 Destiny Pharma Ltd Novel process
GB0602125D0 (en) 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
US8882267B2 (en) * 2006-03-20 2014-11-11 High Performance Optics, Inc. High energy visible light filter systems with yellowness index values
US20120075577A1 (en) 2006-03-20 2012-03-29 Ishak Andrew W High performance selective light wavelength filtering providing improved contrast sensitivity
US20070255357A1 (en) * 2006-04-28 2007-11-01 Ondine International, Ltd. Nasal decolonization of microbes
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US8784790B2 (en) 2008-06-12 2014-07-22 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
US8859760B2 (en) 2008-07-29 2014-10-14 Frontier Scientific, Inc. Compositions for killing or preventing the growth of microbes
MX2011001005A (es) 2008-07-29 2011-09-01 Frontier Scient Inc Uso de derivados de tetraquis (n-alquilpiridinio)-porfirina para eliminacion de microbios o prevencion del crecimiento.
EP2346324A4 (en) 2008-10-06 2012-10-10 Microbial Defense Systems Llc ANTIMICROBIAL COMPOSITION AND METHODS OF MAKING AND USING
BRPI0920042B1 (pt) * 2008-10-24 2021-06-29 Destiny Pharma Limited Uso de um composto na preparação de um medicamento para o tratamento de uma infecção de biofilme bacteriano
US20140119985A1 (en) * 2010-12-22 2014-05-01 Ortner Cleanroom Engineering Gmbh Photodynamic Control of Microbial Growth on Surfaces
BR112013028673B1 (pt) 2011-05-10 2020-06-16 Next Science IP Holdings Pty Ltd Sólido antimicrobiano e métodos de fazer e usar o mesmo
CN103601727A (zh) * 2013-10-23 2014-02-26 中国医学科学院生物医学工程研究所 一种新型的胺类化合物修饰原卟啉的用途
CN104151386B (zh) * 2013-11-12 2017-01-11 毕毅良 苦马豆素衍生物及其科研试剂的制备方法
AU2017211392A1 (en) 2016-01-29 2018-09-13 Wichita State University Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
US10722582B2 (en) * 2018-04-12 2020-07-28 Purdue Research Foundation Targeted antimicrobial photodynamic therapy
CN110713603B (zh) * 2019-09-18 2020-12-01 山东大学 一种聚合物、其制备方法及作为检测细菌及抗菌材料的应用
CN111777616B (zh) * 2020-08-11 2023-04-07 湖南科技大学 基于自组装的可检测透明质酸酶的卟啉衍生物、其制备方法及应用
GB202102556D0 (en) 2021-02-23 2021-04-07 Destiny Pharma Ltd Method for reducing antibiotic resistance emergence
CN115260204A (zh) * 2022-05-17 2022-11-01 滨州医学院 一种用作光动力抗菌剂的季铵化卟啉衍生物及其制备方法和应用

Family Cites Families (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387658A1 (fr) * 1977-03-25 1978-11-17 Ciba Geigy Ag Procede pour combattre les microorganismes
SU721442A1 (ru) 1977-09-12 1980-03-15 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им. М.В. Ломоносова Способ получени -незамещенных порфиринов
EP0330801A1 (en) 1983-02-08 1989-09-06 Schering Aktiengesellschaft Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
FR2566766A1 (fr) 1984-07-02 1986-01-03 Rataud Pierre Procede d'argenture decorative sur glace
US4986256A (en) 1985-02-28 1991-01-22 The United States Of America As Represented By The Department Of Health And Human Services Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
JPS61275228A (ja) 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド 治療用タンパク組成物中のビ−ルスの光動的不活性化
US4775625A (en) * 1986-11-21 1988-10-04 The Medical College Of Wisconsin, Inc. Inactivating enveloped viruses with a merocyanine dye
US5571908A (en) 1987-01-02 1996-11-05 Sun Company, Inc. (R&M) Porphyrins
US5663328A (en) * 1987-01-02 1997-09-02 Sun Company, Inc. (R&M) Haloporphyrins and their preparation and use as catalysts
US5990363A (en) 1987-01-02 1999-11-23 Sun Company, Inc. Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes
US5489716A (en) * 1987-01-02 1996-02-06 Sun Company, Inc. (R&M) Reactions catalyzed by haloporphyrins
US5077394A (en) 1987-04-17 1991-12-31 Sandoz Ltd. Porphyrins and uses thereof
US4892941A (en) 1987-04-17 1990-01-09 Dolphin David H Porphyrins
US4851403A (en) 1987-04-21 1989-07-25 Johnson Matthey, Inc. Radiation sensitizers
US4878891A (en) * 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
DE3731689A1 (de) 1987-09-21 1989-03-30 Degussa Rhenium-oxo-porphyrin-komplexe
