CU24512B1 - Derivados de oxopiridina sustituidos - Google Patents

Derivados de oxopiridina sustituidos

Info

Publication number
CU24512B1
CU24512B1 CU2018000001A CU20180001A CU24512B1 CU 24512 B1 CU24512 B1 CU 24512B1 CU 2018000001 A CU2018000001 A CU 2018000001A CU 20180001 A CU20180001 A CU 20180001A CU 24512 B1 CU24512 B1 CU 24512B1
Authority
CU
Cuba
Prior art keywords
formula
substitute
oxopyridine derivatives
derivatives
humans
Prior art date
Application number
CU2018000001A
Other languages
English (en)
Other versions
CU20180001A7 (es
Inventor
Dr Jens Ackerstaff
Dr Pascal Ellerbrock
Stefan Heitmeier
Prof Dr Alexander Hillisch
Nuñez Dr Eloisa Jimenez
Dr Dieter Lang
Dr Daniel Meibom
Dr Katharina Meier
Dr Susanne Röhrig
Dr Jan Stampfuss
Dr Adrian Tersteegen
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CU20180001A7 publication Critical patent/CU20180001A7/es
Publication of CU24512B1 publication Critical patent/CU24512B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

<p>La invención se refiere a derivados de oxopiridina sustituidos de fórmula (I)</p> <p>ESPACIO PARA FÓRMULA (I)</p> <p>los cuales se presentan como inhibidores del factor XIa altamente potentes con un comportamiento farmacocinético significativamente potenciado, en particular una mayor exposición de dicho compuesto en la sangre por encima de la concentración eficaz mínima dentro de un intervalo de dosificación dado. Estos compuestos son útiles para el tratamiento de trastornos cardiovasculares, en particular de trastornos trombóticos o tromboembólicos, en humanos y animales.</p>
CU2018000001A 2015-07-09 2016-07-05 Derivados de oxopiridina sustituidos CU24512B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15176099 2015-07-09
EP16157350 2016-02-25
PCT/EP2016/065787 WO2017005725A1 (en) 2015-07-09 2016-07-05 Substituted oxopyridine derivatives

Publications (2)

Publication Number Publication Date
CU20180001A7 CU20180001A7 (es) 2018-06-05
CU24512B1 true CU24512B1 (es) 2021-05-12

Family

ID=56345141

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2018000001A CU24512B1 (es) 2015-07-09 2016-07-05 Derivados de oxopiridina sustituidos

Country Status (39)

Country Link
US (4) US10421742B2 (es)
EP (1) EP3319956B1 (es)
JP (1) JP6871180B2 (es)
KR (1) KR102596164B1 (es)
CN (2) CN108026072B (es)
AU (1) AU2016289746B2 (es)
CA (1) CA2990901C (es)
CL (1) CL2018000039A1 (es)
CO (1) CO2018000113A2 (es)
CR (1) CR20180017A (es)
CU (1) CU24512B1 (es)
CY (1) CY1123996T1 (es)
DK (1) DK3319956T3 (es)
DO (1) DOP2018000004A (es)
EA (1) EA036208B1 (es)
EC (1) ECSP18001308A (es)
ES (1) ES2856554T3 (es)
GE (2) GEAP201914692A (es)
HR (1) HRP20210459T1 (es)
HU (1) HUE053552T2 (es)
IL (1) IL256556B (es)
JO (1) JO3703B1 (es)
LT (1) LT3319956T (es)
MA (1) MA42376B1 (es)
MX (1) MX377903B (es)
MY (1) MY196640A (es)
NI (1) NI201800001A (es)
PE (1) PE20180538A1 (es)
PH (1) PH12018500057A1 (es)
PL (1) PL3319956T3 (es)
RS (1) RS61584B1 (es)
SI (1) SI3319956T1 (es)
SV (1) SV2018005610A (es)
TN (1) TN2018000011A1 (es)
TW (1) TWI717367B (es)
UA (1) UA122341C2 (es)
UY (1) UY36780A (es)
WO (1) WO2017005725A1 (es)
ZA (1) ZA201800826B (es)

