CY1107750T1 - Πολυσωματιδιακα σκευασματα ελεγχομενης αποδεσμευσης εκλεκτικου αναστολεα επαναπροσληψης σεροτονινης - Google Patents
Πολυσωματιδιακα σκευασματα ελεγχομενης αποδεσμευσης εκλεκτικου αναστολεα επαναπροσληψης σεροτονινηςInfo
- Publication number
- CY1107750T1 CY1107750T1 CY20071101262T CY071101262T CY1107750T1 CY 1107750 T1 CY1107750 T1 CY 1107750T1 CY 20071101262 T CY20071101262 T CY 20071101262T CY 071101262 T CY071101262 T CY 071101262T CY 1107750 T1 CY1107750 T1 CY 1107750T1
- Authority
- CY
- Cyprus
- Prior art keywords
- release
- controlled
- ssri
- formulation
- polymosphatic
- Prior art date
Links
- 238000013270 controlled release Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 abstract 4
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960004038 fluvoxamine Drugs 0.000 abstract 1
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Ένα πολυσωματιδιακό σκεύασμα ελεγχόμενης αποδέσμευσης εκλεκτικού αναστολέα επαναπρόσληψης σεροτονίνης (SSRI) για στοματική χορήγηση περιλαμβάνει σωματίδια του εν λόγω SSRI ή ενός φαρμακευτικώς αποδεκτού άλατος αυτού επικαλυμμένα με πολυμερές ελέγχου της ταχύτητας το οποίο καθιστά δυνατή την ελεγχόμενη αποδέσμευση του εν λόγω SSRI, μέσα σε μια περίοδο όχι μικρότερη από περίπου 12 ώρες μετά την στοματική χορήγηση. Το σκεύασμα, το οποίο περιέχει για παράδειγμα φλουβοξαμίνη ή ένα φαρμακευτικώς αποδεκτό άλας αυτής, είναι κατάλληλο για καθημερινή χορήγηση μία φορά ή δύο φορές. Το σκεύασμα μπορεί να περιλαμβάνει ένα μείγμα δύο ή περισσότερων πληθυσμών σωματιδίων, πελετών ή μικρο-δισκίων που έχουν διαφορετικά in vitro και/ή in vivo χαρακτηριστικά αποδέσμευσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13502899P | 1999-05-20 | 1999-05-20 | |
IE19990406A IE990406A1 (en) | 1999-05-20 | 1999-05-20 | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations. |
EP00925548A EP1178780B1 (en) | 1999-05-20 | 2000-05-10 | Multiparticulate controlled release selective serotonin reuptake inhibitor formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107750T1 true CY1107750T1 (el) | 2013-04-18 |
Family
ID=26320248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101262T CY1107750T1 (el) | 1999-05-20 | 2007-10-04 | Πολυσωματιδιακα σκευασματα ελεγχομενης αποδεσμευσης εκλεκτικου αναστολεα επαναπροσληψης σεροτονινης |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1852111A1 (el) |
JP (1) | JP2003500348A (el) |
AT (1) | ATE367153T1 (el) |
AU (1) | AU782059B2 (el) |
CA (2) | CA2698347A1 (el) |
CY (1) | CY1107750T1 (el) |
CZ (1) | CZ302388B6 (el) |
DE (1) | DE60035579T2 (el) |
DK (1) | DK1178780T3 (el) |
DZ (1) | DZ3256A1 (el) |
ES (1) | ES2290027T3 (el) |
HU (1) | HU229569B1 (el) |
PT (1) | PT1178780E (el) |
RU (1) | RU2275191C2 (el) |
SK (1) | SK286865B6 (el) |
WO (1) | WO2000071099A1 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6482440B2 (en) * | 2000-09-21 | 2002-11-19 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
BR0100334A (pt) * | 2001-01-17 | 2002-09-24 | Diffucap Chemobras Quimica E F | Processo para a preparação de composições de liberação programada contendo venlafaxina e o produto resultante |
RU2311903C2 (ru) * | 2001-11-07 | 2007-12-10 | Синтон Б.В. | Таблетки тамзулосина |
IL146462A (en) * | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
CA2415154C (en) * | 2002-12-24 | 2009-06-16 | Biovail Laboratories Inc. | Modified release formulations of selective serotonin re-uptake inhibitors |
PT1502587E (pt) | 2003-07-30 | 2007-01-31 | Pharmathen Sa | Formulação de libertação prolongada para cloridrato de venlafaxina |
US7470435B2 (en) | 2003-11-17 | 2008-12-30 | Andrx Pharmaceuticals, Llc | Extended release venlafaxine formulation |
CA2476101A1 (en) * | 2004-08-12 | 2006-02-12 | Bernard Charles Sherman | Extended-release capsules comprising venlafaxine hydrochloride |