US4962197A (en) * 1988-02-12 1990-10-09 Rowland Institute For Science Photo-inactivation of cancer cells
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5192788A (en) 1988-05-23 1993-03-09 Georgia State University Foundation, Inc. Porphyrin antiviral compositions
US5109016A (en) 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
FR2632187B1 (fr) 1988-06-02 1990-09-14 Centre Nat Rech Scient Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides
FR2633925B1 (fr) 1988-07-06 1990-10-26 Elf Aquitaine Procede d'oxydation par catalyse biomimetique d'alcools benzyliques et de composes apparentes
DE68928607T2 (de) 1988-07-14 1998-07-23 Toyohakka Kogyo K K Porphyrinderivate
US5041209A (en) 1989-07-12 1991-08-20 Western Research Institute Process for removing heavy metal compounds from heavy crude oil
FR2650761B1 (fr) 1989-08-10 1994-03-04 Elf Aquitaine Ste Nale Catalyseur d'oxydation a base de metalloporphyrine sur support
US5223494A (en) 1989-09-25 1993-06-29 The Rockefeller University Orally administered porphyrins to control intestinal iron absorption
US4917784A (en) 1989-09-26 1990-04-17 The United States Of America As Represented By The United States Department Of Energy Process for light-driven hydrocarbon oxidation at ambient temperatures
FR2656866B1 (fr) 1990-01-10 1992-05-15 Cis Bio Int Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant.
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5545516A (en) * 1990-05-01 1996-08-13 The American National Red Cross Inactivation of extracellular enveloped viruses in blood and blood components by phenthiazin-5-ium dyes plus light
US5236915A (en) 1990-05-31 1993-08-17 Health Research, Inc. Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents
EP0461958B1 (fr) 1990-06-15 1994-09-14 Synthelabo Dérivés de 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanes, leur préparation et leur application en thérapeutique
DE69123704T2 (de) * 1990-11-02 1997-04-30 Zeneca Ltd Polysubstituierte Phthalocyanine
US5149697A (en) 1991-04-18 1992-09-22 Glaxo Inc. Cobalt porphyrin pharmaceutical compositions
US5262401A (en) * 1991-06-28 1993-11-16 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
AU663106B2 (en) 1991-08-02 1995-09-28 Meiji Milk Products Co., Ltd. Porphyrin-based anti-HIV drug
US5212300A (en) * 1991-09-12 1993-05-18 Sun Company, Inc. (R&M) Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation
US5280115A (en) * 1991-09-12 1994-01-18 Sun Company, Inc. (R&M) Nitrated metalloporphyrins as catalysts for alkane oxidation
US6362175B1 (en) 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
US5603820A (en) 1992-04-21 1997-02-18 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide sensor
US5493017A (en) * 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5471162A (en) 1992-09-08 1995-11-28 The Regents Of The University Of California High speed transient sampler
DE4232925A1 (de) 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung
US5312896A (en) 1992-10-09 1994-05-17 Sri International Metal ion porphyrin-containing poly(imide)
DE4305523A1 (de) 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5345008A (en) * 1993-06-09 1994-09-06 Sun Company, Inc. (R&M) Decomposition of organic hydroperoxides with nitrated porphyrin complexes
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
TW247876B (en) 1993-12-28 1995-05-21 New York Blood Ct Inc Pharmaceutical compositions for prevention or treating HIV-1 or HIV-2 infection
US5608054A (en) 1993-12-29 1997-03-04 Sun Company, Inc. (R&M) Porphyrins and metal complexes thereof having haloalkyl side chains
WO1995033463A2 (en) 1994-06-02 1995-12-14 Bar-Ilan University Synergistic antibiotic compositions containing a perphyrin and an antibiotic
US5563132A (en) 1994-06-21 1996-10-08 Bodaness; Richard S. Two-step cancer treatment method
EP0775157B1 (en) 1994-07-22 2001-10-31 Duke University Human serum albumin-porphyrin complexes with the ability to bind oxygen and therapeutic uses thereof
FR2723694B1 (fr) 1994-08-19 1996-09-27 Oreal Utilisation de sels de derives cationiques de porphine comme agents photosensibilisants de bacteries de type gram-negatif
