CY1106113T1 - Παραγωγα 4-φαινυλ-πυριδινης ως ανταγωνιστες του υποδοχεα νευροκινινης-1 - Google Patents

Παραγωγα 4-φαινυλ-πυριδινης ως ανταγωνιστες του υποδοχεα νευροκινινης-1

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Publication number
CY1106113T1
CY1106113T1 CY20061100918T CY061100918T CY1106113T1 CY 1106113 T1 CY1106113 T1 CY 1106113T1 CY 20061100918 T CY20061100918 T CY 20061100918T CY 061100918 T CY061100918 T CY 061100918T CY 1106113 T1 CY1106113 T1 CY 1106113T1
Authority
CY
Cyprus
Prior art keywords
neurokinin
phenyl
receptor antagonists
pyridine derivatives
receptor
Prior art date
Application number
CY20061100918T
Other languages
English (en)
Inventor
Torsten Hoffmann
Patríck SCHNIDER
Heinz Stadler
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of CY1106113T1 publication Critical patent/CY1106113T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αναφέρεται σε ενώσεις των γενικών τύπων (ΙΑ) και (IB) στους οποίους R1 είναι (a), (b), (c), (d) ή είναι -NH(CH2)2OH, -NR3C(Ο)CH3 ή -NR3C(O)-κυκλοπροπύλιο, R2 είναι μεθύλιο ή χλώριο, R3 είναι υδρογόνο ή μεθύλιο, R είναι υδρογόνο ή -(CH2)2OH και n είναι 1 ή 2 και φαρμακευτικώς παραδεκτά άλατα δια προσθήκης οξέος αυτών. Αυτές οι ενώσεις έχουν μία καλή συγγένεια προς τον NK-1-υποδοχέα και ως εκ τούτου μπορούν να χρησιμοποιηθούν στην θεραπευτική αγωγή ή πρόληψη ασθενειών που σχετίζονται με αυτόν τον υποδοχέα.
CY20061100918T 2000-07-24 2006-07-04 Παραγωγα 4-φαινυλ-πυριδινης ως ανταγωνιστες του υποδοχεα νευροκινινης-1 CY1106113T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00115846 2000-07-24
PCT/EP2001/008432 WO2002008232A1 (en) 2000-07-24 2001-07-20 4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists
EP01960529A EP1305319B1 (en) 2000-07-24 2001-07-20 4-phenyl-pyridine derivatives as neurokinin-1 receptor antagonists

Publications (1)

Publication Number Publication Date
CY1106113T1 true CY1106113T1 (el) 2011-06-08

Family

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Family Applications (1)

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CY20061100918T CY1106113T1 (el) 2000-07-24 2006-07-04 Παραγωγα 4-φαινυλ-πυριδινης ως ανταγωνιστες του υποδοχεα νευροκινινης-1

Country Status (38)

Country Link
US (2) US6576762B2 (el)
EP (1) EP1305319B1 (el)
JP (1) JP4118673B2 (el)
KR (1) KR100527214B1 (el)
CN (1) CN1192032C (el)
AR (1) AR029875A1 (el)
AT (1) ATE322496T1 (el)
AU (2) AU2001282005B2 (el)
BR (1) BR0112695A (el)
CA (1) CA2416874C (el)
CY (1) CY1106113T1 (el)
CZ (1) CZ2003528A3 (el)
DE (1) DE60118569T2 (el)
DK (1) DK1305319T3 (el)
EC (1) ECSP034446A (el)
ES (1) ES2260265T3 (el)
GT (1) GT200100148A (el)
HK (1) HK1058360A1 (el)
HR (1) HRP20030031A2 (el)
HU (1) HU229231B1 (el)
IL (2) IL153837A0 (el)
JO (1) JO2321B1 (el)
MA (1) MA26933A1 (el)
MX (1) MXPA03000367A (el)
MY (1) MY129224A (el)
NO (1) NO20030353L (el)
NZ (1) NZ523452A (el)
PA (1) PA8522801A1 (el)
PE (1) PE20020258A1 (el)
PL (1) PL366173A1 (el)
PT (1) PT1305319E (el)
RU (1) RU2276139C2 (el)
SI (1) SI1305319T1 (el)
TW (1) TWI287003B (el)
UY (1) UY26851A1 (el)
WO (1) WO2002008232A1 (el)
YU (1) YU2803A (el)
ZA (1) ZA200300219B (el)

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US10538491B2 (en) 2015-03-16 2020-01-21 Vanderbilt University 4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators
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PA8522801A1 (es) 2002-09-30
NZ523452A (en) 2004-07-30
AU2001282005B2 (en) 2006-10-19
WO2002008232A1 (en) 2002-01-31
TWI287003B (en) 2007-09-21
HK1058360A1 (en) 2004-05-14
GT200100148A (es) 2002-05-16
DK1305319T3 (da) 2006-08-14
IL153837A (en) 2008-06-05
US20020038030A1 (en) 2002-03-28
MA26933A1 (fr) 2004-12-20
MY129224A (en) 2007-03-30
CN1444589A (zh) 2003-09-24
CN1192032C (zh) 2005-03-09
KR20030015898A (ko) 2003-02-25
EP1305319B1 (en) 2006-04-05
AU8200501A (en) 2002-02-05
CA2416874A1 (en) 2002-01-31
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HU229231B1 (en) 2013-09-30
UY26851A1 (es) 2002-01-31
US6624176B2 (en) 2003-09-23
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NO20030353D0 (no) 2003-01-23
HRP20030031A2 (en) 2004-02-29
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AR029875A1 (es) 2003-07-16
SI1305319T1 (sl) 2006-08-31
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CZ2003528A3 (cs) 2003-09-17
IL153837A0 (en) 2003-07-31
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