WO2007015270A2 (en) * | 2005-08-02 | 2007-02-08 | Lupin Limited | Novel controlled release compositions of selective serotonin reuptake inhibitors |
JP2008231025A (ja) * | 2007-03-20 | 2008-10-02 | Kyowa Yakuhin Kogyo Kk | マレイン酸フルボキサミン錠剤 |
WO2018206923A1 (en) * | 2017-05-11 | 2018-11-15 | Opal Ip Limited | Novel formulations |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2077023T3 (es) * | 1989-03-10 | 1995-11-16 | Yamanouchi Pharma Co Ltd | Material de recubrimiento que controla la liberacion de un medicamento para formulaciones de actividad prolongada. |
JPH04234812A (ja) * | 1990-03-16 | 1992-08-24 | Yamanouchi Pharmaceut Co Ltd | 持続性製剤用顆粒 |
JPH0826977A (ja) * | 1994-07-19 | 1996-01-30 | Tanabe Seiyaku Co Ltd | 溶出制御型経口製剤 |
JP4072597B2 (ja) * | 1994-12-27 | 2008-04-09 | ナムローゼ・フェンノートシャップ・オルガノン | 持続性製剤 |
GB9514842D0 (en) * | 1995-07-20 | 1995-09-20 | Smithkline Beecham Plc | Novel formulation |
PE57198A1 (es) * | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
FR2754710B1 (fr) * | 1996-10-22 | 1998-12-31 | Prographarm Lab | Procede de preparation d'une forme pharmaceutique multiparticulaire a liberation controlee plurisequentielle |
US5910319A (en) * | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
AU739261B2 (en) * | 1997-07-01 | 2001-10-11 | Pfizer Inc. | Sertraline salts and sustained-release dosage forms of sertraline |
UA63953C2 (uk) * | 1997-07-01 | 2004-02-16 | Пфайзер Продактс Інк. | Дозована форма уповільненого вивільнення, що містить сертралін, (варіанти) та спосіб лікування (варіанти) |
UA77145C2 (en) * | 1997-11-05 | 2006-11-15 | Wyeth Corp | Extended release dosage formulation |
-
2000
- 2000-05-10 JP JP2000619406A patent/JP2003500348A/ja active Pending
- 2000-05-10 ES ES00925548T patent/ES2290027T3/es not_active Expired - Lifetime
- 2000-05-10 CA CA2698347A patent/CA2698347A1/en not_active Abandoned
- 2000-05-10 DK DK00925548T patent/DK1178780T3/da active
- 2000-05-10 DE DE60035579T patent/DE60035579T2/de not_active Expired - Lifetime
- 2000-05-10 SK SK1896-2001A patent/SK286865B6/sk not_active IP Right Cessation
- 2000-05-10 AT AT00925548T patent/ATE367153T1/de active
- 2000-05-10 AU AU44267/00A patent/AU782059B2/en not_active Ceased
- 2000-05-10 PT PT00925548T patent/PT1178780E/pt unknown
- 2000-05-10 RU RU2001134614/15A patent/RU2275191C2/ru not_active IP Right Cessation
- 2000-05-10 WO PCT/IE2000/000060 patent/WO2000071099A1/en active IP Right Grant
- 2000-05-10 DZ DZ003256A patent/DZ3256A1/fr active
- 2000-05-10 CZ CZ20014618A patent/CZ302388B6/cs not_active IP Right Cessation
- 2000-05-10 CA CA2374039A patent/CA2374039C/en not_active Expired - Fee Related
- 2000-05-10 EP EP07008264A patent/EP1852111A1/en not_active Withdrawn
- 2000-05-10 HU HU0201884A patent/HU229569B1/hu not_active IP Right Cessation
- 2000-05-10 EP EP00925548A patent/EP1178780B1/en not_active Expired - Lifetime
-
2007
- 2007-10-04 CY CY20071101262T patent/CY1107750T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU782059B2 (en) | 2005-06-30 |
RU2275191C2 (ru) | 2006-04-27 |
DE60035579D1 (de) | 2007-08-30 |
CA2698347A1 (en) | 2000-11-30 |
WO2000071099A1 (en) | 2000-11-30 |
JP2003500348A (ja) | 2003-01-07 |
HUP0201884A3 (en) | 2006-07-28 |
SK286865B6 (sk) | 2009-06-05 |
AU4426700A (en) | 2000-12-12 |
SK18962001A3 (sk) | 2002-04-04 |
DZ3256A1 (fr) | 2000-11-30 |
EP1852111A1 (en) | 2007-11-07 |
CZ302388B6 (cs) | 2011-04-27 |
CA2374039C (en) | 2011-01-11 |
DK1178780T3 (da) | 2007-11-12 |
ES2290027T3 (es) | 2008-02-16 |
CZ20014618A3 (cs) | 2002-05-15 |
EP1178780B1 (en) | 2007-07-18 |
CA2374039A1 (en) | 2000-11-30 |
DE60035579T2 (de) | 2008-04-17 |
EP1178780A1 (en) | 2002-02-13 |
HUP0201884A2 (en) | 2002-09-28 |
ATE367153T1 (de) | 2007-08-15 |
PT1178780E (pt) | 2007-10-25 |
HU229569B1 (hu) | 2014-02-28 |
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