US5703230A (en) * 1994-12-02 1997-12-30 University Of British Columbia Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same
US6013241A (en) 1995-01-23 2000-01-11 Schering Aktiengesellschaft Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum
US5610175A (en) 1995-04-06 1997-03-11 Cytopharm, Inc. 9-Substituted porphycenes
US5637608A (en) * 1995-04-06 1997-06-10 Cytopharm, Inc. 9-substituted porphycenes
WO1997005152A1 (en) 1995-08-02 1997-02-13 Warner-Lambert Company Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix
US5877165A (en) 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US6620805B1 (en) 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
US6004530A (en) 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
EP0812920A1 (en) 1996-06-14 1997-12-17 Packard Instrument B.V. Use of porphyrins in instrumental detection methods
US6002026A (en) 1996-07-26 1999-12-14 The Trustees Of Princeton University Catalytic oxygenation of hydrocarbons by metalloporphyrin and metallosalen complexes
US5756492A (en) 1996-09-09 1998-05-26 Sangstat Medical Corporation Graft survival prolongation with porphyrins
US6104714A (en) 1996-09-26 2000-08-15 International Business Machines Corporation Method and apparatus for allowing communication in an isochronous traffic of asynchronous transfer mode (ATM) cells in a ring network
US6028025A (en) 1996-10-21 2000-02-22 Massachusetts Institute Of Technology Metalloporphyrin oxidation catalyst covalently coupled to an inorganic surface and method making same
US6124452A (en) 1997-12-19 2000-09-26 University Of Nebraska-Lincoln Octafluoro-meso-tetraarylporphyrins and methods for making these compounds
US6066628A (en) 1997-01-09 2000-05-23 Emory University Non-iron metalloporphyrins and methods of use
CA2278245A1 (en) 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
US6087493A (en) 1997-02-05 2000-07-11 Regents Of The University Of Texas System Porphyrin compounds as telomerase inhibitors
EP1091742A4 (en) 1997-02-14 2007-05-30 Miravant Pharm Inc PHOTOSENSITIVE INDIUM, FOR TPD
US6462070B1 (en) * 1997-03-06 2002-10-08 The General Hospital Corporation Photosensitizer conjugates for pathogen targeting
IL120891A0 (en) 1997-05-22 1997-09-30 Technion Res & Dev Foundation Photodynamic and sonodynamic therapy and agents for use therefor
DE19743903A1 (de) 1997-07-16 1999-04-15 Deutsch Zentr Luft & Raumfahrt Verwendung von metallierten und/oder unmetallierten polymergebundenen Porphyrinen
US5864044A (en) * 1997-07-24 1999-01-26 Universite De Sherbrooke Syntheses of trisulfonated phthalocyanines and their derivatatives using boron (111) subphthalocyanines as intermediates
IT1294325B1 (it) 1997-08-14 1999-03-24 Molteni L E C Dei Fratelli Ali Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici
US6524379B2 (en) 1997-08-15 2003-02-25 Kimberly-Clark Worldwide, Inc. Colorants, colorant stabilizers, ink compositions, and improved methods of making the same
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
US6194566B1 (en) 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
US6399769B1 (en) 1998-01-20 2002-06-04 Kimberly-Clark Worldwide, Inc. Method of making sulfanatophenyl substituted porphines
JP3673888B2 (ja) 1998-03-09 2005-07-20 独立行政法人科学技術振興機構 ポルフィリン類金属錯体の製造方法
US6103892A (en) 1998-04-08 2000-08-15 The Trustees Of Columbia University In The City Of New York Catalyst that oxidizes steroids and other substrates with catalytic turnover
WO1999055388A1 (en) 1998-04-24 1999-11-04 Duke University Substituted porphyrins
US6136841A (en) 1998-06-02 2000-10-24 Schering Aktiengesellschaft 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production and their use in photodynamic therapy and MRI diagnosis
US6147070A (en) 1998-06-05 2000-11-14 Facchini; Francesco Methods and compositions for controlling iron stores to treat and cure disease states
NL1009472C2 (nl) 1998-06-23 1999-12-27 Univ Leiden Werkwijze voor het inactiveren van virussen.
