CY1107198T1 - Μεθοδος παραγωγης κρυσταλλου - Google Patents

Μεθοδος παραγωγης κρυσταλλου

Info

Publication number
CY1107198T1
CY1107198T1 CY20081100182T CY081100182T CY1107198T1 CY 1107198 T1 CY1107198 T1 CY 1107198T1 CY 20081100182 T CY20081100182 T CY 20081100182T CY 081100182 T CY081100182 T CY 081100182T CY 1107198 T1 CY1107198 T1 CY 1107198T1
Authority
CY
Cyprus
Prior art keywords
methyl
trifluoroethoxy
sulfinyl
benzimidazole
pyridyl
Prior art date
Application number
CY20081100182T
Other languages
English (en)
Inventor
Hideo Hashimoto
Hideaki Maruyama
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of CY1107198T1 publication Critical patent/CY1107198T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο παραγωγής ενός κρυστάλλου της (R)-2-[[[3-μεθυλ-4-(2,2,2-τριφθοροαιθοξυ)-2-πυριδυλ]μεθυλ]σουλφινυλ]βενζιμιδαζόλης ˙ n'Η2O (όπου n' είναι περίπου 0 έως περίπου 0,1) ή ενός άλατος αυτής, η οποία χαρακτηριστικά περιλαμβάνει την κρυστάλλωση από ένα διάλυμα ή εναιώρημα οργανικού διαλύτη στο οποίο η (R)-2-[[[3-μεθυλ-4-(2,2,2-τριφθοροαιθοξυ)-2-πυριδυλ] μεθυλ] σουλφινυλ] βενζιμιδα-ζόλη ˙ nΗ2O (όπου n είναι περίπου 0,1 έως περίπου 1,0) ή ένα άλας αυτής έχει διαλυθεί ή τεθεί σε εναιώρηση, και παρόμοια, και παρέχει μία πρακτική μέθοδο για την αποδοτική παραγωγή ενός οπτικά ενεργού παραγώγου του σουλφοξειδίου που έχει εξαιρετικά υψηλή περίσσεια εναντιομερούς με υψηλή απόδοση σε μεγάλη βιομηχανική κλίμακα.
CY20081100182T 2000-05-15 2008-02-14 Μεθοδος παραγωγης κρυσταλλου CY1107198T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000141670 2000-05-15
EP01930131A EP1293507B1 (en) 2000-05-15 2001-05-15 Process for producing crystal

Publications (1)

Publication Number Publication Date
CY1107198T1 true CY1107198T1 (el) 2012-11-21

Family

ID=18648753

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100182T CY1107198T1 (el) 2000-05-15 2008-02-14 Μεθοδος παραγωγης κρυσταλλου

Country Status (12)

Country Link
US (4) US7169799B2 (el)
EP (3) EP1293507B1 (el)
KR (2) KR101035534B1 (el)
CN (2) CN100562318C (el)
AU (1) AU2001256732A1 (el)
CA (3) CA2409044C (el)
CY (1) CY1107198T1 (el)
DE (1) DE60131649T2 (el)
DK (1) DK1293507T3 (el)
ES (3) ES2511774T3 (el)
PT (1) PT1293507E (el)
WO (1) WO2001087874A1 (el)

