CY1105238T1 - Ιμιδαζολυλο-κυκλικες ακεταλες - Google Patents
Ιμιδαζολυλο-κυκλικες ακεταλεςInfo
- Publication number
- CY1105238T1 CY1105238T1 CY20061101365T CY061101365T CY1105238T1 CY 1105238 T1 CY1105238 T1 CY 1105238T1 CY 20061101365 T CY20061101365 T CY 20061101365T CY 061101365 T CY061101365 T CY 061101365T CY 1105238 T1 CY1105238 T1 CY 1105238T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ny1y2
- hydrogen
- optionally substituted
- heteroaryl
- group
- Prior art date
Links
- 150000001241 acetals Chemical class 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 azido, carboxy Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101150020251 NR13 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 abstract 1
- 239000002451 tumor necrosis factor inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Περιγράφονται ενώσεις του τύπου (I) όπου: το R1 είναι προαιρετικά υποκατεστημένο ετεροαρύλιο, το R2 είναι προαιρετικά υποκατεστημένο αρύλιο ή προαιρετικά υποκατεστημένο ετεροαρύλιο, το R3 είναι μια ομάδα -L1-R7 ή -L2-R8 [όπου το L1 είναι μια προαιρετικά υποκατεστημένη σύνδεση αλκυλενίου, το R7 είναι υδρογόνο, αρύλιο, κυανο-ομάδα, κυκλοαλκύλιο, ετεροαρύλιο, ετεροκυκλοαλκύλιο, νιτρο-ομάδα, -S(O)nR9, -NHSO2R9, -C(=Z)OR10, -C(=Z)R10, -N(R11)-C(=Z)R9, -NY1Y2, -S02-NY1Y2, -C(=Z)-NY1Y2, -N(R11)-C(=Z)-NY1Y2, Ν(OR10)-C(=Z)-ΝΥ1Υ2 -Ν(OR10)-C(=Ζ)R10, C(=NOR10)R10-C(=Z)NR100R12, -N(R11)-C(=NR13)-NY1Y2 ή -N(R11)-C(=Z)OR11, το L2 είναι ένας άμεσος δεσμός ή μια ευθεία ή διακλαδισμένη αλυσίδα άνθρακα που περιέχει από 2 έως περίπου 6 άτομα άνθρακα και περιέχει έναν διπλό ή τριπλό δεσμό άνθρακα-άνθρακα, και το R8 είναι υδρογόνο, αρύλιο, κυκλοαλκενύλιο, κυκλοαλκύλιο, ετεροαρύλιο ή ετεροκυκλοαλκύλιο], το R4 είναι μια ομάδα -L3-R14 [όπου το L3 είναι ένας άμεσος δεσμός ή μια προαιρετικά ποκατεστημένη σύνδεση αλκυλενίου, και ρο R14 είναι υδρογόνο, αλκύλιο, αζιδο-ομάδα, καρβοξύ (ή ένας βιοϊσοστερές οξέος) κυκλοαλκυλοξύ, ετεροαρύλιο, ετεροαρυλαλκυλοξύ, ετεροαρυλοξύ, ετεροκυκλοαλκύλιο, ετεροκυκλοαλκυλοξύ, νιτρο-ομάδα, -ΝΥ4Υ5, -N(R10)-C(=Z)-R15, -N(R10)-C(=Z)-L4-R16, -NH-C(=Z)-NH-R15, -NH-C(=Z)-NH-L4-R16,-N(R10)-S02-R15, -N(R10)-S02-L4-R16, -S(O)nR9, -C(=Z)-NY4Y5 ή -C(=Z)-OR9], το R5 είναι υδρογόνο, αλκύλιο ή υδροξυαλκύλιο ή τα R4 και R5, όταν είναι προσαρτημένα στο ίδιο άτομο άνθρακα, δύνανται να σχηματίζουν με το εν λόγω άτομο άνθρακα έναν δακτύλιο κυκλοαλκυλίου, κυκλοαλκενυλίου ή ετεροκυκλοαλκυλίου ή μια ομάδα C=CH2, το R6 σημαίνει υδρογόνο ή αλκύλιο, και το m είναι μηδέν ή ένας ακέραιος 1 ή 2, και Ν-οξείδια αυτών και τα εστερικά προφάρμακά τους, και φαρμακευτικώς ανεκτά άλατα και επιδιαλυτωμένα σύμπλοκα (π.χ. ένυδρα άλατα) των ενώσεων του τύπου (I) και Ν-οξείδια αυτών, και τα εστερικά προφάρμακά τους. Οι ενώσεις αποτελούν αναστολείς του TNF και είναι χρήσιμες ως φάρμακα.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9712270.9A GB9712270D0 (en) | 1997-06-12 | 1997-06-12 | Chemical compounds |
US5218597P | 1997-07-10 | 1997-07-10 | |
GBGB9724678.9A GB9724678D0 (en) | 1997-11-21 | 1997-11-21 | Chemical compounds |
US8549998P | 1998-05-14 | 1998-05-14 | |
PCT/GB1998/001711 WO1998056788A1 (en) | 1997-06-12 | 1998-06-12 | Imidazolyl-cyclic acetals |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105238T1 true CY1105238T1 (el) | 2010-03-03 |
Family
ID=27451664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101365T CY1105238T1 (el) | 1997-06-12 | 2006-09-21 | Ιμιδαζολυλο-κυκλικες ακεταλες |
Country Status (26)
Country | Link |
---|---|
US (2) | US6602877B1 (el) |
EP (1) | EP0988301B1 (el) |
JP (1) | JP4380803B2 (el) |
KR (1) | KR100704059B1 (el) |
CN (1) | CN100443481C (el) |
AT (1) | ATE335735T1 (el) |
AU (1) | AU742293B2 (el) |
BR (1) | BR9810007B1 (el) |
CA (1) | CA2293436C (el) |
CY (1) | CY1105238T1 (el) |
CZ (1) | CZ9904452A3 (el) |
DE (1) | DE69835518T2 (el) |
DK (1) | DK0988301T3 (el) |
ES (1) | ES2270520T3 (el) |
HK (1) | HK1032586A1 (el) |
HU (1) | HUP0003309A3 (el) |
IL (2) | IL133311A0 (el) |