US6251367B1 (en) 1998-07-24 2001-06-26 Schering Aktiengesellschaft Paramagnetic 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
US6632808B1 (en) 1998-08-11 2003-10-14 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of amyloid formation
WO2000012512A1 (en) 1998-08-28 2000-03-09 Destiny Pharma Limited Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them
FI982422A0 (fi) 1998-11-09 1998-11-09 Arctic Diagnostics Oy Porfyriiniyhdisteitä, niiden konjugaatit sekä määritysmenetelmiä pohjautuen näiden konjugaattien käyttöön
EP1144512B1 (en) 1999-01-19 2003-04-23 Kimberly-Clark Worldwide, Inc. Novel colorants, colorant stabilizers, ink compositions, and improved methods of making the same
ES2254142T3 (es) 1999-01-25 2006-06-16 National Jewish Medical And Research Center Porfirinas sustituidas y su uso terapeutico.
US6433162B1 (en) * 1999-03-05 2002-08-13 Emory University Method for synthesizing porphyrin compounds
US6107326A (en) * 1999-04-12 2000-08-22 Cytopharm, Inc. Porphycenes for treatment of microbial populations
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
WO2000074674A1 (en) 1999-06-03 2000-12-14 Research Foundation Of The City University Of New York Novel porphyrin derivatives for photodynamic therapy
US6324091B1 (en) * 2000-01-14 2001-11-27 The Regents Of The University Of California Tightly coupled porphyrin macrocycles for molecular memory storage
US6208553B1 (en) * 1999-07-01 2001-03-27 The Regents Of The University Of California High density non-volatile memory device incorporating thiol-derivatized porphyrins
US6436171B1 (en) 1999-07-22 2002-08-20 The Boc Group, Inc. Oxygen-selective adsorbents
AU1087401A (en) 1999-10-13 2001-04-23 Uab Research Foundation Metalloporphyrin treatment of neurologic disease
US6245707B1 (en) 1999-10-28 2001-06-12 The United States Of America As Represented By The Secretary Of The Army Methanol tolerant catalyst material
US20040208855A1 (en) 1999-11-17 2004-10-21 Allison Beth Anne Use of PDT to inhibit intimal hyperplasia
KR100667644B1 (ko) 1999-11-30 2007-01-12 가부시키가이샤 히까리케미카루겡뀨쇼 니트로이미다졸 담지 포르피린 착체
US6272038B1 (en) * 2000-01-14 2001-08-07 North Carolina State University High-density non-volatile memory devices incorporating thiol-derivatized porphyrin trimers
US6212093B1 (en) 2000-01-14 2001-04-03 North Carolina State University High-density non-volatile memory devices incorporating sandwich coordination compounds
US6368558B1 (en) 2000-03-21 2002-04-09 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
WO2001071318A1 (en) 2000-03-21 2001-09-27 The Board Of Trustees Of The University Of Illinois Colorimetric artificial nose having an array of dyes and method for artificial olfaction
ES2215522T3 (es) 2000-06-15 2004-10-16 L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA' DI ESERCIZIO SOCIETA' PER AZIONI Ptalocianinas metalizadas sustituidas, su preparacion y su utilizacion.