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EP3197896B1 (de) * 2014-09-24 2019-01-30 Bayer Pharma Aktiengesellschaft Substituierte oxopyridin-derivate
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JO3703B1 (ar) * 2015-07-09 2021-01-31 Bayer Pharma AG مشتقات أوكسوبيريدين مستبدلة
HUE057289T2 (hu) 2016-08-31 2022-05-28 Jiangsu Hengrui Medicine Co Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása
RS63338B1 (sr) * 2018-03-15 2022-07-29 Bayer Ag Proces pripreme dva derivata 4-{[(2s)-2-{4-[5-hloro-2-(1h-1,2,3-triazol-1-il)fenil]-5-metoksi-2-oksopiridin-1(2h)-il}butanoil]amino}-2-fluorobenzamida
IL277811B2 (en) 2018-04-10 2023-12-01 Bayer Pharma AG A consequence of oxopyridine is transformed
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AR115870A1 (es) 2018-07-31 2021-03-10 Sumitomo Chemical Co MÉTODO PARA CONTROLAR EL HONGO DE LA ROYA DE LA SOJA QUE TIENE RESISTENCIA AL INHIBIDOR DE SITIO Qₒ
KR20210105939A (ko) * 2018-12-17 2021-08-27 바이엘 악티엔게젤샤프트 혈전성 또는 혈전색전성 장애 및/또는 혈전성 또는 혈전색전성 합병증의 치료 및/또는 예방을 위한 치환된 옥소피리딘 유도체
PE20211790A1 (es) 2018-12-21 2021-09-09 Bayer Ag Derivados de oxopiridina sustituidos
US20220144848A1 (en) 2018-12-21 2022-05-12 Bayer Aktiengesellschaft Substituted oxopyridine derivatives
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CN114621140B (zh) * 2020-12-10 2023-08-11 中国科学院上海药物研究所 芳基二氟乙酰胺化合物及其制备方法和用途
MX2023010614A (es) 2021-03-09 2023-09-19 Bayer Ag Formas cristalinas de (4s)-24-cloro-4-etil-7?-fluoro-35-metoxi-3?, 5-dioxo-14-(trifluoro-metil)-3?h-6-aza-3(4,1)-piridina-1(1)-[1,2, 3]triazola-2(1,2),7(1)-dibencenaheptafano-74-carboxamida.
MX2023010629A (es) 2021-03-09 2023-09-19 Bayer Ag Formas de dosificacion farmaceuticas que comprenden (4s)-24-cloro-4-etil-7?-fluoro-35-metoxi-3?,5-dioxo-14-(trifluoro metil)-3?h-6-aza-3(4,1)-piridina-1(1)-[1,2,3]triazola-2(1,2),7(1) -dibencenaheptafano-74-carboxamida.
WO2022189280A1 (en) 2021-03-09 2022-09-15 Bayer Aktiengesellschaft Solvates of (4s)-24-chloro-4-ethyl-73-fluoro-35-methoxy-32,5-dioxo-14-(trifluoro-methyl)-32 h-6- aza-3(4,1)-pyridina-1(1)-[1,2,3]triazola-2(1,2),7(1)-dibenzenaheptaphane-74-carboxamide
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
CN113666826B (zh) * 2021-07-30 2024-03-26 五邑大学 一种芳基或杂芳基甲氧基化反应的方法
CN116199672A (zh) * 2021-11-30 2023-06-02 成都泰和伟业生物科技有限公司 一种嘧啶酰胺类衍生物及其制备方法和用途
WO2023174399A1 (zh) * 2022-03-18 2023-09-21 苏州晶云药物科技股份有限公司 取代的氧代吡啶类衍生物的晶型及其制备方法
CN116262734B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 氧代吡啶类化合物及其制备方法和用途
CN116262735B (zh) * 2022-11-18 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116262740A (zh) * 2022-11-18 2023-06-16 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
CN116082303B (zh) 2022-12-21 2025-02-25 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其中间体和应用
CN116262736B (zh) * 2022-12-26 2025-05-13 成都施贝康生物医药科技有限公司 新型氧代吡啶类化合物及其制备方法和用途
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CN116621742B (zh) * 2023-06-09 2025-05-06 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
KR20260021743A (ko) 2023-06-09 2026-02-13 청두 시베이캉 바이오메디칼 테크놀로지 컴퍼니 리미티드 옥소피리딘 화합물의 신규 제조방법, 핵심 중간체 및 그 용도
CN116535392B (zh) * 2023-06-26 2023-09-05 成都施贝康生物医药科技有限公司 一种氧代吡啶类化合物的制备方法及中间体和应用
CN116751136B (zh) * 2023-06-21 2025-08-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116621728B (zh) * 2023-06-09 2025-07-29 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116730861A (zh) * 2023-06-21 2023-09-12 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN116874387B (zh) * 2023-06-21 2025-08-26 成都施贝康生物医药科技有限公司 氧代吡啶类化合物的新型制备方法及关键中间体
CN119894901A (zh) 2023-06-30 2025-04-25 深圳信立泰药业股份有限公司 一种多取代的大环化合物及其制备方法与应用
CN117164563B (zh) * 2023-09-07 2025-06-10 成都施贝康生物医药科技有限公司 氧代嘧啶类化合物及其制备方法和用途
CN117164562B (zh) * 2023-09-07 2025-06-13 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
CN117164565B (zh) * 2023-09-07 2025-05-27 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164561A (zh) * 2023-09-07 2023-12-05 成都施贝康生物医药科技有限公司 一种氧代嘧啶类化合物及其制备方法和用途
CN117164566B (zh) * 2023-09-07 2025-06-06 成都施贝康生物医药科技有限公司 一种氧代哒嗪类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
SV2018005610A (es) 2018-04-27
WO2017005725A1 (en) 2017-01-12
NZ739109A (en) 2024-09-27
AU2016289746B2 (en) 2020-08-20
UA122341C2 (uk) 2020-10-26
HUE053552T2 (hu) 2021-07-28
KR102596164B1 (ko) 2023-11-01
PH12018500057A1 (en) 2018-07-09
IL256556A (en) 2018-02-28
TN2018000011A1 (en) 2019-07-08
CN113292539B (zh) 2023-12-22
CA2990901C (en) 2024-11-12
CA2990901A1 (en) 2017-01-12
TWI717367B (zh) 2021-02-01
EP3319956A1 (en) 2018-05-16
MA42376A (fr) 2018-05-16
TW201706261A (zh) 2017-02-16
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NI201800001A (es) 2018-10-19
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CO2018000113A2 (es) 2018-06-12
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US20190367478A1 (en) 2019-12-05
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US20250282748A1 (en) 2025-09-11
RS61584B1 (sr) 2021-04-29
CL2018000039A1 (es) 2018-07-13
AU2016289746A1 (en) 2018-01-25
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US10421742B2 (en) 2019-09-24
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MY196640A (en) 2023-04-25
BR112018000209A2 (pt) 2018-09-04
US20230024752A1 (en) 2023-01-26
EA036208B1 (ru) 2020-10-14
MX377903B (es) 2025-03-10
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US20180194745A1 (en) 2018-07-12
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