CY1106219T1 - Στepεο απο του στοματος χορηγουμενο φαρμακευτικο μορφωμα μεταβλητης απελευθερωσης που πepιεχει μια ασταθη στα οξεα της βενζιμιδαζολης - Google Patents
Στepεο απο του στοματος χορηγουμενο φαρμακευτικο μορφωμα μεταβλητης απελευθερωσης που πepιεχει μια ασταθη στα οξεα της βενζιμιδαζοληςInfo
- Publication number
- CY1106219T1 CY1106219T1 CY20061101540T CY061101540T CY1106219T1 CY 1106219 T1 CY1106219 T1 CY 1106219T1 CY 20061101540 T CY20061101540 T CY 20061101540T CY 061101540 T CY061101540 T CY 061101540T CY 1106219 T1 CY1106219 T1 CY 1106219T1
- Authority
- CY
- Cyprus
- Prior art keywords
- variable
- stepeo
- unsatisfactory
- oral
- release pharmaceutical
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 239000010410 layer Substances 0.000 abstract 4
- 239000012530 fluid Substances 0.000 abstract 2
- 239000008188 pellet Substances 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000003763 carbonization Methods 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 239000011229 interlayer Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Το φαρμακευτικό μόρφωμα αποτελείται από ένα πλήθος σβώλων που περιλαμβάνουν έναν αδρανή πυρήνα, ένα στρώμα με το δραστικό συστατικό, ένα ή περισσότερα ενδιάμεσα στρώματα που περιλαμβάνουν με τη σειρά τους τουλάχιστον ένα σύστημα μεταβλητής απελευθέρωσης και ένα εξωτερικό στρώμα ανθεκτικού στα εντερικά υγρά επιχρίσματος. Οι σβώλοι αυτοί μπορούν να αποκτώνται μέσω της εφαρμογής των διαφόρων στρωμάτων με τη βοήθεια τεχνικών ανθράκευσης υποστρώματος ρευστού μέσου και με τη χρήση υδαρών διαλυμάτων ή εναιωρημάτων των συστατικών των στρωμάτων του εν λόγω είδους. Τα φαρμακευτικά μορφώματα μπορούν να είναι κάψουλες σκληρής ζελατίνης ή ταμπλέτες και είναι κατάλληλα προς χρήση για την πρόληψη και τη θεραπεία διαταραχών που σχετίζονται με τη μη φυσιολογική έκκριση γαστρικού οξέος.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009902027A ES2168043B1 (es) | 1999-09-13 | 1999-09-13 | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106219T1 true CY1106219T1 (el) | 2011-06-08 |
Family
ID=8309905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101540T CY1106219T1 (el) | 1999-09-13 | 2006-10-25 | Στepεο απο του στοματος χορηγουμενο φαρμακευτικο μορφωμα μεταβλητης απελευθερωσης που πepιεχει μια ασταθη στα οξεα της βενζιμιδαζολης |
Country Status (12)
Country | Link |
---|---|
US (1) | US6780436B1 (el) |
EP (1) | EP1086694B1 (el) |
JP (1) | JP4885347B2 (el) |
KR (1) | KR100724201B1 (el) |
AT (1) | ATE334679T1 (el) |
AU (1) | AU777322B2 (el) |
CA (1) | CA2318008C (el) |
CY (1) | CY1106219T1 (el) |
DE (1) | DE60029712T2 (el) |
DK (1) | DK1086694T3 (el) |
ES (2) | ES2168043B1 (el) |
PT (1) | PT1086694E (el) |
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ES2198195B1 (es) * | 2001-12-18 | 2004-10-01 | Laboratorios Del Dr. Esteve, S.A. | Forma de dosificacion farmaceutica oral comprimida, con recubrimiento enterico, que contiene un compuesto de bencimidazol labil en medio acido. |
IL164221A0 (en) | 2002-04-09 | 2005-12-18 | Flamel Tech Sa | Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim |
MXPA04009968A (es) | 2002-04-09 | 2004-12-13 | Flamel Tech Sa | Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s). |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
EP2596792A1 (en) * | 2002-10-16 | 2013-05-29 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
AU2003245033A1 (en) * | 2003-05-08 | 2004-11-26 | Podili Khadgapathi | An improved and stable pharmaceutical composition containing substituted benzimidazoles and a process for its preparation |
US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
AU2003272086A1 (en) * | 2003-10-14 | 2005-04-27 | Natco Pharma Limited | Enteric coated pellets comprising esomeprazole, hard gelatin capsule containing them, and method of preparation |