US6857926B1 (en) * 2000-06-19 2005-02-22 Advanced Lighting Technologies, Inc. Method of making arc tubes
US6403788B1 (en) 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
US6420648B1 (en) * 2000-07-21 2002-07-16 North Carolina State University Light harvesting arrays
US6407330B1 (en) * 2000-07-21 2002-06-18 North Carolina State University Solar cells incorporating light harvesting arrays
FR2812637B1 (fr) 2000-08-01 2002-10-25 Anulm Ass Nantaise Pour L Util Nouveaux composes derives de dihydroporphyrine et leurs applications
JP4049357B2 (ja) * 2000-08-11 2008-02-20 独立行政法人科学技術振興機構 ポルフィリン環が互いにメゾ−メゾ炭素結合と2つのβ−β炭素の結合との三つの結合により一方向に縮環したポルフィリン化合物およびその合成方法
EP1318807A4 (en) 2000-08-11 2008-02-20 Ceramoptec Gmbh LIGHT-SENSITIVE OINTMENT
US6573258B2 (en) * 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
EP1197229A1 (en) 2000-10-13 2002-04-17 Boston Clinics PDT B.V. Method of inactivating microorganisms
EP1197147A1 (en) 2000-10-13 2002-04-17 Boston Clinics PDT B.V. Method of inactivating viral particles in a blood product
US6900197B2 (en) 2000-12-15 2005-05-31 Mitokor Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
ES2330728T3 (es) 2001-01-19 2009-12-15 National Jewish Health Medicamento para proteccion en radioterapia.
GB0104177D0 (en) 2001-02-20 2001-04-11 Isis Innovation Aryl-aryl dendrimers
PT102572B (pt) 2001-03-05 2004-01-30 Univ Aveiro Sintese e aplicacao de porfirinas em formulacoes aintivirais
PT102581B (pt) 2001-03-14 2004-01-30 Univ Aveiro Aplicacao de porfirinas em formulacoes antifungicas
EP1255167B1 (en) 2001-04-12 2013-11-13 Canon Kabushiki Kaisha Porphyrin compound, and electrophotographic photosensitive member, process-cartridge and apparatus using the compound
WO2002088128A1 (en) * 2001-04-30 2002-11-07 North Carolina State University Rational syntheses of heteroleptic lanthanide sandwich coordination complexes
US6906050B2 (en) 2001-05-31 2005-06-14 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis
EP1401506A4 (en) 2001-05-31 2005-02-16 Miravant Pharm Inc METAL TETRAPYRROLIC PHOTOSENSITIZATION AGENTS FOR PHOTODYNAMIC THERAPY
EP1439842A4 (en) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
US6566517B2 (en) 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
GB0114155D0 (en) 2001-06-11 2001-08-01 Unilever Plc Complex for catalytically bleaching a substrate
DE10132490B4 (de) 2001-07-03 2007-04-12 Hahn-Meitner-Institut Berlin Gmbh Platinfreies Chelat-Katalysatormaterial für die selektive Sauerstoffreduktion und Verfahren zu seiner Herstellung
EP1279676A1 (en) 2001-07-19 2003-01-29 Institut Curie Porphyrin derivatives for photodynamic therapy
JP5000050B2 (ja) 2001-08-31 2012-08-15 浩 前田 抗腫瘍剤及びその製造方法
US7025734B1 (en) 2001-09-28 2006-04-11 Advanced Cardiovascular Systmes, Inc. Guidewire with chemical sensing capabilities
WO2003057176A2 (en) 2002-01-08 2003-07-17 Emory University Porphyrins with virucidal activity
IL147898A (en) 2002-01-30 2007-05-15 Yuval Golan A method of treating cancer based on the Ugar effect
US20030176326A1 (en) * 2002-03-15 2003-09-18 Ceramoptec Industries Inc. Photosensitzers for photodynamic therapy of microbial infections
US6951935B2 (en) * 2002-03-28 2005-10-04 University Of Tennessee Research Foundation Heteroatom-substituted porphyrins and methods for synthesis of same
US20060030718A1 (en) 2002-03-28 2006-02-09 University Of Tennessee Research Foundation Cobalt-based catalysts for the cyclization of alkenes
US7417142B2 (en) 2002-03-28 2008-08-26 The University Of Tennessee Research Foundation, Inc. Chiral porphyrins, chiral metalloporphyrins, and methods for synthesis of the same
NL1020336C2 (nl) 2002-04-09 2003-10-13 Photobiochem Leiden N V Toepassing van een verbinding voor de bereiding van een farmaceutisch preparaat voor het behandelen van brandwonden, en een werkwijze voor het behandelen van brandwonden.