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CA2510849A1 (en) * 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
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JPWO2006121151A1 (ja) * 2005-05-13 2008-12-18 第一三共株式会社 １−メチルカルバペネム化合物の結晶
WO2006132217A1 (ja) * 2005-06-07 2006-12-14 Takeda Pharmaceutical Company Limited ベンズイミダゾール化合物の塩の結晶
CN101389316A (zh) 2005-12-28 2009-03-18 武田药品工业株式会社 控制释放固体制剂
JP5366558B2 (ja) 2006-12-28 2013-12-11 武田薬品工業株式会社 口腔内崩壊性固形製剤
CN102014638A (zh) * 2007-10-12 2011-04-13 武田制药北美公司 与食物摄入无关的治疗胃肠病症的方法
US8214093B2 (en) * 2007-11-04 2012-07-03 GM Global Technology Operations LLC Method and apparatus to prioritize transmission output torque and input acceleration for a hybrid powertrain system
JP2011507977A (ja) * 2007-12-31 2011-03-10 武田薬品工業株式会社 （ｒ）−２−［［［３−メチル−４−（２，２，２−トリフルオロエトキシ）−２−ピリジニル］メチル］スルフィニル］−１ｈ−ベンズイミダゾールの溶媒和物結晶形
JP2011513202A (ja) 2008-03-10 2011-04-28 武田薬品工業株式会社 ベンズイミダゾール化合物の結晶
WO2010039885A2 (en) * 2008-09-30 2010-04-08 Teva Pharmaceutical Industries Ltd. Crystalline forms of dexlansoprazole
IT1391776B1 (it) 2008-11-18 2012-01-27 Dipharma Francis Srl Procedimento per la preparazione di dexlansoprazolo
IT1392813B1 (it) * 2009-02-06 2012-03-23 Dipharma Francis Srl Forme cristalline di dexlansoprazolo
US20110009637A1 (en) * 2009-02-10 2011-01-13 Dario Braga Crystals of Dexlansoprazole
WO2011004387A2 (en) 2009-06-18 2011-01-13 Matrix Laboratories Ltd Process for the preparation of dexlansoprazole polymorphic forms
IT1395118B1 (it) 2009-07-29 2012-09-05 Dipharma Francis Srl Procedimento per la preparazione di dexlansoprazolo cristallino
US20130197232A1 (en) * 2010-01-29 2013-08-01 Ranbaxy Laboratories Limited Process for the preparation of crystalline forms of dexlansoprazole
CA2795056C (en) 2010-03-31 2015-03-24 Ranbaxy Laboratories Limited Salts of dexlansoprazole and their preparation
WO2011121548A1 (en) 2010-03-31 2011-10-06 Ranbaxy Laboratories Limited Process for the preparation of dexlansoprazole
KR101908748B1 (ko) 2010-12-03 2018-10-16 다케다 야쿠힌 고교 가부시키가이샤 구강내 붕괴정
SG10201602311XA (en) 2010-12-27 2016-04-28 Takeda Pharmaceutical Orally disintegrating tablet
WO2012104805A1 (en) 2011-02-01 2012-08-09 Ranbaxy Laboratories Limited Process for the preparation of dexlansoprazole
WO2012176140A1 (en) 2011-06-21 2012-12-27 Ranbaxy Laboratories Limited Process for the preparation of dexlansoprazole
CN102234265B (zh) * 2011-08-08 2013-11-20 天津市汉康医药生物技术有限公司 兰索拉唑化合物
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Also Published As

Publication number Publication date
ES2293988T3 (es) 2008-04-01
DE60131649D1 (de) 2008-01-10
EP2281821A1 (en) 2011-02-09
KR20090076980A (ko) 2009-07-13
CA2762960C (en) 2014-07-22
AU2001256732A1 (en) 2001-11-26
PT1293507E (pt) 2008-01-16
KR101035534B1 (ko) 2011-05-23
ES2511774T3 (es) 2014-10-23
KR20080067713A (ko) 2008-07-21
EP1897877A2 (en) 2008-03-12
US20070004779A1 (en) 2007-01-04
EP1293507B1 (en) 2007-11-28
CA2762960A1 (en) 2001-11-22
EP1897877B1 (en) 2014-09-24
US7169799B2 (en) 2007-01-30
CA2701704A1 (en) 2001-11-22
US20100004458A1 (en) 2010-01-07
CN1280287C (zh) 2006-10-18
CA2701704C (en) 2011-09-06
DE60131649T2 (de) 2008-10-30
WO2001087874A1 (fr) 2001-11-22
CN1437592A (zh) 2003-08-20
CA2409044A1 (en) 2002-11-14
US8212046B2 (en) 2012-07-03
ES2521690T3 (es) 2014-11-13
EP1293507A4 (en) 2005-09-07
US20110257405A1 (en) 2011-10-20
EP2281821B1 (en) 2014-10-22
EP1293507A1 (en) 2003-03-19
EP1897877A3 (en) 2008-12-10
US7994332B2 (en) 2011-08-09
DK1293507T3 (da) 2007-12-27
US7569696B2 (en) 2009-08-04
CA2409044C (en) 2013-02-19
US20030153766A1 (en) 2003-08-14
CN100562318C (zh) 2009-11-25
CN1803137A (zh) 2006-07-19

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