CY1107344T1 - Διαδικασια για την παρασκευη εστερων οξικου οξεος διοξανιου - Google Patents

Διαδικασια για την παρασκευη εστερων οξικου οξεος διοξανιου

Info

Publication number
CY1107344T1
CY1107344T1 CY20071100215T CY071100215T CY1107344T1 CY 1107344 T1 CY1107344 T1 CY 1107344T1 CY 20071100215 T CY20071100215 T CY 20071100215T CY 071100215 T CY071100215 T CY 071100215T CY 1107344 T1 CY1107344 T1 CY 1107344T1
Authority
CY
Cyprus
Prior art keywords
group
preparation
formula
acid chloride
dioxanic
Prior art date
Application number
CY20071100215T
Other languages
English (en)
Inventor
Van Hermanus Carolus Catherina Karel Bakel
Dominique Monique Charles Callant
Jacob Hermanus Mattheus Hero Kooistra
Peter Johannes Dominicus Maas
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of CY1107344T1 publication Critical patent/CY1107344T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Διαδικασία για την παρασκευή ενός εστέρα του τύπου (1), όπου το R2 αντιπροσωπεύει μία ομάδα αναχώρησης, CN, ΟΗ ή μία COOR5 ομάδα, τα R3 και R4, το καθένα ανεξάρτητα, αντιπροσωπεύουν μία 1-3 C αλκυλ ομάδα, και τα R2 και R5, το καθένα ανεξάρτητα, αντιπροσωπεύουν ένα υπόλειμμα εστέρα, όπου το αντίστοιχο άλας με τύπο (2), όπου το Μ αντιπροσωπεύει Η ή ένα αλκαλικό (γαίας) μέταλλο σ' έναν αδρανή διαλύτη έρχεται σε επαφή με ένα μέσο σχηματισμού χλωριδίου οξέος για να σχηματιστεί το αντίστοιχο χλωρίδιο οξέος, και το χλωρίδιο οξέος έρχεται σε επαφή με μία αλκοόλη με τύπο R2ΟΗ υπό την παρουσία Ν-μεθυλ-μορφολίνης. Κατά προτίμηση το Μ αντιπροσωπεύει ένα αλκαλικό μέταλλο, και το R2 αντιπροσωπεύει μία αλκυλ ομάδα, συγκεκριμένα μία t.-βουτυλ ομάδα. (1), (2).
CY20071100215T 2002-06-17 2007-02-16 Διαδικασια για την παρασκευη εστερων οξικου οξεος διοξανιου CY1107344T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100715A EP1375493A1 (en) 2002-06-17 2002-06-17 Process for the preparation of an dioxane acetic acid ester
EP03741639A EP1515962B1 (en) 2002-06-17 2003-06-12 Process for the preaparation of dioxane acetic acid esters

Publications (1)

Publication Number Publication Date
CY1107344T1 true CY1107344T1 (el) 2012-12-19

Family

ID=29716908

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100215T CY1107344T1 (el) 2002-06-17 2007-02-16 Διαδικασια για την παρασκευη εστερων οξικου οξεος διοξανιου

Country Status (27)

