CU23842B1 - Derivados de n5-(2-etoxi-etil)-n3-(2-piridinil)-3,5-piperidin-dicarboxamida - Google Patents

Derivados de n5-(2-etoxi-etil)-n3-(2-piridinil)-3,5-piperidin-dicarboxamida

Info

Publication number
CU23842B1
CU23842B1 CU2009000226A CU20090226A CU23842B1 CU 23842 B1 CU23842 B1 CU 23842B1 CU 2009000226 A CU2009000226 A CU 2009000226A CU 20090226 A CU20090226 A CU 20090226A CU 23842 B1 CU23842 B1 CU 23842B1
Authority
CU
Cuba
Prior art keywords
compound
treatment
class
dicarboxamida
piridinil
Prior art date
Application number
CU2009000226A
Other languages
English (en)
Other versions
CU20090226A7 (es
Inventor
Takeru Ehara
Yuko Hitomi
Osamu Irie
Shimpei Kawakami
Masaki Susuki
Atsushi Toyao
Fumiaki Yokokawa
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39926743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23842(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20090226A7 publication Critical patent/CU20090226A7/es
Publication of CU23842B1 publication Critical patent/CU23842B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente invención se refiere a un compuesto de la fórmula I: ESPACIO PARA LA FÓRMULA en donde R1, R2, R3, R4 y R5 son como se definen en la memoria descriptiva, para utilizarse en el diagnóstico y el tratamiento terapéutico de un animal de sangre caliente, en especial para el tratamiento de una enfermedad (= trastorno) que dependa de la actividad de la renina; al uso de un compuesto de esta clase para la preparación de una formulación farmacéutica para el tratamiento de una enfermedad que dependa de la actividad de la renina; al uso de un compuesto de esta clase en el tratamiento de una enfermedad que dependa de la actividad de la renina; a formulaciones farmacéuticas de un compuesto de esta clase; a un método de tratamiento, el cual comprende administrar un compuesto de esta clase, y a un método para su fabricación.
CU2009000226A 2007-06-25 2009-12-22 Derivados de n5-(2-etoxi-etil)-n3-(2-piridinil)-3,5-piperidin-dicarboxamida CU23842B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07012412 2007-06-25
EP07111290 2007-06-28
PCT/EP2008/057964 WO2009000811A1 (en) 2007-06-25 2008-06-23 N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors

Publications (2)

Publication Number Publication Date
CU20090226A7 CU20090226A7 (es) 2012-02-15
CU23842B1 true CU23842B1 (es) 2012-10-15

Family

ID=39926743

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2009000226A CU23842B1 (es) 2007-06-25 2009-12-22 Derivados de n5-(2-etoxi-etil)-n3-(2-piridinil)-3,5-piperidin-dicarboxamida

Country Status (26)

Country Link
US (2) US8383650B2 (es)
EP (2) EP2181105B1 (es)
JP (1) JP5086433B2 (es)
KR (1) KR101238479B1 (es)
CN (1) CN101687847B (es)
AR (1) AR067132A1 (es)
AU (1) AU2008267287B2 (es)
BR (1) BRPI0813900A2 (es)
CA (1) CA2689109A1 (es)
CL (1) CL2008001872A1 (es)
CO (1) CO6251267A2 (es)
CR (1) CR11153A (es)
CU (1) CU23842B1 (es)
EA (1) EA016446B1 (es)
EC (1) ECSP099825A (es)
ES (2) ES2541107T3 (es)
GT (1) GT200900324A (es)
HN (1) HN2009003463A (es)
IL (1) IL202494A0 (es)
MA (1) MA31538B1 (es)
NZ (1) NZ582098A (es)
PE (1) PE20090425A1 (es)
SG (1) SG182223A1 (es)
TN (1) TN2009000530A1 (es)
TW (1) TWI404714B (es)
WO (1) WO2009000811A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2541107T3 (es) 2007-06-25 2015-07-16 Novartis Ag Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina
US20180048921A1 (en) * 2016-08-12 2018-02-15 Microsoft Technology Licensing, Llc Real-time playback diagnostics