RU2238950C2 (ru) 2002-04-25 2004-10-27 Небольсин Владимир Евгеньевич Производные гемина и их фармацевтически приемлемые соли, способ получения, применение и фармацевтическая композиция
JP4808961B2 (ja) 2002-06-04 2011-11-02 オフィス オブ テクノロジー ライセンシング スタンフォード ユニバーシティ 被包化された体空間内から体組織を迅速に吸引及び採取するための装置
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
MXPA04012045A (es) 2002-06-04 2005-08-16 Wellspring Pharmaceutical Corp Preparacion de compuestos de haluro de metal mesoporfirina.
JP2006501163A (ja) 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
US20040019204A1 (en) 2002-07-23 2004-01-29 Chi-Ming Che Intramolecular amidation of sulfamate esters catalyzed by metalloporphyrins
US20040127479A1 (en) 2002-08-27 2004-07-01 Merck Patent Gmbh Peroxynitrite rearrangement catalysts
US20040063681A1 (en) 2002-09-16 2004-04-01 Chi-Ming Che Methods for using gold (III) complexes as anti-tumor and anti-HIV agents
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
PT1422311E (pt) 2002-11-19 2007-03-30 Hitachi Tool Eng Película dura e ferramenta revestida por película dura
GB0227259D0 (en) 2002-11-21 2002-12-31 Photobiotics Ltd Porphyrin derivatives
US20040116403A1 (en) 2002-12-06 2004-06-17 Klimko Peter G. Superoxide dismutase mimics for the treatment of ocular disorders and diseases
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
NL1022597C2 (nl) 2003-02-05 2004-08-06 Photobiochem N V Toepassing van een fotosensitizerverbinding voor de bereiding van een farmaceutisch preparaat, werkwijze voor het bereiden van een farmaceutisch preparaat en een werkwijze voor het behandelen van een zoogdier.
FR2854633B1 (fr) 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
US7008937B2 (en) 2003-06-10 2006-03-07 Frontier Scientific, Inc. Porphyrins and metalloporphyrins for inhibiting heme iron uptake
US20050008687A1 (en) 2003-07-07 2005-01-13 Makoto Yuasa Metal-porphyrin-complex-embedded liposomes, production process thereof, and medicines making use of the same
DE10335457B4 (de) 2003-08-02 2005-08-18 Schott Ag Verfahren zur quantitativen Bestimmung der Eignung von optischen Materialien für optische Elemente bei hohen Energiedichten, derart bestimmte optische Materialien sowie deren Verwendung
NL1025049C2 (nl) 2003-12-18 2005-06-21 Photobiochem N V Werkwijze voor de bereiding van porfyrinederivaten.
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
EP1740094A4 (en) 2004-03-29 2008-09-03 Inotek Pharmaceuticals Corp PYRIDYL-SUBSTITUTED PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF
US6995260B2 (en) 2004-05-20 2006-02-07 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US7738423B2 (en) 2004-07-09 2010-06-15 Alcatel-Lucent Usa Inc. Cell switching and packet combining in a wireless communication system
US7582750B2 (en) 2004-08-17 2009-09-01 University Of Hong Kong Method for conversion of terminal alkenes to aldehydes using ruthenium (IV) porphyrin catalysts

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CN1753896A (zh) 2006-03-29
GB2397067B (en) 2005-05-11
US7244841B2 (en) 2007-07-17
PT1578750E (pt) 2008-02-22
CN101200468A (zh) 2008-06-18
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AU2003295157A8 (en) 2004-07-14
AU2003295157B8 (en) 2010-12-02
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