Country Link
US (1) US7442811B2 (el)
EP (2) EP1375493A1 (el)
JP (1) JP4632784B2 (el)
KR (1) KR101008920B1 (el)
CN (2) CN101812045B (el)
AT (1) ATE348825T1 (el)
AU (1) AU2003277230B2 (el)
BR (1) BR0311884A (el)
CA (1) CA2490205C (el)
CY (1) CY1107344T1 (el)
DE (1) DE60310559T2 (el)
DK (1) DK1515962T3 (el)
EG (1) EG24561A (el)
ES (1) ES2278174T3 (el)
HK (1) HK1073303A1 (el)
IL (1) IL165767A0 (el)
IS (1) IS2477B (el)
MX (1) MXPA04012651A (el)
NO (1) NO328946B1 (el)
NZ (1) NZ537260A (el)
PL (1) PL207130B1 (el)
PT (1) PT1515962E (el)
RU (1) RU2315761C2 (el)
SI (1) SI1515962T1 (el)
UA (1) UA79970C2 (el)
WO (1) WO2003106447A1 (el)
ZA (1) ZA200409986B (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
DK1578731T3 (da) 2002-12-16 2010-02-15 Astrazeneca Uk Ltd Fremgangsmåde til fremstilling af pyrimidinforbindelser
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
GB0514078D0 (en) * 2005-07-08 2005-08-17 Astrazeneca Uk Ltd Chemical process
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
CN105198856B (zh) * 2014-06-27 2017-10-13 上海弈柯莱生物医药科技有限公司 一种2‑(6‑取代1,3‑二噁烷‑4‑基)乙酸衍生物的制备方法
RU2596623C1 (ru) * 2015-07-20 2016-09-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уфимский государственный нефтяной технический университет" Способ получения 1,4-диоксанкарбоксилатов
CN111675689B (zh) * 2020-06-16 2021-08-24 浙江工业大学 一种瑞舒伐他汀中间体的化学合成方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB885516A (en) * 1958-01-16 1961-12-28 Arthur Henry Clarkson Higher fatty acid esters of dextran
US3325466A (en) * 1961-01-11 1967-06-13 American Cyanamid Co Tertiary butyl group as a carboxyl protecting group in the synthesis of peptides
GB9005966D0 (en) 1990-03-16 1990-05-09 May & Baker Ltd New compositions of matter
JP3097143B2 (ja) 1991-02-21 2000-10-10 チッソ株式会社 生理活性物質合成用光学活性化合物の製造法および光学活性中間体化合物
WO1993006235A1 (en) 1991-09-20 1993-04-01 Zeneca Limited Process for the preparation of enantiomerically pure 4-hydroxytetrahydro-2-pyranone derivatives
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
GB9523924D0 (en) 1995-11-23 1996-01-24 Zeneca Ltd Production of optically active 2-substituted tetrahydropyran-4-ones
US6278001B1 (en) * 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
FR2741620B1 (fr) 1995-11-28 1997-12-26 Oreal Procede de preparation de composes a groupement beta-hydroxy -delta-lactone analogues de la (+) compactine et de la (+) mevinoline
CA2329893A1 (en) * 1998-04-30 1999-11-11 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
JP3803551B2 (ja) 1998-08-05 2006-08-02 株式会社カネカ 光学活性２−［６−（ヒドロキシメチル）−１，３−ジオキサン−４−イル］酢酸誘導体の製造法
HUP0103021A3 (en) * 1998-12-10 2002-04-29 Kaneka Corp Process for producing simvastatin derivatives
GB9903472D0 (en) * 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
CA2339357A1 (en) * 1999-06-04 2000-12-14 Kenji Inoue Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
WO2001072706A1 (en) 2000-03-28 2001-10-04 Biocon India Limited Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
DK1578731T3 (da) 2002-12-16 2010-02-15 Astrazeneca Uk Ltd Fremgangsmåde til fremstilling af pyrimidinforbindelser
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2004113314A1 (en) 2003-06-23 2004-12-29 Biocon Limited Novel boronate esters
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
TWI276043B (en) 2004-09-09 2007-03-11 Seiko Epson Corp Display apparatus
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
AU2003277230B2 (en) 2007-07-05
IL165767A0 (en) 2006-01-15
SI1515962T1 (sl) 2007-04-30
KR20050042461A (ko) 2005-05-09
EP1515962B1 (en) 2006-12-20
WO2003106447A1 (en) 2003-12-24
MXPA04012651A (es) 2005-08-15
EP1515962A1 (en) 2005-03-23
DE60310559D1 (de) 2007-02-01
NO20045491L (no) 2005-01-14
IS7617A (is) 2004-12-28
PL375077A1 (en) 2005-11-14
CA2490205A1 (en) 2003-12-24
PL207130B1 (pl) 2010-11-30
ATE348825T1 (de) 2007-01-15
UA79970C2 (en) 2007-08-10
KR101008920B1 (ko) 2011-01-17
DE60310559T2 (de) 2007-12-27
HK1073303A1 (en) 2005-09-30
JP2005533065A (ja) 2005-11-04
DK1515962T3 (da) 2007-03-26
CN1662520A (zh) 2005-08-31
RU2004139042A (ru) 2005-08-10
CN101812045B (zh) 2012-07-18
EG24561A (en) 2009-10-25
EP1375493A1 (en) 2004-01-02
ES2278174T3 (es) 2007-08-01
CA2490205C (en) 2011-04-19
NO328946B1 (no) 2010-06-28
BR0311884A (pt) 2005-04-05
CN101812045A (zh) 2010-08-25
IS2477B (is) 2008-12-15
RU2315761C2 (ru) 2008-01-27
PT1515962E (pt) 2007-02-28
US7442811B2 (en) 2008-10-28
US20060122407A1 (en) 2006-06-08
NZ537260A (en) 2006-06-30
CN1662520B (zh) 2010-08-11
JP4632784B2 (ja) 2011-02-16
ZA200409986B (en) 2005-10-19
AU2003277230A1 (en) 2003-12-31

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