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2129679C (en) 1991-12-18 2000-05-09 Neng-Yang Shih Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring
IL111176A0 (en) 1993-10-07 1994-12-29 Du Pont Merck Pharma Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
NZ315677A (en) 1995-09-07 2000-02-28 F 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
CA2238081A1 (en) 1995-11-22 1997-05-29 S. Jane Desolms Inhibitors of farnesyl-protein transferase
JP2001526178A (ja) 1997-08-28 2001-12-18 メルク エンド カムパニー インコーポレーテッド ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤
EP1087937A1 (en) 1998-06-17 2001-04-04 Du Pont Pharmaceuticals Company Cyclic hydroxamic acids as metalloproteinase inhibitors
US6274735B1 (en) 1998-08-10 2001-08-14 Hoffmann-La Roche Inc. Process and intermediates for preparation of substituted piperidines
US6610692B1 (en) 1998-10-30 2003-08-26 Merck & Co., Inc. Thrombin inhibitors
AU3389300A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AU3386700A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
US6362201B1 (en) 1999-03-02 2002-03-26 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
WO2000063173A1 (en) 1999-04-14 2000-10-26 F. Hoffmann-La Roche Ag Process for the preparation of substituted piperidines
US6197959B1 (en) 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
US6376672B1 (en) 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
BR0109467A (pt) 2000-03-17 2003-06-03 Bristol Myers Squibb Pharma Co Composto derivados de (beta)-aminoácidos cìclicos, composição farmacêutica, método de tratamento de condições ou doenças mediadas por mps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso de composto
FR2811673B1 (fr) 2000-07-17 2002-09-13 Rhodia Chimie Sa Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes
EP1326619A2 (en) 2000-10-11 2003-07-16 Merck & Co., Inc. Pyrrolidine modulators of ccr5 chemokine receptor activity
WO2002076440A2 (en) 2001-03-23 2002-10-03 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease with piperidin derivates
EP1389194A2 (en) 2001-04-27 2004-02-18 Vertex Pharmaceuticals Incorporated Inhibitors of bace
WO2003024899A2 (en) 2001-09-17 2003-03-27 Bristol-Myers Squibb Company CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
CA2483241C (en) 2002-04-29 2011-05-31 Actelion Pharmaceuticals Ltd Novel diazabicyclononene derivatives
ES2315568T3 (es) 2002-05-20 2009-04-01 Bristol-Myers Squibb Company Inhibidores del virus de la hepatitis c basados en cicloalquilo p1' sustituido.
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
US20040214832A1 (en) 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
US20040204455A1 (en) 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
US20060217371A1 (en) 2003-04-28 2006-09-28 Olivier Bezencon Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors
AU2004234039A1 (en) 2003-04-29 2004-11-11 Actelion Pharmaceuticals Ltd Novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives
US20060205768A1 (en) 2003-04-30 2006-09-14 Olivier Bezencon Tropane derivatives and their use as ace inhibitors
EP1622685A1 (en) 2003-04-30 2006-02-08 Actelion Pharmaceuticals Ltd. 9-azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors
JP2006524654A (ja) 2003-04-30 2006-11-02 アクテリオン　ファマシューティカルズ　リミテッド 新規アザビシクロノネン誘導体