FR2861990B1 (fr) * | 2003-11-10 | 2006-02-10 | Nouveaux Produits Pharma | Comprimes faiblement doses a reseau de polymeres |
AU2005264864B2 (en) | 2004-06-16 | 2011-08-11 | Takeda Pharmaceutical Company Limited | Multiple PPI dosage form |
AR052225A1 (es) * | 2004-11-04 | 2007-03-07 | Astrazeneca Ab | Formulaciones de tabletas de liberacion modificada par inhibidores de la bomba de protones |
AR051654A1 (es) * | 2004-11-04 | 2007-01-31 | Astrazeneca Ab | Nuevas formulaciones de pellets de liberacion modificada para inhibidores de la bomba de protones |
US20060210637A1 (en) * | 2005-03-17 | 2006-09-21 | Qpharma, Llc | Stable tablet dosage forms of proton pump inhibitors |
US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
WO2006111853A2 (en) * | 2005-04-18 | 2006-10-26 | Aurobindo Pharma Limited | Stable solid dosage forms of acid labile drug |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
CN101208090B (zh) * | 2005-04-28 | 2012-03-21 | 卫材R&D管理有限公司 | 稳定化的组合物 |
EP1880718B1 (de) * | 2006-07-10 | 2011-09-21 | Dr. R. Pfleger Chemische Fabrik GmbH | Pharmazeutische Zubereitung für die orale Verabreichung mit gesteuerter Wirkstofffreisetzung im Dünndarm und Verfahren zu ihrer Herstellung |
EP2319504A1 (en) | 2009-11-07 | 2011-05-11 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical solid dosage form |
ES2667402T3 (es) * | 2011-11-02 | 2018-05-10 | Laboratorios Del Dr. Esteve, S.A. | Composición farmacéutica de omeprazol |
WO2013111149A1 (en) * | 2011-12-21 | 2013-08-01 | Hetero Research Foundation | Controlled release solid oral compositions of dexlansoprazole |
CN103202820B (zh) * | 2012-01-11 | 2016-03-30 | 浙江亚太药业股份有限公司 | 一种稳定的兰索拉唑肠溶胶囊及其制备方法 |
CN104586809A (zh) * | 2015-01-08 | 2015-05-06 | 浙江亚太药业股份有限公司 | 一种埃索美拉唑镁微丸肠溶片及制备方法 |
WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10736855B2 (en) | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
HUE053242T2 (hu) * | 2016-09-15 | 2021-06-28 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Orális pirofoszfát szövetmeszesedés csökkentésében történõ alkalmazásra |
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-
1999
- 1999-09-13 ES ES009902027A patent/ES2168043B1/es not_active Expired - Fee Related
-
2000
- 2000-09-12 US US09/660,022 patent/US6780436B1/en not_active Expired - Lifetime
- 2000-09-12 CA CA2318008A patent/CA2318008C/en not_active Expired - Fee Related
- 2000-09-12 AU AU57919/00A patent/AU777322B2/en not_active Ceased
- 2000-09-13 AT AT00500203T patent/ATE334679T1/de active
- 2000-09-13 ES ES00500203T patent/ES2269088T3/es not_active Expired - Lifetime
- 2000-09-13 DE DE60029712T patent/DE60029712T2/de not_active Expired - Lifetime
- 2000-09-13 PT PT00500203T patent/PT1086694E/pt unknown
- 2000-09-13 DK DK00500203T patent/DK1086694T3/da active
- 2000-09-13 EP EP00500203A patent/EP1086694B1/en not_active Expired - Lifetime
- 2000-09-13 JP JP2000277838A patent/JP4885347B2/ja not_active Expired - Fee Related
- 2000-09-14 KR KR1020000053939A patent/KR100724201B1/ko not_active IP Right Cessation
-
2006
- 2006-10-25 CY CY20061101540T patent/CY1106219T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU5791900A (en) | 2001-03-15 |
DE60029712T2 (de) | 2007-08-02 |
EP1086694A3 (en) | 2002-09-25 |
CA2318008C (en) | 2010-08-17 |
US6780436B1 (en) | 2004-08-24 |
AU777322B2 (en) | 2004-10-14 |
ES2269088T3 (es) | 2007-04-01 |
DK1086694T3 (da) | 2006-12-04 |
CA2318008A1 (en) | 2001-03-13 |
EP1086694B1 (en) | 2006-08-02 |
ES2168043A1 (es) | 2002-05-16 |
JP2001199878A (ja) | 2001-07-24 |
PT1086694E (pt) | 2006-12-29 |
KR20020020974A (ko) | 2002-03-18 |
ES2168043B1 (es) | 2003-04-01 |
ATE334679T1 (de) | 2006-08-15 |
JP4885347B2 (ja) | 2012-02-29 |
EP1086694A2 (en) | 2001-03-28 |
DE60029712D1 (de) | 2006-09-14 |
KR100724201B1 (ko) | 2007-05-31 |
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