CY1106116T1 - Παραγωγα βενζαμιδινης - Google Patents
Παραγωγα βενζαμιδινηςInfo
- Publication number
- CY1106116T1 CY1106116T1 CY20061100927T CY061100927T CY1106116T1 CY 1106116 T1 CY1106116 T1 CY 1106116T1 CY 20061100927 T CY20061100927 T CY 20061100927T CY 061100927 T CY061100927 T CY 061100927T CY 1106116 T1 CY1106116 T1 CY 1106116T1
- Authority
- CY
- Cyprus
- Prior art keywords
- benzamidine derivatives
- benzamidine
- derivatives
- prevention
- useful
- Prior art date
Links
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical class NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 150000003937 benzamidines Chemical class 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Manufacture Of Alloys Or Alloy Compounds (AREA)
Abstract
Παράγωγα βενζαμιδίνης του τύπου (I) ή φαρμακευτικώς αποδεκτά άλατα αυτών δεικνύουν εξαιρετική ανασταλτική δραστικότητα έναντι παράγοντα Xa και είναι χρήσιμα για θεραπεία ή πρόληψη διαταραχών πήξης αίματος:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30719299 | 1999-10-28 | ||
PCT/JP2000/007469 WO2001030756A1 (fr) | 1999-10-28 | 2000-10-25 | Derives de benzamidine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106116T1 true CY1106116T1 (el) | 2011-06-08 |
Family
ID=17966162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061100927T CY1106116T1 (el) | 1999-10-28 | 2006-07-04 | Παραγωγα βενζαμιδινης |
Country Status (26)
Country | Link |
---|---|
US (3) | US6555556B1 (el) |
EP (1) | EP1245564B1 (el) |
KR (1) | KR100642953B1 (el) |
CN (2) | CN1293052C (el) |
AT (1) | ATE322479T1 (el) |
AU (1) | AU776193B2 (el) |
BR (1) | BR0015120A (el) |
CA (1) | CA2389156C (el) |
CY (1) | CY1106116T1 (el) |
CZ (1) | CZ20021432A3 (el) |
DE (1) | DE60027204T2 (el) |
DK (1) | DK1245564T3 (el) |
ES (1) | ES2261248T3 (el) |
HK (1) | HK1047431B (el) |
HU (1) | HUP0203161A3 (el) |
IL (2) | IL149306A0 (el) |
MX (1) | MXPA02004218A (el) |
NO (1) | NO323147B1 (el) |
NZ (1) | NZ518581A (el) |
PL (1) | PL354619A1 (el) |
PT (1) | PT1245564E (el) |
RU (1) | RU2222529C2 (el) |
TR (1) | TR200201654T2 (el) |
TW (1) | TWI226886B (el) |
WO (1) | WO2001030756A1 (el) |
ZA (1) | ZA200203278B (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1245564T3 (da) * | 1999-10-28 | 2006-08-14 | Sankyo Co | Benzamidinderivater |
CZ20032728A3 (cs) * | 2001-04-05 | 2004-02-18 | Sankyo Company, Limited | Benzamidinové deriváty |
WO2002089803A1 (en) * | 2001-05-07 | 2002-11-14 | Sankyo Company, Limited | Composition for iontophoresis |
MXPA04009007A (es) * | 2002-03-15 | 2005-07-01 | Kissei Pharmaceutical | Nuevos cristales de derivado de 5-hidroxicarbamimidoil-2-hidroxi-bencenosulfonamida. |
US20070254930A1 (en) * | 2004-11-23 | 2007-11-01 | Dong Wha Pharm. Ind. Co., Ltd. | Oral Preparation Having Improved Bioavailability |
CN103159620A (zh) * | 2013-03-28 | 2013-06-19 | 广西师范大学 | 一种2-羟基间苯二甲酸的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
ES2193202T3 (es) | 1994-12-02 | 2003-11-01 | Yamanouchi Pharma Co Ltd | Nuevo derivado de amidinonaftilo o sal de este. |
BR9612423B1 (pt) * | 1996-01-02 | 2010-11-30 | composto de n-[(amino-imino-metil ou amino-metil) fenil] propil amidas substituìdas, e, composição farmacêutica. | |
JP3565864B2 (ja) * | 1996-09-12 | 2004-09-15 | シエーリング アクチエンゲゼルシヤフト | 環式アミノ酸または環式ヒドロキシ酸誘導体により置換されたベンズアミジン誘導体および抗擬固薬としてのこれらの使用 |
TW542822B (en) * | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
US6399627B1 (en) * | 1999-02-11 | 2002-06-04 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US6350761B1 (en) * | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
DK1245564T3 (da) * | 1999-10-28 | 2006-08-14 | Sankyo Co | Benzamidinderivater |
-
2000
- 2000-10-25 DK DK00970070T patent/DK1245564T3/da active
- 2000-10-25 TR TR2002/01654T patent/TR200201654T2/xx unknown
- 2000-10-25 CA CA002389156A patent/CA2389156C/en not_active Expired - Fee Related
- 2000-10-25 MX MXPA02004218A patent/MXPA02004218A/es active IP Right Grant
- 2000-10-25 CN CNB008178003A patent/CN1293052C/zh not_active Expired - Fee Related
- 2000-10-25 KR KR1020027005382A patent/KR100642953B1/ko not_active IP Right Cessation
- 2000-10-25 AU AU79574/00A patent/AU776193B2/en not_active Ceased
- 2000-10-25 PL PL00354619A patent/PL354619A1/xx unknown
- 2000-10-25 CZ CZ20021432A patent/CZ20021432A3/cs unknown
- 2000-10-25 PT PT00970070T patent/PT1245564E/pt unknown
- 2000-10-25 CN CNA2004100634713A patent/CN1572882A/zh active Pending
- 2000-10-25 NZ NZ518581A patent/NZ518581A/en unknown
- 2000-10-25 BR BR0015120-3A patent/BR0015120A/pt not_active Application Discontinuation
- 2000-10-25 EP EP00970070A patent/EP1245564B1/en not_active Expired - Lifetime
- 2000-10-25 DE DE60027204T patent/DE60027204T2/de not_active Expired - Lifetime
- 2000-10-25 HU HU0203161A patent/HUP0203161A3/hu unknown
- 2000-10-25 ES ES00970070T patent/ES2261248T3/es not_active Expired - Lifetime
- 2000-10-25 IL IL14930600A patent/IL149306A0/xx active IP Right Grant
- 2000-10-25 AT AT00970070T patent/ATE322479T1/de not_active IP Right Cessation
- 2000-10-25 RU RU2002111343/04A patent/RU2222529C2/ru not_active IP Right Cessation
- 2000-10-25 WO PCT/JP2000/007469 patent/WO2001030756A1/ja active IP Right Grant
- 2000-10-27 TW TW089122706A patent/TWI226886B/zh not_active IP Right Cessation
-
2002
- 2002-04-23 IL IL149306A patent/IL149306A/en not_active IP Right Cessation
- 2002-04-24 ZA ZA200203278A patent/ZA200203278B/en unknown
- 2002-04-25 US US10/132,042 patent/US6555556B1/en not_active Expired - Fee Related
- 2002-04-26 NO NO20021990A patent/NO323147B1/no not_active IP Right Cessation
- 2002-11-06 US US10/288,838 patent/US20040010009A1/en not_active Abandoned
- 2002-12-05 HK HK02108844.9A patent/HK1047431B/zh not_active IP Right Cessation
-
2003
- 2003-11-07 US US10/704,355 patent/US20040248981A1/en not_active Abandoned
-
2006
- 2006-07-04 CY CY20061100927T patent/CY1106116T1/el unknown
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