NO (1) | NO326660B1 (el) |
NZ (1) | NZ501714A (el) |
PL (1) | PL199893B1 (el) |
PT (1) | PT988301E (el) |
RU (1) | RU2221795C2 (el) |
SK (2) | SK171099A3 (el) |
TR (1) | TR199903098T2 (el) |
TW (1) | TWI235751B (el) |
WO (1) | WO1998056788A1 (el) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
CA2341370A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
DE69933680T2 (de) | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
ATE336484T1 (de) | 1998-08-29 | 2006-09-15 | Astrazeneca Ab | Pyrimidine verbindungen |
DE69903976T2 (de) * | 1998-12-16 | 2003-07-24 | Aventis Pharma Ltd | Heteroaryl-zyklische acetale |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
US6291457B1 (en) | 1999-07-01 | 2001-09-18 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
MXPA02005106A (es) | 1999-11-22 | 2002-11-07 | Smithkline Beecham Plc | Compuestos novedosos. |
DE60015599T2 (de) | 1999-11-23 | 2005-11-03 | Smithkline Beecham Corp. | 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN |
US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0100762D0 (en) * | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
US7199124B2 (en) | 2001-02-02 | 2007-04-03 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0112348D0 (en) * | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
JP4212470B2 (ja) | 2001-06-26 | 2009-01-21 | アムジェン フレモント インク. | Opglへの抗体 |
EP1432703A1 (en) * | 2001-09-05 | 2004-06-30 | Smithkline Beecham Plc | Heterocycle-carboxamide derivatives as raf kinase inhibitors |
GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
WO2003076434A1 (en) | 2002-03-09 | 2003-09-18 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
TWI317286B (en) | 2003-12-31 | 2009-11-21 | Targeting delivery system | |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1934213A1 (en) | 2005-09-30 | 2008-06-25 | Astra Zeneca AB | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
CA2625668A1 (en) * | 2005-10-24 | 2007-05-03 | Peter John Harrington | Preparation of cyclic, ketalized ketones by favorskii rearrangement and the use thereof for the preparation of glucokinase activator 70 |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
RU2011151603A (ru) * | 2009-05-19 | 2013-06-27 | ДАУ АГРОСАЙЕНСИЗ ЭлЭсСи | Соединения и способы борьбы с грибами |
CN111356687B (zh) * | 2019-03-27 | 2021-03-30 | 广州必贝特医药技术有限公司 | 含嘧啶的三取代咪唑类化合物及其应用 |
KR20220151635A (ko) | 2020-03-11 | 2022-11-15 | 에보텍 인터내셔널 게엠베하 | 통합 스트레스 반응 경로의 조절제 |
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1998
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- 1998-06-12 KR KR1019997011695A patent/KR100704059B1/ko not_active IP Right Cessation
- 1998-06-12 DE DE69835518T patent/DE69835518T2/de not_active Expired - Lifetime
- 1998-06-12 AU AU79259/98A patent/AU742293B2/en not_active Ceased
- 1998-06-12 TR TR1999/03098T patent/TR199903098T2/xx unknown
- 1998-06-12 CN CNB988079119A patent/CN100443481C/zh not_active Expired - Fee Related
- 1998-06-12 SK SK1710-99A patent/SK171099A3/sk unknown
- 1998-06-12 HU HU0003309A patent/HUP0003309A3/hu unknown
- 1998-06-12 BR BRPI9810007-6A patent/BR9810007B1/pt not_active IP Right Cessation
- 1998-06-12 SK SK3-2009A patent/SK286940B6/sk not_active IP Right Cessation
- 1998-06-12 PL PL337314A patent/PL199893B1/pl not_active IP Right Cessation
- 1998-06-12 ES ES98929548T patent/ES2270520T3/es not_active Expired - Lifetime
- 1998-06-12 AT AT98929548T patent/ATE335735T1/de active
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- 1998-06-12 IL IL13331198A patent/IL133311A0/xx active IP Right Grant
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- 1998-06-12 DK DK98929548T patent/DK0988301T3/da active
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- 1998-06-12 WO PCT/GB1998/001711 patent/WO1998056788A1/en active Application Filing
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1999
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2001
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