KR20060015573A (ko) 2003-05-02 2006-02-17 액테리온 파마슈티칼 리미티드 신규한 디아자비시클로노넨 유도체
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
WO2005040120A1 (en) 2003-10-09 2005-05-06 Actelion Pharmaceuticals Ltd Tetrahydropyridine derivatives
RU2374228C2 (ru) 2003-11-26 2009-11-27 Новартис Аг Производные 4-фенилпиперидина в качестве ингибиторов ренина
US7582782B2 (en) 2003-11-26 2009-09-01 Novartis Ag Organic compounds
WO2005070871A2 (en) 2004-01-23 2005-08-04 Speedel Experimenta Ag Amino alcohol derivatives and their activity as renin inhibitors
DE602005022060D1 (de) 2004-01-23 2010-08-12 Novartis Ag Diaminoalkohole und deren verwendung als renininhibitoren
JP2007518777A (ja) 2004-01-23 2007-07-12 シュペーデル・エクスペリメンタ・アーゲー アミノアルコール誘導体およびレニン阻害剤としてのその使用
TW200609215A (en) 2004-03-19 2006-03-16 Speedel Experimenta Ag Organic compounds
DE602005012481D1 (de) 2004-03-19 2009-03-12 Speedel Experimenta Ag 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck
AR053406A1 (es) 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
TW200631929A (en) 2004-12-10 2006-09-16 Speedel Experimenta Ag ω -phenyloctanamides
GB0428250D0 (en) 2004-12-23 2005-01-26 Novartis Ag Organic compounds
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0504850D0 (en) 2005-03-09 2005-04-13 Novartis Ag Organic compounds
JP2008532983A (ja) 2005-03-11 2008-08-21 シュペーデル・エクスペリメンタ・アーゲー レニン阻害剤として有用な複素環置換アルカンアミド
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
TW200722424A (en) 2005-03-31 2007-06-16 Speedel Experimenta Ag Substituted piperidines
BRPI0609534A2 (pt) 2005-03-31 2010-04-13 Speedel Experimenta Ag piperidinas 3,4,5-substituìdas
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
GB0510810D0 (en) 2005-05-26 2005-06-29 Novartis Ag Organic compounds
GB0511063D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
EP1937248B1 (en) 2005-09-17 2010-06-02 Novartis Ag Alcanoic acid amides substituted by saturated o-heterocycles
CA2622082A1 (en) 2005-09-17 2007-03-22 Speedel Experimenta Ag 5-amino-4-hydroxy-7- (imidazo [1,2-a] pyridin-6- ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension
PE20071079A1 (es) * 2005-11-15 2007-12-16 Cytokinetics Inc Compuestos de piperidina como inhibidores de la proliferacion celular
ES2430139T3 (es) * 2005-12-30 2013-11-19 Novartis Ag Compuestos de piperidina 3,5-sustituido como inhibidores de renina
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
JP2009525304A (ja) 2006-01-30 2009-07-09 シュペーデル・エクスペリメンタ・アーゲー α，β−不飽和化合物からのアルコールの立体選択的製造方法
BRPI0712430A2 (pt) 2006-06-08 2012-07-03 Speedel Experimenta Ag piperidinas 2,5-di-substitìdas.
GB0611696D0 (en) 2006-06-13 2006-07-26 Novartis Ag Organic compounds
GB0611697D0 (en) 2006-06-13 2006-07-26 Novartis Ag Organic compounds
TW200831463A (en) 2006-09-12 2008-08-01 Speedel Experimenta Ag Nitrate esters of aminoalcohols
EP1908471A1 (en) 2006-10-04 2008-04-09 Speedel Experimenta AG Tetrahydropyridines as renin inhibitors
EP1921069A1 (de) 2006-11-08 2008-05-14 Speedel Experimenta AG Verfahren zur Herstellung von 2-Alkyl-3-heterocyclyl-prop-2-en-1-olen
WO2008113835A1 (en) 2007-03-21 2008-09-25 Novartis Ag Process for preparing (r or s)-5-{1-azido-3-[6-methoxy-5-(3-methoxy-propoxy)-pyridin-3-ylmethyl]-4-methyl-pentyl}-3-alkyl-dihydro-furan-2-one
ES2541107T3 (es) 2007-06-25 2015-07-16 Novartis Ag Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina

Also Published As

Publication number Publication date
CR11153A (es) 2010-01-21
EP2527338A1 (en) 2012-11-28
SG182223A1 (en) 2012-07-30
ES2543641T3 (es) 2015-08-20
EP2181105A1 (en) 2010-05-05
WO2009000811A1 (en) 2008-12-31
HN2009003463A (es) 2012-12-10
KR20100023003A (ko) 2010-03-03
US8497286B2 (en) 2013-07-30
EA201000037A1 (ru) 2010-06-30
CO6251267A2 (es) 2011-02-21
NZ582098A (en) 2012-03-30
TW200911782A (en) 2009-03-16
ECSP099825A (es) 2010-01-29
CU20090226A7 (es) 2012-02-15
EA016446B1 (ru) 2012-05-30
TWI404714B (zh) 2013-08-11
CN101687847B (zh) 2013-11-06
US20130005770A1 (en) 2013-01-03
US8383650B2 (en) 2013-02-26
CL2008001872A1 (es) 2009-02-20
KR101238479B1 (ko) 2013-03-04
EP2527338B1 (en) 2015-05-06
MA31538B1 (fr) 2010-07-01
US20080319018A1 (en) 2008-12-25
GT200900324A (es) 2011-11-03
EP2181105B1 (en) 2015-04-29
AR067132A1 (es) 2009-09-30
PE20090425A1 (es) 2009-05-12
BRPI0813900A2 (pt) 2014-12-30
ES2541107T3 (es) 2015-07-16
JP2010531328A (ja) 2010-09-24
AU2008267287B2 (en) 2012-02-16
CA2689109A1 (en) 2008-12-31
TN2009000530A1 (en) 2011-03-31
IL202494A0 (en) 2010-06-30
JP5086433B2 (ja) 2012-11-28
AU2008267287A1 (en) 2008-12-31
CN101687847A (zh) 2010-03-31

Similar Documents

Publication Publication Date Title
ECSP088587A (es) Compuestos de piperidina 3,5-sustituida como inhibidores de renina
ECSP11011113A (es) Piridiloxi-indoles inhibidores del vegf-r2 y uso de los mismos para el tratamiento de enfermedades
MX2007011009A (es) Compuestos de piperidina 3,4,5-substituidos.
UY29562A1 (es) Compuestos heterocíclicos de amino benzoilo, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones
CO6300957A2 (es) Derivados de imidazo -[1,2,b]-piridazina para el tratamiento de enfermedad mediada por cinasa de tirosina c-met
CU20110221A7 (es) Derivados de 1h-imidazo-[4,5-c]-quinolinona
GT200500359A (es) Compuestos organicos
BRPI0519443A2 (pt) composto orgÂnicos
ECSP099409A (es) Derivados de sulfonil-fenil-2h-[1,2,4]oxadiazol-5-ona, procedimientos para su preparación y su uso como agentes farmacéuticos
CR9749A (es) Derivados de xantina como agonistas de hm74a selectivos
CL2007003289A1 (es) Compuestos derivados de biciclocarboxiamida; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de enfermedades provocadas por la hiperactivacion del receptor vc1 como dolor, enfermedad de vejiga, inflam
UY30419A1 (es) Nuevos benzoxazoles heteroaril sustituidos
ECSP10010694A (es) DERIVADOS DE BENZOXAZINONA QUE ACTÚAN COMO AGONISTAS DE RECEPTORES ADRENÉRGICOS ß2 PARA EL TRATAMIENTO DE TRASTORNOS RESPIRATORIOS
GT200500328A (es) Sal l-tartrato de n-1-adamantil-2-{3-[(2r)-2-({(2r)-2-hidroxi-2[4-hidroxi-3-(hidroximetil)fenil]etil}amino)propil]fenil}acetamida.
CU20120081A7 (es) Nuevas formas polimorfas de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo
WO2010051196A8 (en) Novel substituted azabenzoxazoles
CU20090226A7 (es) Derivados de n5-(2-etoxi-etil)-n3-(2-piridinil)-3,5-piperidin-dicarboxamida
CO6290762A2 (es) Nuevos derivados quinazolin-2, 4-diona y una composicion farmaceutica para prevenir a tratar la enfermedad neurocerebral
WO2009114136A3 (en) Fenretinide derivatives and uses thereof as therapeutic, diagnostic and imaging agents
BRPI0606750A2 (pt) composto ou um sal farmaceuticamente aceitável do mesmo, e,composição farmacêutica
UY29832A1 (es) Derivados de 2-aminotiazoles y 2-aminooxazoles, procesos para su preparación y su uso como compuestos farmacéuticos.
WO2007144129A3 (en) Pyrrolidine derivatives useful against diseases that depends on activity of renin
UA99461C2 (en) N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
ECSP066772A (es) Compuestos de pirazolina sustituidos para reducir trigliceridos en la sangre
UY28208A1 (es) Derivados cicloalquilo que tienen grupos acido carboxilico bioisostéricos, procesos para su preparación y su uso como composiciones farmaceuticas.

Legal Events

Date Code Title Description
FG Grant of patent
FD Lapse (for not paying fees)